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17/12/2018

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  • -  2 1 . .  : Metformin (Glucophage, Glucomin)
  • -  . : Glibenclamide (Gluben, Glibetic) - Glipizide (Gluco-rite)
  • -  , . : Repaglinide (Novonorm)
  • -  . : Rosiglitazone (Avandia, Rossini)
  • -  . 2. : Acarbose (Prandase)
  • -  .   ( - ). .  . -2 :  DPP4 - ,  Sitagliptin (Januvia), . DPP4 .  GLP1 -   .  Exenatide (Byetta) Liraglutide (Victoza)   , .
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' (Panax quinquefolium) - , , , . , ' "" (LDL) . ' .

' (Panax ginseng) –  , , , , . , ' . ' .

/ (Trigonella foenum graecum) -  ( )  , .

(Momordica charantia) -  ,   ,  , , .  .

(Ganoderma lucidum) – , , , . , (, , ). .

(Withania somnifera) – , , , . , , -LDL, -VLDL , , , -HDL.

(Astragalus membranaceus) – , , , . .

(Schisandra chinensis) - , , , - . .

(Stevia rebaudiana)   .

(Curcuma longa) - , , . 
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(Allium sativum) –  , , , .

(Ocimum sanctum)   , .

(Silybum marianum–  , . , (, ). , , ( ), ( ). : , . .

(Olea europaea)   . . . , .

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, .   (Allium sativum),  (Crataegus spp),  (Calendula officinalis),  (Ginkgo biloba), / ' ' (Camellia sinensis), (Aesculus hippocastanum.

 

:

  1.  Allium sativum, Cinnamomum zeylanicum, Galega officinalis, Ganoderma lucidum, Gymnema sylvestre, Momordica charantia, Olea europaeaRehmannia glutinosa, Stevia rebaudiana, Trigonella foenum graecum
  2.  Astragalus membranaceus, Glycyrrhiza glabra, Withania somnifera, Codonopsis pilosula, Eleutherococcus senticosus, Panax ginseng, Panax quinquefolium, Ganoderma lucidum, Centella asiatica, Schisandra chinensis, Atractylodes macrocephala, Lepidium meyenii, Rhodiola rosea
  3.  Ganoderma lucidum, Curcuma longa, Camellia sinensis, Crataegus spp, Ginkgo biloba, Salvia miltiorrhiza

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30% Gymnema sylvestre
30% Ganoderma lucidum
25% Olea europaea
15% Rehmania glutinosa

: 5-10 ", 3

 

, , (, , '):

 

30% Eleutherococcus senticosus
30% Gymnema sylvestre
25% Cinnamomum zeylanicum
15% Rehmania glutinosa

: 5-10 ", 3  

 

, , :

 

120mg Gymnema sylvestre
120mg Trigonella foenum graecum
110mg Panax quinquefolium
50mcg Chromium

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, :
(Myristica fragrans) .
(Capsicum frutescens) , . 
(Elettaria cardamomum ) .

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, , (Myristica fragrans), (Rosmarinus officinalis), (Thymus vulgaris ct thymol), '' (Zingiber officinalis), (Vanilla plaifolia), (Citrus paradise), (Citrus bergamia), (Citrus aurantium sinensis), (Citrus limonum).
, '' (Zingiber officinalis), (Litsea cubeba), (Origanum marjorana), (Melaleuca viridiflora) (Foeniculum vulgare).
, ' (Juniperus communis), (Cupressus semperirens), (Pinus sylvestris), (Helichrysum Italicum) (Rosa damascene).
, (Chamamelum nobilis), (Helichrysum Italicum), (Citrus paradise), (Citrus bergamia), (Mentha piperita), (Rosmarinus officinalis), (Thymus vulgaris ct thymol).


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- " 500
 
(Thymus vulgaris ct thymol) 20 
(Capsicum frutescens) 5
(Rosmarinus officinalis) 10


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 (2018) - 12 - 2. 137 , :

  • 500-600 , . 
  • 1,200-1,500 .

, 97 . 

HbA1c(0.5% 0.3%, ), (5 " 6.8 ", ), (1.3 " 2.8 "), . , , . 

2. 

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2688344

( 2014)    2.

,     .

, , , , , , .

, -, , - , .

http://www.ncbi.nlm.nih.gov/pubmed/24910231

 (2018) 2. , 46% . 6 . 

- 64 -26 . , , (-16% -3%) . , . , 2, . , 2.  

https://www.ncbi.nlm.nih.gov/pubmed/30078554

, .

( 2014), -   .

304 1950 2013 ,  .

, , ,   .

, 2, , ,  , , , 2.

http://www.ncbi.nlm.nih.gov/pubmed/25406801

( 2013) - 20 3,000 .   , 2. -, , .

http://www.ncbi.nlm.nih.gov/pubmed/23364002?dopt=Abstract

( 2013) .   , ,  .

-  -, , ,  DASH  , .

. , .

http://care.diabetesjournals.org/content/early/2013/10/07/dc13-2042.full.pdf+html

( 2014), 577 :

, .

6 , -1986, 23 174 ,

-40% -30% (11.9% 19.6%; 28.1% 38.4%), .

, -45% (72.6% 89.9%).

  , .

http://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)70057-9/abstract

- ( 2014)   2.

, 2 , , .

http://www.ncbi.nlm.nih.gov/pubmed/25001435

( 2014)      .

344 2 65 .  . , .

http://www.ncbi.nlm.nih.gov/pubmed/25255799

( 2015)   HbA1c .  -11,000 2 -6 .  HbA1c  -8%,  HbA1c  HbA1c .  , -8%  HbA1c  .

http://www.ncbi.nlm.nih.gov/pubmed/25664182

( 2015) (HbA1c), ,  - .

- 3,494 20 .

1.13% 3.09% . -.

, , .

http://www.ncbi.nlm.nih.gov/pubmed/25852207

, ( 2014)     . 163 2 4 5 : / (58% ) / (40% ).

 DASH.

, , , ,  LDL -HDL, -23% .

http://www.ncbi.nlm.nih.gov/pubmed/25514303

- ( 2015)       , .

(GFR) ,   1, 2    . 15 1965 .

1, 2. 

http://www.ncbi.nlm.nih.gov/pubmed/26710078

2 ( 2015)   1.

http://www.ncbi.nlm.nih.gov/pubmed/26642117

( 2015), ,  LDL    .

http://www.ncbi.nlm.nih.gov/pubmed/26409460

  .

30 2 ( 0.5-23 ) (600-700 ) 8 , . , .

14 " 6 .

12 ( 7 /), 10 .

(-7.1% -5.8% -8.4% -8.0%) 6 .

2. 

http://www.ncbi.nlm.nih.gov/pubmed/27002059

( 2016)   2  . 64,660 (27,809 -36,851 ) 45-75 2.

147 (Potential renal acid load - PRAL) (Net endogenous acid production - NEAP).

-5 1,191 2 PRAL 2 , -25% .

PRAL 2 50. NEAP 2 2 .

http://www.ncbi.nlm.nih.gov/pubmed/27052540

( 2016)   '-   , 2. 

http://www.ncbi.nlm.nih.gov/pubmed/27164183

( 2016)   . 1,531 4 , .

, 52 . 2 - - , , , . CRP .

, , , .

http://www.ncbi.nlm.nih.gov/pubmed/27144647

( 2016) , .

63 (18-85) (BMI 20-35). , -3 , () 50 . 5 .

20% 25%. , . , , .

, . 

https://www.ncbi.nlm.nih.gov/pubmed/27604773

( 2016) , , , , , .

6 , 100 ( -11% , 15% , 17% -19% ), .

50 (4% , 8% , 9% , 18% , 19% , 13% , 22% , 24% , 32% ).

, , , .

, , . , .  

https://www.ncbi.nlm.nih.gov/pubmed/27597529

( 2016) / HDL 2. -47,000 , -15,000 (eGFR) -60 " , -LDL 130 "/".

4 12.8% eGFR -60 " , 7.6% -30% -eGFR. , 23.2% -4% eGFR .

-150 "/" HDL -40 "/" -50 "/" -35% -44%, , . HDL 2. 

https://www.ncbi.nlm.nih.gov/pubmed/27703024

( 2016) , , -.

24 , (30% , 30% , 40% ) (15% , 30% , 55% ) 6 . , , ; , , ; , , , , .

100% -: -100 "/" (Oral Glucose Challenge Test) - 140 "/".  33% -. 
, (p=0.001), (p=0.04), (p=0.001), (p=0.001) (p=0.001) -.

https://www.ncbi.nlm.nih.gov/pubmed/27843552

- ( 2017) - ". , 1999-2002 -2009-2012, - .

, - , , , , , , , , 3 - , 2.  
2012 -700,000 " - (-500,000 , -128,000 -68,000 2). -318,000 . , -9.5% , 8.5% , 8.2% , 7.8% 3 , 7.6% , 7.5% , -7.4% . , -2,000 " , 4 -3 . .
https://www.ncbi.nlm.nih.gov/pubmed/28267855

 ( 2017), 29 , , .
https://www.ncbi.nlm.nih.gov/pubmed/28272464

(Singapore Chinese Health Study) , , , Heme, 2. , ( 2017), 63,257 , 45-74 1993-1998. , 11 5,207 2. ( ) , -23% (54 / 10 /), -15% (26 / 14 /) -7% (61 / 48 /). Heme , 2 . 2, Heme ; , ROS(Reactive oxygen species), , . Heme Heme, . 
https://www.ncbi.nlm.nih.gov/pubmed/28535164

 ( 2017) . , , . , , ( -) .

, , , . , .

, , . , .  
https://www.ncbi.nlm.nih.gov/pubmed/29022562

 ( 2017) , . , , , BMI .

- (1.7% 5.3%), BMI . -LDL -HDL - -. - , , ( ) -. 
https://www.ncbi.nlm.nih.gov/pubmed/28891681

- ( 2017) , , , 2.

, 912 . 6 12 , - 0.45% , 0.55 -BMI, 2.1 " -0.17 / -LDL. 2, .
https://www.ncbi.nlm.nih.gov/pubmed/29092883

 ( 2017) 2. -49 , 2 .

306 20-65, 2 -6 , BMI 27-45 .  , -850 3-5 (59% , 13% , 26% , 2% ), 2-8 , . 15 " , -6.5%. (best-practice care by guidelines). 
:

  • 15 " 36 (24%) , . 
  • 68 (46%) 6 (4%) . 
  • , (76 ) 86% 15 ".  
  • 10 " -1 " . 
  • 7.2 , 2.9 . 
  • 4% , 1% .  (biliary colic) , . . .

2. 
: - . 
https://www.ncbi.nlm.nih.gov/pubmed/29221645

 ( 2018) 2. (SCFA), , SCFA 2. 
, 2 (), 12 . (27 ) (16 ) .

. , SCFA. , , GLP-1 ( - Glucagon-like peptide-1), . , . SCFA 2. 
https://www.ncbi.nlm.nih.gov/pubmed/29590046

 ( 2017), , 2 . 197 , . 100 " " , -97 " ", , , , , .

, -59% (<130 mg/dL), 2.1 (HbA1c<7%) -37% LDL (<100 mg/dL). , , BMI, , -HDL. 2. 
https://www.ncbi.nlm.nih.gov/pubmed/29308450

 ( 2018), 17 , ( ) , .

https://www.ncbi.nlm.nih.gov/pubmed/29617350

 

 

-

 

(2011)  -        , .

(LDL), ,  , , 2 .

(Obesity).

http://www.ncbi.nlm.nih.gov/pubmed/21443484

( 2010)       2.

418 , 2   ( ) (-30 ), . 55 - 80 -.

, ( ) 2 52% .

http://www.ncbi.nlm.nih.gov/pubmed/20929998

( 2013) -  ,  2. -22 -11 2,330 2.

-  .

"   -  -20%. -.

http://www.ncbi.nlm.nih.gov/pubmed/23975324

( 2013) .   , ,  .

-  - , ,  DASH  , .

. , .

http://care.diabetesjournals.org/content/early/2013/10/07/dc13-2042.full.pdf+html

( 2014)    2.

,   .

, , , , , , .

,   -, , - , .

http://www.ncbi.nlm.nih.gov/pubmed/24910231

( 2013)   2.

21 :  , , .

 - , , -  .

, , .

.

http://www.ncbi.nlm.nih.gov/pubmed/24312178

( 2015)   - .

- , 642 - . -4 : , , , .

, .

-

http://www.ncbi.nlm.nih.gov/pubmed/26474775

- ( 2016)    - .

, 100 , , , . - .

. - , ( -29%, 57% -30%, ).

- -14% (13 ) (4%, 3 ) (9%, 9 ).

,  , . , , , , .

, , 2 .  

http://www.ncbi.nlm.nih.gov/pubmed/27428849

( 2016) - , 3 3,482 2 55.

, 2,611 (75%) 500 " 3 , . -6 69 .

-48% 500 " 3 -500 " . - .

http://www.ncbi.nlm.nih.gov/pubmed/27541690

 ( 2017), , - .

, , . -, , ( ), , , , , , , . DASH, . , . 
, 2 .
https://www.ncbi.nlm.nih.gov/pubmed/28521334

 ( 2017) , , 2 . - , - 2 . 
- – , , , - , , , , , , . , -, - - ( , ) 2 . - , 2 , . , , -, , , .

2, .
https://www.ncbi.nlm.nih.gov/pubmed/29194424

 

 

- ( ) ( )

 

- (2018) - . , 664 , 99% 2 / . ", 4 -74 , . , -, 0.29% , 0.56 / , 0.12 / -LDL, 2.15 " , 0.74 BMI -2.86 " . , HDL .

- 2 . 

https://www.ncbi.nlm.nih.gov/pubmed/29960809

 (2018) . 11 , " 433 -55 .

(" ") ( ). 3-74 , 23 . ( ) , , , , , HbA1c, , -LDL.

.

https://drc.bmj.com/content/6/1/e000534

 - . 

(2014) (cohort) -14 -66 .   (PRAL, NEAP).

1,372 2,  BMI  -25.

  2, , / : (, , ') . 

2.

http://www.ncbi.nlm.nih.gov/pubmed/24232975

( 2009)       2  2.

, . . .

.

http://www.ncbi.nlm.nih.gov/pubmed/19386029

( 2016) 2.  -3 , -70,000 ( 1984-2012), -90 ( 1991-2011) -40,000 ( 1986-2010).

2-4 (PDI) , (hPDI) ( , , , , , ) ( , , ) .

, - (uPDI) . 
-16,000 2, 2 2, -BMI.

, , , 2.

http://www.ncbi.nlm.nih.gov/pubmed/27299701

( 2010)   ( )  2,  , .

.

2. .

http://www.ncbi.nlm.nih.gov/pubmed/20425575

( 2009)       2.  74 49 50 .   , .

http://www.ncbi.nlm.nih.gov/pubmed/19339401

( 2011) 14  RCT      2. ,   ,      .

    , , .

http://www.ncbi.nlm.nih.gov/pubmed/20713332

( 2013)     .

2 .

100,000 "   4 ,    , .  .

.

http://www.ncbi.nlm.nih.gov/pubmed/23779232

( 2013)       2.

http://www.ncbi.nlm.nih.gov/pubmed/23719550

( 2014)   , 50-65  75%   4   18 .

, 65 .

, 5 . 

, . 

65 .

, .

  .

,     .

, .

http://www.cell.com/cell-metabolism/retrieve/pii/S155041311400062X

( 2014)     2. (cohort) -12 2 - -16 -12 .

, , 2. .

 BMI  30.

http://www.ncbi.nlm.nih.gov/pubmed/24722499

( 2014)       2.

50 2 50 .

.

, , . 

:

.

, ( ) .

, ,  , ,  2.

http://www.ncbi.nlm.nih.gov/pubmed/25222490

- ( 2014)       2. -6 255 ,  HbA1c  .

2.

http://www.ncbi.nlm.nih.gov/pubmed/25414824

( 2013) .   , , .

, , .

.

, .

http://care.diabetesjournals.org/content/early/2013/10/07/dc13-2042.full.pdf+html

( 2015) - . 17  B12,  B12  .

20 . 

http://www.ncbi.nlm.nih.gov/pubmed/26011582

( 2014)    2.

,   .

, , , , ,  , , .

, -, , -    , .

http://www.ncbi.nlm.nih.gov/pubmed/24910231

( 2016)   , , 2.

.

93 2 , , 12 .

, " " ( 0.5% 0.2% p=0.017). , ( 0.9% , - 0.5% " ").

2. 

http://www.ncbi.nlm.nih.gov/pubmed/27253526

( 2016) , - ,
, . , ,
2 2. . , 2. 
(200-300 " ) ,
, . , , . -  .
, (WCRF) - , , , . , , . . - 


, . , . , .

,   . 

https://www.ncbi.nlm.nih.gov/pubmed/27882862

( 2017) , , 2 (BMI 35 ). 74 , : ; 500 . 
-60% , 15% -25% , , , . . -50% , 20% 30% , 7% -200 "/. , .
3 -6 , MRI . ( 6.2 " 3.2 ", p<0.01), () . MRI - , (subfascial) , , - . 
- , . 2.  
https://www.ncbi.nlm.nih.gov/pubmed/28604251

 ( 2017), , - .

, , . -, , ( ), , , , , , , . DASH, . , . 
, 2 .
https://www.ncbi.nlm.nih.gov/pubmed/28521334

( 2018), . 76 . , 16 , . 75% , 15% -10% , , . , 20-30 . B12 500 "/. - .
. -BMI . , . 

https://www.ncbi.nlm.nih.gov/pubmed/29425120

 ( 2017) - . - , . , 2 . , -40% -29%. , -50% 2. , . - .

https://www.ncbi.nlm.nih.gov/pubmed/28792455 

 ( 2018) 2, , .

45 , : , , , . , " 20 .

(6.3 " 4.4 " ), ( 0.4% ) -LDL (  11.9 12.7 "/"), . . 2. 
Physicians Committee for Responsible Medicine, .
https://www.ncbi.nlm.nih.gov/pubmed/29398571

 

 

-

 

( 2014)     - -  - 2.

.  59 - (20% ) - (55-60% ).

6 , - IL-6 - IL-1Ra. 

, - .

http://www.ncbi.nlm.nih.gov/pubmed/24779961

 

,(2018)  , 2. 55,465 50-65, -15 , 7,417 2. , , , .

(16 ) 2 -11% -7% . , – , - . , 2 - - , /. 

https://www.ncbi.nlm.nih.gov/pubmed/30016529

, (2018) , . , . : 1) 2) . . , , 123 , - 12 .

. . , pipecolic acid betaine valine betaine . , glycine betaine - proline betaine . , , .

https://www.ncbi.nlm.nih.gov/pubmed/30256894

( 2015)     2. 115 2 :

1) (14% , 28% , 58% ),

2) (53% , 17% , 30% ).

, , (HbA1c), ,  CRP, -LDL.

, , ( , )  HDL.

http://www.ncbi.nlm.nih.gov/pubmed/26224300

( 2016)   1 .

13 1 .

: , () ( ).

, 3 , -3 . , , . .

, , .

http://www.ncbi.nlm.nih.gov/pubmed/26861923

( 2014) 2   - .   61   2   - -  . 

- , - .

http://www.ncbi.nlm.nih.gov/pubmed/25271116

( 2013)   2.

21 :  , , .

 -  , -  .

, , .

.

http://www.ncbi.nlm.nih.gov/pubmed/24312178

( 2014)      

.

http://www.nutritionjrnl.com/article/S0899-9007(14)00332-3/abstract

( 2014),    ( , , , )  2.

- BMI , , 2.

http://www.ncbi.nlm.nih.gov/pubmed/25424603

( 2013) .   , , .

,   , . .

, .

http://care.diabetesjournals.org/content/early/2013/10/07/dc13-2042.full.pdf+html

( 2014)    2.

,     .

, , , , , , .

, -, , - , .

http://www.ncbi.nlm.nih.gov/pubmed/24910231

- " ( 2014) 2. 5 , , , -25% 2.

100 " 11% 2.

http://www.ncbi.nlm.nih.gov/pubmed/24674850

2.

( 2014)    2. , . .

http://www.ncbi.nlm.nih.gov/pubmed/25527674

( 2013) - 20 3,000 .   , 2.   -, .

http://www.ncbi.nlm.nih.gov/pubmed/23364002?dopt=Abstract

(2014)       122 6 :

1. .

2. .

3. .

-BMI  .

, .

..

http://www.ncbi.nlm.nih.gov/pubmed/24787494

( 2014)       (14% )  (53% )  2.

24 115 2 .

.

, 2.

.

http://www.ncbi.nlm.nih.gov/pubmed/25071075

( 2016)   .

,   .

- - -. , - - , , -HDL . , .

2. .

http://www.ncbi.nlm.nih.gov/pubmed/26878317

 ( 2016), . (: adropin )  .

- . - , .

, , .

. , . 5 /" ( 3.30, 2.73 /"). 

http://www.ncbi.nlm.nih.gov/pubmed/27460714

, , 2 .

https://www.ncbi.nlm.nih.gov/pubmed/27818258

( 2016) . 32 50-65 ( 100 "/") 3 , . 
-4 : (60% ) (30%), ( ) . 
, , , . -39% -31% .

GIP . , . .

https://www.ncbi.nlm.nih.gov/pubmed/27798656

 ( 2017) - (LCHF) , , .

- 26% 130 . , , , , , , , , , , , .
- -LDL LCHF. , - LCHF , , , , ApoB, , LDL, , , HDL . .

, , , .
https://www.ncbi.nlm.nih.gov/pubmed/28053201

,  ( 2017) 2, , , 3 , .  
https://www.ncbi.nlm.nih.gov/pubmed/29129786

 ( 2018) ( ) .

29 , 55-75 BMI 25-35. : - 35% , 20% -45% , 60% , 20% -20% ( 10% , , ). 4 , (50% , 20% -30% ). (respiratory quotient - 1 ) 24 , : , , .

, 24 , , ( , ). , -LDL . , . 
https://www.ncbi.nlm.nih.gov/pubmed/29490097

,( 2018) , .

, . . 316 , 42% 1.

16, 11 2.2 . 36 5.67%. 2% ( ).

, . 

https://www.ncbi.nlm.nih.gov/pubmed/29735574

 

 

 |  |   |  |   |  |  | 

 

-

 

( 2015)   .

, .

, , , . , , , , , , .

-, , - Q10, , , -, , , , , 3, , , , , C E.

-, - , (Morus alba) , , , , - Q10 ( Armolipid Plus). 

http://www.ncbi.nlm.nih.gov/pubmed/25895559
http://www.ncbi.nlm.nih.gov/pubmed/25870124

- ( 2015)    2. 14 -2 .

, HbA1c, ,  -LDL. . 

2. 

http://www.ncbi.nlm.nih.gov/pubmed/26690472

- ( 2015)   .

- 35 -8 - .

2, ( 37 "/") ( 0.97%), . , , - 2.

, .

http://www.ncbi.nlm.nih.gov/pubmed/26561625

( 2015)    (Fagopyrum esculentum) 

, ,  , , -, - - - .

- , D-chiro-inositol, , . 

http://www.ncbi.nlm.nih.gov/pubmed/26270637

( 2013)   ( 1) . -1,600 .

 C  (FCP) .

 FCP    3  .

.

http://www.ncbi.nlm.nih.gov/pubmed/23801797

 

3 , (2018) ", 2. :

  • 71,602 , 1984-2012.
  • 88,604 , 1991-2013. 
  • 41,908 , 1986-2012.

2-4 , . , , , . 

, 15,947 2, , , -13% , . , , 12 , . , , 2, , , .

-NIH.

https://www.ncbi.nlm.nih.gov/pubmed/30074058

2 .

( 2013)     .

6,000 2.

5.5 , 31.7% -8.3% .

    .

     .

.

http://www.ncbi.nlm.nih.gov/pubmed/23939297

(2014)   , 2.

   .

, , .

.

2.

,  , ,   .

http://www.ncbi.nlm.nih.gov/pubmed/25422368

http://www.ncbi.nlm.nih.gov/pubmed/25172947

http://www.ncbi.nlm.nih.gov/pubmed/25249574

( 2014)     .

http://www.ncbi.nlm.nih.gov/pubmed/25066548

( 2011) 14  RCT      2. ,    ,      .

    , , .

http://www.ncbi.nlm.nih.gov/pubmed/20713332

( 2015) 44 -   ( )

-

http://www.ncbi.nlm.nih.gov/pubmed/26500686

( 2012)     .
   ( 2). : (Murraya koenigii Sprengel), , (Trigonella foenum-graecum), (Momordica charantia Descourt) (Solanum tuberosum).

http://www.ncbi.nlm.nih.gov/pubmed/23411283

( 2014)        21 " -24 .

   , ,  .

  ,  , .

, .

, , , , () (), , .

   ,  " .

http://www.ncbi.nlm.nih.gov/pubmed/25168916

( 2015)    2, , .

, - 2,681 , 688 . , ( ) 2. 6   ,   .

, 2, -6 . 

http://www.ncbi.nlm.nih.gov/pubmed/25948672

( 2015)   . - 8 " 316,051 , 15,573 2.

, 10 0.3% .

, 45 (3 ) 20% 7.5 ( ). .

http://www.ncbi.nlm.nih.gov/pubmed/26098118

 ( 2015 )     .

http://www.ncbi.nlm.nih.gov/pubmed/26134388

( 2015)  18 3     .

http://www.ncbi.nlm.nih.gov/pubmed/26147654

( 2014)  , . , , , .

http://www.ncbi.nlm.nih.gov/pubmed/24921903

( 2014),   3 .

28 -3 .

LDL   - 0.30mmol/L - 0.25mmol/L . .  HDL  .

http://www.ncbi.nlm.nih.gov/pubmed/25411276

(2015) - .

: , C -E.

, , .

-, .   . ,  , , , , . , .

  . . 

http://www.ncbi.nlm.nih.gov/pubmed/26156538

( 2016)   .

.

2, , , , .

-.

, , , -30 , -, , .   

http://www.ncbi.nlm.nih.gov/pubmed/27264638

- ( 2016)   , , .

16 2 -2 (-4 ). 109 , , . , ( ).

180 .

, . ( , , -, ) . 

http://www.ncbi.nlm.nih.gov/pubmed/27278405

( 2016) , 2.

6,367 15-76 - , , , , .

, 2. , ( ) .

-, . 
, . 

http://www.ncbi.nlm.nih.gov/pubmed/27329792

( 2015) 13 , .

, , -100 " , (FMD) -900 " . 
, . 
32 , 2 , 100-500 , -900 " , -50-200 -100 .

, .

http://www.ncbi.nlm.nih.gov/pubmed/26125676

-   -.

19 1,131 . 166-2,110 "/ ( ) 2-52 .

. , , 0.10 / -0.06 / HDL , CRP vascular cell adhesion molecule 1)VCAM-1), .

, . 

https://www.ncbi.nlm.nih.gov/pubmed/27683874

( 2016) . , SDG-  (secoisolariciresinol diglucoside), , 1 2.

1 -SDG -72-75%. (malondialdehyde) . SDG 2 , HbA1c.

SDG 1 2 . 

https://www.ncbi.nlm.nih.gov/pubmed/26561065

- ( 2016)    , . - 20 , -800,000 , 28 () -29% , -7% , -21% , -15% -22% -52% , -39% , -35% , -75% -73% .

, , 4.4 -20 2013.
, , .  .

https://www.ncbi.nlm.nih.gov/pubmed/27916000

(2015) , , .

, . , - , , - , , .

https://www.ncbi.nlm.nih.gov/pubmed/26118770

( 2017) . , .

, , , , , . , , , . -.

, . , .

http://onlinelibrary.wiley.com/doi/10.1111/nbu.12244/full

- ( 2017) .

16 -, 731 , , 614 .

: (p=0.03), (p=0.007), (p=0.01) (p=0.001). , HbA1c : p=0.55. , 2. , 2, . 

https://www.ncbi.nlm.nih.gov/pubmed/28097367

-  ( 2017) , .

159 19-68, BMI 25-47, -3 : (PolyGlycopleX®), (PSY), . 5 " 3 12 , .

, (PGX PSY) (8.2% -7%, ), -LDL ( 13.9% -8.1%, ), (9% -9.4%, ) 3 . , PGX -HDL.

, 2. 
https://www.ncbi.nlm.nih.gov/pubmed/28146065

 ( 2017) 2, , , .

2,332 , 42-60 1984-1989. -19 432 2.

, , 2, -35% -33% . 1% , 5% 2, . , 1% , , 18% 2, -BMI.

2.
https://www.ncbi.nlm.nih.gov/pubmed/28397639
http://www.nutraingredients.com/Research/Plant-protein-may-prove-a-more-effective-diabetic-defence-Study

 ( 2017) 2 - .

3,349 , - . , -4.3 266 2.

, , (-29 ), , -35% -33%, , 2 (-13 ). , , . ( -30 ) - (30 ), (38 ), (30 ) (100 ) - 2.

, , -, 2 .  
https://www.ncbi.nlm.nih.gov/pubmed/28392166

 ( 2017) , ( ) . , - . , 2
https://www.ncbi.nlm.nih.gov/pubmed/28615356

,  ( 2016), , , (IRS1). 
https://www.ncbi.nlm.nih.gov/pubmed/27248994

- ( 2016) - .

18 , ( ) - ( ) - - 4 . 20-136 / - 3-10 /.

, , -, . ( ), , 2, .


https://www.ncbi.nlm.nih.gov/pubmed/26840185

 ( 2017), , 5,683 18, 2.
https://www.ncbi.nlm.nih.gov/pubmed/28749415

-  ( 2017), 22 2, , . , , – .
https://www.ncbi.nlm.nih.gov/pubmed/28761664

 ( 2017), 6 2. -20 , -10 (, , ", , , , , , ) 1970-2010.

-40,000 49-76 BMI 23-28, 2. (366 ) 4,347 2, 35%.

2. , , BMI, , 3. 2, . 
https://www.ncbi.nlm.nih.gov/pubmed/29032079

 ( 2017) , . 31 40 / , ProLYOtin®, 12 .

( ) , , . , , , . - . .
https://www.ncbi.nlm.nih.gov/pubmed/29053995

 ( 2017) (total antioxidant capacity) 2. , (EPIC), 64,223 52 . 15 , 1,751 2.

, ( 17.55 -8.72 /), , , . (23%), (19%), - (15%) , , , (12%).

2, , -26-30% 2. , 15 /, . 
https://www.ncbi.nlm.nih.gov/pubmed/29119242

 ( 2017), (Japan Diabetes Complications Study), 2 40-70 6.5%.

1,353 , , 8 .   9.9 / ( ) 97.7 / ( ). , 3 . , 20 / , -20 /, 3 (p<0.01). . 

https://www.ncbi.nlm.nih.gov/pubmed/29222638

 (2017) (Parboiled) - - 2 .
( ) , ; . .

45 21, 15 2, . , , 50 , - . 120 . , 2, . , 2, . . 2.  
http://www.nutritionjrnl.com/article/S0899-9007(17)30211-3/fulltext

 ( 2018) , -, . , .

- , . , , , , , . , , , .

, . , , . , . .
https://www.ncbi.nlm.nih.gov/pubmed/29399808

, ( 2018)  357 40-70,

https://www.ncbi.nlm.nih.gov/pubmed/29571924

-, 2 .

128 -, ( 12 ) ( -2 ), . -. , 3 , 6 (" 12 ).

, , , . - 2 . , , . 

.

https://www.ncbi.nlm.nih.gov/pubmed/29741558

 ( 2018) , .

24 , 4 50 - . ( , ). , .

, . , . -20% -35%, , . , .

https://www.ncbi.nlm.nih.gov/pubmed/29659967

 

 

 

( 2013)         2. "  (cohort)  " -80 .

12 2.

, ,  . 2, , , , .

.

http://www.ncbi.nlm.nih.gov/pubmed/23990623

2 , .

, . (2013)   .

, 63 2 .

   – 2 2 . 12 , -125 -51 . 

, (HbA1c), , . 

2 ,   .

http://www.nutritionj.com/content/pdf/1475-2891-12-29.pdf

2, .

( 2013), 14 66,118   ,   2. , 2. ,  .

http://ajcn.nutrition.org/content/early/2013

 (cohort)  ( 2013),     ,    2.

2,332 42-60 .  

-19 432 2.

, ( ) -24% .

, 35%  .

, BMI, , .

http://www.ncbi.nlm.nih.gov/pubmed/24257723

( 2013)    2.

http://www.ncbi.nlm.nih.gov/pubmed/23684435

( 2014)   2.

85 2 37-60, 50 30-60 .

, .

2 12 ,  1 -3 1.5 " " ( 5 ).

,  2.

.

, .

http://www.ncbi.nlm.nih.gov/pubmed/25223711

( 2014) 10 4  ,    .

 (GI = 49), .

http://www.ncbi.nlm.nih.gov/pubmed/25191601

( 2014)  20 ,   (10 12 )  .

http://www.ncbi.nlm.nih.gov/pubmed/25210462

(2015)  , ,     " .

http://www.sciencedirect.com/science/article/pii/S0963996914007844

( 2016) - (Vitis vinifera) – - .

. , , .

, : , , . , , , , .

. 150-600 "/"/ , . 

https://www.ncbi.nlm.nih.gov/pubmed/26800498

 ( 2016) - , , , , . 

https://www.ncbi.nlm.nih.gov/pubmed/25872898

 (2015), 35 , 750 " - . 
https://www.ncbi.nlm.nih.gov/pubmed/26471075

 ( 2016) Delphinol, ( ', delphinidin), -.
https://www.ncbi.nlm.nih.gov/pubmed/28025651

 ( 2017) , , .
https://www.ncbi.nlm.nih.gov/pubmed/28259166

 ( 2017) , , 2 . , , , .  
https://www.ncbi.nlm.nih.gov/pubmed/28612853

 ( 2017) . 20-27.

19 , (, , , , ) – , 3 . 9 , – . 25 25 .

( ), , . ( ), ( ), ( ). , . 
.
https://www.ncbi.nlm.nih.gov/pubmed/28991222

 ( 2017) -129 - , 2, , , . , , , . , , , .

(, , ) , , , , . - , . .

, . . 
https://www.ncbi.nlm.nih.gov/pubmed/28393409

 ( 2017) , . , 16 109 50 :

  1. : (400 " ), 200 " 200 " , 400 " 200 " . 
  2. : 200 " , 200 " .  
  3. 200 " , 200 " . 

180 . . , .
, punicalagin - . 
https://www.ncbi.nlm.nih.gov/pubmed/29021286

 

 

 

2, .

( 2013), 14 66,118        2.

, 2. ,  .

http://ajcn.nutrition.org/content/early/2013

, 2 ,
(European Prospective Investigation into Cancer and Nutrition). 

  -12,000 2 -16,000 . , 336   , , 2 -20%. -BMI, . ,     .

http://www.diabetologia-journal.org/files/Romaguera.zip

( 2015)    2 
, , . , ( ),  . 
, " 5% ,  .

http://www.ncbi.nlm.nih.gov/pubmed/25639270

( 2013) 74   ,    , 4 .

, " .

http://www.ncbi.nlm.nih.gov/pubmed/23959566

( 2014)  Nature    , -   . - .

http://www.ncbi.nlm.nih.gov/pubmed/25231862

- ( 2014) ,      ,  2. 

.

http://www.ncbi.nlm.nih.gov/pubmed/25030779

( 2015)     , 2 , 

, ( ). .

http://www.ncbi.nlm.nih.gov/pubmed/26429086

" ( 2015)   .

http://www.ncbi.nlm.nih.gov/pubmed/25485685

- ( 2015) 17     2, .

http://www.ncbi.nlm.nih.gov/pubmed/26199070

2,856 ( 2016), , , , -   .

http://www.ncbi.nlm.nih.gov/pubmed/27216413

( 2015) 10 2 , (- ) . 

http://care.diabetesjournals.org/content/39/3/e38

(2016) ( ) , , -, .

- 14 1,685 52 . , -7 2,076 .

, - (p<0.001) (p=0.006). , 3 (6 ) -46% - . - .

-BMI.  
:  , , . , 2. : http://www.naturopedia.com/search_res.asp?rId=119#speci-suger

http://jn.nutrition.org/content/early/2016/11/09/jn.116.234047.abstract

-  ( 2017) ( ) - .

-1,000 -30 -400,000 . -BMI. -BMI , , , 2 .

, -. 
https://www.ncbi.nlm.nih.gov/pubmed/28716847

 

 

 

- 28 ( 2014)   ,  2 ( ).

http://www.ncbi.nlm.nih.gov/pubmed/24459154

( 2014)       2

http://www.ncbi.nlm.nih.gov/pubmed/24771089

( 2015),     -12,000 .

, , 3 26% .

.

http://www.ncbi.nlm.nih.gov/pubmed/25978631

( 2015)   GLP-1 .

19 . (flow-mediated dilation- FMD) 180 .

, , , , GLP-1 . 
:  , .  . 

http://www.ncbi.nlm.nih.gov/pubmed/26337017

 (2018) ( ) . , , , . 82,737 , -50 . -16 4,945 .

, ( 411 "/) -24% ( 46 "/). , -23% 4 , . (, ) . , . 

.

https://www.ncbi.nlm.nih.gov/pubmed/30347034

 ( 2018), , 1. , 1.

, 1,040 . , : " " ( 1 ), " " (1-3 ), " " (3-5 ) " " (5 ). 1.8 2.1, , . (eGFR). 1,
https://www.ncbi.nlm.nih.gov/pubmed/29501444

,  (2018) (NHANES), – . , , , . , .

1,974 -1,974 1 2. 57 , 407 -351 . , , -43% 100 " , -50% 100-200 " -61% 200 " . . , . . 

4,863 , . 60 , 1,283 . ( 28.2 " ), -26% 28.2-213.5 " -22% 213.5 " . .  
https://www.ncbi.nlm.nih.gov/pubmed/30294299

https://www.ncbi.nlm.nih.gov/pubmed/30215779

 

 

 

 

( 2014) -4,000  11      2.

http://www.ncbi.nlm.nih.gov/pubmed/24510203

 

 (2018) , , 2. 16 -12 , -60,000 BMI. , : (15:0, 17:0) 7 (t16:1n-7). 9 15,180 2.

, , -18-35% 2. . 2. 

, Fatty Acids and Outcomes Research Consortium ( -FORCE) , ( NIH). 

https://www.ncbi.nlm.nih.gov/pubmed/30303968

( 2014)       .

, , .

, 2. 

http://www.ncbi.nlm.nih.gov/pubmed/24636056

( 2014)       2.

15 50 150 " .

28% .

.

, .

http://www.ncbi.nlm.nih.gov/pubmed/25005331

( 2015) -25,000 -10 2, .

http://www.ncbi.nlm.nih.gov/pubmed/25944371

( 2016) , - ,
, . , ,
2 2. . , 2. 
(200-300 " ) ,
, . , , . -  .
, (WCRF) - , , , . , , . . - 


, . , . , .

, . 

https://www.ncbi.nlm.nih.gov/pubmed/27882862

 

 

 

2 .

( 2013)     6,000 2. 

5.5 , 31.7% -8.3% .

         .

.

http://www.ncbi.nlm.nih.gov/pubmed/23939297

    2.

( 2014) 11 ,   .

-5 1,031 , 1,147 -1,136 .

, , -17% ,  -15% -13% , .

2.

http://www.ncbi.nlm.nih.gov/pubmed/24578358

- ( 2016)   2. 26 -700,000 , -31,000 2.

,  ( 2 ) 2 ( -17% -26% ).

, 2. , -2 . .

http://www.ncbi.nlm.nih.gov/pubmed/26843157

 ( 2017), -70,000 , 3-4 2 - , . 
https://www.ncbi.nlm.nih.gov/pubmed/28748324

 

 

 

( 2014)       2.

54 - :

50% -35% ( 57 ), , -55% -30% .

4 , .

, .

,  - .

http://www.ncbi.nlm.nih.gov/pubmed/25125505

( 2014) 30   .

http://www.ncbi.nlm.nih.gov/pubmed/24980134

 

 

 

( 2012)   30 18-30,  BMI  (BMI > 30).

  50 ,   6 . , . 

.

, .

, .

http://www.ncbi.nlm.nih.gov/pubmed/23102179

- 16 ( 2013)       2,  , 2.

http://www.ncbi.nlm.nih.gov/pubmed/24331002

(2014)    Undaria pinnatifida, Mekabu .

Mekabu , .

http://www.ncbi.nlm.nih.gov/pubmed/25264047

- ( 2016) (Allium sativum) , 2: , , .

26 2 61 , 1,200 " 4 4 – 4 . , .

, , (plethysmography), (CRP). 2.  

https://www.ncbi.nlm.nih.gov/pubmed/26954484

- ( 2016) - .

18 , ( ) - ( ) - - 4 . 20-136 / - 3-10 /.

, , -, . ( ), , 2, .


https://www.ncbi.nlm.nih.gov/pubmed/26840185

, , 2.

-3,000 40 , . -6 , 3.3% , 15.5% , 17.9% -6.7% 2. ( ) ( ) -64% , -32% -26% . , 10 30% , -9% -6% . 2. , .

- .

https://www.ncbi.nlm.nih.gov/pubmed/28319598

 

 

 

 |   |   |   |   | 

 

-

-  (2018) , , , , , , , , . -5 , -137 . , ( ). 

, -8-9 . -39% , -26% , -25% , -46% , -24% -8% . . . , . 

https://www.ncbi.nlm.nih.gov/pubmed/28890167

( 2015)   .  :

  • -90 .
  • -70-130 "/" - 80-130 "/".
  • -80 "/ -90 " .
  • " LDL.
  • .
  • .

http://care.diabetesjournals.org/content/38/Supplement_1/S4.long

 (2018) -58,000 , . - , 2 , .

https://www.ncbi.nlm.nih.gov/pubmed/29971437

( 2015)     2 .

8,749 - 45-73, 625 6 . -46% , . 24% 12% . 2.

, .

http://www.ncbi.nlm.nih.gov/pubmed/25754552

( 2013) 194 2 58  (HbA1c)  7.5%.  " "   , .

2 ,  .

http://care.diabetesjournals.org/content/early/2013/03/28/dc12-2697.abstract

( 2015) -10     2 , .

http://www.ncbi.nlm.nih.gov/pubmed/25706240

( 2014)      D  2. , - , , , , .   D  , (NO) .

http://www.ncbi.nlm.nih.gov/pubmed/25342734

( 2015)     2 .

-3 3,232 ,   () .   ( 3.4% ).  .

http://www.ncbi.nlm.nih.gov/pubmed/25851102

447 ( 2015)     . 

http://www.ncbi.nlm.nih.gov/pubmed/26580236

19 (2016)   .

http://www.ncbi.nlm.nih.gov/pubmed/27191727

( 2016) .

.

-600,000 -73,000 -10 . , 1.13% HDL 0.57% , 3.58% , 2.37% LDL 0.31% .

, .

http://www.ncbi.nlm.nih.gov/pubmed/27218271

  ( 2016), 788 7.3   2

http://www.ncbi.nlm.nih.gov/pubmed/27355399

, , (Integrated Naturopathy and Yoga - INY) 2.

101 2 15 30 , , , .

3 . HbA1c -7% 1% 50% 3 .

65% , 19% . 1.7% , .

.

http://www.ncbi.nlm.nih.gov/pubmed/27534941

( 2016) 2.

, 2000, : -7% 150 -. .

. - , .

, . 1.26 MET (p=0.026). - (MET Metabolic Equivalent of Task) .  .

, . 

https://www.ncbi.nlm.nih.gov/pubmed/27887769

( 2016) 2 .

2,095 10-19, 39, 2,005 20-39, 59. 126 "/", 200 "/", 6.5% .

5.7% 4 7 , -5.4%. . 2 -, ( ).

https://www.ncbi.nlm.nih.gov/pubmed/27810987

 ( 2018), , , 2.

-60,000 , 2 2008-2013 . , – , , , , , . , BMI .

, -29% -42% , . , BMI .  . .
https://www.ncbi.nlm.nih.gov/pubmed/29440054

 ( 2018), , 2.

-300,000 , -8,000 2. -220,000 , . :

 

: :
15% 3 24%
18% 3-8 11%
44% 8 36%
9%    

    
2, . 2. 2, .
https://www.ncbi.nlm.nih.gov/pubmed/29440150

, ( 2018) 20 , , .

https://doi.org/10.1093/sleep/zsy061.116

 

  -
 

- ( 2018) .

103 -40 , " 100 . , , , HDL , 2, . , , , . , . , .

, , .

https://www.ncbi.nlm.nih.gov/pubmed/29982151

( 2014), 577   :

,   .

6 , -1986, 23 . 174 , -40% -30% (11.9% 19.6%; 28.1% 38.4%), . , -45% (72.6% 89.9%).

  , .

http://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)70057-9/abstract

( 2014)   ,   2 .

 (cohort)  4,554 , -16 " 635 2 100 9% . , -6 .

, .

http://www.ncbi.nlm.nih.gov/pubmed/24841449

( 2014)   -15-20% .  " .

.

http://www.ncbi.nlm.nih.gov/pubmed/25412336

( 2014)   . 600,000 " 3 . 150 .

.

http://www.ncbi.nlm.nih.gov/pubmed/25523350

  ( 2014) 2 .

http://www.ncbi.nlm.nih.gov/pubmed/25539939

( 2015)     2 .
-3 3,232 ,   () .  ( 3.4% ).

.

http://www.ncbi.nlm.nih.gov/pubmed/25851102

( 2015)     2 . 53 66 . , , - 2 .

, / , .

.

http://www.ncbi.nlm.nih.gov/pubmed/26168073

-4,300 -25 ( 2016)   2, -BMI. 

http://www.ncbi.nlm.nih.gov/pubmed/27181604

- ( 2016) 2.

- 28  MET (metabolic equivalent of task) .

11.25 MET ( -150 ) -26% 2, . , - 60 MET 53% . , . 

https://www.ncbi.nlm.nih.gov/pubmed/27747395

.   41 2 30 10 .

7 , 3 .

, . , .

https://www.ncbi.nlm.nih.gov/pubmed/27747394

( 2016) (Flow-mediated dilation - FMD) 2.

12 2 , 12 -11 . , , .

(p<0.01), 2, , . 2 .

2 .

https://www.ncbi.nlm.nih.gov/pubmed/27638878

 ( 2017) .

, 12-24 . 36 BMI 24, -4 , : 1) , 2) 30 , 3) 2 30 , 4) 30 + 2 30 . 5 .

, 30 , 30 . . 

https://www.ncbi.nlm.nih.gov/pubmed/28673802

 ( 2018), -500,000 , U ( ), , 3-4 , 5-6 .
https://www.ncbi.nlm.nih.gov/pubmed/29441753

( 2018), , 2. 44,828 20-80 (impaired fasting glucose) . -4 : , , , -18 .

, -12%, 20% -25% , , . , 19% , (WHO). , -7 . 2
https://www.ncbi.nlm.nih.gov/pubmed/29331993

 ( 2018) , , , - 2.

31 60-69, .

( ) , 3 , 12 , .

(non-exercising controls) , , .

. 2 . 

https://www.ncbi.nlm.nih.gov/pubmed/29564847

 

 

 

-

 

,    ( 2013)   8% -BMI  .

http://www.ncbi.nlm.nih.gov/pubmed/23706362

( 2014)     2 .

http://www.ncbi.nlm.nih.gov/pubmed/25476696

( 2015)    .   Rosiglitazone  - Thiazolidinedione   PPAR    , . 
,     .

http://www.ncbi.nlm.nih.gov/pubmed/25788674

(2014)       .  122 6 :

1. .

2. .

3. .

-BMI  .

, .  ..

http://www.ncbi.nlm.nih.gov/pubmed/24787494

- ( 2015)      2. (HbA1c), . 11 " 6,574 2.

5% , 5% , . , .

http://www.ncbi.nlm.nih.gov/pubmed/25935570

( 2015)     2 .

53 66 .

, , - 2 .

, / , .

.

http://www.ncbi.nlm.nih.gov/pubmed/26168073

( 2013) - 20 3,000 .   , 2. -, , .

http://www.ncbi.nlm.nih.gov/pubmed/23364002?dopt=Abstract

( 2014)       2. (cohort) -12 2 - -16 -12 .

, , 2. .  BMI  30.

http://www.ncbi.nlm.nih.gov/pubmed/24722499

( 2015),  2 , .

http://www.ncbi.nlm.nih.gov/pubmed/26628414

 ( 2017) " " 2 .

, 4,495 9-10, . , - , - 2,031 .

, 3 (ponderal index, ) -1.9%, -4.5%, -3.3%, -9.2% -10.5%. , , - . , . 
2, .
https://www.ncbi.nlm.nih.gov/pubmed/28288985

 ( 2017), , , 2, .

100 30-60 2 ( 5 ) - - 50 .

. , - . 2 , 2 .
https://www.ncbi.nlm.nih.gov/pubmed/28447116

 ( 2017) ( , ) .

436 , 20 , BMI 29 . (). , ( ) . -5 " -35-37 .

, ( ) ( -2 " ). , , . , .

.
https://www.ncbi.nlm.nih.gov/pubmed/27935767

 ( 2017), -120,000 , BMI , 2. , .

https://www.ncbi.nlm.nih.gov/pubmed/28678979

 ( 2017) .

129 , Why WAIT - 12 , . 
, : A 7% B 7% . . 

-9.7% , 6.4% 5 – 3.5% A -9% B. HbA1c, A -7.5% -6.7% -7.7% -8% 5 . B -7.4% -6.4% -6.8% -7.3% 5 . , A -LDL -HDL 5 ( -LDL -97 -87 "/" -HDL -45 -52 "/"), . , B 5 -18 .

5 , , .

https://www.ncbi.nlm.nih.gov/pubmed/28090332

 

 

-

 

-4,000 9-10 ( 2014)     2.
http://www.ncbi.nlm.nih.gov/pubmed/25181492
( 2015) ,     (32 ) (12 )  .
,   , .  .
-350  -30 .
http://www.ncbi.nlm.nih.gov/pubmed/25711955
" ( 2015)   (-700 )   (PPHG) 2.
http://www.ncbi.nlm.nih.gov/pubmed/25724569
( 2015),    .  22 2 , .   .
2.
http://www.ncbi.nlm.nih.gov/pubmed/26220945

 

 

-

 

( 2015)   . , 12-16 24-28 .

. BMI.

, .  

http://www.ncbi.nlm.nih.gov/pubmed/26589686

( 2013)   .
1835 1,  53 1 .
, 4-5 .
, .
http://www.ncbi.nlm.nih.gov/pubmed/23836309

(2015)  1,035 ,    2,

http://annals.org/article.aspx?articleid=2471594

, (2018) -420,000 , 1995-2012 -7 , 1,000 :

  • 1.8
  • 4.4 1
  • 3.6 2
  • 2.9 26
  • 2.1 26

https://www.ncbi.nlm.nih.gov/pubmed/29936530

( 2014)   , ,  .

,   . , .

http://www.ncbi.nlm.nih.gov/pubmed/25489250

( 2014)     ,     2   .

 (cohort)  4,554 -16 " 635 2

100 9% . , -6 .

, .

http://www.ncbi.nlm.nih.gov/pubmed/24841449

( 2014)    , .

http://www.ncbi.nlm.nih.gov/pubmed/24696449

( 2015)  2,280     . 

http://www.ncbi.nlm.nih.gov/pubmed/26657945

( 2015)     .

260 6-12 .

3 - .

43% -57% . BMI   .

http://www.ncbi.nlm.nih.gov/pubmed/25262459

( 2016) 197 3 2. 

http://www.ncbi.nlm.nih.gov/pubmed/27423999

, (2018) , 1. , 1996-2002 -25 . " 63,529 67,565 . 13 1 15.6 0.37% (247 ).

1, 31% 10 . ( 20 ), ( -7 ), 2 1. 1, . 

, .

https://www.ncbi.nlm.nih.gov/pubmed/30232082

- ( 2016) , . 25 .

, , -38% -34%, . , -20% . 10 8 .

, .
https://www.ncbi.nlm.nih.gov/pubmed/27485519

 ( 2017) ( , ) .

436 , 20 , BMI 29 . (). , ( ) . -5 " -35-37 .

, ( ) ( -2 " ). , , . , .

.
https://www.ncbi.nlm.nih.gov/pubmed/27935767

( 2017), -24,000 , . 
https://www.ncbi.nlm.nih.gov/pubmed/28763446
- ( 2017), . 263 -200 22-44, 5-28 . 3 , : (Pr/K) (PRAL - potential renal acid load).

, HbA1c, -LDL. Pr/K. Pr/K PRAL 7 9, , . 

https://www.ncbi.nlm.nih.gov/pubmed/29054469
( 2017), . 19 1,398 , : - , , DASH , , , , , , . 
DASH , , , , , 2
, DASH . , , . 

https://www.ncbi.nlm.nih.gov/pubmed/28236296
 ( 2017), - . 1,000 8-12 ( 92 "/"), - . 24-28 . 874 , 177 - 23.4% 17.1% .

- -25% , , , , . - .

https://www.ncbi.nlm.nih.gov/pubmed/29049303

( , 2017), -90,000 , -43% , -30% .
https://www.ncbi.nlm.nih.gov/pubmed/29049820

-  ( 2017) 3 E , .

60 , , , 1,000 " 3 -400 " E, - 6 .

, , . -CRP. , (10.3% 33.3%, p=0.03).
.  
https://www.ncbi.nlm.nih.gov/pubmed/27881297

 ( 2018) , - , .

1,238 18-30 , 1985-1986. 30 , 182 , 6.6 1,000 , 18 -5.1 .

, (" ) 6 -25% , 6 12 -48% 12 -47% . , . , , , . 
https://www.ncbi.nlm.nih.gov/pubmed/29340577

- ( 2018) . 260 , , 173 , , .

19 , " -22% . , 6 , -31% . , , , 1 . , -, , , , .

https://www.ncbi.nlm.nih.gov/pubmed/29489823

 

 

-

 

( 2016) -31,000 2 HbA1c -7% , -20% (, ), .

http://www.ncbi.nlm.nih.gov/pubmed/27273792

( 2016)    B12  ('). -2,000 850 " 3.2 . 9 .

 B12  5 13 . ,  B12. ,  B12   B12.

 B12  . 

http://www.ncbi.nlm.nih.gov/pubmed/26900641

(crossover)   ( 2015).

, NM504 - Gastrointestinal microbiome modulator, , - , .

" 11 2, . 500 " NM504, .

. ; , + , + . -, . 

+ , ( 6.78 4.45, p=0.0006) (121.3 151.9 "/", p<0.02).

NM504 2.

http://www.ncbi.nlm.nih.gov/pubmed/25802471

( 2015)    .  Rosiglitazone  - Thiazolidinedione   PPAR    , . 
,     .

http://www.ncbi.nlm.nih.gov/pubmed/25788674

  ,   2.  ( 2015)   -63,000   1994-2014. 
,   2, -LDL
" -LDL  2. 
, " ,  .

http://www.ncbi.nlm.nih.gov/pubmed/25756439

( 2014)    (, , ) .

1996-2009, -15,000   -47,000 .
:  -40%  -34% -12% . . 

.
    2 , ,   .  

http://www.ncbi.nlm.nih.gov/pubmed/25217178

( 2015)     2 .

8,749 - 45-73, 625 6 . -46% , . 24% 12% .

2.

, .

http://www.ncbi.nlm.nih.gov/pubmed/25754552

 

 

 

 |  |  |   | 

 

 

( 2015) 100   , (MRI).

http://www.ncbi.nlm.nih.gov/pubmed/26369383

( 2016),   2 ( 7% 100 "/ 12% 0.5 /, ),

http://www.ncbi.nlm.nih.gov/pubmed/26861925

( 2016)   2 .

http://www.ncbi.nlm.nih.gov/pubmed/26928090

-35,000 ( 2016)   2  .

http://www.ncbi.nlm.nih.gov/pubmed/27120802

-300,000 ( 2016)   -6 1 8.  

http://jama.jamanetwork.com/article.aspx?articleid=2518250

( 2016) 996 , , 25-45 ( ). . . 

https://www.ncbi.nlm.nih.gov/pubmed/28001453

 ( 2017) 2.

3,639 , , . , -4 : ( 40), ( 40-44), ( 45-55) ( 55).

9.2 , 348 2. , , 3.7, 2.4 -1.6 2, . , 2 -4% . 2 -BMI, , , CRP, . 2 .
https://www.ncbi.nlm.nih.gov/pubmed/28721436

 ( 2017) . , . . (, ) . ,
. , , , . , - ( ). , . - 6-7 . , , . , 5-HT4 .


https://www.ncbi.nlm.nih.gov/pubmed/27987136

 ( 2016) ' (Aloe vera) 2. , -, , -, , .

60 , ' ' , ( ). 3 -6 . ' , ( 1.07 0.67 , p<0.001) ( 1.23 0.67 , p<0.001) (1.83 1.10 ", p<0.001) (1.07 0.80 ", p<0.003).
https://www.ncbi.nlm.nih.gov/pubmed/26447752

,(2018) 67 25-50 -4 ( , , ), - ( , , ) . https://www.ncbi.nlm.nih.gov/pubmed/30050073

 

- –

 

( 2013)   , , .

http://care.diabetesjournals.org/content/early/2013/03/28/dc12-1272.short

( 2015)     2. 115 2 :

1) (14% , 28% , 58% ),

2) (53% , 17% , 30% ).

, , (HbA1c), ,  CRP, -LDL.

, , ( , )  HDL.

http://www.ncbi.nlm.nih.gov/pubmed/26224300

 (2018) - .

3,628 18-30 1985-1986, 25 . , 12.7% -53.8% -, 10.7 -9.5 , . - , -15% -7%, . , - - . 

- - .

https://www.ncbi.nlm.nih.gov/pubmed/29317451

- ( 2013) 6 " -900   2.

, .

2. 2 .

http://www.ncbi.nlm.nih.gov/pubmed/23900314

    2.

( 2014) 11 ,   .  -5 1,031 , 1,147 -1,136 .

, , -17% -15% -13% .  , .

,  2.

http://www.ncbi.nlm.nih.gov/pubmed/24578358

( 2014), 577   :  , .

6 , -1986, 23 .  174 , -40% -30% (11.9% 19.6%; 28.1% 38.4%), .

, -45% (72.6% 89.9%).

  , .

http://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)70057-9/abstract

( 2014)     (14% )  (53% )  2.

24 115 2 .

.

, 2.

.

http://www.ncbi.nlm.nih.gov/pubmed/25071075

( 2014) 30   .

http://www.ncbi.nlm.nih.gov/pubmed/24980134

- ( 2015)     2. 40 -100,000 . 10 " -13% , , , , .

140 " . " .

http://www.ncbi.nlm.nih.gov/pubmed/25668264

  ,   2.  ( 2015)     -63,000   1994-2014.  ,   2, -LDL
" -LDL  2. 
, " ,  .

http://www.ncbi.nlm.nih.gov/pubmed/25756439

( 2014)      (, , ) .

1996-2009, -15,000   -47,000 .
:  -40%  -34% -12% . . 

.  ,     2 , ,   .  

http://www.ncbi.nlm.nih.gov/pubmed/25217178

( 2015)     2 . 8,749 - 45-73, 625 6 .

-46% , . 24% 12% . 2.

, .

http://www.ncbi.nlm.nih.gov/pubmed/25754552

, ( 2014)     .

163 2 4 5 : / (58% ) / (40% ).  DASH.

, , , ,  LDL -HDL, -23% .

http://www.ncbi.nlm.nih.gov/pubmed/25514303

( 2016)   .

9,715 -15 . , 810 , 188 .

, -5 , 5 . . , , .  

http://www.ncbi.nlm.nih.gov/pubmed/26848062

( 2015) 13 , .

, , -100 " , (FMD) -900 " . 
, . 
32 , 2 , 100-500 , -900 " , -50-200 -100 .

, .

http://www.ncbi.nlm.nih.gov/pubmed/26125676

( 2015)   2 .

, 13,655 -435,165 . -9 , 2,607 , 19.1% -50.5 1,000 24.1% -72.7 .

, , . 2.

http://www.ncbi.nlm.nih.gov/pubmed/26247098

( 2016) - , 3 3,482 2 55.

, 2,611 (75%) 500 " 3 , . -6 69 .

-48% 500 " 3 -500 " . - .

http://www.ncbi.nlm.nih.gov/pubmed/27541690

( 2016)   , , - 2 .

387 52 , 129 (, 2 ).

, , , 2.

2 .

- . 2

http://www.ncbi.nlm.nih.gov/pubmed/27556410

- ( 2016)   . , -200,000 -12,000 2 , , 194,000 -13,000 2 .

-15% 2 -18% 2. , 7.5 " 17 5% 2. 

http://www.ncbi.nlm.nih.gov/pubmed/27530472

 ( 2017), , (-) , 2 .

1,948 -85 9-10. , 26% -, 46% -28% . - , , ( C, ). , -LDL -3.5 -3.7 "/" -.

-
https://www.ncbi.nlm.nih.gov/pubmed/29199181

 ( 2018), 2,840 14,684 , , . 

https://www.ncbi.nlm.nih.gov/pubmed/29545006

 

 

( 2010)   ( )  2, , .

  .

2. .

http://www.ncbi.nlm.nih.gov/pubmed/20425575

2 .

( 2013)     

6,000 2. 

5.5 , 31.7% -8.3% .

  .       .

.

http://www.ncbi.nlm.nih.gov/pubmed/23939297

  ( 2013)       2.

http://www.ncbi.nlm.nih.gov/pubmed/23719550

( 2015)    , , ,  2.

http://www.ncbi.nlm.nih.gov/pubmed/25493953

( 2015)     (CIN  Contrast-Induced Nephropathy) 2   . 120 :

, (2 3 , 3 -3 ), (3 3 , 3 -3 ).

, , CIN 2 - . 

http://www.ncbi.nlm.nih.gov/pubmed/26427112

( 2014)      (,   ) .

1996-2009, -15,000   -47,000 .
:  -40%  -34% -12% . . 

.  ,     2 , ,   .  

http://www.ncbi.nlm.nih.gov/pubmed/25217178

- ( 2015)   . 60 200 " 12 . (−3.1 ± 4.6 +0.5 ± 6.2 μIU/mL), (−0.9 ± 1.4 +0.1 ± 1.7, HOMA-IR) (−11.3 ± 16.3 +2.3 ± 22.0, HOMA-B) - (+2.3 ± 21.7 -27.7 ± 35.2 U/mL). , . 

http://www.ncbi.nlm.nih.gov/pubmed/26686847

( 2015)      .  954 .  , -11%  

HbA1 4%    HbA1c 3 ,  -80% 20% 2-3% - HbA1c.

http://www.ncbi.nlm.nih.gov/pubmed/25392197

( 2015) 623 2,       . 

http://www.ncbi.nlm.nih.gov/pubmed/26563378

- - ( 2015)   Tangshen (DKD).

7 : Astragalus membranaceus (35.3%),Euonymus alatus (17.6%), Rehmannia glutinosa (14.1%), Citrus aurantium (11.8%), Cornus officinalis(10.6%), Rheum palmatum (7.1%), Panax notoginseng (3.5%). 

180 , 122 8 -58 , (ACEIs ARBs), 24 . , , (0.21- 0.36 ). , eGFR.

, .

http://www.ncbi.nlm.nih.gov/pubmed/25938778

 

 

 

( 2014)   ,  ,    , .

.

. , , .

, , ,  . 

http://www.ncbi.nlm.nih.gov/pubmed/25010529

5000 ( 2014)         2, .

http://www.ncbi.nlm.nih.gov/pubmed/25102002

( 2014) 13,000 48-67    20  .    -19%   .

, - ,  , .

http://www.ncbi.nlm.nih.gov/pubmed/25437406

- ( 2016) , 12 1,137 , -, , .

https://www.ncbi.nlm.nih.gov/pubmed/27720402

 ( 2016), , 2.

50 , , - 6 . : 0.2% (Glycyrrhiza glabra), (Musa paradisiaca) 19.42%, (Curcuma longa) 2.43%, (Pandanus odoratissimus) 9.70%, 4.85% (Aloe vera) .

77% 12.5% (p<0.001). . 2 . 
, . 
https://www.ncbi.nlm.nih.gov/pubmed/27934800

,(2018) , 2 -32% , 25-44.

https://www.ncbi.nlm.nih.gov/pubmed/29898968

 ( 2018), , , HbA1c 10 .

5,189 , 10 . HbA1c 15.9-126.3 / (3.6-13.7%), -48 / (6.5%). 1 / , , -, . , , . .  
https://www.ncbi.nlm.nih.gov/pubmed/29368156

 

 

 

( 2014),       1 2 . 1997-2008. , .

.

http://www.ncbi.nlm.nih.gov/pubmed/25488912

- ( 2015) ,    .  9 2,408 , -   10 "/"   14% .
- .

http://www.ncbi.nlm.nih.gov/pubmed/25556126

( 2015)      . 497 2,830 .

( ), .

, . , .

http://www.ncbi.nlm.nih.gov/pubmed/25593034

( 2014) .  , 50-65  , 75% 4   18 .

, 65 .

, 5 . 

, . 

65 . ,    .

.

,   .

, .

http://www.cell.com/cell-metabolism/retrieve/pii/S155041311400062X

( 2016)    , 2.

12,132 2 15,919 .

3, (ALA) 2 EPA -DHA 2. 6, (LA) (EDA) 2, (AA) GLA, dihomo-GLA, DTA - n6-DPA 2.

PUFA 2.

http://www.ncbi.nlm.nih.gov/pubmed/27434045

-,(2018) 2,249 , 2.25 4.27, , .

https://www.ncbi.nlm.nih.gov/pubmed/29688833

( 2016)    BMI, 2 . -70 " 3, 2.

-1.5 14 ". 2,162 .

5 -BMI , -38% -25%. , 5 " -8% 2 2.6 . , BMI .

https://www.ncbi.nlm.nih.gov/pubmed/27742674

 ( 2017), 1998-2010, 2 -30% , . ( 2) 55, .
https://www.ncbi.nlm.nih.gov/pubmed/28436468

 ( 2017) . -175 -12 , 2012 (BMI 25) 10 .

-5% 2012 2002, -627 793 . , 24.5% -38.4% .

, 2 . , 26.1% -31.9% 1980-2002. , .
http://www.thelancet.com/journals/landia/article/PIIS2213-8587(17)30366-2/fulltext

 

 

 

 |  |  |   |   |  |   |  |   |   |  |   |  |   |   |   |   |  | 

 

 

- ( 2016) (Aloe Vera) .
, (283 ), HbA1c ( - 89). 2, . , (30-150 "/) ' (100-1,000 "/).
-46.6 "/" (p<0.0001) -1.05% (p=0.004). 200 "/", 109.9 "/" . , . 
https://www.ncbi.nlm.nih.gov/pubmed/27152917

- ( 2016) (aloe vera) 2 . , " 415 . (2 , 1 , 2.8 , 0.2 ) 6-12 . 
, ( 30 "/", p=0.02), HbA1c ( 0.41%, p<0.00001) , -LDL -HDL. , - , . 
https://www.ncbi.nlm.nih.gov/pubmed/27347994

( 2015) (Danoderma lucidum) .
5 398 .
3 , 2. , .
( 1.4 -3 ) , 12-16 . 2.
http://www.ncbi.nlm.nih.gov/pubmed/25686270

- ( 2015) .
- 35 -8 - .
2, ( 37 "/") ( 0.97%), . , , - 2.
, .
http://www.ncbi.nlm.nih.gov/pubmed/26561625

( 2017) . , .
- , , : (Momordica charantia), (Trigonella foenum graecum), ' (Gymnema sylvestre),Coccinia indica, (Opuntia), ' / (Panax ginseng / quinquefolius), (, Artemisia dracunculus), (Cinnamomum cassia), (, Plantago spp) (Allium sativum). , .
- 2. 
https://www.ncbi.nlm.nih.gov/pubmed/28729836 

(2016) - 2 . : 

  1. – (Cichorium intybus), (Curcuma longa) (Passiflora incarnata). 
  2. (Marrubium vulgare) (Momordica charantia).
  3. - (Aloe), (Berberis vulgaris) (Momordica charantia). 
  4. – (Ficus racemosa) (Punica granatum).

, , : (Aloe), (Capparis spinosa) (Cinnamomum cassia), (Citrullus Colocynthis), (Momordica charantia), ' (Panax ginseng), (Plantago spp), (Silybum marianum), (Trigonella foenum-graecum), (Urtica dioica).

2, .
: , ' (Gymnema sylvestre), 4 . 
https://www.ncbi.nlm.nih.gov/pubmed/26306505

 (2018) . 16 -3 . - , ( ) , . - .

. , , . , . 

https://www.ncbi.nlm.nih.gov/pubmed/29287194

 (2017) , . BMID (Bacteria-Mucosal Immunity-Inflammation-Diabetes), , .

, -, , , (Momordica charantia), , , (Morus) , . , .

https://www.ncbi.nlm.nih.gov/pubmed/29164155

( 2014) , , .

: (Astragalus membranaceus) .
(Ginkgo biloba) " , , .
(Salvia miltiorrhiza) " , " .
(Cordyceps sinensis) .
(Trigonella foenum-graecum) - .
, .
(Curcuma longa) - .
(Crataegus spp) ACE .
, (Silybum marianum) . , .
' (Panax quinquefolium) " , , - .
http://www.ncbi.nlm.nih.gov/pubmed/24818164

( 2011) .
( ) : (Stevia rebaudiana), (Cinnamomum zeylanicum), (Trigonella foenum graecum), (Allium sativum), ' (Gymnema sylvestre), (Momordica charantia) ' (Panax ginseng, Panax quinquefolium).
http://www.ncbi.nlm.nih.gov/pubmed/22107597 

( 2011) .
' (Panax ginseng), ' (Panax quinquefolium), (Momordica charantia), (Coptis chinensis), (Lagerstroemia Speciosa), (Trigonella foenum graecum), ' (Gymnema sylvestre) (Cinnamomum zeylanicum). ( , , ).
http://www.ncbi.nlm.nih.gov/pubmed/21826590

( 2007) (Eugenia jambolana), (Momordica charantia), (Ocimum sanctum), (Phyllanthus amarus), (Trigonella foenum graecum) .
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275761/
- ( 2015) 27 2,569 ( Hydrastis canadensis , Berberis vulgaris, Coptis chinensis,Phellodendron amurense ) 2, .
http://www.ncbi.nlm.nih.gov/pubmed/25498346

( 2004) .
. (Momordica charantia), (Trigonella foenum graecum), ' (Gymnema sylvestre), (Curcuma longa) .
http://www.ncbi.nlm.nih.gov/pubmed/15165418

( 2003) .
( ) ' - (Panax spp), (Allium sativum), (Ocimum sanctum), ' (Gymnema sylvestre), (Momordica charantia), (Trigonella foenum graecum), (Silybum marianum), , , E, , .
http://www.ncbi.nlm.nih.gov/pubmed/12663610

( 2017) (Stevia rebaudiana), , -, , , . 
https://www.ncbi.nlm.nih.gov/pubmed/28792778

- ( 2016) (Trigonella foenum-graecum) , , . 
https://www.ncbi.nlm.nih.gov/pubmed/27879673

( 2016) 2008-2015 (Berberis vulgaris) - , , , , , , , , .
https://www.ncbi.nlm.nih.gov/pubmed/27528198

( 2015) , , . . 
http://www.ncbi.nlm.nih.gov/pubmed/26591510

( 2014) - , . .
- , .
http://www.ncbi.nlm.nih.gov/pubmed/24818152

( 2014) .
, , , , , .
(Berberis vulgaris), (Hydrastis canadensis), (Coptis chinensis).
http://www.ncbi.nlm.nih.gov/pubmed/25183302

(2015) '' 2 , . - '' , .
'' , , .
, '' - , . 
http://www.ncbi.nlm.nih.gov/pubmed/26080605

( 2014) (Allium cepa) 2. ( ), .
, 2. , , .
, .
http://www.ncbi.nlm.nih.gov/pubmed/25194613

( 2013) (Passiflora incarnate) – , . , .
- , , - . , .
http://www.ncbi.nlm.nih.gov/pubmed/24140586

- ( 2016), , (Rosmarinus officinalis), , .
, , . , , , , , . , -, . , , .
,
https://www.ncbi.nlm.nih.gov/pubmed/27178264

- ( 2016) (Rubus idaeus) , , , , , .
https://www.ncbi.nlm.nih.gov/pubmed/26773014 

( 2016) - , , , , , . 
https://www.ncbi.nlm.nih.gov/pubmed/26634804

( 2015) ( ) 1.
' . , .
, . 
http://www.ncbi.nlm.nih.gov/pubmed/26606153

 

 

 (Cinnamomum zeylanicum)

 

- ( 2012)    (Cinnamomum zeylanicum),  .

, , , , . , , "" (LDL) , "" (HDL) . , .

http://www.ncbi.nlm.nih.gov/pubmed/22671971

- ( 2012)     44 2. 8 , 3 , . 

, , , HbA1c, , BMI    .

.

http://www.ncbi.nlm.nih.gov/pubmed/22973482?dopt=Abstract

- (- 2013)     . 10 , " 543 2, .

-120 " 6 4-18 , , LDL   HDL. , (HbA1c).

. , .

http://www.ncbi.nlm.nih.gov/pubmed/24019277

( 2012)   30 18-30,  BMI  (BMI > 30).

50 ,   6 . , . . 

, .

, .

http://www.ncbi.nlm.nih.gov/pubmed/23102179

-     . 48 60 , 1 , 2 + .

, .

http://apjcn.nhri.org.tw/server/APJCN/23/4/Turmeric.pdf

( 2011)   . ( )   (Cinnamomum zeylanicum).

http://www.ncbi.nlm.nih.gov/pubmed/22107597 

( 2011)   .

  (Cinnamomum zeylanicum). ( , , ).

http://www.ncbi.nlm.nih.gov/pubmed/21826590

( 2015)   (Cinnamomum burmannii)

http://www.ncbi.nlm.nih.gov/pubmed/26258147

- (Cinnamomum zeylanicum) Vaccinium arctostaphylos, , , -BMI 2.

105 - . " ( 1 ) 90 .

– -BMI. , , Vaccinium arctostaphylos (p<0.05) -p=0.02) BMI).

2. 

http://www.ncbi.nlm.nih.gov/pubmed/26362826

 ( 2016) , 2.

204 , - 3 (Cinnamomum zeylanicum), 3 (Elettaria cardamomum), 1 (Crocus sativus) 3 '' (Zingiber officinale) 3 8 –   .  ICAM-1 ( : Intercellular adhesion molecule-1), , .

. , , '' ICAM-1 '' . , 2.  
https://www.ncbi.nlm.nih.gov/pubmed/26758574

( 2016)

https://journals.lww.com/tnpj/Fulltext/2016/11000/Herbal_supplements_used_to_treat_common_chronic.6.aspx

 

 (Gymnema sylvestre)

 

( 1990) 22 2 18-20 ,   400 "   ' (Gymnema sylvestre , .

5 ( ').

 ' .

http://www.ncbi.nlm.nih.gov/pubmed/2259217

( 1990), 27 1 ,   400 "   ' (Gymnema sylvestre . .

http://www.ncbi.nlm.nih.gov/pubmed/2259216

 ( 2003/ 2011 )   . ( )  ' (Gymnema sylvestre).

http://www.ncbi.nlm.nih.gov/pubmed/12663610

http://www.ncbi.nlm.nih.gov/pubmed/22107597 

( 2011)   .

 ' (Gymnema sylvestre).

( , , ).

http://www.ncbi.nlm.nih.gov/pubmed/21826590

( 2004)   . .   ' (Gymnema sylvestre) .

http://www.ncbi.nlm.nih.gov/pubmed/15165418

(- 2015)     2.

32 30-60 . ' (Gymnema sylvestre), (Artemisia absinthium) (Citrullus Colocynthis) 1 ( ), 30 .

' : -37%,  -5%,   -13% LDL -19%.

 LDL  6%  HDL  3%.

, ,    HDL -35%, 6%, 6% -5% .

, . 

http://www.ncbi.nlm.nih.gov/pubmed/26665406

 

 

' (Panax quinquefolium)

 

( 2012) ' (Panax quinquefolium) . ' (-3 ) . , , .
' ( ).
, ' () . , ' "" (LDL). ' .
http://www.ncbi.nlm.nih.gov/pubmed/23390846
( 2011) .
' (Panax quinquefolium). ( , , ).
http://www.ncbi.nlm.nih.gov/pubmed/21826590
( 2014) , , .
' (Panax quinquefolius) " , , - .
http://www.ncbi.nlm.nih.gov/pubmed/24818164
( 2017) - ' (Panax ginseng) ' (Panax quinquefolius), -, , , -, , , , , ,
https://www.ncbi.nlm.nih.gov/pubmed/27930975
( 2014) ' . 16 ' (Panax ginseng, Red ginseng, Panax quinquefolium) ( , , , ) . (56.3%) 339 (2 , 5 , -2 ) (43.7%) 431 ( ", 2 , -4 ). ' (p=0.03). , , . (p=0.01). 
https://www.ncbi.nlm.nih.gov/pubmed/25265315
- ( 2013) ' (' , ' , ' , ' , ' ' ) 2 . 8 ' (Panax quinquefolius) ' , , . 3-5 . ' . , (HOMA-IR) ( ). , (HbA1c) . . , .
https://www.ncbi.nlm.nih.gov/pubmed/22969004

( 2003/ 2011 ) . ( ) ' (Panax spp).
http://www.ncbi.nlm.nih.gov/pubmed/12663610
http://www.ncbi.nlm.nih.gov/pubmed/22107597
(2000) ' (Panax quinqefolium) . 10 ( : 63:BMI 27.7, - :HbA1c 7.3) . (Sulfonylurea Sulfonylurea-- Metformin). -16 : 3, 6 9 ' ( 3.21% Ginsenosides), 120, 80, 40 (25 ). . (' ) (p<0.05). , ' 30 , 45 , - 120 (p<0.05). . ' .
https://www.ncbi.nlm.nih.gov/pubmed/10977009
(2000) ' (Panax quinqefolium) . 10 ( : 34, BMI: 25.6, : 73 ") -9 ( : 62:BMI 29,: 81 - :HbA1c 8) . (Sulfonylurea Sulfonylurea-- Metformin). 3 ' 40 (25 ). . ' . , 40 , ( 31%, p<0.05). , ( 17% - 22% , p<0.05).
https://www.ncbi.nlm.nih.gov/pubmed/10761967
(1995) ' . 36 ' 100 200 " ( ) . ' , . 200 " (Glycated Hemoglobin), - *Aminoterminal propeptide of type III procollagen) PIIINP) . ( ). 
* . .
https://www.ncbi.nlm.nih.gov/pubmed/8721940

( 2007) ' (CHD-Coronary heart disease) . 84 (Impaired glucose tolerance) . , ' (Panax quinquefolium saponins) . . (p<0.01). ' (25.8% 12.17%) . (Function of beta cells of homeostasis model) ' (p<0.01) ( p<0.05). , - LDL (p<0.05). , : (Fasting insulin), (Insulin sensitive index) (Insulin resistance index) (p>0.05). 
https://www.ncbi.nlm.nih.gov/pubmed/18198636

(2003) (crossover design) ' (Panax ginseng) . , 12 (BMI: 28) ' 6 40 (75 ). . , . ( PPD:PPT) .
https://www.ncbi.nlm.nih.gov/pubmed/12571655
(2004) (multiple crossover design) ' ( 75 ). 12 ' (Panax ginseng, Panax red ginseng, Panax quinquefolius, wild Panax quinquefolius, Panax vietnemensis, Eleutherococcus senticosus, Panax japanicus, Panax notoginseng) 3 40 . ( ' ) . ' (p<0.05). ' 90 (p<0.05) (BMI>25). , ' ' 90 (p<0.06) ' ' 90 , ' 120 (p<0.05). ' .
https://www.ncbi.nlm.nih.gov/pubmed/15190050

( 2015) ' (Panax quinquefolius) ' (Panax ginseng) . , 13 10 ' ( - 30%, 50%, 70% '). 40 . ' -30% ' -50% (p<0.05).
https://www.ncbi.nlm.nih.gov/pubmed/25446600

 

 

 

 - Syn Syzygium cumini, Eugenia cumini, Eugenia jambolana) Syzygium jambolanum)   .  , . 

( 2013)   .

,   .

, .

http://online.liebertpub.com/doi/abs/10.1089/acm.2011.0752

( 2007)       (Eugenia jambolana),  (Momordica charantia),   (Ocimum sanctum),  (Phyllanthus amarus),  (Trigonella foenum graecum) .

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275761/

 

 

(Allium sativum)

 

( 2013)     , . 60 , Metformin     .

12 , . , , . (HbA1c).

– , , -LDL  -HDL.  , (CRP)  ADA (adenosine deaminase) .

.

 CRP -ADA  .

http://www.ncbi.nlm.nih.gov/pubmed/23378779?dopt=Abstract

 ( 2003/ 2011 )     .   ( )   (Allium sativum).

http://www.ncbi.nlm.nih.gov/pubmed/12663610

http://www.ncbi.nlm.nih.gov/pubmed/22107597

 

 

(Panax ginseng)

 

( 2014) ' (Panax ginseng) ( ). -16 , 770 .
' , 30 . : , , (HbA1c) .
' ( ), ( 0.31 mmol/L). ', . , .
'
http://www.ncbi.nlm.nih.gov/pubmed/25265315

( 2011) ' . (Parallel) (Crossoverr) , ' . ' 2.7 -6 , ' 780 " . 12 . , ' 12 . , .
https://www.ncbi.nlm.nih.gov/pubmed/22139546
(2005) ' . .
http://www.ncbi.nlm.nih.gov/pubmed/16047557
( 2003/ 2011) . ( ) ' (Panax spp).
http://www.ncbi.nlm.nih.gov/pubmed/12663610
http://www.ncbi.nlm.nih.gov/pubmed/22107597

( 2011) . ' (Panax ginseng).
( , , ).
http://www.ncbi.nlm.nih.gov/pubmed/21826590

( 2017) - ' (Panax ginseng) ' (Panax quinquefolius), -, , , -, , , , , , .
https://www.ncbi.nlm.nih.gov/pubmed/27930975

 

. , ' ', ' , ' : 

 

'

 

( 2003) (multiple crossover designn) ' ( 75 ). 11 ' 1, 2, 3 40 . 11 ' 3, 6 9 40 . ( ') . (-40, 0, 15, 30, 45, 60, 90, 120 ) , (p=0.05).
https://www.ncbi.nlm.nih.gov/pubmed/14684758

( 2009) ' (HbA1c), , 24 . 17 4% ' (G115) ' 200 " 57 . 27 57 11 ' (Cheong Kwan Jang) 200 " . . ' .
https://www.ncbi.nlm.nih.gov/pubmed/19017419

( 1995) ' . 36 ' ( ) 100 200 " . ' , - , (p<0.05) . ' 200 " , () ( PIIINP- Amino Terminal Peptide of Procollagen III ) . .
https://www.ncbi.nlm.nih.gov/pubmed/8721940

( 2008) (Crossover study) ' . 20 ( 51.5) (HbA1c 7.4, BMI 28.5) ( ) / , ' 2.2 . , , , . ( 75 ). ' ( 45% -12% , p<0.05), (p<0.05). ' (p<0.05). . , ' ( C, E) ( MDA) , .
https://www.ncbi.nlm.nih.gov/pubmed/18355331

 

'


( 2006) ' ( 50 ). , ' , ' 6 40 . , 12 2, 4 6 ( ). ( / ) . , ' -29% ( p=0.052 ), ' . ' Rg1 . , ( 17%, p=0.057), .
https://www.ncbi.nlm.nih.gov/pubmed/16582025
( 2011) (Crossover designn) ' . 12 , 13 ' (body) , ' (rootlets) . . ' ' . , ( ) -27% (p<0.05) .
https://www.ncbi.nlm.nih.gov/pubmed/21619921
( 2008) (Crossover designn) ' ( HbA1c 6.5). 19 ( 64, BMI 28.99 ) ' 6 ( , ' 1.92%) 40 12 ( ). 4-6 , 12 . ' 75 ( 8-11%) ( 34% ,( p<0.05 ( 33% p<0.05 ). , ' - 33% ' (p<0.05) . ' (p=0.052). (HbA1c=6.5) ( ) . .
https://www.ncbi.nlm.nih.gov/pubmed/16860976

( 2011) ' 'Re . 15 (BMI=34) 2 , ' ( 3 -8 ) ' 13.7% ' Re ) 250 " -500 " ). . Re, Rb₁ -Rb₂ , .
https://www.ncbi.nlm.nih.gov/pubmed/21411505
(2013) ' (BMI 23-24.9) (BMI>25) . 68 (BMI>=23) 6 ' 12 . , ( , LDL, HDL ) .
https://www.ncbi.nlm.nih.gov/pubmed/23945406

( 2013) ' .
93 ' . ' (DHEAS), (GH) (E2). , HbA1c, .
, , .
http://www.ncbi.nlm.nih.gov/pubmed/23675990

- ( 2014) ' . 41 5 ' 12 . , .
http://www.ncbi.nlm.nih.gov/pubmed/24456363

 

'


( 2014) ' . 42 ( 6.5 /) ' 2.7 . (p<0.01) ' . , '. , .
https://www.ncbi.nlm.nih.gov/pubmed/25015735

 

 

(Urtica)

 

(2013)     2 . 46 500 " 8 3 , .

, ,  HbA1c.

, .

2.

http://www.ncbi.nlm.nih.gov/pubmed/24273930

( 2014)    (Urtica dioica)  (Juglans regia)  . - . 2 "/" 0.4 "/" -60%.

http://www.ncbi.nlm.nih.gov/pubmed/25140210

 

 

(Silybum marianum)

 

( 2014) (Silybum marianum) . 600 " , . -20% , . , , , .
https://www.ncbi.nlm.nih.gov/pubmed/25396404

 

 (2018) - , (Silybum marianum), - , . 

https://www.ncbi.nlm.nih.gov/pubmed/29736939


(2014) (NAFLD). . -, , - - . , , , . , . , .
https://www.ncbi.nlm.nih.gov/pubmed/25514914
( 2003/ 2011) . ( ) (Silybum marianum).
http://www.ncbi.nlm.nih.gov/pubmed/12663610
http://www.ncbi.nlm.nih.gov/pubmed/22107597
(1993, 1997) . 60 ( 45-70) 5 . 600 " 6 . 60 (), ( ), 600 " 12 . (p<0.01), (p<0.01), (p<0.01), (p<0.01), (p<0.01), C ( ) (p<0.01), (p<0.01) . , ( ) (p<0.01), .
http://www.sciencedirect.com/science/article/pii/S0011393X05806605
https://www.ncbi.nlm.nih.gov/pubmed/9126802
( 2015) (Silymarin) . 40 . 420 " 45 . ( - 12.85%, 30.32% -8.43% -SOD, , p<0.05). , 26.83% CRP 12.01% (Melondialdehyde) (p<0.05 ).
https://www.ncbi.nlm.nih.gov/pubmed/25765835
(2006) 51 2 . 600 " . , (HbA1c) ( : p<0.001), (p<0.001), (p<0.0001), LDL ( : p<0.005), (p<0.004) (AST, ALT) ( : p<0.008-0.0001). , , . (p<0.0001) (p<0.0001) . 
https://www.ncbi.nlm.nih.gov/pubmed/17072885
( 2015) (Berberol) 1. 588 " Berberis aristata -105 " . 85 (2 ) 6 . , . , , , , -LDL -HDL . . .
https://www.ncbi.nlm.nih.gov/pubmed/26384091
( 2015) (Berberol) - . 588 " Berberis aristata -105 " . 137 + 6 . ( 9 "/") ( 0.7 μU/ 0.35 HOMA-index) . , ( 23.4 "/" , 19.6 "/" -LDL -23.1 "/" ). - .
https://www.ncbi.nlm.nih.gov/pubmed/25577665
(2013) (Crossover design) Berberol (). 588 " Berberis aristata -105 " . 105 . , 2 . / , (/) . , , -LDL -HDL . , , (HOMA-IR) (RBP-4) , . . . . 
https://www.ncbi.nlm.nih.gov/pubmed/24152839
( 2015) (Kepar) . 78 4 2 160 " , 102 ( Silybum marianum) -24 " (Commiphora mukul), - 14 " -2.5 " . 4 (-81.1 -79.4 ", p<0.0001), -BMI (-29.6 -29.3, p=0.001) (-105 -102 ", p=0.0004) (-6.5 -6.4 , p=0.014) (-4.8 -4.5 , p=0.03) . . 
https://www.ncbi.nlm.nih.gov/pubmed/25632052

 

 

 |   |   | 

 


(2013) (Curcuma longa) , . , , , , , .
https://www.ncbi.nlm.nih.gov/pubmed/24348712
(2012) . 240 ( 30-64) ( 75-85%) 1500 " . 16.4% (p<0.001). , (HOMA-β)(p<0.01), (p<0.001) (HOMA-IR) (p<0.05) ( C) (p<0.05).
https://www.ncbi.nlm.nih.gov/pubmed/22773702
(crossover trial) (2010) . 14 6 (75 ). , (p<0.02). .
https://www.ncbi.nlm.nih.gov/pubmed/20937162

 


( 2016) .
.
2, , , , .
-.
, , , -30 , -, , .  
http://www.ncbi.nlm.nih.gov/pubmed/27264638
- (2017) 2. 118 2, 8 . 1,000 " 10 " . , (p<0.001). , TAC : total antioxidant capacity -SOD, -superoxide dismutase (p<0.001) -MDA -malondialdehyde. -BMI . . 
https://www.ncbi.nlm.nih.gov/pubmed/27928704
- (2014) . 48 60 ( BMI=18.5-30, 100-125) , 1 , 2 +. . . (p=0.05), (p<0.01) (APP, PS1, PS2, GSK-3β). (327).
http://www.ncbi.nlm.nih.gov/pubmed/25516316
(2011) . 40 2 ( ACE, ) 1500 " ( -66.3 " ) . , (TGF-β, TNF-α -IL-8) (TGF-β p<0.006, TNF-α , IL-8 p<0.02, p<0.001, ) (TGF-β p<0.006, TNF-α p<0.007, IL-8 , p<0.03, p<0.02). 
https://www.ncbi.nlm.nih.gov/pubmed/21627399
(2011) (Meriva) (diabetic microangiopathy).
25 ( 1:2 ( 1 ( ) . . (p<0.05 skin flux), (p<0.05 venoarteriolar response) (p<0.05 edema), (p<0.05 PO2). 
https://www.ncbi.nlm.nih.gov/pubmed/22108476
(2016) 2. 50 , , - 6 . : (Glycyrrhiza glabra) -0.2%, (Musa paradisiaca) -19.42%, (Curcuma longa) -2.43%, (Pandanus odoratissimus) -9.70%, (Aloe vera) -4.85% . 77% 12.5% (p<0.001). . 2 .
https://www.ncbi.nlm.nih.gov/pubmed/27934800

 


(2014) . 240 ( 35 , ≥126, ≥200 " , HbA1c ≥6.5) ( 75-85%) 250 " . , (Pulse wave velocity, )(p<0.01), (HOMA-IR)(p<0.01), (p<0.01), (p<0.01), (p<0.01), (p<0.05) (p<0.01) (p<0.01). -BMI , -LDL, ALT, -HDL.
https://www.ncbi.nlm.nih.gov/pubmed/24445038
 


(2008) (NCB-02) - . 72 - ( 78% , 72% ) 300 " , Atrovastatin ( 10 " ) . 67 . , ( ), 1 ( ) 6 -TNFɑ -Atrovastatin . 
https://www.ncbi.nlm.nih.gov/pubmed/18588355
- (2017) () (Curcuminoids C3 Complex ®, Sabinsa), 2. 118 , (1,000 "/ + 10 "/ ) , , 12 . , (p<0.05) , HDL a HDL. -LDL (p>0.05). 2 .
: " , Sabinsa . 
http://www.sciencedirect.com/science/article/pii/S0965229917303370
https://www.ncbi.nlm.nih.gov/pubmed/28735818

- (2014) , . 65 ( 95% ) 1890 " 12 . , -LDL (p<0.01) , ( , , HDL) . , .

https://www.ncbi.nlm.nih.gov/pubmed/25131839
(2015) (Biperine®) . 44 -2% , 95% 1600 " 400 " . -1.88 -4.91%, (-0.7 -8.43%), (-2.36 -4.14%), (-0.74 -2.51%) -BMI (-2.10 -6.43%)(p<0.01 ). . ( p<0.05, p<0.01, p<0.05, -BMI p<0.01). .
https://www.ncbi.nlm.nih.gov/pubmed/26592847
- (2015) (Curcuma longa) (Nigella sativa), , . 250 . -4 , 1.5 , 2.4 , 900 " + 1.5 . 8 ( p=0.001, p=0.02, LDL p<0.001 HDL p=0.02) (p=0.02), (p=0.009), -(LDL (p<0.001 (CRP (p<0.001 . , , (CRP p=0.007, p=0.04, p=0.02, p<0.001, p=0.03, HDL p=0.04, p<0.001 LDL), .
https://www.ncbi.nlm.nih.gov/pubmed/25847554
 

 

(Stevia rebaudiana)

 

- ( 2014) 9       .   .  A. .

http://www.ncbi.nlm.nih.gov/pubmed/25412840

( 2011)   . ( )   (Stevia rebaudiana).

http://www.ncbi.nlm.nih.gov/pubmed/22107597 

 

 

 (Momordica charantia)

 

 |   |   |   |  | 

 


( 2012) 2 ( ) (Momordica charantia). 479 . . . 2. -Metformin Glibenclamide. . 
https://www.ncbi.nlm.nih.gov/pubmed/22895968

( 2015) (Momordica charantia) 2.
- , .
- .
, .
- , - 2. 
http://www.ncbi.nlm.nih.gov/pubmed/26459126

( 2014) - .
-, - (, , ). , . , 2. 
http://www.ncbi.nlm.nih.gov/pubmed/24295371

( 2003/ 2011) . ( ) (Momordica charantia).
http://www.ncbi.nlm.nih.gov/pubmed/12663610
http://www.ncbi.nlm.nih.gov/pubmed/22107597
( 2011) . (Momordica charantia). ( , , ).
http://www.ncbi.nlm.nih.gov/pubmed/21826590
( 2004) . . (Momordica charantia) .
http://www.ncbi.nlm.nih.gov/pubmed/15165418
( 2007) (Momordica charantia) .
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275761/


. , . :
 


( 1999) (Momordica charantia) 100 . ( ) (75 ) ( -18%, p<0.001). 86 (86%). (5%) .
https://www.ncbi.nlm.nih.gov/pubmed/10758656

( 1993) 54% (p<0.01). 100 . . , . .
http://onlinelibrary.wiley.com/doi/10.1002/ptr.2650070405/abstract
 
: ( 2009) ( ) ( ) 50 " 100 " (75 ). . , , . 
https://www.ncbi.nlm.nih.gov/pubmed/19665538
 

 


(2016) ( 10% Charantin) ( 1 ) . (HbA1c)(p=0.0002). .
http://www.eurekaselect.com/76671
 

 


( 2007) (Momordica charantia) ( 2) . 40 (HbA1C) 7%-9% . . 0.2% (p=0.4825). , , ( , ALT, AST, ). 
https://www.ncbi.nlm.nih.gov/pubmed/17493509

(2014) " (DBCare) 2 . 11 , (Momordica charantia). 35 2 ( 3 – 900 " ) 12 . . ( , , BMI , , ) ( - 70 " ) (7 1, p=0.048) . . 
https://www.ncbi.nlm.nih.gov/pubmed/24533608
 

 


( 2003) (Fructosamine) . 2-3 . 50 6 (Riboflavin) 4 . . - 350.8 - 319.1 " , - 349.1 - 333.9 " . 
https://www.ncbi.nlm.nih.gov/pubmed/14723327
 

 

 


( 2009) (Momordica charantia) (Rosiglitazone (Avandia . 50 (55 " ) -Rosiglitazone ( 4 " ) 24 . . * ( . : 60.2 57.6, p=0.01, 112 88.35, p<0.04). , ( 160-200 " : 192 170.6, p<0.03. : 216.45 170.6, p<0.01). , , ( 61.05, 187, 239, 183) . 
* . 
https://www.ncbi.nlm.nih.gov/pubmed/19362455

( 2011) (Momordica charantia) -Metformin . 129 ( 500 " 0.04-0.05% charantin) 500 ", 1000 ", 2000 " Metformin ( 1000 " ). 2000 " Metformin (Fructosamine), ( 10.2 16.8 , , p=0.04). 500 1000 ". , -Metformin, . ( , ). 
https://www.ncbi.nlm.nih.gov/pubmed/21211558

( 2005) - - 2. 95 -3 : 2 /, 4 / (Glibenclamide 55 "/) 10 . , , ( HbA1c ), , 4 . , , , , . - , .
https://www.ncbi.nlm.nih.gov/pubmed/25623883
 

 

 (Trigonella foenum graecum)

 

 ( 2003/ 2011)     . ( )   (Trigonella foenum graecum).

http://www.ncbi.nlm.nih.gov/pubmed/12663610

http://www.ncbi.nlm.nih.gov/pubmed/22107597

( 2011)   .    (Trigonella foenum graecum). ( , , ).

http://www.ncbi.nlm.nih.gov/pubmed/21826590

( 2004)   . .    (Trigonella foenum graecum) .

http://www.ncbi.nlm.nih.gov/pubmed/15165418

( 2007)        (Trigonella foenum graecum) .

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275761/

 ( 2014)    , ,  .

 (Trigonella foenum-graecum) - . , .

http://www.ncbi.nlm.nih.gov/pubmed/24818164

(2014)   (Trigonella foenum greacum)  2.  88 10 5 8 . , . 2. 

http://www.ncbi.nlm.nih.gov/pubmed/26098483

( 2015)   2 -. 3 140 30-70.

5 , . 2 , 4.2 .

, -LDL, .

10 -, .

http://www.ncbi.nlm.nih.gov/pubmed/26436069

( 2016) (Trigonella foenum-graceum) .

, . .

Trigonelline . Diaszhenin . 

http://www.ncbi.nlm.nih.gov/pubmed/25922446

 

 

 


( 2015) (Ganoderma lucidum) . 398 .
, 2. , . ( 1.4 -3 , 13-300 ) , 12-16 . 2.
http://www.ncbi.nlm.nih.gov/pubmed/25686270
(2004) Ganopoly (Ganoderma lucidum) 25% . 5.4 12 . , , . .
http://www.dl.begellhouse.com/journals/708ae68d64b17c52,0738f8d34e863c74,1629a45749954343.html

 

 

 

( 2000) ( 2) ( ). 6 2 ( ) 3 30 -6 Daonil ( : Glibenclamide). Daonil ( 12%, p<0.01). ( 6% , p<0.01, 22% , p<0.01 20% , p<0.01).
6 3 30 . ( 10%), ( 15%), - LDL 6% -VLDL ( 15%). (p<0.01). , -HDL. . . 
https://www.ncbi.nlm.nih.gov/pubmed/11116534

( 2008) ( ®Sensoril Essentra) (Chronic stress). 130 125 " , 125 " , 250 " 60 . 12% withanolides -1% withaferin A , 125 " -1 ( 8:1). 32 . (A modified Hamilton Anxiety Scale – Mham-A) (p<0.001) -70%. 250 " . , 250 " : -30.5% -DHEA-S -32.5%. 35.2% -CRP, (6.1%), (13.1%), (11.7%), -LDL 17.4%  -VLDL 23.9%. -HDL -17.3% -9.1%. (6.6%) (3.3% -6.4% ). (p<0.05 p<0.01). .
https://blog.priceplow.com/wp-content/uploads/2014/08/withania_review.pdf

( 2012) . 18 18-30 ( 8:1) : 750 " 10 ( -6 ), 1000 " 10 ( -8 ) -1250 " 10 ( -10 ). ( , , ). . (p<0.05). -LDL, -VLDL -HDL , ( ) ( -93.27 -86.27) (-27.78 -25.52). (Muscle force: Quadriceps, Back extensor, p<0.05). ( , , , , ESR) . , ( , , , , ).
https://www.ncbi.nlm.nih.gov/pubmed/23125505 

(- 2013) . -150 /', HDL -40 -50 100 /'.30 1200 " . ( 12%) ( 13%) (p<0.05).
https://www.ncbi.nlm.nih.gov/pubmed/24014929

 

 

 

- ( 2016), , (Astragalus membranaceus) 2. 13 , 1,054 , - .
, . , HbA1c. 2, .
https://www.ncbi.nlm.nih.gov/pubmed/27269392

- ( 2016) () 1.
416 , 1,608 . (Rehmannia glutinosa) (Astragalus membranaceus).
-33%, ( 180 ) -40%. . 1. 
https://www.ncbi.nlm.nih.gov/pubmed/27340102

 

 

(Camellia sinensis) . ( 2013) - 17 . (Hb A1c). 
, .
http://www.ncbi.nlm.nih.gov/pubmed/23803878

- ( 2014) , 2 . 
92 500 " 3 , , 16 . 
, , HDL, .
, GLP-1 ( Glucagon-like peptide 1) , . 

http://www.ncbi.nlm.nih.gov/pubmed/24614112

( 2016), 30 2, 600 ", 200 ", 12 , -, -BMI. 
https://www.ncbi.nlm.nih.gov/pubmed/26692322

( 2015) (Camellia sinensis) .
28 19-28 (50 + 100 " ) - - . 4 (-257 " EGCG) . CO2, .
(p=0.003).
http://www.ncbi.nlm.nih.gov/pubmed/26226166

- ( 2014) , 2 . 
92 500 " 3 , , 16 . 
, , HDL, .
, GLP-1 ( Glucagon-like peptide 1) , . 

http://www.ncbi.nlm.nih.gov/pubmed/24614112

( 2016), 30 2, 600 ", 200 ", 12 , -, -BMI. 
https://www.ncbi.nlm.nih.gov/pubmed/26692322

( 2015) (Camellia sinensis) .
28 19-28 (50 + 100 " ) - - . 4 (-257 " EGCG) . CO2, .
(p=0.003).
http://www.ncbi.nlm.nih.gov/pubmed/26226166

 

 


(Centella asiatica)

(2001) (TTFCA) . 50 . 30 (total triterpenoid fraction of Centella asiatica – -40% asiaticoside, 30% asiatic acid -30% madecassic acid) 120 " . . : (RF) , ( ) ( )(p<0.05-0.01). , .
https://www.ncbi.nlm.nih.gov/pubmed/11666124
(2001) (TTFCA) . 100 , , . ( ). (total triterpenoid fraction of Centella asiatica – -40% asiaticoside, 30% asiatic acid -30% madecassic acid) 120 " 12 , . , . , , ( 38% 22% ) ( 38% 9.5% )(p<0.05). 22.7% ( ) . (P<0.05). 
https://www.ncbi.nlm.nih.gov/pubmed/11666119
 

 

 

( 2017) (Ziziphus jujube) , 2. , 116 - . 10 -100 " , 3 , 12 . , -55% , 15% -30% -500 . 
, (0.68% 0.44%), (24.3 11.2 "/"), -LDL ( 19.9 6.6 "/") (43.3 27.2 "/"). -HDL . 2. 
https://www.ncbi.nlm.nih.gov/pubmed/28271568

- ( 2017), , (Nigella sativa) , 2, .
114 , ( ) , 2 / , , .
, -LDL -HDL , . , , . 
: ( ), . , . 
https://www.ncbi.nlm.nih.gov/pubmed/28151458

- - (Ginkgo biloba), , 2 . 60 , : - 120 " – 90 .

, , HbA1c, , , BMI, . . , . 2. 

https://www.ncbi.nlm.nih.gov/pubmed/29670330

- ( 2016), , (Tribulus terrestris) 2, .
98 , 1,000 "/ - 3 . , : ( -169 -144 "/"), ( -234 -195 "/"), (HbA1c) ( -8.16% -7.67%), ( -179 - 160 "/") -LDL ( -103 -86 "/"). -HDL. 2. 
https://www.ncbi.nlm.nih.gov/pubmed/27255456

( 2016) (Moringa Oleifera) .
10 : 0, 1, 2, -4 , .
6 .
(μU/ml 2.3, 2.7, 3.3, 4.1, ), . 4 -74% .
4 2. 
: , . 
http://www.ncbi.nlm.nih.gov/pubmed/27276742

( 2013) (Cynara scolymus) . 55 (IFG). 600 " 8 .
, HOMA ( ) .
, .
http://www.ncbi.nlm.nih.gov/pubmed/23440660

( 2013) (Salvia officinalis) 2.
80 / ( 500 " , 3 3 ) .
.
.
, 2.
http://www.ncbi.nlm.nih.gov/pubmed/24050577

( 2011) ' (Aloe spp) , , . 
90 100 " 200 " ' 6 , . ,
- , , -LDL -VLDL -HDL, . ,
, .
http://www.ncbi.nlm.nih.gov/pubmed/24426052

( 2015) '' - 41 2. 2 '' 12 . , '' , . , '' 2.
http://www.ncbi.nlm.nih.gov/pubmed/25561919

- ( 2015) '' 2.
50 20-60 , '' 3 3 . , , , PON1 ( ), , 12 .
, '' (,HbA1c, ) CRP, PON1 . 
http://www.ncbi.nlm.nih.gov/pubmed/25719344

(2015) . 28 ( ) 12 . , , , , , (AST,ALT) . , ( ) , ruminococcus ( ) LDL . 
https://www.ncbi.nlm.nih.gov/pubmed/26048342

( 2014), (Glycine max) , , , . 
, ( 100-125 " ") -3 . 4 , 12 : 1. - 2 , 2. 300 " , 0.3% , 3. 2 . ( ) , , HOMA-IR , . 
, BMI , . . -LDL, HDL . 
, , , .
http://www.ncbi.nlm.nih.gov/pubmed/24873894

, .
( 2014) 7 50 , .
(): 14 2 , 300 .
, .
, . , .
http://www.ncbi.nlm.nih.gov/pubmed/25132122

, (2018) 103 60 -,

https://www.ncbi.nlm.nih.gov/pubmed/27001275

( 2015) (CIN Contrast-Induced Nephropathy) 2 . 120 : , (2 3 , 3 -3 ), (3 3 , 3 -3 ). , , CIN 2 - . 
http://www.ncbi.nlm.nih.gov/pubmed/26427112

( 2014) (Pleurotus cytidiosus - Pleurotus ostreatus) . 
88 50 " " . 
, 14 2 .
, , .
(GK) .
http://www.ncbi.nlm.nih.gov/pubmed/25382404

(- 2016), , .
32 2 , : ( ), (12 ), (5 " ) . 30 . , ABI ( - ), .
ABI, . , , . , , . 
: , , . 
https://www.ncbi.nlm.nih.gov/pubmed/27680049

- ( 2015) ' . , 50 ' .
, ' . 
http://www.ncbi.nlm.nih.gov/pubmed/25948674

- ( 2013) Vaccinium arctostaphylos 2.
http://www.ncbi.nlm.nih.gov/pubmed/23727759

( 2013) Salacia reticulata .
http://www.ncbi.nlm.nih.gov/pubmed/23767865

( 2016) , 2.
204 , - 3 (Cinnamomum zeylanicum), 3 (Elettaria cardamomum), 1 (Crocus sativus) 3 '' (Zingiber officinale) 3 8 – . ICAM-1 ( : Intercellular adhesion molecule-1), , .
. , , '' ICAM-1 '' . , 2.
https://www.ncbi.nlm.nih.gov/pubmed/26758574

( 2016) , , - (xerophthalmia) - .
60 , , ( 6 ), . -3 . : (Atractylodes macrocephala), (Glycyrrhiza glabra), ' (Panax ginseng), (Poria cocos), (Rehmannia glutinosa), (Dioscorea). 
(85% 52%, p<0.05). , IL-1, IL-8 - TNF-α (p<0.05) .
.
https://www.ncbi.nlm.nih.gov/pubmed/27820648

(- 2015) 2.
32 30-60 . ' (Gymnema sylvestre), (Artemisia absinthium) (Citrullus Colocynthis) 1 ( ), 30 .
' : -37%, -5%, -13% LDL -19%.
LDL 6% HDL 3%.
, , HDL -35%, 6%, 6% -5% .
, . 
http://www.ncbi.nlm.nih.gov/pubmed/26665406

3 2, ( 2015) . 114 2 -2 ( ) 2 .
, , HbA1c . , .
http://www.ncbi.nlm.nih.gov/pubmed/25706772

- ( 2016) Tangshen Formula .
Tangshen Formula , , : Astragalus membranaceus, Rehmannia glutinosa, Rheum palmatum
180 , L-FABP ( - Liver-type fatty acid binding protein) 30 -30 .
8 24 . 30 (). 
(UAER) L-FABP . L-FABP .
L-FABP , , 5.9, 11.4 -18.5 "/", . 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962377/

- - ( 2015) Tangshen (DKD).
7 : Astragalus membranaceus (35.3%),Euonymus alatus (17.6%), Rehmannia glutinosa (14.1%), Citrus aurantium (11.8%), Cornus officinalis(10.6%),Rheum palmatum (7.1%), Panax notoginseng (3.5%). 
180 , 122 8 -58 , (ACEIs ARBs), 24 . , , (0.21- 0.36 ). , eGFR.
, .
http://www.ncbi.nlm.nih.gov/pubmed/25938778

( 2016) jianyutangkang – JYTK. 3 :
 Eleutherococcus senticosus, Euonymus alatus, Anemarrhena asphodeloides. 
, 59 4.5 -53 26 . , .
( 2 1.4 /, p<0.01) HbA1c ( 0.8% 0.6%, p<0.01). , , , LDL -18 . 2.
https://www.ncbi.nlm.nih.gov/pubmed/26860796

- ( 2015) Jinlida 2 .
Jinlida 2 17 , :
Panax ginseng, Atractylodes lancea, Sophora flavescens, Rehmannia glutinosa, Polygonum multiflorum, Poria cocos, Coptis chinensis, Anemarrhena asphodeloides, Epimedium brevicornum ,Salvia miltiorrhiza 
186 9 3 , , 12 . 
HbA1c ( 0.92% 0.53%). , . .
.
http://www.ncbi.nlm.nih.gov/pubmed/26098833

( 2015) 2. 93 , -500 " 3 , -500 " 2 . 
500 " 83.3 " , : Berberis aristata, Cyperus rotundus, Cedrus deodara, Phyllanthus emblica, Terminalia chebula, Terminalia bellirica. 
24 25% 24% 31% -24% .
, HbA1c . , .
, , 2. 
http://www.ncbi.nlm.nih.gov/pubmed/26275648

- ( 2014) -400 tianqi 2 , .
http://www.ncbi.nlm.nih.gov/pubmed/24432995

( 2016) glyoxalase 1 ( Glo1) .
(trans-resveratrol) (hesperetin) Glo1, - (MG).
32 18-80 (BMI=25-40), 8 .
BMI>27.5 27% Glo1 ( p<0.05) 37% - (p<0.05) 5% (p<0.01) . 
http://www.ncbi.nlm.nih.gov/pubmed/27207552

( 2017) 4 1, . Liu-Wei-Di-Huang-Wan 3 / 3 . 
(Rehmannia glutinosa), (Dioscorea villosa), (Poria cocos), (Paeonia spp). 
https://www.ncbi.nlm.nih.gov/pubmed/28137518

( 2014) (Hyperoil) , (Hypericum perforatum) / (Azadirachta indica). (). .
, . 
http://www.ncbi.nlm.nih.gov/pubmed/25378221

( 2016) . 
http://www.ncbi.nlm.nih.gov/pubmed/26946622

1 ( 2016) - (Balanites aegyptiaca) (Petroselinum sativum). 
http://www.ncbi.nlm.nih.gov/pubmed/27019854

( 2017) (Sambucus nigra) - .
https://www.ncbi.nlm.nih.gov/pubmed/28303711

( 2016) 23 - . , 2 . (Hibiscus sabdariffa) (IC50 : 35.8 ± 0.8 µg/mL) - (IC50 : 29.3 ± 0.5 µg/mL), (Tamarindus indica) (IC50 : 152.0 ± 7.0 µg/mL) - (IC50 : 139.4 ± 9.0 µg/mL).
.
https://www.ncbi.nlm.nih.gov/pubmed/26632284

( 2016) - Portulaca oleracea - Coccinia grandis GLUT4 .
https://www.ncbi.nlm.nih.gov/pubmed/26820984

( 2015) - Staphylococcus aureus .
http://www.ncbi.nlm.nih.gov/pubmed/26639493

( 2015) (Artemisia dracunculus) , AMPK .
http://www.ncbi.nlm.nih.gov/pubmed/25980421

( 2014) (Urtica dioica) (Juglans regia) - - .
http://www.ncbi.nlm.nih.gov/pubmed/25140210

 ( 2017) - '' (Zingiber officinale) . '' , , , .

1-3 '' 8-12 , , , . '' , , , . , '' .
https://www.ncbi.nlm.nih.gov/pubmed/28505392

, ( 2017) , 2 , .

30 , 40 , ( ).

6.4 :

, , -162 -146 "/", -8.4% -7.7%, -LDL -138 -108 "/" -203 -166 "/".

, .

, , .

2 . 
 

:  

https://www.ncbi.nlm.nih.gov/pubmed/28214690

 

 

 

 |  |  -  3 |  |   |   | 

 

 

( 2014)     .

, , C  . CoQ10  . , , .

ALA, , (Cinnamomum zeylanicum) .

.

http://www.ncbi.nlm.nih.gov/pubmed/25371590

- (2018) -. 19 , 2000-2016. ( ) 30-1,000 " , . , , , BMI . , , . , -300 " 12 -LDL.

https://www.clinicalnutritionjournal.com/article/S0261-5614(18)31198-1/fulltext

- ( 2016)   1,000 " D -1,000 " .

http://www.ncbi.nlm.nih.gov/pubmed/26781763

-  (2018) E ( Tocovid) 2. E , . , , E. 45 , - 200 " 8 - .

Nε-CML, (AGE), , 1 /" - Nε-CML 1.5. , , . Nε-CML Tocovid . 

ExcelVite, . 

: , E , E . 

https://www.ncbi.nlm.nih.gov/pubmed/30227659

(crossover)   ( 2015).

, NM504 - Gastrointestinal microbiome modulator, , - , .

" 11 2, . 500 " NM504, .

. ; , + , + . -, . 

+ , ( 6.78 4.45, p=0.0006) (121.3 151.9 "/", p<0.02).

NM504 2.

http://www.ncbi.nlm.nih.gov/pubmed/25802471

 (2018) - -. 68 35-75 -, (BMI 27). : 4 . 12 ( ) MRI, , . , , .

, , . , TNF-α. , , . -

https://www.ncbi.nlm.nih.gov/pubmed/30010698

( 2016)   .

67 1 2 - .

(EyePromise DVS) , , , 6 .

: C, D, E, , 3 (EPA - DHA), -, Q10, , , , --, , , , .

6 .

, ( , , ), (LDL, HDL, ), CRP . , HbA1c, TNF-α.

, , , . 

:  ZeaVision .

http://www.ncbi.nlm.nih.gov/pubmed/26089210

( 2015), 51 2,   - Lactobacillus sporogenes, , 50 " - .

, (1.0- 3.68 μIU/mL, p=0.002) HOMA-IR - HOMA-B, (2.86- 20.14 mg/dL, p=0.02) VLDL (0.57- 4.03 mg/dL, p=0.02) . 

http://www.ncbi.nlm.nih.gov/pubmed/26209256

 (2018) 2. , , .

33 2, - - 12 12 . 3 , 380 " . 5 - , , , , , - . .

AGEs HbA1c. - AGEs , 2. 

https://www.ncbi.nlm.nih.gov/pubmed/29941991

- ( 2016)   , 2 .

40 , . 4 30 , 7,678 , 6,845 , 701 , 14,755 , 26,299 2 -10,983 .

, . 100 "  ( , ) 22% , 7% ( ), 19% 2 -10% .

https://www.ncbi.nlm.nih.gov/pubmed/27927203

( 2016) - - ( , ) , , , , , , . 

https://www.ncbi.nlm.nih.gov/pubmed/26601968

- ( 2018) - Q10 , - Q10 , -. 
https://www.ncbi.nlm.nih.gov/pubmed/29402381

 (2018), 44 2, , 8 "/ 8 . 
https://www.ncbi.nlm.nih.gov/pubmed/29384321

 ( 2016) . 
https://www.ncbi.nlm.nih.gov/pubmed/27285791

 (2016) - , 2. - . , , , .

, . -, . , .
https://www.ncbi.nlm.nih.gov/pubmed/28003714

 (2018) - , . 

(IP-A -IP-B) ( ) 32 . (IP-A) 5 ( , , , ' ) 150 . :

  • IP-A: 600 " (Morus alba),1,200 " -400 " .
  • IP-B: 600 " (Morus alba),1,200 " , 400 " , 2,000 " -3,000 " ( ).

- , 4-14 . / 11 , 15 -125 .

, , 20-35 . , (100.2 112.5 "/", p<0.01) (45.9 68.2 /", p<0.01) - 20 . 2.

MarMar Investment . 

https://www.ncbi.nlm.nih.gov/pubmed/30044398

 

 | 

 

( 2011)     40  2.

 -2 ,     (42 ") 3 ,  A1C.

http://www.ncbi.nlm.nih.gov/pubmed/21570271

( 2011)       400 " -25 9-12 6 .

http://www.ncbi.nlm.nih.gov/pubmed/21241290

-       . , - ( 2014)  .

16 809 , 440 . .

http://www.ncbi.nlm.nih.gov/pubmed/24293356

( 2003)   .

( ) ( )    .

http://www.ncbi.nlm.nih.gov/pubmed/12663610

( 2011)         , -52 -2 : 27 - 25 6 2.

http://www.ncbi.nlm.nih.gov/pubmed/21205110

( 2014) .  -14,000 20 -9 .  ( + ) ,   HDL .

" , , .

http://www.jscimedcentral.com/Nutrition/nutrition-2-1038.pdf

- ( 2015)     - .

http://www.ncbi.nlm.nih.gov/pubmed/25937055

( 2016)     1,276 30-75.

- , -48% , -69% 2 -42% .

0.17 "/" 16% .  

http://www.ncbi.nlm.nih.gov/pubmed/26931571

- ( 2015)   . 60 200 " 12 . (−3.1 ± 4.6 +0.5 ± 6.2 μIU/mL), (−0.9 ± 1.4 +0.1 ± 1.7, HOMA-IR) (−11.3 ± 16.3 +2.3 ± 22.0, HOMA-B) - (+2.3 ± 21.7 -27.7 ± 35.2 U/mL). , . 

http://www.ncbi.nlm.nih.gov/pubmed/26686847

(2015)   .

 , , , .

 , , , ,  , .

, . , .

, .  

http://www.ncbi.nlm.nih.gov/pubmed/26780281

- ( 2017) , .

11 , 543 . 365-450 "/ , 1-6 . ( , ) (), (4.18 " ) (2.27 " ).

, - 2, .

https://www.ncbi.nlm.nih.gov/pubmed/28724644

 ( 2017), , 5,683 18, 2.
https://www.ncbi.nlm.nih.gov/pubmed/28749415

- ( 2017), 199 1 199 , ( / ) 1 16. 
https://www.ncbi.nlm.nih.gov/pubmed/29113123

-  (2018) , - - 2.

50 , - 83 "/ - . 43% -TSH, 11% (p<0.001), FT4 FT3. , - BMI ( : 24% 8.5%), , .


http://www.annexpublishers.co/articles/JNH/5202-Selenium-Supplementation-in-Obese-Patients-with-Subclinical-Hypothyroidism-and-Type-2-Diabetes.pdf

 ( 2018), , ( , ), .

https://www.ncbi.nlm.nih.gov/pubmed/29389872

 

 | 

 

(2013) 2,582 , 2 .

http://care.diabetesjournals.org/content/early/2013/09/23/dc13-1397.short

(2004) -6 222,523 45 , 2.

https://www.ncbi.nlm.nih.gov/pubmed/14693967

(2016) 21 -1,372 , 4 HOMA-IR .

https://www.ncbi.nlm.nih.gov/pubmed/27329332

(2007) 2 : , , . 

https://www.ncbi.nlm.nih.gov/pubmed/17645588

https://www.ncbi.nlm.nih.gov/pubmed/17502538

(2006) 9 , 370 2, 360 " 4-16 , HDL.

https://www.ncbi.nlm.nih.gov/pubmed/16978367

,   (1998), , 128 2 1,000 " 30 , ( -2-3 ).

https://www.ncbi.nlm.nih.gov/pubmed/9589224?dopt=Abstract

:

(2015) 70 (35 -35 ) 250 " , 6 . , HOMA-IR ( ) -HOMA-B ( ) .

https://www.ncbi.nlm.nih.gov/pubmed/26016859

(2014) 300 " 3 26 2, -28 . , , , HbA1C, , -LDL .

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219896/

(2011) 52 , , 365 " ( ) 6 , 27 , -25 . 0.32 mmol/l 0.16 mmol/l , 9.42 pmol/l 20.29 pmol/l  0.514 (ISI– HOMA) , 0.813 . , . 

https://www.ncbi.nlm.nih.gov/pubmed/21205110

(2011) 54 -52 , 2.5 3 , , , , HOMA‐β .

https://www.ncbi.nlm.nih.gov/pubmed/21241290

(2004) 110 1 (60 -50 ) 300 " 5 , . 39% EMG) – Electromyography, ), 49% -12% . , 8% , 31% -61% .

https://www.ncbi.nlm.nih.gov/pubmed/15319143

(2003) 63 ,   300 " 16 , 37.5% 27.5% , 30.4% HbA1C 14.4% 9.5% HOMA-IR ( ) 6.4% . 

https://www.ncbi.nlm.nih.gov/pubmed/12663588

 

: ,  ,  , ,  .

.

 

 
 

( , 3)

 

-  (2017) ( 3) . 60 40-85, : 1) , 1,000 " 3 12 2) .

, (, ), , . , CRP

https://www.ncbi.nlm.nih.gov/pubmed/28716357

( 2010) 6 34 37-70 2, 2     3  ( )    , ( – ) . .

http://www.ncbi.nlm.nih.gov/pubmed/20071644

( 2010) 97 2 ( 60-70) 12   4     . , , .

http://www.ncbi.nlm.nih.gov/pubmed/20121889

( 1996) 11    . 3 , 3 3 . 35 " " 3 ( ) 3 .

http://www.ncbi.nlm.nih.gov/pubmed/8732710

3 2. 

( 2013), ,     3  (EPA, DPA, DHA, ALA) , , 2

2,212 42-60 . 

-19 , 422 , 3 (EPA, DHA, DPA) -33% 3

 ALA, . 

, 3 , .

http://www.ncbi.nlm.nih.gov/pubmed/24026545

- ( 2015)   3  ALA  2.

20 3  ALA  60 .

.  ALA  2 .

http://www.ncbi.nlm.nih.gov/pubmed/25933493

( 2015)   3   .

http://www.ncbi.nlm.nih.gov/pubmed/25925322

( 2016)    , 2.

12,132 2 15,919 .

3, (ALA) 2 EPA -DHA 2. 6, (LA) (EDA) 2, (AA) GLA, dihomo-GLA, DTA - n6-DPA 2.

PUFA 2.

http://www.ncbi.nlm.nih.gov/pubmed/27434045

( 2016)    .

, -4 : , + , , + .

, , , . (anti-obesogenic) .

, ( ), ( ) - - , . 
, . , .

https://www.ncbi.nlm.nih.gov/pubmed/27558442

-  ( 2017) , .

17 , 672 . 2, . 1-4 / 4-24 .

. , - . , . , , 2 . 
https://www.ncbi.nlm.nih.gov/pubmed/28673352

-  ( 2017) 3 , - EPA DHA.

-51 , " -3,000 3 . , , , , 2 . , 22 -70, (60-100 ) 3 0.5-15 /.

, 3 , , , 2.23 . -DHA , -EPA.  
https://www.ncbi.nlm.nih.gov/pubmed/29284786

- ( 2018), 3 . 3 , .

77,917 , 64 , -10 ( 500 ). 4.4 6,273 -12,001 . 3 (EPA 226-1,800 "/) ( , ). - 3 , , , , . 3 .  

https://www.ncbi.nlm.nih.gov/pubmed/29387889

 


 

 

- ( 2014)      B6  -.

9 -27 -  CABG,  PCI  . ,   B6 (5-10 " ) -.

, -  B6  -.

http://www.ncbi.nlm.nih.gov/pubmed/24461473

- ( 2015)     ( B3)  2. , , -  0.27  HDL, 0.25  LDL  0.39   . ,   ,  .

http://www.ncbi.nlm.nih.gov/pubmed/25306426

( B3) .

( 2016), ,   (NR) .

- 2 , NR , , .

NR NADP(+) / NADPH .

, NR . 

http://www.ncbi.nlm.nih.gov/pubmed/27230286

( 2016)    B12  ('). -2,000 850 " 3.2 . 9 .

 B2  5 13 . ,  B12. ,  B12   B12.

 B12  . 

http://www.ncbi.nlm.nih.gov/pubmed/26900641

( 2016)    B12  154 , (54) .

,  B12  .

,  B12  .

 B12  , . 

http://www.ncbi.nlm.nih.gov/pubmed/26927168

( 2003)   .

( ) ( )  E.

http://www.ncbi.nlm.nih.gov/pubmed/12663610

( 2014)   A      A  2.

 A  , .

 A   A  .

http://www.ncbi.nlm.nih.gov/pubmed/25451926

- ( 2015)      K1  -.

82  K1 (1 ") 4 .

, . ,  K1  -.

http://www.ncbi.nlm.nih.gov/pubmed/25654061

( 2016)   - K .

K K 2.

K , , , - . 

http://www.nutritionjrnl.com/article/S0899-9007(16)00041-1/abstract

( 2015)     D   BMI     D  .

http://www.ncbi.nlm.nih.gov/pubmed/25706239

( 2016)   D .

D , 1 2 .

D 1.

2, D , .

D 1 -2, D .

, D

http://www.ncbi.nlm.nih.gov/pubmed/27030935

( 2015) 82 -    K1  1,000 " 4     .

http://www.ncbi.nlm.nih.gov/pubmed/25782427

- ( 2015)   .

12 100 " 3 6 .

, .

.

http://www.ncbi.nlm.nih.gov/pubmed/25982678

( 2014)   D  2.

58 4,000 D .

D HbA1c . D 2. 

http://www.ncbi.nlm.nih.gov/pubmed/26171357

( 2014)     .

, , C  . CoQ10  . , , .

ALA, , (Cinnamomum zeylanicum) .

.

http://www.ncbi.nlm.nih.gov/pubmed/25371590

- ( 2016)   1,000 " D -1,000 " .

( 2016) 270   GABApentin B preGABAlin, . 

http://www.ncbi.nlm.nih.gov/pubmed/26885528

( 2016)  

, , . , , , , , , , ( , , , , ) , .

. (NTD).

, -

http://www.ncbi.nlm.nih.gov/pubmed/27008500

2,394 , .

http://www.nutritionjrnl.com/article/S0899-9007(16)30196-4/abstract

( 2017), 66 2, MGP - Matrix Gla-Protein, K, . 

https://www.ncbi.nlm.nih.gov/pubmed/27927630

 ( 2018) D 2.

, 1972, 903 1997-1999. D 1977-1979. 2009, 47 2 -337 -.

D 2: -69% 30-39 /", -71% 40-49 /" -81% -50 /" – -30 /". D .

D 2 -. 

https://www.ncbi.nlm.nih.gov/pubmed/29672520

 

 

 

- ( 2014) 11      .

.

, " 388 , , , .

.

( ) .

http://www.ncbi.nlm.nih.gov/pubmed/24695890

( 2016)   EGCG .

3 . 38 38 BMI 29.7. 282 "/ EGCG -80 "/ , 12 .

.

, .

, , .  

http://www.ncbi.nlm.nih.gov/pubmed/27194304

( 2003)   .

( )   .

http://www.ncbi.nlm.nih.gov/pubmed/12663610

( 2014)     .

, , C  . CoQ10  . , , .

- ( 2015)   2.

58 160 " 24 . , , , .

, , .

, ? , , , . ...

http://jn.nutrition.org/content/early/2015/02/04/jn.114.205674.abstract

( 2016)   .

.

2, , , , .

-.

, , , -30 ,   -, .   

http://www.ncbi.nlm.nih.gov/pubmed/27264638

- ( 2016)   . , -200,000 -12,000 2 , , 194,000 -13,000 2 .

-15% 2 -18% 2. , 7.5 " 17 5% 2. 

http://www.ncbi.nlm.nih.gov/pubmed/27530472

- ( 2017) - Q10 (, , 22, ).

- , 2009-2015 428 . , , . 8-12 -Q10 100-500 " . 
, Q10 , , TNF-α. CRP IL-6. Q10 , .

https://www.ncbi.nlm.nih.gov/pubmed/28125601

-  ( 2017) , 1 2. 14 , 4,345 A, C, E, , , - Q10 - .

( , ) , (GFR). .

, .  
https://www.ncbi.nlm.nih.gov/pubmed/28570649

( , 2016), 31 -, ' (Delphinol®), 180 " ( ) -LDL 3 . 
https://www.ncbi.nlm.nih.gov/pubmed/27820958

 

 

 

- ( 2014), 46 -.

3  -  , 8 .

  - .

.

http://www.ncbi.nlm.nih.gov/pubmed/25364661

( 2003)   .

( ) ( ) .

http://www.ncbi.nlm.nih.gov/pubmed/12663610

 

 

 

 

( 2015)     1 ,  1.

http://www.ncbi.nlm.nih.gov/pubmed/26552054

( 2015)   , 2. , 17 4 .

3 , 7 . .

http://www.ncbi.nlm.nih.gov/pubmed/25630516

( 2015)     .

-, 149 .

, , . , .

http://www.ncbi.nlm.nih.gov/pubmed/25687568

( 2014)   ( + )  . 13 513 .

 -LDL    - HDL . . ,    . 

http://www.ncbi.nlm.nih.gov/pubmed/25456608

( 2015) 2. 7 - -13 .

2. , , .

.

http://www.ncbi.nlm.nih.gov/pubmed/26499995

( 2016) , 2.

6,367 15-76 - , , , , .

, 2. , ( ) .

-, . 
, . 

http://www.ncbi.nlm.nih.gov/pubmed/27329792

 ( 2017) - , .

, , . . , . , .

, Bifidobacterium, . 
https://www.ncbi.nlm.nih.gov/pubmed/28436760

 ( 2017) 2. 2, 2 .

(" "), () . , , , . , 2 .
, , - ( ) , (" L. plantarum WCFS1). 2 Bifidobacterium -Lactobacillus. 
.
https://www.ncbi.nlm.nih.gov/pubmed/29052181

-  (2018) - 2 . 61 , 6 . Ecologic®Barrier, 8 * 2 (2.5 ) , .

, , -70% ( ), 38% , 38% , 64% , 48% , 19% , 19% -HDL, TNF-α, IL-6 -CRP . , , . 2, -.

.

* Bifidobacterium bifidum W23, Bifidobacterium lactis W52, Lactobacillus acidophilus W37, Lactobacillus brevis W63, Lactobacillus casei W56, Lactobacillus salivarius W24, Lactococcus lactis W19 and L. lactis W58.

https://www.ncbi.nlm.nih.gov/pubmed/30170781

-  ( 2017) -.

100 BMI 25 -180 "/" . 100 " 10 Lactobacillus casei strain Shirota - 8 .

, , - HbA1c . . , -LDL HDL. -, . 
https://www.ncbi.nlm.nih.gov/pubmed/29387517

 ( 2018) -, MSPrebiotic®, . : 42 70 -42 30-50, -. 30 / - 12 . . TNF-α .

. , , , , . . , 2.
MSPrebiotics Inc. . 
: , , : 
http://www.naturopedia.com/article.asp?rId=1415
https://www.ncbi.nlm.nih.gov/pubmed/29410955