קדד קרומי, אסטרגלוס - Astragalus membranaceus

עודכן בתאריך 04/09/2025

Astragalus - Huang Qi

משפחה בוטנית: פרפרניים – (Fabaceae (Leguminosae

אסטרגלוס או קדד קרומי הוא צמח מרפא נפוץ ברחבי העולם בעל היסטוריה של אלפיים שנות שימוש ברפואה הסינית המסורתית.

שמו הסיני (Huang Qi) מרמז על עליונותו ברפואה הסינית כצמח מחזק וכאדפטוגן (Qi tonic).

ברפואה הסינית נודע הצמח כמחזק טחול, דם וצ'י ושימש לחיזוק כללי ולהגברת העמידות של הגוף במצבי פציעה ומחלות שונות, לרבות מחלות נשימתיות, חולשת מערכת העיכול, מחלות לב ומחלות כליה.
אסטרגלוס הינו צמח רב שנתי הגדל בבר בסין, במונגוליה ובקוריאה לגובה של 50-150 סנטימטרים, במורד גבעות או על גדות נחלים.

שני זנים עיקריים הדומים בשימושם הרפואי הם A. membranaceus ו-A. membranaceus var. mongholicus (הידוע גם כ-A. mongholicus) – שניהם מוגדרים ברפואה הסינית כשורש אסטרגלוס. עקב הידלדלות המשאבים הטבעיים של הצמח ולאור התצרוכת העולמית הגבוהה, הצמח מגודל כיום בסין בגידול חקלאי מסחרי. השורשים נקצרים באביב או בסתיו.
אסטרגלוס נחשב לצמח עדין ובטוח לשימוש לתקופות ארוכות.
אסטרגלוס מותר לשיווק בישראל.

חלק הצמח בשימוש

שורש

איכויות

טמפרטורה: חמים

לחות: יבש

טעם: מתקתק

רכיבים פעילים עיקריים

סאפונינים טריטרפנואידים (Astragalosides I-VII, Astragalus saponins I-III), פוליסכרידים, פלבונואידים, חומצות אמינו (arginine, aspartic acid, asparagine, proline, alanine), חומצות אורגניות (ferulic acid, vanillic acid, isoferulic acid, hydroxy phenyl acrylic acid, caffeic acid), חומצות שומן (linoleic acid, linolenic acid, palmitic acid, daucosterol, lupeol, 13-sitosterol), ויטמינים: חומצה פולית, כולין, בטאין, יסודות קורט: נחושת, כרום, ברזל, אבץ, סלניום, מוליבדנום, קובלט ועוד.

פעילות רפואית

להלן פעילויות רפואיות שהצמח ורכיביו הדגימו בשלל מחקרים (קליניים, בע״ח או מעבדה)*:

אדפטוגן, נוֹגד סַרטן, מווסת חיסון, נוֹגד אַלרגיה, נוֹגד דַלקת, נוֹגד חִמצון, נוֹגד אַנמיה, מעלה ספירות לבנות, מוריד רמות סוכר בדם (היפוגליקמי), מגן/מחזק לב, נוגד טרשת עורקים, מפחית לחץ דם, מגן כבד, מגן כליות, נוֹגד וִירוסים.

*העדויות לגבי הפעילויות הרפואיות מוצגות בסעיפי מנגנוני פעולה בהמשך.

התוויות

התוויות המגובות במחקרים קליניים*:
חולשה חיסונית, נויטרופניה, אנמיה, סרטן, מחלות אוטואימוניות, אלרגיות, תסמונת התשישות הכרונית, דלקת כבד, הפטיטיס, אי ספיקת לב, דלקת זיהומית של הלב, שבץ, תעוקת חזה, אסתמה, אי ספיקת כליות, סוכרת, נפרופתיה סוכּרתית, הרפס, איידס.

התוויות המגובות במחקרים פרה-קליניים (בעלי חיים ומעבדה)*:

טרשת עורקים, לחץ דם גבוה, חרדה, סטרס, הפרעות זיכרון, אלצהיימר, פרקינסון, אפילפסיה, אי פריון בקרב גברים.

התוויות נוספות אשר עדיין לא קיימות להן ראיות מחקריות:
שלשול.

*סיכום המחקרים נמצא כאן.

מינונים

תמצית נוזלית בריכוז 1:3, 45% אלכוהול – 6-24 מ"ל ביום.
תמצית יבשה בריכוז 5:1 – 300-1500 מ"ג ביום.
מרתח – 9-30 גרם ביום.
בפורמולה – 25-40%.

הערת המערכת: בחלק מהמחקרים שנערכו בסין ניתנה תמיסת אסטרגלוס בהזרקה או בעירוי, לרוב בריכוז של 2 גרם צמח למיליליטר תמיסת מלח, בטווח מינונים של 10-60 מ"ל ליום למבוגרים ובמינון של 0.5-1 מ"ל/ק"ג משקל גוף ליום לילדים. חשוב לציין כי לא ברורים ההבדלים בפעילות הרפואית בין נטילה פומית לבין עירוי של הצמח.

רגישות
לא ידועה רגישות מיוחדת לאסטרגלוס ₍₁₎.

תופעות לוואי
אסטרגלוס נחשב לצמח בטוח לשימוש. לא ידוע על למידע השלם למנויים

מינון יתר
אסטרגלוס נחשב לצמח בטוח לשימוש. לא ידוע על על תופעות הנגרמות ממינון יתר ₍₁₎.

אזהרות וצעדי מנע

קיימת אזהרה תיאורטית לפיה אסטרגלוס עלול להגביר את הפעילות למידע השלם למנויים

התוויות נגד

על-פי הרפואה הסינית, אסטרגלוס אינו למידע השלם למנויים

רעילות

לא ידועה כל רעילות הנגרמת משימוש למידע השלם למנויים

תגובות הדדיות עם תרופות / צמחי מרפא / תוספי תזונה

תרופות למחלת הסרְטן

צמחי מרפא ותוספי תזונה

השפעה על חילוף חומרים תרופתי

השפּעת אסטרגלוס על חילוף חומרים תרופתי כמעט ולא נבדקה. למעט למידע השלם למנויים

תרופות מדכאות חיסון

השילוב אפשרי אך יש לנקוט זהירות.
בסקירה שיטתית ומטא-אנליזה ₍₅₇₅₎ שכללה 14 מחקרים קליניים למידע השלם למנויים

תרופות להורדת סוכר

אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
השילוב אפשרי, אך למידע השלם למנויים

תרופות להורדת לחץ דם {תרופות משתנות, חוסמי הקולטן לאנגיוטנסין 2, חוסמי בטא, Perindopril (מעכבת ACE)}

אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
על אף שהשילוב למידע השלם למנויים

אסטרגלוס ורמהנְיה בשילוב עם תרופות להורדת לחץ דם (מעכבי ACE, חוסמי הקולטן לאנגיוטנסין II) לטיפול בנפרופתיה סוּכרתית

השילוב אפשרי.

מומלץ לשלב אסטרגלוס למידע השלם למנויים

אינטרפרון אלפא (IFN-α)

השילוב אפשרי.

ניתן לשלב אסטרגלוס יחד עם למידע השלם למנויים

תרופות אנטי רטרוויראליות לטיפול באיידְס (Zlcitabine, Zidovudine)

אין מניעה לשלב.

מחקר קליני אחד ₍₇₇₎ מצא כי למידע השלם למנויים

תרופות אנטי ויראליות (זובירקס)

אין מניעה לשלב.

מידע מקדמי (מעבדה ובעלי חיים) מצביע על למידע השלם למנויים

אינטרלוקין 2 (IL-2)

אין מניעה לשלב.

מידע מקדמי (מעבדה ובעלי חיים) מצביע למידע השלם למנויים

טיפול קונבנציונאלי בשחפת

השילוב אפשרי ואף עשוי להיות מומלץ.

סקירה שיטתית ומטה-אנליזה₍₈₂₎ נועדה להעריך את היעילות של למידע השלם למנויים

תרופות לטיפול בפעילות יתר של בלוטת התריס (Tapazole/Methimazole)

השילוב אפשרי.

מידע ראשוני ממחקר קליני יחיד₍₈₃₎ מעיד כי השילוב עשוי למידע השלם למנויים

תרופות לטיפול באנמיה אפלסטית (Stanozolol)

השילוב אפשרי.

מחקר קליני יחיד₍₈₄₎ מצביע על שיפור למידע השלם למנויים

גליקוזידים קרדיאלים (Digoxin)

אין מניעה לשילב והשילוב אף עשוי להיות מומלץ.

מחקר קליני יחיד₍₈₅₎ מצביע על אפשרות של שיפור תפקוד הלב בשילוב למידע השלם למנויים

תרופות נוגדות דלקת סטרואידליוֹת

אין מניעה לשלב.

מידע מקדמי_(86-87) (מחקר קליני חסר ומחקרי מעבדה ובעלי חיים) מצביע על למידע השלם למנויים

התרופה Indomethacin
אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
במחקרים בבעלי חיים _(352-354) נמצא כי למידע השלם למנויים

תרופות נוגדות קרישה

אין מניעה לשילב.

למרות אזהרות המופיעות במקורות שונים, העדויות הקיימות עד כה למידע השלם למנויים

תרופות הורמונליות

אין מניעה לשלב.

למרות אזהרות המופיעות במקורות שונים, העדויות הקיימות עד כה אינן למידע השלם למנויים

ליתיום

אין מניעה לשלב, איך יש לנקוט זהירות.
בעת שימוש יש לנטר את רמות התרופה בדם.
אמנם אין עדויות קליניות העוסקות בשילוב למידע השלם למנויים

תיאופילין

אין מניעה לשלב, אך יש לנקוט זהירות.

מידע מקדמי (מחקר יחיד בבע"ח) מצביע על למידע השלם למנויים

תרופות להורדת שומנים בדם
אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
מחקר עוקבה רטרוספקטיבי ₍₄₆₁₎ ו מחקר קליני ₍₅₇₆₎ שנערכו בקרב למידע השלם למנויים

תרופות אנטי-ויראליות לטיפול בהפטיטיס
אין מניעה לשלב.
מחקר עוקבה רטרוספקטיבי ₍₄₆₁₎, שכלל 657,144 חולי סוכרת למידע השלם למנויים

התרופה Entecavir
אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
במחקר קליני ₍₅₃₇₎, שילוב אסטרגלוס כחלק מפורמולת למידע השלם למנויים

H1N1 חיסון נגד שפעת
אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
במחקר בבעלי חיים ₍₅₅₂₎ נמצא כי פוליסכריד למידע השלם למנויים

Voriconazole - תרופה אנטי-פטרייתית ממשפחת הטריאזולים
אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
במחקר בבעלי חיים ₍₃₄₄₎, מתן של למידע השלם למנויים

Ambroxol hydrochloride
אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
בסקירה שיטתית ומטא-אנליזה ₍₃₅₆₎ שכללה 14 למידע השלם למנויים

התרופה Dexrazoxane
אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
על-פי מטא-אנליזה ₍₃₂₁₎ ושני מחקרים קליניים _(322,323), שילוב של למידע השלם למנויים

תרופות למחלת הסרְטן

כימותרפיה - כללי

אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.
נכון להיום, אין מחקרים קליניים הבוחנים באופן ישיר את למידע השלם למנויים

התרופה Cisplatin

השילוב אפשרי ואף עשוי להיות מומלץ.

סקירות שיטתיות _(97,101) ומחקר קליני אחד ₍₁₀₂₎ דיווחו על שיפור למידע השלם למנויים

פרוטוקול MVP הכולל Cisplatin, Vinblastine ו- Mitomycin C

אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.

מחקר קליני ₍₉₅₎ הראה כי מתן אסטרגלוס בעירוי יחד עם למידע השלם למנויים

כימותרפיה מסוג וינקה אלקלואידים Vinorelbine,Vinblastine

במחקר קליני אקראי מבוקר פלסבו₍₁₀₂₎ נבחנה יעילות הזרקת פוליסכרידים שמוצו למידע השלם למנויים

התרופה (Fluorouracil) 5-fu

השילוב אפשרי ואף עשוי להיות מומלץ.

מטא-אנליזות _{(409,412,435,449)} של למידע השלם למנויים.

התרופה Irinotecan

השילוב אפשרי ואף עשוי להיות מומלץ.

מטא-אנליזות _(412,435) של מחקרים קליניים מבוקרים למידע השלם למנויים

התרופה Capecitabine

השילוב אפשרי ואף עשוי להיות מומלץ.

מטא-אנליזות _(412,435) של מחקרים קליניים מבוקרים _{(413-434,436-443)} מצאו כי למידע השלם למנויים

התרופה Docetaxel

אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.

מטא-אנליזה רשתית ₍₄₄₅₎ של 85 מחקרים קליניים מבוקרים, שכללו למידע השלם למנויים

התרופה Raltitrexed

אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.

מטא-אנליזה ₍₄₁₂₎ של מחקרים קליניים מבוקרים _(413-434) מצאה כי למידע השלם למנויים

התרופה Leucovorin / Folinic Acid / Calcium Folinate

השילוב אפשרי ואף עשוי להיות מומלץ.

מטא-אנליזות _{(409,412,435)} של מחקרים קליניים למידע השלם למנויים

התרופה Oxaliplatin

השילוב אפשרי ואף עשוי להיות מומלץ.

מטא-אנליזות _{(340,409,412,435,444,449)} של מחקרים קליניים מבוקרים _{(102,410,411,413-434)} מצאו כי למידע השלם למנויים

תרופות ממשפחת Anthracyclines

אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.

שילוב אסטרגלוס עם תרופות ממשפחת למידע השלם למנויים

התרופה Apatinib

אין מניעה לשלב.

על-פי סקירה ₍₃₂₇₎ ומחקר פרה-קליני למידע השלם למנויים

Cyclophosphamide כתרופה כימותרפית

אין מניעה לשלב, והשילוב אף עשוי להיות מומלץ.

במספר מחקרים קליניים _(34,35,86) וכן בדיווח מקרה ₍₃₆₎, שילוב של למידע השלם למנויים

רדיותרפיה

שילוב עם אסטרגלוס אפשרי ואף עשוי להיות מומלץ.

על-פי מטא-אנליזה ₍₃₇₇₎ שכללה 29 מחקרים למידע השלם למנויים

צמחי מרפא ותוספי תזונה

תוספי סִידן

אין מניעה לשלב.

מידע מקדמי (מעבדה ובעלי חיים) מצביע על למידע השלם למנויים

אנג'לִיקה סינית
אין מניעה לשלב.

סקירה שיטתית מונה את יתרונות הפורמולה למידע השלם למנויים

רהמנְיה

השילוב אפשרי ואף עשוי להיות מומלץ.

מידע ממחקרים קליניים_(35,52) מצביע על למידע השלם למנויים

מרווה סִינית

השילוב אפשרי ואף עשוי להיות מומלץ.
ניתן ואף רצוי לשלב אסטרגלוס עם מרווה סינית. משלב למידע השלם למנויים

לפה גדוֹלה

השילוב אפשרי.

במחקר קליני יחיד הודגמה יעילות מוגברת של משלב הצמחים למידע השלם למנויים

ג'ינסנְג קוריאני
אין מניעה לשלב.

מידע מקדמי (מחקר יחיד בבע"ח) מצביע על אפשרות של פעילות אנטי למידע השלם למנויים

שוּש קירח
אין מניעה לשלב.

מידע מקדמי (מחקר יחיד בבע"ח) מצביע על אפשרות של סינרגיה למידע השלם למנויים

עוּזרר
אין מניעה לשלב.

מידע מקדמי (מחקר יחיד בבע"ח) מצביע למידע השלם למנויים

אטרקטִילודס
אין מניעה לשלב.

מידע מקדמי (מחקר מעבדה) מצביע על פעילות נוגדת חמצון סינרגית.
במחקר מעבדה₍₁₃₂₎ נבחנה הפעילות למידע השלם למנויים

שכִיזנדרה
אין מניעה לשלב.

מידע מקדמי (מחקר יחיד בבע"ח) מצביע על אפשרות של סינרגיה בפעילות נוגדת חמצון ומשקמת כבד.
מחקר שנערך בעכברים מושרי פגיעה כבדית₍₁₃₃₎ שטופלו למידע השלם למנויים

לִיגוסטיקום

אין מניעה לשלב.

אין מניעה לשלב אסטרגלוס עם ליגוסטיקום אך יעילות משלב הצמחים בטיפול למידע השלם למנויים

ארכובִית סינית
אין מניעה לשילוב.

מידע מקדמי (מחקר יחיד בבע"ח) מצביע על יעילות למידע השלם למנויים

ויטמין B12

השילוב אפשרי ואף עשוי להיות מומלץ.

במטא-אנליזה אחת ₍₃₅₅₎, רפואה סינית מסורתית המבוססת על למידע השלם למנויים

ג’ינסנג סיני (Panax notoginseng)

השילוב אפשרי ואף עשוי להיות מומלץ.

במטא-אנליזה אחת ₍₃₂₀₎ שכללה 17 מחקרים למידע השלם למנויים

בטטת בר Dioscorea villosa

השילוב אפשרי ואף עשוי להיות מומלץ.

סקירה שיטתית ומטא-אנליזה ₍₃₃₁₎ של שבעה למידע השלם למנויים

הריון

אסטרגלוס מתאים לשימוש במהלך ההיריון ₍₁₃₄₎.
במחקרים פרה-קליניים, נמצא כי למידע השלם למנויים

הנקה

אין מספיק מידע בנושא, אך אסטרגלוס נחשב כבטוח לשימוש גם בהנקה ₍₃₄₅₎.

מחקרים קליניים ומנגנוני פעולה

המחקרים הקליניים ומנגנוני הפעולה פתוחים למנויים בלבד.

מקורות

Mills S, Bone K. Principles and practice of Phytotherapy. Modern Herbal Medicine, 2ed. Churchill Livingstone, 2013. https://www.elsevier.com/books/principles-and-practice-of-phytotherapy/9780443069925
Denzler K, Moore J, Harrington H, et al. Characterization of the Physiological Response following In Vivo Administration of Astragalus membranaceus. Evid Based Complement Alternat Med.2016;2016:6861078. https://www.hindawi.com/journals/ecam/2016/6861078/
Tong X, Xiao D, Yao F, Huang T. Astragalus membranaceus as a cause of increased CA19-9 and liver and kidney cysts: a case report. J Clin Pharm Ther. 2014 Oct;39₍₅₎:561-3. Epub 2014 May 8. https://www.ncbi.nlm.nih.gov/pubmed/24806627
Brinker F. Herb Contraindications and Drug Interactions, 4th ed. Sandy (OR): Eclectic Medical Publications; 2010.
Upton R (ed.). Astragalus Root. American Herbal Pharmacopoeia, Santa Cruz, Cal., 1999. http://files.achs.edu/resource/nat302/ahp-Astragalus.pdf
Pan HF, Fang XH, Li WX, Ye DQ, Wu GC, Li XP. Radix Astragali: a promising new treatment option for systemic lupus erythematosus. Med Hypotheses. 2008 Aug;71₍₂₎:311-2. https://www.ncbi.nlm.nih.gov/pubmed/18440160
Tu LH, Huang DR, Zhang RQ, Shen Q, Yu YY, Hong YF, Li GH. Regulatory action of Astragalus saponins and buzhong yiqi compound on synthesis of nicotinic acetylcholine receptor antibody in vitro for myasthenia gravis. PubMed. 1994. https://www.ncbi.nlm.nih.gov/pubmed/8088200
Yang ZC, Qu ZH, Yi MJ, Wang C, Ran N, Xie N, Fu P, Feng XY, Lv ZD, Xu L. Astragalus extract attenuates allergic airway inflammation and inhibits nuclear factor κB expression in asthmatic mice. Am J Med Sci. 2013 Nov;346₍₅₎:390-5. https://www.ncbi.nlm.nih.gov/pubmed/23267235
Wang G, Liu CT, Wang ZL, Yan CL, Luo FM, Wang L, Li TQ. Effects of Astragalus membranaceus in promoting T-helper cell type 1 polarization and interferon-gamma production by up-regulating T-bet expression in patients with asthma. PubMed. 2006. https://www.ncbi.nlm.nih.gov/pubmed/17361521
Chen W, Li Y, Yu M. Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice. PubMed. 2008. https://www.ncbi.nlm.nih.gov/pubmed/18924264
He Y, Du M, Gao Y, Liu H, Wang H, Wu X, Wang Z. Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels. PLoS One. 2013 Oct 4;8₍₁₀₎:e76495. https://www.ncbi.nlm.nih.gov/pubmed/24124567
Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Vista, CA: Eastland Press, 1993. https://www.eastlandpress.com/products/eastland-herb
Bone K. Clinical Applications of Ayurvedic and Chinese Herbs. Phytotherapy Press, Warwick, Queensland, Austral., 1996. https://openlibrary.org/works/OL9521942W
Miller LG. Herbal medicinals – selected clinical considerations focusing on known or potential drug-herb interactions. Arch. Intern. Med., 158:2200-2211, 1998. https://www.ncbi.nlm.nih.gov/pubmed/9818800
Zhang YH, Zhang YJ, Guo YL, Li WJ, Yu C. Astragaloside IV inhibited the activity of CYP1A2 in liver microsomes and influenced theophylline pharmacokinetics in rats. J Pharm Pharmacol. 2013 Jan;65₍₁₎:149-55. https://www.ncbi.nlm.nih.gov/pubmed/23215698
Shi P, Lin X, Yao H. A comprehensive review of recent studies on pharmacokinetics of traditional Chinese medicines _(2014-2017) and perspectives. Drug Metab Rev. 2018;50₍₂₎:161–92. https://www.ncbi.nlm.nih.gov/pubmed/29258334
Zhang GY, Ou RL, Li FY, et al. Regulation of drug-metabolizing enzymes and efflux transporters by Astragali radix decoction and its main bioactive compounds: implication for clinical drugdrug interactions. J Ethnopharmacol. 2016, 180:104–113. https://pubmed.ncbi.nlm.nih.gov/26805467
Lau C, Mooiman KD, Maas-Bakker RF, Beijnen JH, Schellens JH, Meijerman I. Effect of Chinese herbs on CYP3A4 activity and expression in vitro. J Ethnopharmacol. 2013 Sep 16; 149₍₂₎:543-9. https://www.ncbi.nlm.nih.gov/pubmed/23876595
Pao LH, Hu OY, Fan HY, Lin cc, Liu LC, Huang PW. Herb-drug interaction of 50 chinese herbal medicines on CYP3A4 activity in vitro and in vivo. AM J Chin Med. 2012; 40₍₁₎: 57-75. https://www.ncbi.nlm.nih.gov/pubmed/22298448
Brewer CT, Chen T. Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450. Int J Mol Sci. 2017 Nov 8;18₍₁₁₎. pii: E2353. https://www.ncbi.nlm.nih.gov/pubmed/29117101
Yu C, Chai X, Yu L, Chen S, Zeng S. Identification of novel pregnane X receptor activators from traditional chinese medicines. J. Ethnopharmacol. 2011;136:137–143. https://www.ncbi.nlm.nih.gov/pubmed/21524698
Liu W, Liu G, Liu J. Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats. Pharm Biol. 2019 Dec;57₍₁₎:449–52. https://www.ncbi.nlm.nih.gov/pubmed/31290355
Zhou Q, Ye Z, Ruan Z, Zeng S. Investigation on modulation of human P-gp by multiple doses of Radix Astragali extract granules using fexofenadine as a phenotyping probe. J Ethnopharmacol. 2013 Apr 19;146₍₃₎:744-9. https://www.ncbi.nlm.nih.gov/pubmed/23422332
Lou Y, Guo Z, Zhu Y, Zhang G, Wang Y, Qi X, et al. Astragali radix and its main bioactive compounds activate the Nrf2-mediated signaling pathway to induce P-glycoprotein and breast cancer resistance protein. J Ethnopharmacol. 2019 Jan 10;228:82–91. https://www.ncbi.nlm.nih.gov/pubmed/30243825
Tian QE, De Li H, Yan M, et al. Effects of Astragalus polysaccharides on P-glycoprotein efflux pump function and protein expression in H22 hepatoma cells in vitro. BMC Complement Altern Med. 2012 Jul 11;12:94. https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-12-94.
Sloan kettering, Astragalus membranacus monograph. https://www.mskcc.org/cancer-care/integrative-medicine/herbs/Astragalus
Stargrove MB, Treasure J, McKee DL. Herb, Nutrient, and Drug Interactions, Elsevier, 2008. https://www.us.elsevierhealth.com/herb-nutrient-and-drug-interactions-9780323029643.html
Wei X, Zhang J, Li J, Chen S. Astragalus mongholicus and Polygonum multiflorum’s protective function against cyclophosphamide inhibitory effect on thymus. Am J Chin Med 2004;32:669-680. https://www.ncbi.nlm.nih.gov/pubmed/15633803
Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J. Clin. Lab. Immunol., 25₍₃₎:125-129, 1988. https://www.ncbi.nlm.nih.gov/pubmed/3260961
Zhu XL, Zhu BD. Mechanisms by which Astragalus membranaceus injection regulates hematopoiesis in myelosuppressed mice. Phytother. Res., 21₍₇₎:663-667, 2007. https://www.ncbi.nlm.nih.gov/pubmed/17421056
Sun Y, Hersh EM, Talpaz M, et al. Immune restoration and/or augmentation of local graft versus host reaction by traditional Chinese medicinal herbs. Cancer 1983;52:70-3. https://www.ncbi.nlm.nih.gov/pubmed/6336578
Wang DC. Influence of Astragalus membranaceus (AM) polysaccharide FB on immunologic function of human periphery blood lymphocyte. Zhonghua Zhong Liu Za Zhi 1989;11:180-183. https://www.ncbi.nlm.nih.gov/pubmed/2612327
Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J. 1995 Aug;36₍₄₎:387-90. https://www.ncbi.nlm.nih.gov/pubmed/8919152
Su L, Mao JC, Gu JH. Effect of intravenous drip infusion of cyclophosphamide with high-dose Astragalus injection in treating lupus nephritis. Zhong Xi Yi Jie He Xue Bao. ₍₂₀₀₇₎ . https://www.ncbi.nlm.nih.gov/pubmed/17498486
Li M, Ma JJ, Zhao XL, Zhu Y. Treating lupus nephritis by a drug pair of radix astragali and rehmanniae radix combined with glucocorticoid: a preliminary clinical study. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Aug;34₍₈₎:956-9. https://www.ncbi.nlm.nih.gov/pubmed/25223180
Leehey DJ, Casini T, Massey D. Remission of membranous nephropathy after therapy with Astragalus membranaceus. Am J Kidney Dis. 2010 Apr;55₍₄₎:772. https://www.ncbi.nlm.nih.gov/pubmed/20338467
Tian H, Lu J, He H, Zhang L, Dong Y, Yao H, Feng W, Wang S. The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. Ethnopharmacol. 2016 Sep 15;191:206-215. https://www.ncbi.nlm.nih.gov/pubmed/27269392
Pang F. Clinical research of Astragalus in improvement of insulin resistance and insulin secretion in type 2 diabetes mellitus. Zhongguo Yi Yao Dao Kan, 2013, v.15;No.118, 1420-1421.
Wang XX, Li M, Yan M, et al. Effect of Astragalus-supplemented enteral nutrition on metabolism in tyoe-2 diabetic patients with ischemic stroke. Chang Wai Yu Chang Nei Ying Yang, 2007, No.57, 108-110.
Zhao JH. Clinical effect analysis of Huangqi on adjuvant treatment in type2 diabetes. Shi Yong Lin Chuang Yi Yao Za Zhi, 2010, v.14, 60-61.
Zhou L, Zhang SH, Yu Z, Zou KL. A clinical study on the influence of Radix Astragali for diabetic insulin resistance and serum adioponectin. Xin Zhong Yi, 2007, No.396, 82-83+88.
Huang CL, Lu YP. Effect of Astragalus injection on insulin resistance in auxiliary treating patients with diabetes mellitus type 2. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23₍₁₀₎:779-780. https://www.ncbi.nlm.nih.gov/pubmed/14626197
Park JH, Kim BK, Park MK, and et al. Anti-diabetic activity of herbal drugs. Kor J Pharmacogn 1997;28₍₂₎:72-74.
Jia W, Gao WY, Xiao PG. Antidiabetic drugs of plant origin used in China: compositions, pharmacology, and hypoglycemic mechanisms. Zhongguo Zhong.Yao Za Zhi. 2003;28₍₂₎:108-113. https://www.ncbi.nlm.nih.gov/pubmed/15015278
Liu YH, Yang L, Liu J. [Clinical observation on treatment of early diabetic nephropathy by milkvetch injection combined with captopril]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25₍₁₁₎:993-995. https://www.ncbi.nlm.nih.gov/pubmed/16355614
Lu DC, Su ZJ, Rui T. [Effect of jian yan ling on serum lipids, apoprotein and lipoprotein-a]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994;14₍₃₎:142-144, 131-2. https://www.ncbi.nlm.nih.gov/pubmed/7950180.
Wu Y, Ou-Yang JP, Wu K, et al. Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacol.Sin. 2005;26₍₃₎:345-352. https://www.ncbi.nlm.nih.gov/pubmed/15715932
Shen P, Liu MH, Ng TY, et al. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro. J Nutr 2006;136₍₄₎:899-905. https://www.ncbi.nlm.nih.gov/pubmed/16549448
Zhang DQ, Zhang JJ, Wang JX, et al. [Effects of Qilan Tangzhining capsule on glucose and lipid metabolism in rats with diabetes mellitus and hyperlipemia]. Zhongguo Zhong.Yao Za Zhi. 2005;30₍₁₀₎:773-777. https://www.ncbi.nlm.nih.gov/pubmed/16075719
Zhang F, Wei Y, Zhou Y, et al. Pharmacokinetics and hepatic uptake of gliquidone affected by Huangqi injection. Eur J Drug Metab Pharmacokinet. 2014 Dec;39₍₄₎:255-61. https://www.ncbi.nlm.nih.gov/pubmed/24085486
Yuan YM, Gao JW, Shi Z, et al. Herb-drug pharmacokinetic interaction between radix astragali and pioglitazone in rats. J Ethnopharmacol. 2012 Nov 21;144₍₂₎:300-4. https://www.ncbi.nlm.nih.gov/pubmed/23026308
Qi-Yan Z, Wei-Jing L, Wei-Wei Sun, et al. The efficacy and safety of Chinese herbal medicine combined with ACEI/ARB for treatment of incipient diabetic nephropathy: A meta-analysis. TMR Integrative Medicine, 2, ₍₁₎: 7-29. https://www.tmrjournals.cn/public/articlePDF/20201202/1f5303228b0c22bd84fB64cbB22fbf18.pdf
Zhang L, Shergis JL, Yang L, et al. Astragalus membranaceus (Huang Qi) as adjunctive therapy for diabetic kidney disease: An updated systematic review and meta-analysis. J Ethnopharmacol. 2019 Jul 15;239:111921. https://www.ncbi.nlm.nih.gov/pubmed/31034954
Li M, Wang W, Xue J, Gu Y, Lin S. Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. J Ethnopharmacol. ₍₂₀₁₁₎ . https://www.ncbi.nlm.nih.gov/pubmed/20951192
Nan Fang Yi Ke Da Xue Xue Bao. Integrated treatment of traditional Chinese medicine and western medicine for early- and intermediate-stage diabetic nephropathy. Zhao L, et al . ₍₂₀₀₇₎ . https://www.ncbi.nlm.nih.gov/pubmed/17666348
Wang HY, Chen YP. Clinical observation on treatment of diabetic nephropathy with compound fructus arctii mixture. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24₍₇₎:589-592. https://europepmc.org/abstract/med/15307694
Lu ZM, Yu YR, Tang H, Zhang XX. The protective effects of Radix Astragali and Rhizoma Ligustici chuanxiong on endothelial dysfunction in type 2 diabetic patients with microalbuminuria. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jul;36₍₄₎:529-32. https://www.ncbi.nlm.nih.gov/pubmed/16078580
Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong.Univ Sci Technolog.Med Sci 2004;24₍₄₎:379-384. https://www.ncbi.nlm.nih.gov/pubmed/15587404
Fu S, et al. Huangqi injection {a traditional Chinese patent medicine} for chronic heart failure: a systematic review. PLoS One. ₍₂₀₁₁₎. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089614/
Yang QY, Lu S, Sun HR. Clinical effect of Astragalus granule of different dosages on quality of life in patients with chronic heart failure. Chin J Integr Med. ₍₂₀₁₁₎. https://www.ncbi.nlm.nih.gov/pubmed/21390582
Li NY, Yu H, Li XL, et al. Astragalus Membranaceus Improving Asymptomatic Left Ventricular Diastolic Dysfunction in Postmenopausal Hypertensive Women with Metabolic Syndrome: A Prospective, Open-Labeled, Randomized Controlled Trial. Chin Med J (Engl). 2018 Mar 5;131₍₅₎:516-526. https://www.ncbi.nlm.nih.gov/pubmed/29483384
Ai P, Yong G, Dingkun G, et al. Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide. J Ethnopharmacol. Mar 28 2008;116₍₃₎:413-421. https://www.semanticscholar.org/paper/Aqueous-extract-of-Astragali-Radix-induces-human-of-Ai-Yong/bdfcaaddb05de65947b1b04b897307d69ea2897d
Qian ZW, Mao SJ, Cai XC, et al. Viral etiology of chronic cervicitis and its therapeutic response to a recombinant interferon. Chin Med J (Engl). 1990 Aug;103₍₈₎:647-51. https://www.ncbi.nlm.nih.gov/pubmed/2173655
Wei H, Sun R, Xiao W, et al. Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients. Oncol.Rep. 2003;10₍₅₎:1507-1512. https://www.ncbi.nlm.nih.gov/pubmed/12883732
Lin Y, Wang B, Luo XQ. Clinical study of Astragalus's preventing the recurrence of asthma in children. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Aug;31₍₈₎:1090-2. https://www.ncbi.nlm.nih.gov/pubmed/21910341
Mao SP, Cheng KL, Zhou YF. Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24₍₂₎:121-3. https://www.ncbi.nlm.nih.gov/pubmed/15015443
Peng JZ, Wu SH, Zhang LL, Hou YD, Colby B. Studies on inhibitory effects of nIFNs and rIFNs in combination with antiviral drugs on adenovirus multiplication. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1984 Apr;6₍₂₎:116-9. https://www.ncbi.nlm.nih.gov/pubmed/6085759
Ono K, Nakane H, Meng ZM, Ose Y, Sakai Y, Mizuno M. Differential inhibitory effects of various herb extracts on the activities of reverse transcriptase and various deoxyribonucleic acid (DNA) polymerases. Chem Pharm Bull (Tokyo). 1989 Jul;37₍₇₎:1810-2. https://www.ncbi.nlm.nih.gov/pubmed/2478305
Yuan WL, Chen HZ, Yang YZ, et al. Chin. Effect of Astragalus membranaceus on electric activities of cultured rat beating heart cells infected with Coxsackie B-2 virus. Chin Med J (Engl). 1990;103₍₃₎:177–182. https://www.ncbi.nlm.nih.gov/pubmed/2164463
Sun Y, Yang J. Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type 1. Di Yi Jun Yi Da Xue Xue Bao. 2004;24₍₁₎:57–58. https://www.ncbi.nlm.nih.gov/pubmed/14724098
Cui, X, Wang, Y, Kokudo, N, Fang, D, Tang, W. Traditional Chinese medicine and related active compounds against hepatitis B virus infection. Biosci.Trends 2010;4₍₂₎:39-47. https://www.ncbi.nlm.nih.gov/pubmed/20448340
Liu WJ, Liu B, Guo QL., Zhang YC, Yuan YJ, Fu XD, Deng ZH, Lin J. Influence of ganciclovir and Astragalus membranaceus on proliferation of hematopoietic progenitor cells of cord blood after cytomegalovirus infection in vitro. Zhonghua Er.Ke.Za Zhi. 2004;42₍₇₎:490-494. View abstract. https://www.ncbi.nlm.nih.gov/pubmed/15324563
Zhu H, Zhang Y, Ye G, Li Z, Zhou P, Huang C. In vivo and in vitro antiviral activities of calycosin-7-O-beta-D-glucopyranoside against coxsackie virus B3. PubMed. 2009. https://www.ncbi.nlm.nih.gov/pubmed/19122283
Chen XJ, Bian ZP, Lu S, Xu JD, Gu CR, Yang D, Zhang JN. Cardiac protective effect of Astragalus on viral myocarditis mice: comparison with Perindopril. PubMed. 2006. https://www.ncbi.nlm.nih.gov/pubmed/16710898
Zhang L, Liu Y, Yu Z. [Study on the anti–herpes simplex virus activity of a suppository or ointment form of Astragalus membranaceus combined with interferon alpha 2b in human diploid cell culture]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 1998;12:269-271. https://www.ncbi.nlm.nih.gov/pubmed/12526333
Hou YD, Ma GL, Wu SH et al. Effect of Radix Astragali seu Hedysari on the interferon system. Chin Med J (Engl) 1981;94:35-40. https://www.ncbi.nlm.nih.gov/pubmed/6164521
Sangkitporn S, Shide L, Klinbuayaem V, et al. Efficacy and safety of zidovudine and zalcitabine combined with a combination of herbs in the treatment of HIV-infected Thai patients.. Southeast Asian J Trop Med Public Health. 2005 May; 36₍₃₎: 704-8. https://www.ncbi.nlm.nih.gov/pubmed/16124442
Zuo L, Dong X, Sun X. The curative effects of Astragalus membranaceous Bunge (A6) in combination with acyclovir on mice infected with HSV-1. Virol Sin 1995.
Chu DT, Lepe-Zuniga J, Wong WL et al. Fractionated extract of Astragalus membranaceus, a Chinese medicinal herb, potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2. J Clin Lab Immunol 1988;26:183-187. https://www.ncbi.nlm.nih.gov/pubmed/3264344/
Chu D, Sun Y, Lin J et al. [F3, a fractionated extract of Astragalus membranaceus,potentiates lymphokine-activated killer cell cytotoxicity generated by low-dose recombinant interleukin-2]. Zhong Xi Yi Jie He Za Zhi 1990;10:34-36, 35. https://www.ncbi.nlm.nih.gov/pubmed/2350835
Chu DT, Lin JR, Wong W. [The in vitro potentiation of LAK cell cytotoxicity in cancer and aids patients induced by F3, a fractionated extract of Astragalus membranaceus]. Zhonghua Zhong Liu Za Zhi 1994;16:167-171. https://www.ncbi.nlm.nih.gov/pubmed/7956691
Jiang RH, Xu HB, Fu J. Outcomes of Chinese herb medicine for the treatment of multidrug-resistant tuberculosis: a systematic review and meta-analysis. Complement Ther Med. 2015 Aug;23₍₄₎:544-54. Epub 2015 Jun 10. https://www.ncbi.nlm.nih.gov/pubmed/26275647
QuWen, Song Wenxiu. Effects of Huangqi injection with Tapazole on treatment of Graves′ disease complication Leukopenia. Tianjin Pharmacy 2000-04. http://en.cnki.com.cn/Article_en/CJFDTotal-TJYA200004046.htm
Wang MS, Li J, Di HX, Li ZL, Yang SL, Hou W, Yan JY, Zhao XM. Clinical study on effect of Astragalus Injection and its immuno-regulation action in treating chronic aplastic anemia. Chin J Integr Med. 2007 Jun;13₍₂₎:98-102. https://www.ncbi.nlm.nih.gov/pubmed/17609906
Yang QY, Lu S, Sun HR. Effects of Astragalus on cardiac function and serum tumor necrosis factor-alpha level in patients with chronic heart failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2010;30₍₇₎:699-701. https://www.ncbi.nlm.nih.gov/pubmed/20929124
Niu GH, Sun X, Zhang CM. Effect of compound Astragalus recipe on lymphocyte subset, immunoglobulin and complements in patients with myasthenia gravia. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29₍₄₎:305-8. https://www.ncbi.nlm.nih.gov/pubmed/19526753
Li WZ, et al. Protective effect of extract of Astragalus on learning and memory impairments and neurons' apoptosis induced by glucocorticoids in 12-month-old male mice. Anat Rec (Hoboken). ₍₂₀₁₁₎ . https://www.ncbi.nlm.nih.gov/pubmed/21538932
He CL, Yi PF, Fan QJ, et al. Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-kappaB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells. Immunopharmacol Immunotoxicol. Apr 2013;35₍₂₎:215-224. https://www.ncbi.nlm.nih.gov/pubmed/23171279
Zhang CZ, Wang SX, Zhang Y, Chen JP, Liang XM. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol. 2005 Apr 26;98₍₃₎:295-300. https://europepmc.org/abstract/med/15814262
Chen J, Zhang X, Wang Y, Ye Y, Huang Z. Differential ability of formononetin to stimulate proliferation of endothelial cells and breast cancer cells via a feedback loop involving MicroRNA-375, RASD1, and ERα. Mol Carcinog. 2018 Jul;57₍₇₎:817-830. https://pubmed.ncbi.nlm.nih.gov/29722068/
Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl). 1998 Jan;111₍₁₎:17-23. https://www.ncbi.nlm.nih.gov/pubmed/10322646
Gong R, Wang P, Dworkin L.What we need to know about the effect of lithium on the kidney. Am J Physiol Renal Physiol. 2016 Dec 1;311₍₆₎:F1168-F1171. https://www.ncbi.nlm.nih.gov/pubmed/27122541
Qi F, Zhao L, Zhou A, et al. The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer. Biosci Trends. 2015 Feb;9₍₁₎:16-34. https://www.ncbi.nlm.nih.gov/pubmed/25787906
Duan P, Wang ZM. [Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2002;22:515-517. https://www.ncbi.nlm.nih.gov/pubmed/12592686
Zou Yh, Liu Xm. [Effect of Astragalus injection combined with chemotherapy on quality of life in patients with advanced non–small cell lung cancer]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2003;23:733-735. https://www.ncbi.nlm.nih.gov/pubmed/14626183
Lee KY, Jeon YJ. Macrophage activation by polysaccharide isolated from Astragalus membranaceus. Int Immunopharmacol 2005;5:1225-1233. https://europepmc.org/abstract/med/15914327
McCulloch M, See C, Shu XJ, et al. Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non-small-cell lung cancer: meta-analysis of randomized trials. J Clin Oncol. 2006 Jan 20;24₍₃₎:419-30. https://www.ncbi.nlm.nih.gov/pubmed/16421421
Zhao KS, Mancini C, Doria G. Enhancement of the immune response in mice by Astragalus membranaceus extracts. Immunopharm., 20:225-234, 1990. https://www.ncbi.nlm.nih.gov/pubmed/2149722
Yoshida Y, Wang MQ, Liu JN, et al. Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular. Int. J. Immunopharm.,19₍₇₎:359-370, 1997. https://www.ncbi.nlm.nih.gov/pubmed/9568540
Yan PH, Yan M, Wang XM, Wang SH. [Effect of Huangqi injection on short-term prognosis in children with acute lymphoblastic leukemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2014 Feb;16₍₂₎:141-6. https://pubmed.ncbi.nlm.nih.gov/24568906/
Cao A, He H, Wang Q, et al. Evidence of Astragalus injection combined platinum-based chemotherapy in advanced nonsmall cell lung cancer patients: A systematic review and meta-analysis. Medicine (Baltimore). 2019 Mar;98₍₁₁₎:e14798. https://www.ncbi.nlm.nih.gov/pubmed/30882655
Guo L, Bai SP, Zhao L, Wang XH. Astragalus polysaccharide injection integrated with vinorelbine and cisplatin for patients with advanced non-small cell lung cancer: effects on quality of life and survival. Med Oncol. 2012 Sep;29₍₃₎:1656-62. https://www.ncbi.nlm.nih.gov/pubmed/21928106
Ming H, Chen Y, Zhang F, et al. [Astragalus polysaccharides combined with cisplatin decreases the serum levels of CD44 and collagen type IV and hyaluronic acid in mice bearing Lewis lung cancer]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Jul;31₍₇₎:909-13. https://www.ncbi.nlm.nih.gov/pubmed/26146060
Xiong M, He Q, Wang J, Lai H. Astragalosides reduce cisplatin ototoxicity in guinea pigs. ORL J Otorhinolaryngol Relat Spec. 2011;73₍₃₎:131-6. https://www.ncbi.nlm.nih.gov/pubmed/21494054
Chen Y, Bi L, Luo H, Jiang Y, et al. Water extract of ginseng and astragalus regulates macrophage polarization and synergistically enhances DDP's anticancer effect. J Ethnopharmacol. 2019 Mar 25;232:11-20. https://www.ncbi.nlm.nih.gov/pubmed/30529424
Auyeung KK, Law PC, Ko JK. Combined therapeutic effects of vinblastine and Astragalus saponins in human colon cancer cells and tumor xenograft via inhibition of tumor growth and proangiogenic factors. Nutr Cancer. 2014;66₍₄₎:662-74. https://www.tandfonline.com/doi/abs/10.1080/01635581.2014.894093
Kang SC, Kim HJ, Kim MH. Effects of Astragalus membranaceus with supplemental calcium on bone mineral density and bone metabolism in calcium-deficient ovariectomized rats. Biol Trace Elem Res. 2013 Jan;151₍₁₎:68-74. https://www.ncbi.nlm.nih.gov/pubmed/23136088
Cheng X, Wei B, Sun L, et al. Astragaloside I Stimulates Osteoblast Differentiation Through the Wnt/beta-catenin Signaling Pathway. Phytother Res. Jul 10 2016. https://www.ncbi.nlm.nih.gov/pubmed/27397144
Jin Y, Qu C, Tang Y, Pang H, et al. Herb pairs containing Angelicae Sinensis Radix (Danggui): A review of bio-active constituents and compatibility effects. J Ethnopharmacol. 2016 Apr 2;181:158-71. https://www.ncbi.nlm.nih.gov/pubmed/26807913
Zong HX, Li J, Zhao Y, Ding ZX. Clinical observation on danggui buxue oral solution. Zhongchengyao, 1999, 21, 132-133.
Gao QT, Cheung JK, Li J, et al. A Chinese herbal decoction, Danggui Buxue Tang, prepared from Radix Astragali and Radix Angelicae Sinensis stimulates the immune responses. Planta Med. 2006 Oct;72₍₁₃₎:1227-31. Epub 2006 Aug 10. https://www.ncbi.nlm.nih.gov/pubmed/16902872
Tao YY, Chen Y, Chen GF, et al. Anti- hepatic fibrosis effect of Ādanggui buxue decoctionāwith different proportions of Radix Astraga and Angelica sinensis in rats. Shanghai Zhongyiyao Daxue Xuebao, 2008, 22, 40-44.
Meng LQ, Putten VV, Qu L, et al. Altered expression of gene profiles modulated by a combination of Astragali Radix and Angelicae Sinensis Radix in obstructed rat kidney authors. Planta Med. 2010, 76, 1431-1438. https://pubmed.ncbi.nlm.nih.gov/20195958/
Liu IM, Tzeng TF, Liou SS. A Chinese herbal decoction, dang gui bu xue tang, prepared from Radix Astragali and Radix Angelicae sinensis, ameliorates insulin resistance induced by a high-fructose diet in rats. Evid-based. Compl. Alt. 2011, 1-11. https://pubmed.ncbi.nlm.nih.gov/19233878/
Shi XQ, Shang EX, Tang YP, et al. [Interaction of Nourishing and Tonifying Blood Effects of the Combination of Angelicae Sinensis Radix and Astragali Radix Studied by Response Surface Method]. Yao Xue Xue Bao. 2012 Oct;47₍₁₀₎:1375-83. https://pubmed.ncbi.nlm.nih.gov/23289152/
Gao QT, Cheung JKH, Choi RCY, et al. A Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis induces the expression of erythropoietin in cultured Hep3B cells. Planta Med. 2008, 74, 392-395. https://pubmed.ncbi.nlm.nih.gov/18484529/
Zheng KYZ, Choi RCY, Xie HQH, et al. The expression of erythropoietin triggered by danggui buxue tang, a Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells. J. Ethnopharmacol. 2010, 132, 259-267. https://pubmed.ncbi.nlm.nih.gov/20723591/
Lei Y, Wang JH, Chen KJ. Comparative study on angiogenesis effect of Astragalus Membranaceus and Angelica sinensis in chick embryo choriollantoic membrane. Zhongguo Zhongyao Zazhi, 2003a, 28, 876-878. https://pubmed.ncbi.nlm.nih.gov/15015388/
Gao QT, Cheung JKH, Li J, et al. A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes. Febs. Lett. 2007a, 581, 5087-5093. https://pubmed.ncbi.nlm.nih.gov/17923124/
Dong TTX, Zhao KJ, Gao QT, et al. Chemical and Biological Assessment of a Chinese Herbal Decoction Containing Radix Astragali and Radix Angelicae Sinensis: Determination of Drug Ratio in Having Optimized Properties. J. Agr. Food Chem. 2006, 54, 2767-2774. https://pubmed.ncbi.nlm.nih.gov/16569074/
Gao QT, Choi RCY, Cheung AWH, et al. Danggui buxue tang-a Chinese herbal decoction activates the phosphorylations of extracellular signal-regulated kinase and estrogen receptor α in cultured MCF-7 cells. Febs Lett. 2007b, 581, 233-240. https://pubmed.ncbi.nlm.nih.gov/17187784/
Yang WJ, Li DP, Li JK, et al. Synergistic antioxidant activities of eight traditional Chinese herb pairs. Biol. Pharm. Bull. 2009, 32, 1021-1026. https://pubmed.ncbi.nlm.nih.gov/19483308/
Li S, Yin XX, Su T, et al. Therapeutic effect of Astragalus and Angelica mixture on the renal function and TCM syndrome factors in treating stage 3 and 4 chronic kidney disease patients. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Jul;3. https://www.ncbi.nlm.nih.gov/pubmed/25137839
Huang GC, et al. Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia. Drug Des Devel Ther. 2016 Mar 2;10:949-57. https://www.ncbi.nlm.nih.gov/pubmed/27041997
Wang WP, Cao QC, Wang HW, Lv YP. Pharmacokinetic study on different compatibilities of dangguibuxuetang. Zhongguo Linchuang Yaolixue yu Zhiliaoxue, 2009, 14, 659-663.
Lau KM, Lai KK, Liu CL, et al. Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing. J Ethnopharmacol. 2012 May 7;141₍₁₎:250-6. https://www.ncbi.nlm.nih.gov/pubmed/22366433
Changtai Z, Hao C, Xifa Z, et al. Meta-Analysis of the Clinical Value of Danshen Injection and Huangqi Injection in Liver Cirrhosis. Evidence-Based Complementary and Alternative Medicine Volume 2013₍₂₀₁₃₎, Article ID 842824, 8 pages: s.n. https://www.hindawi.com/journals/ecam/2013/842824/
Tan YW, Yin YM, Yu XJ. Influence of Salvia miltiorrhizae and Astragalus membranaceus on hemodynamics and liver fibrosis indexes in liver cirrhotic patients with portal hypertension. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 May;21₍₅₎:351-3. https://www.ncbi.nlm.nih.gov/pubmed/12577420
Cho JH, Cho CK, Shin JW, et al. Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study. Complement Ther Med. 2009 Jun;17₍₃₎:141-6. https://www.ncbi.nlm.nih.gov/pubmed/19398067
Zhou Y, Tong X, Ren S, et al. Synergistic anti-liver fibrosis actions of total astragalus saponins and glycyrrhizic acid via TGF-β1/Smads signaling pathway modulation. J Ethnopharmacol. 2016 Aug 22;190:83-90. https://www.ncbi.nlm.nih.gov/pubmed/27282665
Cui K, Zhang S, Jiang X, Xie W. Novel synergic antidiabetic effects of Astragalus polysaccharides combined with Crataegus flavonoids via improvement of islet function and liver metabolism. Mol Med Rep. 2016 Jun;13₍₆₎:4737-44. https://www.ncbi.nlm.nih.gov/pubmed/27081750אטרקטילודיס
Li J, Li F, Xu Y, Yang W, et al. Chemical Composition and Synergistic Antioxidant Activities of Essential Oils From Atractylodes macrocephala and Astragalus Membranaceus. Nat Prod Commun, 2013 Sep;8₍₉₎:1321-4. https://www.ncbi.nlm.nih.gov/pubmed/24273876
Yan F, Zhang QY, Jiao L, et al. Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats. Phytomedicine. 2009 Sep;16₍₉₎:805-13. https://www.ncbi.nlm.nih.gov/pubmed/19345075
Mills S, Bone K, The Essential Guide to Herbal Safety. Churchill Livingstone, 2005. https://www.elsevier.com/books/the-essential-guide-to-herbal-safety/mills/978-0-443-07171-3.
Taixiang W, Munro AJ, Guanjian L. Chinese medical herbs for chemotherapy side effects in colorectal cancer patients. Cochrane Database Syst Rev. 2005 Jan 25;₍₁₎:CD004540. https://www.ncbi.nlm.nih.gov/pubmed/15674951
Chen HW, Lin IH, Chen YJ, Chang KH, Wu MH, Su WH, Huang GC, Lai YL. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest Med. 2012 Feb 1;35₍₁₎:E1-11. https://www.ncbi.nlm.nih.gov/pubmed/22309959
Zhang Qiong; Chen Li. Nanjing Clinical Observations on Acupuncture Point Injection for Adverse Reactions to Stomach Cancer Chemotherapy.Shanghai Journal of Acupuncture and Moxibustion 2014-02. http://en.cnki.com.cn/Article_en/CJFDTotal-SHZJ201402024.htm
Chen L, Xie C, Wu L. Point injection of injectio radici astragali for treatment of post-chemotherapy adverse reactions. J Tradit Chin Med. 2005 Mar;25₍₁₎:21-2. https://www.ncbi.nlm.nih.gov/pubmed/15889516
Zhang XJ, Yan M, Liu Y, Wang XM, Nuriding H. Effects of Huangqi injection on infection factors in children with acute lymphoblastic leukemia. Zhongguo Dang Dai Er Ke Za Zhi. 2014 Feb;16₍₂₎:147-51. https://www.ncbi.nlm.nih.gov/pubmed/24568907
Lau BH, Ruckle HC, Botolazzo T, Lui PD. Chinese medicinal herbs inhibit growth of murine renal cell carcinoma. Cancer Biother 1994;9:153-61. https://www.ncbi.nlm.nih.gov/pubmed/7812364
Cho WC, Leung KN. In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Lett. 2007 Jul 8;252₍₁₎:43-54. Epub 2007 Jan 16. https://www.ncbi.nlm.nih.gov/pubmed/17223259
Wei W, Xiao HT, Bao WR, et al. TLR-4 may mediate signaling pathways of Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells. J Ethnopharmacol. Feb 17 2016;179:243-252. https://www.ncbi.nlm.nih.gov/pubmed/26743224
Auyeung KK, Law PC, Ko JK. Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. Int J Mol Med. 2009 Feb;23₍₂₎:189-96. https://www.ncbi.nlm.nih.gov/pubmed/19148542
Tin MM, Cho CH, Chan K, James AE, Ko JK. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis. 2007 Jun;28₍₆₎:1347-55. Epub 2006 Dec 5. : s.n., Zhong Xi Yi Jie He Xue Bao. 2009 Dec;7₍₁₂₎:1174-80. https://www.ncbi.nlm.nih.gov/pubmed/17148504
Ye MN, Chen HF. Effects of Astragalus injection on proliferation of basal-like breast cancer cell line MDA-MB-468. Zhong Xi Yi Jie He Xue Bao. 2008 Apr;6₍₄₎:399-404. https://www.ncbi.nlm.nih.gov/pubmed/18405609
Cheng XD, Hou CH, Zhang XJ, Xie HY, Zhou WY, Yang L, Zhang SB, Qian RL. Effects of Huangqi (Hex) on inducing cell differentiation and cell death in K562 and HEL cells. Acta Biochim Biophys Sin (Shanghai). 2004 Mar;36₍₃₎:211-7. https://www.ncbi.nlm.nih.gov/pubmed/15202506
Auyeung KK, Mok NL, Wong CM, Cho CH, Ko JK. Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. Int J Mol Med. 2010 Sep;26₍₃₎:341-9. https://www.ncbi.nlm.nih.gov/pubmed/20664949
Deng Y, Chen HF. Effects of Astragalus injection and its ingredients on proliferation and Akt phosphorylation of breast cancer cell lines. Zhong Xi Yi Jie He Xue Bao. 2009 Dec;7₍₁₂₎:1174-80. doi: 10.3736/jcim20091216. https://www.ncbi.nlm.nih.gov/pubmed/20015441
Tseng A, Yang CH, Chen CH, et al. An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract. Oncol Rep. Feb 2016;35₍₂₎:659-668. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689484/
Law PC, Auyeung KK, Chan LY, et al. Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. BMC Complement Altern Med. 2012;12:160. https://www.ncbi.nlm.nih.gov/pubmed/22992293
Huang WH, Liao WR, Sun RX. Astragalus polysaccharide induces the apoptosis of human hepatocellular carcinoma cells by decreasing the expression of Notch1. Int J Mol Med. Aug 2016;38₍₂₎:551-557. https://www.ncbi.nlm.nih.gov/pubmed/27279598
Shon YH, Nam KS. Protective effect of Astragali radix extract on interleukin 1beta-induced in fl ammation in human amnion. Phytother Res. 2003 Nov;17₍₉₎:1016-20. https://www.ncbi.nlm.nih.gov/pubmed/14595579
Ryu M, Kim EH, Chun M, Kang S, Shim B, Yu YB, Jeong G, Lee JS. Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk. J Ethnopharmacol. 2008 Jan 17;115₍₂₎:184-93. Epub 2007 Oct 5. https://www.ncbi.nlm.nih.gov/pubmed/17996413
Ko JK, Lam FY, Cheung AP. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis. World J Gastroenterol. 2005 Oct 7;11₍₃₇₎:5787-94. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479677/
Ko JK, Chik CW. The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines. Cytokine. 2009 Aug;47₍₂₎:85-90. doi: 10.1016/j.cyto.2009.05.014. Epub 2009 Jun 17. https://www.ncbi.nlm.nih.gov/pubmed/19539495
Lee SJ, Oh SG, Seo SW, Ahn HJ, Geum D, Cho JJ, Park CS. Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice. Biol Pharm Bull. 2007 Aug;30₍₈₎:1468-71. https://www.ncbi.nlm.nih.gov/pubmed/17666805
Wang B, Chen MZ. Astragaloside IV possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage. Arch Pharm Res. 2014 Jun;37₍₆₎:793-802. https://www.ncbi.nlm.nih.gov/pubmed/24469603
Zhang WJ, Hufnagl P, Binder BR, Wojta, J. Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression. Thromb.Haemost. 2003;90₍₅₎:904-914. https://www.ncbi.nlm.nih.gov/pubmed/14597987
Tian Z, Liu Y, Yang B, et al. Astagalus Polysaccharide Attenuates Murine Colitis through Inhibiton of the NLRP3 Inflammasome. Planta Med. Jun 9 2016. https://www.ncbi.nlm.nih.gov/pubmed/27280937
Yuan Y, Sun M, and Li KS. Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-alpha and interleukin-8. . World J Gastroenterol. 8-7-2009;15₍₂₉₎:3676-3680. https://www.ncbi.nlm.nih.gov/pubmed/19653348
Li HQ, Qiu JD, Yang LH. Regulation of Astragalus heteropolysaccharides on synoviocytes apoptosis and proinflammatory cytokine secretion of rats with adjuvant arthritis. Yao Xue Xue Bao. 2009 Jul;44₍₇₎:731-6. https://www.ncbi.nlm.nih.gov/pubmed/19806911
Hoo RL, Wong JY, Qiao C, Xu A, Xu H, Lam KS.The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. Nutr Metab (Lond) 2010;7:67. https://www.ncbi.nlm.nih.gov/pubmed/20735814
Xiping Z, Ke W, Yaping Y, Hongchan Z, Qihui C. Protective effect and mechanisms of radix astragali injection on the intestinal mucosa of rats with obstructive jaundice. Mediators.Inflamm. 2010;2010:757191. https://www.ncbi.nlm.nih.gov/pubmed/20300591
Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan 5;118₍₁₎:43-9. https://www.ncbi.nlm.nih.gov/pubmed/15642225
Motomura K, Fujiwara Y, Kiyota N, Tsurushima K, Takeya M, Nohara T, Nagai R, Ikeda T. Astragalosides isolated from the root of Astragalus radix inhibit the formation of advanced glycation end products. J Agric Food Chem. 2009 Sep 9;57₍₁₇₎:7666-72. https://www.ncbi.nlm.nih.gov/pubmed/19681610
Shirataki Y, Takao M, Yoshida S, and et al. Antioxidative components isolated from the roots of Astragalus membranaceus Bunge ( Astragali Radix ). Phytotherapy Research 1997;11:603-605. https://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1099-1573_(199712)11:8%3C603::AID-PTR161%3E3.0.CO;2-U
Xu XY, Li LH, Wu LS, et al. Adjustment effect of Radix Astragalus and Radix Angelicae sinensis on TNF-alpha and bFGF on renal injury induced by ischemia reperfusion in rabbit. Zhongguo Zhong.Yao Za Zhi. 2002;27₍₁₀₎:771-7. https://www.ncbi.nlm.nih.gov/pubmed/12776561
Fengqin L, Yulin W, Xiaoxin Z, Youpeng J, Yan C, Qing-qing W, Hong C, Jia S, Lei H. The heart-protective mechanism of Qishaowuwei formula on murine viral myocarditis induced by CVB3. J Ethnopharmacol. 2-3-2010;127₍₂₎:221-228. https://www.ncbi.nlm.nih.gov/pubmed/19932162
Xiong P, Jiang LZ, Liao XQ. Morphological investigation of the protective effect of astragaloside preconditioning against ischemia-reperfusion lung injury in rats. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2010;30₍₈₎:1864-1867. https://www.ncbi.nlm.nih.gov/pubmed/20813687
Guan Y, Zhou Z, Zhang C, Ruan Y, Wu Z. Effect of A-L tonic capsule on DNA content in rat experimental hepatocarcinogenesis. J Huazhong.Univ Sci Technolog.Med Sci 2002;22₍₁₎:12-3, 16. https://www.ncbi.nlm.nih.gov/pubmed/12658771
Chan JY, Lam FC, Leung PC, Che CT, Fung KP. Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus. Phytother.Res 2009;23₍₅₎:658-665. https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.2694
Han L, Chen KJ. The protective effects of yi-xin-kang capsule on the structure and function of rat myocardial mitochondria. Zhongguo Zhong.Yao Za Zhi. 2001;26₍₁₁₎:773-777. https://www.ncbi.nlm.nih.gov/pubmed/12776352
Wang WW. and Chen YP. Effect of Astragalus and Arctium in different combinations on reactive oxygen species content and nuclear transcription factor kappaB expression in renal tissue of streptozotocin rats. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2008;28₍₁₀₎:917-920. https://www.ncbi.nlm.nih.gov/pubmed/19123331
Toda S, Yase Y, Shirataki Y. Inhibitory effects of astragali radix, crude drug in Oriental medicines on lipid peroxidation and protein oxidative modification of mouse brain homogenate by copper. Phytother.Res 2000;14₍₄₎:294-296. https://www.ncbi.nlm.nih.gov/pubmed/10861978
Zhang BQ, Hu SJ, Qiu LH, Zhu JH, Xie XJ, Sun J, Zhu ZH, Xia Q, Bian K. Effects of Astragalus membranaceus and its main components on the acute phase endothelial dysfunction induced by homocysteine. Vascul.Pharmacol 2007;46₍₄₎:278-285. https://www.ncbi.nlm.nih.gov/pubmed/17196887
Wang D, Shen W, Tian Y, Dong Z, Liu G, Sun Z, Yang S, Zhou S. Protective effect of total flavonoids of radix Astragali on mammalian cell damage caused by hydroxyl radical. Zhongguo Zhong.Yao Za Zhi. 1995;20₍₄₎:240-2. https://www.ncbi.nlm.nih.gov/pubmed/7646797
Shahzad M, Shabbir A, Wojcikowski K, Wohlmuth H, Gobe GC. The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease. Curr Drug Targets. 2016;17₍₁₂₎:1331-40. https://www.ncbi.nlm.nih.gov/pubmed/26343107
Zhang C, Zhu C, Ling Y, Zhou X, Dong C, Luo J, Liu Y. The clinical value of Huangqi injection in the treatment of leucopenia: a meta-analysis of clinical controlled trials. PLoS One. 2013 Dec 12;8₍₁₂₎:e83123. https://www.ncbi.nlm.nih.gov/pubmed/24349444
Weng XS. Treatment of leucopenia with pure Astragalus preparation--an analysis of 115 leucopenic cases. In Zhongguo Zhong Xi Yi Jie He Za Zhi: 1995; 15₍₈₎: 462-464. https://www.ncbi.nlm.nih.gov/pubmed/8580691
Lu ZM, Qian XH, Chen ZW, Zhang CH, Guo LS, Chen J. Prospective clinical study of radix astragali and its compound prescription for treatment of β-thalassemia in children. Zhongguo Dang Dai Er Ke Za Zhi. 2012 May;14₍₅₎:344-9. https://www.ncbi.nlm.nih.gov/pubmed/22613104
Zheng KY, et al. Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1α. J Agric Food Chem. ₍₂₀₁₁₎. https://www.ncbi.nlm.nih.gov/pubmed/21309574
Xu CJ, Jian XC, Cheng HQ. Influence of Astragalus membranaceus injection on the proliferation of rabbit bone marrow stromal cells and differentiation to osteoblast. Zhong.Nan.Da.Xue.Xue.Bao.Yi.Xue.Ban. 2004;29₍₄₎:489-491. https://www.ncbi.nlm.nih.gov/pubmed/16134616
Li NQ. Clinical and experimental study on shen-qo injection with chemotherapy in the treatment of malignant tumor of digestive tract. Zhongguo Zhong.Xi.Yi.Jie.He.ZaZhi. 1992;12₍₁₀₎:579, 588-592. https://europepmc.org/abstract/med/1302539
Zee-Cheng RK. Shi-quan-da-bu-tang (ten significant tonic decoction), SQT. A potent Chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs. Methods Find.Exp Clin Pharmacol 1992;14₍₉₎:725-736. https://www.ncbi.nlm.nih.gov/pubmed/1294861
Ma R, Xie RF .The effect of Radix Astragali on mouse marrow hemopoiesis. J Tradit Chin Med 1983;3₍₃₎:199-204. https://www.ncbi.nlm.nih.gov/pubmed/6556405
Matkovic Z, Zivkovic V, Korica M, Plavec D, Pecanic S, Tudoric N. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res. 2010 Feb;24₍₂₎:175-81. https://www.ncbi.nlm.nih.gov/pubmed/19504468
Wang H, Chang B, Wang B. The effect of herbal medicine including Astragalus membranaceus (fisch) bge, codonpsis pilosula and glycyrrhiza uralensis fisch on airway responsiveness. Zhonghua Jie He He Hu Xi Za Zhi. 1998 May;21₍₅₎:287-8. https://www.ncbi.nlm.nih.gov/pubmed/11326953
Kim JH, Kim MH, Yang G, Huh Y, Kim SH, Yang WM. Effects of topical application of Astragalus membranaceus on allergic dermatitis. Immunopharmacol Immunotoxicol. 2013 Feb;35₍₁₎:151-6. https://www.ncbi.nlm.nih.gov/pubmed/23083228
Xu S, Tian BP, Zhang LH, Hua W, Xia LX, Chen ZH, Li W, Shen HH. Prevention of allergic airway hyperresponsiveness and remodeling in mice by Astragaliradix antiasthmatic decoction. BMC Complement Altern Med. 2013 Dec 25;13:369. https://www.ncbi.nlm.nih.gov/pubmed/24367979
Wang J, Zhang QY, Chen YX. Effects of Astragalus membranaceus on cytokine secretion of peripheral dendritic cells in children with Henoch-Schonlein purpurain the acute phase. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Sep;29₍₉₎:794-7. https://www.ncbi.nlm.nih.gov/pubmed/19960975
Kusum, M., Klinbuayaem, V., Bunjob, M., and Sangkitporn, S. Preliminary efficacy and safety of oral suspension SH, combination of five chinese medicinal herbs, in people living with HIV/AIDS ; the phase I/II study. J.Med.Assoc.Thai. 2004;87₍₉₎:1065-1070. https://www.ncbi.nlm.nih.gov/pubmed/15516007
Wei JA, Sun LM, Chen YX. Effects of Ailing Granule on immuno-reconstruction in HIV/AIDS patients. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Apr;26₍₄₎:319-21. https://www.ncbi.nlm.nih.gov/pubmed/16688998
Dang SS, Jia XL, Song P, Cheng YA, Zhang X, Sun MZ, Liu EQ. Inhibitory effect of emodin and Astragalus polysaccharide on the replication of HBV. World J Gastroenterol. 12-7-2009;15₍₄₅₎:5669-5673. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789219/
Wang S, Li J, Huang H, Gao W, Zhuang C, Li B, Zhou P, Kong D. Anti-hepatitis B virus activities of astragaloside IV isolated from radix Astragali. PubMed. 2009. https://www.ncbi.nlm.nih.gov/pubmed/19122295
Lien AS, Jiang YD, Chih-Hsin Mou MS, Sun MF, Bih-Shya Gau RN, Yen HR. Integrative Traditional Chinese Medicine Therapy Reduces the Risk of Diabetic Ketoacidosis in Patients with Type 1 Diabetes Mellitus. J Ethnopharmacol. 2016 Jun 20. pii: S0378-8741₍₁₆₎3. https://www.ncbi.nlm.nih.gov/pubmed/27340102
Yin X, Zhang S, Kong Y, and et al. Observation on efficiency of jiangtang capsule in treating diabetes mellitus type 2 with hyperlipidemia. Chinese Journal of Integrated Traditional and Western Medicine 2001;7₍₃₎:214-216. https://www.researchgate.net/publication/225161436
Chao M, Zou D, Zhang Y, Chen Y, Wang M, Wu H, Ning G, Wang W. Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients. Endocrine. 2009;36₍₂₎:268-274. https://www.ncbi.nlm.nih.gov/pubmed/19728183
Gao SR, Bu JH, Zhu LZ. Preliminary exploration on effect of qilian decoction in intervention treatment of diabetes mellitus type 2 with insulin resistance and its influence on related inflammatory cytokines. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Jul;24₍₇₎:593-5. https://www.ncbi.nlm.nih.gov/pubmed/15307695
Liang HY, Hou F, Ding YL, Zhang WN, Huang XH, Zhang BY, Liu Y. Clinical evaluation of the antioxidant activity of Astragalus in women with gestational diabetes. Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jul;29₍₇₎:1402-4. https://www.ncbi.nlm.nih.gov/pubmed/19620065
Zou F, Mao XQ, Wang N, Liu J, Ou-Yang JP. Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK. Acta Pharmacol Sin. 2009 Dec;30₍₁₂₎:1607-15. https://www.ncbi.nlm.nih.gov/pubmed/19960007
Mao XQ, Yu F, Wang N, Wu Y, Zou F, Wu K, Liu M, Ouyang JP. Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism. Phytomedicine. 2009 May;16₍₅₎:416-25. https://www.ncbi.nlm.nih.gov/pubmed/19201177
Liu M, Wu K, Mao X, Wu Y, Ouyang J. Astragalus polysaccharide improves insulin sensitivity in KKAy mice: regulation of PKB/GLUT4 signaling in skeletal muscle. J Ethnopharmacol. 2010 Jan 8;127₍₁₎:32-7. doi: 10.1016/j.jep.2009.09.055. Epub 2009 Oct 2. https://www.ncbi.nlm.nih.gov/pubmed/19800959
Wang N, Zhang D, Mao X, Zou F, Jin H, Ouyang J. Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes. Mol.Cell Endocrinol 8-13-2009;307_(1-2):89-98. https://www.ncbi.nlm.nih.gov/pubmed/19524131
Li, HB, Ge YK, Zhang L, Zheng XX. Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells. Life Sci 8-15-2006;79₍₁₂₎:1186-1193. https://www.ncbi.nlm.nih.gov/pubmed/16650877
Yu J, Zhang Y, Sun S, Shen J, Qiu J, Yin X, Yin H, Jiang S. Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats. Can J Physiol Pharmacol. 2006 Jun;84₍₆₎:579-87. https://www.ncbi.nlm.nih.gov/pubmed/16900242
Lei ZY, Qin H, Liao JZ. Action of Astragalus membranaceus on left ventricular function of angina pectoris. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Apr;14₍₄₎:199-202, 195. https://www.ncbi.nlm.nih.gov/pubmed/7950192
Li SQ, Yuan RX, Gao H. Clinical observation on the treatment of ischemic heart disease with Astragalus membranaceus. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Feb;15₍₂₎:77-80. https://www.ncbi.nlm.nih.gov/pubmed/7787395
Zhou ZL, Yu P, Lin D. Study on effect of Astragalus injection in treating congestive heart failure. Zhongguo Zhong Xi Yi Jie He Za Zhi. ₍₂₀₀₁₎. https://www.ncbi.nlm.nih.gov/pubmed/12575607
Zhang JG, Gao DS, Wei GH. Clinical study on effect of Astragalus injection on left ventricular remodeling and left ventricular function in patients with acute myocardial infarction. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22₍₅₎:346-348. https://www.ncbi.nlm.nih.gov/pubmed/12584831
Chen LX, Liao JZ, Guo WQ. Effects of Astragalus membranaceus on left ventricular function and oxygen free radical in acute myocardial infarction patients and mechanism of its cardiotonic action. Zhongguo Zhong. Xi. Yi Jie He Za Zhi. 1995; 15₍₃₎: 141-143. https://www.ncbi.nlm.nih.gov/pubmed/7647526
Yang QY, Chen KJ, Lu S, Sun HR. Research progress on mechanism of action of Radix Astragalus in the treatment of heart failure. Chin J Integr Med 2012;18₍₃₎:235-240. https://link.springer.com/article/10.1007/s11655-012-1022-1
Meng D, Chen XJ, Bian YY, Li P, Yang D, Zhang JN. Effect of astragalosides on intracellular calcium overload in cultured cardiac myocytes of neonatal rats. Am J Chin Med. 2005;33₍₁₎:11-20. https://www.ncbi.nlm.nih.gov/pubmed/15844829
Lei Y, Gao Q, Li YS. Study on effects of Astragalus, Angelica and their combination on vascular endothelial cell proliferation in vitro. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Oct;23₍₁₀₎:753-6. https://www.ncbi.nlm.nih.gov/pubmed/14626189
Zhang WD, et al. Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta Med. ₍₂₀₀₆₎. https://www.ncbi.nlm.nih.gov/pubmed/16450288
Lin Y, Ning XF, Yu W, Li ZP. Effects of astragaloside IV on cardiac collagen content in rats with acute myocardial infarction and its mechanisms. Chin Pharm J (Chin) 2008;43:833-837. https://jglobal.jst.go.jp/en/detail?JGLOBAL_ID=200902275650724764&rel=0
Zhang ZC, Li SJ, Yang YZ, Chen RZ, Chen YZ. Effect of astragaloside on myocardial fibrosis in chronic myocarditis. Chin J Integr Tradit West Med (Chin) 2007;27:728-730. https://www.ncbi.nlm.nih.gov/pubmed/17879539
Xu XL, Ji H, Gu SY, Huang QJ, Chen YP. Effects of astragaloside IV on experimental ventricular remodeling in mice and its mechanism from matrix metalloproteinase aspect. J China Pharm Univ (Chin) 2010;41:70-75. http://www.zgykdxxb.cn/jcpuen/ch/reader/view_abstract.aspx?file_no=20100113&flag=1
Zhou JY, Fan Y, Kong JL, Wu DZ, Hu ZB. Effects of components isolated from Astragalus membranaceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rat. Zhongguo Zhong Yao Za Zhi. 2000;25₍₅₎:300-302. https://www.ncbi.nlm.nih.gov/pubmed/12512456
Chen XJ, Meng D, Feng L, Bian YY, Li P. Protective effect of astragalosides on myocardial injury by isoproterenol in SD rats. Am J Chin Med. 2006;34₍₆₎:1015-25. https://www.ncbi.nlm.nih.gov/pubmed/17163590
Luo Z, et al. Astragalus membranaceus prevents daunorubicin-induced apoptosis of cultured neonatal cardiomyocytes: role of free radical effect of Astragalus membranaceus on daunorubicin cardiotoxicity. Phytother Res. ₍₂₀₀₉₎. https://www.ncbi.nlm.nih.gov/pubmed/19172580
Zhang J, Gu JY, Chen ZS, Xing KC, Sun B. Astragalus polysaccharide suppresses palmitate-induced apoptosis in human cardiac myocytes: the role of Nrf1and antioxidant response. Int J Clin Exp Pathol. 2015 Mar 1;8₍₃₎:2515-24. https://www.ncbi.nlm.nih.gov/pubmed/26045757
Chen CC, Lee HC, Chang JH, Chen SS, Li TC, Tsai CH, Cho DY, Hsieh CL. Chinese Herb Astragalus membranaceus Enhances Recovery of Hemorrhagic Stroke: Double-Blind, Placebo-Controlled, Randomized Study. Evid Based Complement Alternat Med. 2012;2012:708452. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310143/
Liu ZL, Liu ZJ, Liu JP, Kwong JS. Herbal medicines for viral myocarditis. Cochrane Database Syst.Rev. 2012;11:CD003711. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407372/
Hikino H, Funayama S, and Endo K. Hypotensive principle of Astragalus and Hedysarum roots. Planta Medica 1976;30:297-302. https://www.ncbi.nlm.nih.gov/pubmed/1005534
Yao LM, Liu TW, Wu WF. Effects of Astragalus injection in reversing left ventricular hypertrophy induced by renal hypertension in rats. Zhongguo Zhong.Xi.Yi.Jie.He.ZaZhi. 2009;29₍₁₀₎:918-921. https://www.ncbi.nlm.nih.gov/pubmed/20073225
Deng G, Yu YR. Radix Astragali improves impaired endothelial dependent vasodilation in obese rat. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jul;40₍₄₎:608-11. https://www.ncbi.nlm.nih.gov/pubmed/19764554
Li MR, Yu YR, Deng G. Astragalus membranaceus improves endothelial-dependent vasodilator function in obese rats. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jan;30₍₁₎:7-10. https://www.ncbi.nlm.nih.gov/pubmed/20117973
You Y, et al. Anti-atherosclerotic function of Astragali Radix extract: downregulation of adhesion molecules in vitro and in vivo . BMC Complement Altern Med. ₍₂₀₁₂₎. https://www.ncbi.nlm.nih.gov/pubmed/22536886
Li SQ, He H. Effects of Astragalus Membranacus on superoxide dismutase and lipid peroxide in patients with pectoris. Chin J Integr Med Cardio-Cerebrovasc Dis (Chin) 2003; 1231-1234.
Wang YF, et al. polysaccharides on ATP binding Protective effect of Astragalus cassette transporter A1 in THP-1 derived foam cells exposed to tumor necrosis factor-alpha. Phytother Res. ₍₂₀₁₀₎. https://www.ncbi.nlm.nih.gov/pubmed/19653192
Oram JF. ATP-binding cassette transporter A1 and cholesterol trafficking. Curr Opin Lipidol. ₍₂₀₀₂₎. https://www.ncbi.nlm.nih.gov/pubmed/12151852
Fujiwara Y, et al. Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages. J Agric Food Chem. ₍₂₀₁₁₎. https://www.ncbi.nlm.nih.gov/pubmed/21446758
Zhang C, et al. Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings. Clin Exp Pharmacol Physiol. ₍₂₀₀₇₎. https://www.ncbi.nlm.nih.gov/pubmed/17439405
Zhang WD, et al. Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways. Planta Med. ₍₂₀₀₆₎. http://agris.fao.org/agris-search/search.do?recordID=US201301090590
Qiu LH, Xie XJ, Zhang BQ. Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation. Biol Pharm Bull. ₍₂₀₁₀₎ . https://www.ncbi.nlm.nih.gov/pubmed/20410599
Zhang N, et al. Astragaloside IV improves metabolic syndrome and endothelium dysfunction in fructose-fed rats. Molecules. ₍₂₀₁₁₎. https://www.ncbi.nlm.nih.gov/pubmed/21555978
Yang HY, Li J, Yi M. Study on chronical hepatitis B with treatment of integrative traditional Chinese and Western medicine. Zhongguo Zhong Yao Za Zhi. 2006 Aug;31₍₁₅₎:1277-80. https://www.ncbi.nlm.nih.gov/pubmed/17048576
Chen H, Weng L. Comparison on efficacy in treating liver fibrosis of chronic hepatitis B between Astragalus Polygonum anti-fibrosis decoction and jinshuibao capsule. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Apr;20₍₄₎:255-7. https://www.ncbi.nlm.nih.gov/pubmed/11789260
Tang LL, Sheng JF, Xu CH, Liu KZ. Clinical and experimental effectiveness of Astragali compound in the treatment of chronic viral hepatitis B. J Int Med Res 2009;37₍₃₎:662-667. http://journals.sagepub.com/doi/abs/10.1177/147323000903700308
Zhang BZ, Ding F, Tan LW. Clinical and experimental study on yi-gan-ning granule in treating chronic hepatitis B. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13₍₁₀₎:597-9, 580. https://www.ncbi.nlm.nih.gov/pubmed/8312695
Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of Astragalus (ASI, SK) on experimental liver injury. Yao Xue Xue Bao. 1992;27₍₆₎:401-6. https://europepmc.org/abstract/med/1442065
Dang SS, Zhang X, Jia XL, Cheng YA, Song P, Liu EQ, He Q, Li ZF. Protective effects of emodin and Astragalus polysaccharides on chronic hepatic injury in rats. Chin Med J (Engl). 2008 Jun 5;121₍₁₁₎:1010-4. https://www.ncbi.nlm.nih.gov/pubmed/18706249
Wang DQ, Critchley JA, Ding BG, Ma YQ, Zhao HL, Thomas GN, Tian YP, Tomlinson B, Critchley LA, Edward JA. Protection against paracetamol-induced hepatic damage using total flavonoids of Astragalus. Zhongguo Zhong Yao Za Zhi. 2001 Sep;26₍₉₎:617-20. https://www.ncbi.nlm.nih.gov/pubmed/12776431
Wang DQ, Ding BG, Ma YQ, Zhao HL, Neil TG, Brian T, Tian YP, Wang CB, Critchley JA. Studies on protective effect of total flavonoids of Astragalus on liver damage induced by paracetamol. Zhongguo Zhong Yao Za Zhi. 2001 Jul;26₍₇₎:483-6. https://www.ncbi.nlm.nih.gov/pubmed/12776364
Liu H, Wei W, Sun WY, Li X. Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells. J Ethnopharmacol. 4-21-2009;122₍₃₎:502-508. https://www.ncbi.nlm.nih.gov/pubmed/19429320
Ti YX, Pan ZX, Wu C. Intervention of Astragalus injection on the kidney injury after cardiopulmonary bypass of infants congenital heart disease. Zhongguo Zhong Xi Yi Jie He Za Zhi. ₍₂₀₁₁₎. https://www.ncbi.nlm.nih.gov/pubmed/21812263
Qu ZL, Dong H, Wang SD. Effects of Astragalus injection on renal function in patients after cardiac valve replacement with cardiopulmonary bypass. Zhongguo Zhong Xi Yi Jie He Za Zhi. ₍₂₀₀₉₎. https://www.ncbi.nlm.nih.gov/pubmed/19526755
Wu HM, Tang JL, Cao L, Sha ZH, Li Y. Interventions for preventing infection in nephrotic syndrome. Cochrane Database Syst.Rev. 2012;4:CD003964. https://www.ncbi.nlm.nih.gov/pubmed/22513919
Chen LP, Zhou QL, Yang JH. Protective effects of astragali injection on tubular in patients with primary nephrotic syndrome. Zhong Nan Da Xue Xue Bao Yi Xue Ban. ₍₂₀₀₄₎. https://www.ncbi.nlm.nih.gov/pubmed/16145898
Ahmed MS, et al. Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus. Am J Kidney Dis. ₍₂₀₀₇₎. https://www.ncbi.nlm.nih.gov/pubmed/18037104
Zuo C, Xie XS, Qiu HY, Deng Y, Zhu D, Fan JM. Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-beta in rats with unilateral ureteral obstruction. J Zhejiang Univ Sci B. 2009 May;10₍₅₎:380-90. https://www.ncbi.nlm.nih.gov/pubmed/19434765
Zuo C, Xie X, Deng Y, Fan J. Effect of Astragalus mongholicus on expression of transforming growth factor- beta1 in SD rats with unilateral ureteral occlusion. Zhongguo Zhong Yao Za Zhi. 2009 Jan;34₍₂₎:193-8. https://www.ncbi.nlm.nih.gov/pubmed/19385185
Zuo C, Xie X, Deng Y, Fan J. Regulative effect of Astragalus mongholicus on hepatocyte growth factor and transforming growth factor-beta1 in rats with unilateral ureteral obstruction. Wei Sheng Yan Jiu. 2008 Sep;37₍₅₎:566-70. https://www.ncbi.nlm.nih.gov/pubmed/19069655
Zhang YW, Wu CY, Cheng JT. Merit of Astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mRNA expressions of NF-kappaB and IkappaB in renal cortex of streptozotoxin-induced diabetic rats . J Ethnopharmacol. ₍₂₀₀₇₎. http://europepmc.org/abstract/med/17900838
Zhang GZ, Wu XC, Peng XJ, Yi ZW, Mo SH, Tan H. Effects of Astragalus on renal tubulointerestitial lesions and expression of NF-kappaB and MCP-1 in renal tissues in rat experimental IgA nephropathy. Zhongguo Dang Dai Er Ke Za Zhi. 2008 Apr;10₍₂₎:173-8. https://www.ncbi.nlm.nih.gov/pubmed/18433541
Zhang HW, Lin ZX, Xu C, Leung C, Chan LS. Astragalus (a traditional Chinese medicine) for treating chronic kidney disease. Cochrane Database Syst Rev. 2014 Oct 22;₍₁₀₎. https://www.ncbi.nlm.nih.gov/pubmed/25335553
Li SM, Yan JX, Yang L. Effects of Astragalus injection on renal tubular function in patients with IgA nephropathy. Zhongguo Zhong Xi Yi Jie He Za Zhi ₍₂₀₀₆₎. https://www.ncbi.nlm.nih.gov/pubmed/16841664
Yeh TS, Chuang HL, Huang WC, Chen YM, Huang CC, Hsu MC. Astragalus membranaceus improves exercise performance and ameliorates exercise-induced fatigue in trained mice. Molecules. 2014 Mar 3;19₍₃₎:2793-807. https://www.ncbi.nlm.nih.gov/pubmed/24595275
Zhang G, Zhou SM, Zheng SJ, Liu FY, Gao YQ. Astragalus on the anti-fatigue effect in hypoxic mice. Int J Clin Exp Med. 2015 Aug 15;8₍₈₎:14030-5. eCollection 2015. http://www.ijcem.com/files/ijcem0008943.pdf
Lu L, Wang DT, Shi Y, Yin Y, Wei LB, Zou YC, Huang B, Zhao Y, Wang M, Wan H, Li CJ, Diao JX. Astragalus polysaccharide improves muscle atrophy from dexamethasone- and peroxide-induced injury in vitro. Int J Biol Macromol. 2013 Oct;61:7-16. https://www.ncbi.nlm.nih.gov/pubmed/23817095
Oh HA, Choi HJ, Kim NJ, Kim DH. Anti-stress effect of astragaloside IV in immobilized mice. J Ethnopharmacol. 2014 May 14;153₍₃₎:928-32. https://www.ncbi.nlm.nih.gov/pubmed/24709311
Liu CH, Tsai CH, Li TC, et al.,Effects of the traditional Chinese herb Astragalus membranaceus in patients with poststroke fatigue: A double-blind, randomized, controlled preliminary study. J Ethnopharmacol. 2016 Dec 24;194:954-962. https://www.ncbi.nlm.nih.gov/pubmed/27773802
Huang XP, Tan H, Chen BY, Deng CQ. Astragalus extract alleviates nerve injury after cerebral ischemia by improving energy metabolism and inhibiting apoptosis. Biol Pharm Bull. 2012;35₍₄₎:449-54. https://www.ncbi.nlm.nih.gov/pubmed/22466546
Lu MC, Yao CH, Wang SH, et al. Effect of Astragalus membranaceus in rats on peripheral nerve regeneration: in vitro and in vivo studies. J Trauma. 2010 Feb;68₍₂₎:434-40. https://www.ncbi.nlm.nih.gov/pubmed/20154555
Shi R, He L, Hu Y, et al. The regulatory action of radix astragali on M-cholinergic receptor of the brain of senile rats. J Tradit Chin Med 2001;21:232-5. https://www.ncbi.nlm.nih.gov/pubmed/11789335
Dun C, Liu J, Qiu F, et al. Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model. Neuropsychiatr Dis Treat. 2016;12:1617-1621. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936836/
Chan WS, Durairajan SS, Lu JH, et al. Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture. Neurochem Int 2009; 55₍₆₎: 414-422. https://www.ncbi.nlm.nih.gov/pubmed/19409437
Aldarmaa J, Liu Z, Long J, Mo X, Ma J, Liu J. Anti-convulsant effect and mechanism of Astragalusmongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. Neurochem Res. 2010 Jan;35₍₁₎:33-41. https://www.ncbi.nlm.nih.gov/pubmed/19578991
Kim W, Kim SH, Park SK, Chang MS. Astragalus membranaceus ameliorates reproductive toxicity induced by cyclophosphamide in male mice. Phytother Res. 2012 Sep;26₍₉₎:1418-21. https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.4756
Zhen JB, Li WP, Zuo Y, Xu YL, Wang YR. Astragalus protects the testis following testicular torsion/detorsion in rats. Zhonghua Nan Ke Xue. 2008 Oct;14₍₁₀₎:951-3. https://www.ncbi.nlm.nih.gov/pubmed/19157111
Hong CY, Ku J, Wu P. Astragalus membranaceus stimulates human sperm motility in vitro. Am J Chin Med 1992;20:289-294. https://www.ncbi.nlm.nih.gov/pubmed/1471613
Lee D, Lee SH, Song J, Jee HJ, Cha SH, Chang GT. Effects of Astragalus Extract Mixture HT042 on Height Growth in Children with Mild Short Stature: A Multicenter Randomized Controlled Trial. Phytother Res. 2018 Jan;32₍₁₎:49-57. https://www.ncbi.nlm.nih.gov/pubmed/29130588
Song J, Lee SH, Lee D, Kim H. Astragalus Extract Mixture HT042 Improves Bone Growth, Mass, and Microarchitecture in Prepubertal Female Rats: A Microcomputed Tomographic Study. Evid Based Complement Alternat Med. 2017;2017:5219418. https://www.ncbi.nlm.nih.gov/pubmed/28572830
Kim JY, Song M, Lee D, Song J, Park SW, Park J, Park S, Choi HY, Kim H. Effect of HT042, herbal formula, on longitudinal bone growth in spontaneous dwarfrats. Molecules. 2013 Oct 28;18₍₁₁₎:13271-82. https://www.ncbi.nlm.nih.gov/pubmed/24169467
Lee D, Lee SH, Lee YH, Song J, Kim H. Astragalus Extract Mixture HT042 Increases Longitudinal Bone Growth Rate by Upregulating Circulatory IGF-1 in Rats. Evid Based Complement Alternat Med. 2017;2017:6935802. https://www.ncbi.nlm.nih.gov/pubmed/28713437
Kim MY, Kim JY, Lim D, Lee D, Kim Y, Chang GT, Choi HY, Kim H. Skeletal growth and IGF levels in rats after HT042 treatment. Phytother Res. 2012 Dec;26₍₁₂₎:1771-8. https://www.ncbi.nlm.nih.gov/pubmed/22388791
Kim MY, Park Y, Pandit NR, Kim J, Song M, Park J, Choi HY, Kim H. The herbal formula HT042 induces longitudinal bone growth in adolescent femalerats. J Med Food. 2010 Dec;13₍₆₎:1376-84. https://www.ncbi.nlm.nih.gov/pubmed/21091251
Song J, Lee D, Min B, Bae JS, Chang GT, Kim H. Safety evaluation of Astragalus extract mixture HT042 and its constituent herbs in Sprague-Dawley rats. Phytomedicine. 2017 Aug 15;32:59-67. https://www.ncbi.nlm.nih.gov/pubmed/28732808
Xu Z, Qian L, Niu R, Yang Y, Liu C, Lin X. Efficacy of Huangqi Injection in the Treatment of Hypertensive Nephropathy: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2022 Apr 25;9:838256. https://pubmed.ncbi.nlm.nih.gov/35547210/
Chen X. Effect of Huangqi Injection on Antioxidant Capacity and Vascular Elasticity in Patients with Renal Hypertension. J Hainan Med Coll. ₍₂₀₁₅₎ 21:375–7.
Dong G. Huangqi Injection and Fosinopril Sodium in the Treatment of Hypertensive Renal Damage. J Hubei Coll Trad Chin Med. ₍₂₀₀₂₎ 2:46.
Guo J. Analysis of the effect and mechanism of Huangqi injection combined with irbesartan in the treatment of hypertensive nephropathy. China Contemp Med. ₍₂₀₁₇₎ 24:76–8.
Han X. The effect of irbesartan combined with Huangqi injection on renal damage in patients with essential hypertension. Hebei Trad Chin Med. ₍₂₀₁₁₎ 33:1505–6.
He X. Effect of Huangqi Injection on Kidney Injury of Elderly Patients with Hypertension. J Pract Med. ₍₂₀₀₄₎ 8:712–3.
Huang X. Preventive and therapeutic effects of Huangqi injection combined with irbesartan on early renal damage of hypertension. Shaanxi Med J. ₍₂₀₁₁₎ 40:1663–4.
Huang L. Study on the Efficacy and Mechanism of Astragalus Combined with Irbesartan in Treating Hypertensive Nephropathy. Mod Med Health. ₍₂₀₁₇₎ 33:3456–8.
Ji Y. Effect of Huangqi Injection on Kidney Injury of Hypertension. Chin Med Emerg. ₍₂₀₀₆₎ 11:1237–8.
Song P. The effect of huangqi injection combined with irbesartan in the treatment of hypertensive nephropathy. J Univers Health. ₍₂₀₁₉₎ 21:278.
Tang G. The Protective Effect of Astragalus on the Early Renal Damage of Hypertension. Mod J Integr Trad Chin West Med. ₍₂₀₀₆₎ 1:26–27.
Wu X. Observation on Curative Effect of Huangqi Injection in Treating Primary Hypertension with Renal Damage. Prim Med Forum. ₍₂₀₀₇₎ 16:717–8.
Yang J. Clinical Observation of Huangqi Injection Combined with Hyzaar in the Treatment of Essential Hypertension Complicated with Proteinuria. TCM Clin Res. ₍₂₀₁₅₎ 7:29–30.
Zhao Y. Effects of astragalus combined with irbesartan on renal function and urine protein in patients with hypertensive renal impairment. Hainan Med. ₍₂₀₁₅₎ 26:1028–30.
Zhao F. Study on the curative effect of Huangqi injection combined with irbesartan in the treatment of hypertensive nephropathy. Shaanxi Trad Chin Med. ₍₂₀₁₇₎ 38:51–2.
Zhaoyj Y. Clinical Observation of Huangqi Injection in Treating Renal Damage of Primary Hypertension. Chin J Evid Based Cardiovasc Med. ₍₂₀₁₅₎ 7:248–50.
Yang P, He F, Tan M, et al. Marked decrease of tacrolimus blood concentration caused by compound Chinese herbal granules in a patient with refractory nephrotic syndrome. J Clin Pharm Ther. 2021 Feb;46₍₁₎:215-218. https://pubmed.ncbi.nlm.nih.gov/32930420/
Han Z, Guo L, Yu X, et al. Network-driven targeted analysis reveals that Astragali Radix alleviates doxorubicin-induced cardiotoxicity by maintaining fatty acid homeostasis. J Ethnopharmacol. 2022 Apr 6;287:114967. https://pubmed.ncbi.nlm.nih.gov/34995692/
Li A, Cui W, Zhao Y, et al. Exploration of the main effective constituent and the mechanism in Astragali Radix in the treatment for doxorubicin-induced nephropathy by integrating metabolomics and molecular docking. J Ethnopharmacol. 2023 Apr 6;305:116074. https://pubmed.ncbi.nlm.nih.gov/36577490/
Cao Y, Ruan Y, Shen T, et al. Astragalus polysaccharide suppresses doxorubicin-induced cardiotoxicity by regulating the PI3k/Akt and p38MAPK pathways. Oxid Med Cell Longev. 2014;2014:674219. https://pubmed.ncbi.nlm.nih.gov/25386226/
Cao Y, Shen T, Huang X, et al. Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity. Oncotarget. 2017 Jan 17;8₍₃₎:4837-4848. https://pubmed.ncbi.nlm.nih.gov/27902477/
Zhang Y, Zhou Q, Ding X, et al. HILIC-MS-based metabolomics reveal that Astragalus polysaccharide alleviates doxorubicin-induced cardiomyopathy by regulating sphingolipid and glycerophospholipid homeostasis. J Pharm Biomed Anal. 2021 Sep 5;203:114177. https://pubmed.ncbi.nlm.nih.gov/34198197/
Liu Y, Chen L, Wu H, Zhang H. Delivery of astragalus polysaccharide by ultrasound microbubbles attenuate doxorubicin-induced cardiomyopathy in rodent animals. Bioengineered. 2022 Apr;13₍₄₎:8419-8431. https://pubmed.ncbi.nlm.nih.gov/35322740/
Zuo X, Bi L, Cao H. Astragalus polysaccharides affects multidrug resistance gene 1 and P-glycoprotein 170 in adriamycin nephropathy rats via regulating microRNA-16/NF-κB axis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Jan 28;47₍₁₎:26-34. https://pubmed.ncbi.nlm.nih.gov/35545360/
Peng HW, Zhang XJ, Li F. [Mechanisms of Astragalus Polysaccharids Synergized with Doxorubicin against Drug Resistance in HL-60/A Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Jun;25₍₃₎:743-748. https://pubmed.ncbi.nlm.nih.gov/28641628/
Zhou L, Chen L, Wang J, Deng Y. Astragalus polysaccharide improves cardiac function in doxorubicin-induced cardiomyopathy through ROS-p38 signaling. Int J Clin Exp Med. 2015 Nov 15;8₍₁₁₎:21839-48. https://pubmed.ncbi.nlm.nih.gov/26885153/
Abushouk AI, Ismail A, Salem AMA, et al. Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity. Biomed Pharmacother. 2017 Jun;90:935-946. https://pubmed.ncbi.nlm.nih.gov/28460429/
He ZH, Shao LQ, Xuan LY, et al. [Effect of Astragalus injection on cardiomyocyte apoptosis, endoplasmic reticulum stress and expression of connexin in cardiomyopathy rats induced by adriamycin]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018 Feb 8;34₍₂₎:159-163. https://pubmed.ncbi.nlm.nih.gov/29926682/
Su D, Li HY, Yan HR, et al. Astragalus Improved Cardiac Function of Adriamycin-Injured Rat Hearts by Upregulation of SERCA2a Expression. Am J Chin Med. 2009;37₍₃₎:519-29. https://pubmed.ncbi.nlm.nih.gov/19606512/
Ma KY, Wan Q, Wang YL, et al. [The effect of astragalus injection on the expression of endoplasmic reticulum stress chaperonin GRP78 and GRP94 mRNA in adriamycin-injured cardiomyocytes with calumenin silencing by shRNA]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2016 Feb 8;32₍₂₎:154-157. https://pubmed.ncbi.nlm.nih.gov/29931868/
Ma J, Fan S, Chen J, et al. Messenger RNA expressions of vasopressin system and aquaporin-2 in adriamycin-induced nephrotic rats and effects of astragalus membranaceus. Chin Med J (Engl). 1999 Dec;112₍₁₂₎:1068-72. https://pubmed.ncbi.nlm.nih.gov/11721440/
Liu Y, Xu W, Xiong Y, et al. Evaluations of the effect of HuangQi against heart failure based on comprehensive echocardiography index and metabonomics. Phytomedicine. 2018 Nov 15;50:205-212. https://pubmed.ncbi.nlm.nih.gov/30466980/
You H, Lu Y, Gui D, et al. Aqueous extract of Astragali Radix ameliorates proteinuria in adriamycin nephropathy rats through inhibition of oxidative stress and endothelial nitric oxide synthase. J Ethnopharmacol. 2011 Mar 8;134₍₁₎:176-82. https://pubmed.ncbi.nlm.nih.gov/21130857/
Li X, Guo X, Li J, Yuan L, Wang H. Preventing effect of astragalus polysaccharide on cardiotoxicity induced by chemotherapy of epirubicin: A pilot study. Medicine (Baltimore). 2022 Aug 12;101₍₃₂₎:e30000. https://pubmed.ncbi.nlm.nih.gov/35960075/
Yu X, Guo L, Deng X, et al. Attenuation of doxorubicin-induced oxidative damage in rat brain by regulating amino acid homeostasis with Astragali Radix. Amino Acids. 2021 Jun;53₍₆₎:893-901. https://pubmed.ncbi.nlm.nih.gov/33945017/
Wang N, Wei RB, Li QP, et al. Protective effects of astragaloside in rats with adriamycin nephropathy and underlying mechanism. Chin J Nat Med. 2016 Apr;14₍₄₎:270-277. https://pubmed.ncbi.nlm.nih.gov/27114314/
Liu W, Gao FF, Li Q, et al. Protective effect of astragalus polysaccharides on liver injury induced by several different chemotherapeutics in mice. Asian Pac J Cancer Prev. 2014;15₍₂₃₎:10413-20. https://pubmed.ncbi.nlm.nih.gov/25556485/
Ismail ZM, Amin NM, Yacoub MF, Mohamed AM. Myelo-enhancement by astragalus membranaceus in male albino rats with chemotherapy myelo-suppression. Histological and immunohistochemical study. Int J Stem Cells. 2014 May;7₍₁₎:12-22. https://pubmed.ncbi.nlm.nih.gov/24921023/
Cho WC, Leung KN. In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. J Ethnopharmacol. 2007 Aug 15;113₍₁₎:132-41. https://pubmed.ncbi.nlm.nih.gov/17611061/
Qu T, Li Z, Zhao S, Li A, Qin X. A metabonomic analysis reveals novel regulatory mechanism of Huangqi injection on leucopenia mice. Immunopharmacol Immunotoxicol. 2016;38₍₂₎:113-23. https://pubmed.ncbi.nlm.nih.gov/26769054/
Bao W, Zhang Q, Zheng H, et al. Radix Astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression. Int J Biol Macromol. 2021 Jul 31;183:1715-1722. https://pubmed.ncbi.nlm.nih.gov/34044030/
An X, Xu Y, Gui D. Combination of Astragalus membranaceus and Panax notoginseng as Main Components in the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2023 Apr 17;2023:2945234. https://pubmed.ncbi.nlm.nih.gov/37101717/
Rao Y, Wang Y, Lin Z, Zhang X, Ding X, Yang Y, Liu Z, Zhang B. Comparative efficacy and pharmacological mechanism of Chinese patent medicines against anthracycline-induced cardiotoxicity: An integrated study of network meta-analysis and network pharmacology approach. Front Cardiovasc Med. 2023 Apr 24;10:1126110. https://pubmed.ncbi.nlm.nih.gov/37168657/
Jiang ZH, Zhang GJ, Xu LL, Cao ZY. Effect of dexamethasone combined with astragalus injection on cardiac toxicity after Adriamycin chemotherapy. Int J Lab Med. ₍₂₀₁₈₎ 11:1383–5.
Luo RF, Liu M, Zhang SC. Protective effects of Astragalus injection/huachansu injection combined with dexrazoxane against Adriamycin related cardiac toxicity. Chin J Hosp Pharm. ₍₂₀₁₅₎ 7:629–32.
Hong KF, Liu PY, Zhang W, Gui DK, Xu YH. The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Integr Complement Med. 2023 Jul 11. https://pubmed.ncbi.nlm.nih.gov/37433206/
NCCIH database. Astragalus. https://www.nccih.nih.gov/health/astragalus
Ulbricht C, Chao W, Costa D, et al. Clinical evidence of herb-drug interactions: a systematic review by the natural standard research collaboration. Curr Drug Metab. 2008 Dec;9₍₁₀₎:1063-120. https://pubmed.ncbi.nlm.nih.gov/19075623/
Wang P, Wang Z, Zhang Z, et al. A review of the botany, phytochemistry, traditional uses, pharmacology, toxicology, and quality control of the Astragalus memeranaceus. Front Pharmacol. 2023 Aug 23;14:1242318. https://pubmed.ncbi.nlm.nih.gov/37680711/
Lina L, Peiqin Z, Zhu H, Zhang Y. Astragaloside - alleviates epirubicin-induced cardiotoxicity in rats. Chin. J. Clin. Med. 2022, 29 ₍₆₎, 1006–1011.
Sun M, Wang J, Shi Z. Effects of apatinib mesylate combined with astragaloside IV on proliferation, migration and invasion of primary hepatocellular carcinoma cells. Prog. Anat. Sci. 2023, 29, 1.
Liang P, Bi T, Zhou Y, et al. Insights into the Mechanism of Supramolecular Self-Assembly in the Astragalus membranaceus-Angelica sinensis Codecoction. ACS Appl Mater Interfaces. 2023 Oct 18;15₍₄₁₎:47939-47954. https://pubmed.ncbi.nlm.nih.gov/37791782/
Wang C, Li S, Meng J, et al. Meta-analysis of Huangqi (Astragalus membranaceus) and Chinese Yam (Rhizoma Dioscoreae) for Diabetic Nephropathy. Altern Ther Health Med. 2023 Oct 20:AT9294. Epub ahead of print. https://pubmed.ncbi.nlm.nih.gov/37856796/
Song ZL. 48 Cases of Early Diabetic Nephropathy Treated by Guben Huoxue Decoction. Shaanxi Traditional Chinese Medicine. 2014:35.
Zhao LX. 60 Cases of Diabetic Nephropathy Treated with Paidu Huoxue Decoction Combined with Western Medicine. Herald of Traditional Chinese Medicine. 2008.
Zhou XY. 36 Cases of Diabetic Nephropathy Treated with Combination of Traditional Chinese and Western Medicine. Shaanxi Traditional Chinese Medicine. 1999:20-26.
Zhou ZH, Sun BQ. 25 Cases of Diabetic Nephropathy Treated by Qidan Dihuang Decoction. Herald of Traditional Chinese Medicine. 2004.
Li JL. Clinical Observation on 30 Cases of Diabetic Nephropathy Treated by Activating Blood and Tonifying Kidney. Herald of Traditional Chinese Medicine. 2009.
Xu HL. 60 Cases of Diabetic Nephropathy Treated with Bushen Huoxue Decoction. Shaanxi Traditional Chinese Medicine. 2010:31-38.
Dai M. 30 Cases of Diabetic Nephropathy Treated by Shejing Xiaobai Capsule. Herald of Traditional Chinese Medicine. 2010
Shen Z, Cui T, Liu Y, et al. Astragalus membranaceus and Salvia miltiorrhiza ameliorate diabetic kidney disease via the "gut-kidney axis". Phytomedicine. 2023 Dec;121:155129. https://pubmed.ncbi.nlm.nih.gov/37804821/
Chen MH, May BH, Zhou IW, et al. Integrative Medicine for Relief of Nausea and Vomiting in the Treatment of Colorectal Cancer Using Oxaliplatin-Based Chemotherapy: A Systematic Review and Meta-Analysis. Phytother Res. 2016 May;30₍₅₎:741-53. https://pubmed.ncbi.nlm.nih.gov/26912094/
Qiao YF, Jiang FH, Kong BJ. 2001. Effect of Radix Astragalus on the transmission in small intestine in healthy subjects. Trad Chin Drug Res & Clin Pharm 12: 204–205, 235
Yang DZ. [Effect of Astragalus membranaceus on myoelectric activity of small intestine]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Oct;13₍₁₀₎:616-7, 582. https://pubmed.ncbi.nlm.nih.gov/8312701/
Zheng TZ, Li W, Ding YH, et al. 2003. Effects of Huangqi on gastrointestinal motility of mice in vivo. Pharm Clin Chin Materia Medica 19: 25–26.
Wang X, Hu X, Ye C, et al. Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota. J Clin Transl Hepatol. 2024 May 28;12₍₅₎:481-495. https://pubmed.ncbi.nlm.nih.gov/38779521/
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Astragalus. [Updated 2021 Feb 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501891/
Kobayashi K, Sasaki K. Astragalus root increases Treg and Th17 involvement in embryo implantation and pregnancy maintenance by decreasing CTLA-4+ Tregs. Drug Discov Ther. 2024 Mar 20;18₍₁₎:24-33. https://pubmed.ncbi.nlm.nih.gov/38382992/
Chen HQ, Zhang N, Li CX, Zhang HX. Effects of Astragalus membranaceus on systemic lupus erythematosus in a mouse model of pregnancy. Immun Inflamm Dis. 2022 Jun;10₍₆₎:e624. https://pubmed.ncbi.nlm.nih.gov/35634952/
Zhang R, Xing B, Zhao J, et al. Astragaloside IV relieves gestational diabetes mellitus in genetic mice through reducing hepatic gluconeogenesis. Can J Physiol Pharmacol. 2020 Jul;98₍₇₎:466-472. https://pubmed.ncbi.nlm.nih.gov/32160476/
Zhang R, Zhang X, Xing B, et al. Astragaloside IV attenuates gestational diabetes mellitus via targeting NLRP3 inflammasome in genetic mice. Reprod Biol Endocrinol. 2019 Sep 26;17₍₁₎:77. https://pubmed.ncbi.nlm.nih.gov/31558153/
Jiangbo Z, Xuying W, Yuping Z, et al. Effect of astragaloside IV on the embryo-fetal development of Sprague-Dawley rats and New Zealand White rabbits. J Appl Toxicol. 2009 Jul;29₍₅₎:381-5. https://pubmed.ncbi.nlm.nih.gov/19367606/
Xuying W, Jiangbo Z, Yuping Z, et al. Effect of astragaloside IV on the general and peripartum reproductive toxicity in Sprague-Dawley rats. Int J Toxicol. 2010 Sep-Oct;29₍₅₎:505-16. https://pubmed.ncbi.nlm.nih.gov/20884860/
Zhang D, Zhu Y, Li Z, et al. The role of Astragalus polysaccharides in promoting IEC-6 cell migration from polyamine-mediated Ca2+ regulation. Int J Biol Macromol. 2022 May 15;207:179-192. https://pubmed.ncbi.nlm.nih.gov/35217086/
Sun Q, Hu M, Yuan C, et al. Astragaloside IV ameliorates indomethacin-induced intestinal inflammation in rats through inhibiting the activation of NLRP3 inflammasome. Int Immunopharmacol. 2024 Jun 30;135:112281. https://pubmed.ncbi.nlm.nih.gov/38762925/
Law PC, Auyeung KK, Chan LY, Ko JK. Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. BMC Complement Altern Med. 2012 Sep 19;12:160. https://pubmed.ncbi.nlm.nih.gov/22992293/
Jing P, Hongzheng H, Zhenqi WU, et al. Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials. J Tradit Chin Med. 2024 Apr;44₍₂₎:229-242. https://pubmed.ncbi.nlm.nih.gov/38504529/
Zhou Z, Yang L, Hu C, et al. The combination of astragalus injection and ambroxol hydrochloride in the adjuvant treatment of COPD: a systematic review and meta-analysis. Sci Rep. 2023 Dec 12;13₍₁₎:22077. https://pubmed.ncbi.nlm.nih.gov/38087032/
Chen S, Tian X, Li S, et al. Evaluating traditional Chinese medicine (TCM) Jie Geng and Huang Qi combination on reducing surgical site infections in colorectal cancer surgeries: A systematic review and meta-analysis. Int Wound J. 2024 Feb;21₍₂₎:e14769. https://pubmed.ncbi.nlm.nih.gov/38351506/
Cao LX, Chen ZQ, Jiang Z, et al. Rapid rehabilitation technique with integrated traditional Chinese and Western medicine promotes postoperative gastrointestinal function recovery. World J Gastroenterol. 2020;26₍₂₃₎:3271‐3282. https://pubmed.ncbi.nlm.nih.gov/32684741/
Chao TH, Fu PK, Chang CH, et al. Prescription patterns of Chinese herbal products for post‐surgery colon cancer patients in Taiwan. J Ethnopharmacol. 2014;155₍₁₎:702‐708. https://pubmed.ncbi.nlm.nih.gov/24945402/
Fei B, Dai W, Zhao S. Efficacy, safety, and cost of therapy of the traditional Chinese medicine, Catalpol, in patients following surgical resection for locally advanced colon cancer. Med Sci Monit. 2018;24:3184‐3192. https://pubmed.ncbi.nlm.nih.gov/29763415/
Lo LC, Chen CY, Chen ST, et al. Therapeutic efficacy of traditional Chinese medicine, Shen‐Mai San, in cancer patients undergoing chemotherapy or radiotherapy: study protocol for a randomized, double‐blind, placebo‐controlled trial. Trials. 2012;13:232. https://pubmed.ncbi.nlm.nih.gov/23206440/
Sun L, Pang Y, Wang Z, et al. Effect of traditional Chinese medicine combined group psychotherapy on psychological distress management and gut micro‐biome regulation for colorectal cancer survivors: a single‐arm phase I clinical trial. Support Care Cancer. 2023;31₍₁₂₎:698. https://pubmed.ncbi.nlm.nih.gov/37964024/
Wang QZ, Chen XP, Huang JP, Jiang XW. Effects of couplet medicines (Astragalus Membranaceus and Jiaozhen) on intestinal barrier in postoperative colorectal cancer patients. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015;35₍₁₁₎:1307‐1312. https://pubmed.ncbi.nlm.nih.gov/26775475/
Zhao H, Sun W. Effect of enhanced recovery after surgery with integrated traditional Chinese and Western medicine on postoperative stress response of patients with gastrointestinal tumors. Comput Math Methods Med. 2022;2022:3663246. https://pubmed.ncbi.nlm.nih.gov/35844438/
Li S, Qi Y, Ren D, et al. The Structure Features and Improving Effects of Polysaccharide from Astragalus membranaceus on Antibiotic-Associated Diarrhea. Antibiotics (Basel). 2019 Dec 23;9₍₁₎:8. https://pubmed.ncbi.nlm.nih.gov/31877915/
Li J, Jia N, Cui M, Li Y, Jiang D, Chu X. Chinese herb couple against diabetes: integrating network pharmacology and mechanism study. J Biomol Struct Dyn. 2024 Feb 12:1-17. https://pubmed.ncbi.nlm.nih.gov/38345075/
Liu YX, Song XM, Dan LW, et al. Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application. Arch Pharm Res. 2024 Mar;47₍₃₎:165-218. https://pubmed.ncbi.nlm.nih.gov/38493280/
He Z, Liu X, Qin S, et al. Anticancer Mechanism of Astragalus Polysaccharide and Its Application in Cancer Immunotherapy. Pharmaceuticals (Basel). 2024 May 15;17₍₅₎:636. https://pubmed.ncbi.nlm.nih.gov/38794206/
Li C, Hong L, Liu C, Min J, Hu M, Guo W. Astragalus polysaccharides increase the sensitivity of SKOV3 cells to cisplatin. Arch Gynecol Obstet. 2018 Feb;297₍₂₎:381-386. https://pubmed.ncbi.nlm.nih.gov/29103194/
Zhou Z, Meng M, Ni H. Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases. Med Sci Monit. 2017 Jan 26;23:462-469. https://pubmed.ncbi.nlm.nih.gov/28124680/
Wang YN, Gui MB, Qu LP, Zou M, Gao F. [Astragalus polysaccharide inhibits IDO1 expression in colon tumor microenvironment to increase intratumoral CD8~+ T cell infiltration]. Zhongguo Zhong Yao Za Zhi. 2023 Sep;48₍₁₇₎:4722-4730. Chinese. https://pubmed.ncbi.nlm.nih.gov/37802811/
Tian QE, De Li H, et al. Effects of Astragalus polysaccharides on P-glycoprotein efflux pump function and protein expression in H22 hepatoma cells in vitro. BMC Complement Altern Med. 2012 Jul 11;12:94. https://pubmed.ncbi.nlm.nih.gov/22784390/
Wang H, Zhu W, Hong Y, et al. Astragalus polysaccharides attenuate chemotherapy-induced immune injury by modulating gut microbiota and polyunsaturated fatty acid metabolism. Phytomedicine. 2024 Jun;128:155492. https://pubmed.ncbi.nlm.nih.gov/38479258/
Tian W, Zhang P, Yang L, et al. Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway. Am J Chin Med. 2024;52₍₂₎:453-469. https://pubmed.ncbi.nlm.nih.gov/38490806/
Ma DC, Wang Z, Wang MM, et al. [Research progress in Astragali Radix and its active ingredients in treatment of lung cancer]. Zhongguo Zhong Yao Za Zhi. 2024 Jan;49₍₂₎:294-303. Chinese. https://pubmed.ncbi.nlm.nih.gov/38403305/
Wang W, Zhang K, Dai L, et al. Investigating the protective effects of Astragalus polysaccharides on cyclophosphamide-induced bone marrow suppression in mice and bone mesenchymal stem cells. Mol Immunol. 2024 Jul;171:93-104. https://pubmed.ncbi.nlm.nih.gov/38805892/
He H, Zhou X, Wang Q, Zhao Y. Does the couse of astragalus-containing chinese herbal prescriptions and radiotherapy benefit to non-small-cell lung cancer treatment: a meta-analysis of randomized trials. Evid Based Complement Alternat Med. 2013;2013:426207. https://pubmed.ncbi.nlm.nih.gov/24454494/
Cai HB, Dai FG, Min QF, et al. [Clinical study of the effects of radiotherapy in combination with traditional Chinese medicine on non-small cell lung cancer]. Di Yi Jun Yi Da Xue Xue Bao. 2002 Dec;22₍₁₂₎:1112-3. Chinese. https://pubmed.ncbi.nlm.nih.gov/12480588/
Nin YF, Yang LZ, Yang BL, Li YH. Effects of Jiawei Shiquan Fomular on immunologic function in patients with non-small-cell lung cancer undergoing radiotherapy. Chinese Journal of Coal Industry Medicine. 2002;5₍₂₎:p. 155.
Lan XZ, Jiang YH. Observation on therapeutic effects of 26 cases of senile late non-small cell pulmonary carcinoma treated with radiotherapy combined with chinese drugs. Journal of Traditional Chinese Medicine. 2002;43₍₂₎:125–126.
Wu J. Observation of effects of Aidi Injection in the radiotherapy of non-small cell lung cancer. China Journal of Cancer Prevention and Treatment. 2003;10₍₄₎:403-4.
Wen XX. Clinical observation of the effects of radiotherapy in combination with Aidi Injection in treatment of elderly patients with non-small cell lung cancer. Chinese Journal of Hospital Pharmacy. 2005;25₍₉₎:851–852.
Huang J, Li PW, Jia LQ. Complementary effect of Fuzheng Zengxiao Fomular combining with radiotherapy in non-small cell lung cancer. Journal of China-Japan Friendship Hospital. 2005;19₍₅₎:278–280.
Wang HJ, Wang ZX, Guo JF. The clinical study on Jiawei Baihe Gujin decoction combined with radiotherapy in the treatment of stage III non-small cell lung cancer. Chinese Archives of Traditional Chinese Medicine. 2006;24₍₁₀₎:1920-1.
Chen F, Wang XL. The observation of the action-enhancing and toxicity-reducing efficacy of KangAi Injection combined with radiotherapy in treating Stage III/IV non-small cell lung cancer. China Journal of Chinese Materia Medica. 2006;31₍₁₈₎:1553–1554.
Ma JQ. The observation of the synergism effects of KangAi Injection combined with radiotherapy in treating advanved non-small-cell lung cancer. China Journal of Chinese Materia Medica. 2006;31₍₁₈₎:1556–1558.
Zhang G, Xiao B, Mao W. Study on NSCLC treated with Chinese medicine combined with three-dimensional conformal radiotherapy. Chinese Journal of Clinical Oncology and Rehabilitation. 2006;13₍₄₎:325.
Tian YP, Wang QC. The observation of the rapeutic efficacy of AiDi Injection combined with radiotherapy in treatment of elderly patients with advanced NSCLC. Pharmacology and Clinics of Chinese Materia Medica. 2007;23₍₄₎:57–58.
Wang TJ, Jiang Y, Wang HY, Zhao ZF. The observation of the rapeutic efficacy of Shenqifuzheng Injection combined with radiotherapy in treating limited and advanced non-small cell lung cancer. Modern Oncology. 2007;15₍₁₁₎:1672–1674.
Song TT, Jiang YH, Lan XZ. The observation of the rapeutic efficacy of Chinese medicine combined with radiotherapy in treatment of elderly patients with NSCLC. Journal of Practical Oncology. 2007;21₍₂₎:135–136.
Jiang M, Xu JH. The clinical study on Delisheng (DLS) combined with radiotherapy in the treatment of advanced non small cell lung cancer (NSCLC) Guide of China Medicine. 2008;6₍₁₇₎:29–30.
Tingxiong F, Qiu T, Bin N. Clinical observation of Zhenqi Fuzheng capsules combined by radiotherapy in treatment of elderly patients with advanced NSCLC. CHINESE JOURNAL OF PHARMACO EPIDEMIOLOGY. 2008;17₍₁₎:4.
Huang ZG, Hou Y. An evaluation of the efficacy of AD Injection in combination with three-dimensional conformal radiotherapy for elderly patients with non-small-cell-lung carcinoma. Journal of YouJiang Medical College for Nationalities. 2008;30₍₅₎:724-5.
Xie YS, Zhang Q, Wang R. Shenqifuzheng Injection combined with 3-dimensional conformal radiotherapy for 46 cases of advanced non-small cell lung cancer. Herald of Medicine. 2009;28₍₁₀₎:1290–1292.
Liu Y, Jiang HP, Wang YL, et al. The clinical study of treating advanced non-small cell lung cancer combining radiotherapy with Taile oral liquid. Journal of Bethune Military Medical College. 2009;7₍₃₎:136–137.
Wang YX, Zheng SM, Fan HM, He R, Li J, Xiao XR. Shenqi Fuzheng Injection combined with three dimensional conformal radiotherapy for old patient's advanced non-small cell lung cancer. Chongqing Medicine. 2009;38₍₄₎:460-1.
Qin H, Niu D, Jiang C, Wan M, HE F, Zhen J, Zhou Q, Yang B. Effect of astragalus polysaccharide in combination with three-dimensional conformal radiotherapy on elderly patients with non-small cell lung cancer. Chinese Journal of Clinical Oncology. 2009:1401-3.
Jia YS, Lin BH, Wu SQ. Clinical research on Aidi Injection combined with radiotherapy for non-small-cell lung cancer. Chinese Archives of Traditional Chinese Medicine. 2010;28₍₇₎:1556-8.
Ji YH, Zhang JL, Ni MX, Cai J, Liu JB. Effects of Bukangling on the radiotherapy for advanced non-small-cell lung cancer. Journal of Chinese Practical Diagnosis and Therapy. 2011;25₍₁₂₎:1163–1165.
Zhao GY, Dong W, Feng JJ, et al. The observation of the rapeutic efficacy of Chinesse medicine combined with radiotherapy in treatment of elderly patients with stage IIIa/IIIb non-small cell lung cancer. Cancer Research and Clinic. 2011;23₍₄₎:274–276.
Gao YW, Yin LJ, Ding TG, Wang J, Chen W. Shenqi ten blindly particles combined with radiotherapy for elderly patients with non-small cell lung cancer. Chinese Journal of Clinical Oncology and Rehabilitation. 2012;19₍₅₎:397-9.
Mu Y, Ruan YM, Zhou J. Clinical study on Shenqifuzheng Injection combined with radiotherapy for 35 cases of advanced non-small cell lung cancer. Guiding Journal of Traditional Chinese Medicine and Pharmacy. 2012;18₍₁₀₎:39–41.
Wang HY, Jia XJ, Chen YB, Wang TJ. The observation of the rapeutic efficacy of KangAi Injection combined with three dimensional conformal radiotherapy in treating locally anvanced non-small cell lung cancer. Chinese Journal of Gerontology. 2012;32₍₁₇₎:3788–3789.
Cai K, Liu JB, Huang CJ, Yu ZS, Liao TH, Huang LL. Effects of YiQi YangYin drugs on life quality and immunologic function in senile patients with local advanced non-small-cell lung cancer undergoing three dimensional conformal radiotherapy. Western Journal of Traditional Chinese Medicine. 2012;25₍₁₁₎:1–4.
Li ZY, Nin SQ, Yi TN, Liu GQ. The observation of the action-enhancing and toxicity-reducing efficacy of AiDi Injection combined with radiotherapy in treating lung cancer. Journal of Clinical Pulmonary Medicine. 2013;18₍₂₎:367–368.
Yang Z. Clinical study on AiDi Injection combined with radiotherapy for 46 cases of non-small cell lung cancer. China Health Industry. 2013;10₍₅₎:p. 81.
Huang P, Li H, Ren L, et al. Astragaloside IV enhances the sensitivity of breast cancer stem cells to paclitaxel by inhibiting stemness. Transl Cancer Res. 2023 Dec 31;12₍₁₂₎:3703-3717. https://pubmed.ncbi.nlm.nih.gov/38193000/
Guo J, Le Y, Yuan A, et al. Astragaloside IV ameliorates cisplatin-induced liver injury by modulating ferroptosis-dependent pathways. J Ethnopharmacol. 2024 Jun 28;328:118080. https://pubmed.ncbi.nlm.nih.gov/38521426/
Zhang D, Zheng J, Ni M, et al. Comparative efficacy and safety of Chinese herbal injections combined with the FOLFOX regimen for treating gastric cancer in China: a network meta-analysis. Oncotarget. 2017 Aug 18;8₍₄₀₎:68873-68889. https://pubmed.ncbi.nlm.nih.gov/28978164/
Lai YB. Evaluation the clinical efficacy of Astragalus polysaccharide injection combined with chemotherapy in patients with advanced gastric cancer. For All Health. 2014;8:162–162.
Liu YH, Huang J, Wang Y, Zheng ZS. Efficacy of Astragalus polysaccharide injection combined with chemotherapy in the treatment of advanced gastric cancer. The Journal of Practical Medicine. 2011;27:516-8.
Lin S, An X, Guo Y, et al. Meta-Analysis of Astragalus-Containing Traditional Chinese Medicine Combined With Chemotherapy for Colorectal Cancer: Efficacy and Safety to Tumor Response. Front Oncol. 2019 Aug 13;9:749. https://pubmed.ncbi.nlm.nih.gov/31456940/
Lin Y, Li J. Therapeutic effect of Chinese Medicine plus acupoint massage on colorectal cancer-related leukocyte reduction with chemotherapy. Inner Mongol J Tradition Chin Med. 2018, 37:70–1.
Ge S. Effect of Jianpifa on Immune Function of Patients of Colorectal Cancer With Liver Metastasis and Evaluation of Its Clinical Effect. Nanjing: Nanjing University of Chinese Medicine, 2018.
Tang X. Study on self-made Yiqi Jianpi Decoction for treatment of myelosuppression induced by chemotherapy for colorectal cancer patients. Guangxi J Tradit Chin Med. 2017, 40:19–20.
Wang J. Clinical Observation of the Efficacy of Spleen-Tonifying, Yin-Nourishing, Dampness-Resolving and Toxin-Removing Fa Combined With Xelox Chemotherapy in the Treatment of Advanced Colorectal Cancer. Nanjing: Nanjing University of Chinese Medicine, 2016.
Shen G, Cao J. A random parallel control study of Yiqi Huoxue Fang and chemotherapy for the treatment of advanced colorectal cancer patients. J Pract Trad Chin Int Med. ₍₂₀₁₆₎ 30:78–80.
Li Z. Clinical Observation of the Shenlingbaizhu Powder Prevention and Treatment of Delayed Diarrhea Induced By Irinotecan. Chengdu University of Traditional Chinese Medicine, 2016.
Xie H, Qiao J, Luo J, Li M, Huang A. Clinical research of Astragalus polysaccharides, Interleukin-2 and FOLFOX4 chemotherapy for the treatment of advanced colorectal cancer. Anti-tumor Pharmacy. 2016, 6:418–22.
Zhang D, Li Y, Zou H. The effect of Huangqi Jianzhong decoction on immune function in rectal cancer patient treated with chemotherapy. Chin J Ethnomed Ethnopharm. 2015, 24:90–1.
Li G, Xu G. Clinical investigation of Fuzhengjiedu decoction for radical resection in colorectal cancer. Liaoning J Tradit Chin Med. ₍₂₀₁₅₎ 42:1279–81.
Wang Q. Clinical observation of “Hand-Foot bath of Huangqi Guizhi Wuwu decoction” plus calcium and magnesium infusions for preventing Oxaliplatin-induced chronic neurotoxicity. Modern J Integr Trad Chin Westem Med. 2015, 24:318–20.
Qin C. Clinical Observation of “Strengthen the Spleen and Reinforce the Kidney” for the Treatment of Side Effects Induced by Chemotherapy in Advanced Colorectal Cancer. Beijing: Beijing University of Chinese Medicine, 2014.
Chen Y, Wang Y. Study of Huangqi injection plus raltitrexed combined with oxaliplatin in treatment of advanced colorectal cancer. Chin JN Drugs Clin Remed. 2014;33:218-221.
Li Z, Dai A, Yang H, et al. The random parallel control study of Rongjin Fang in preventing the chronic neurotoxicity induced by Oxaliplatin for the treatment of colorectal cancer patients. J Pract Tradit Chin Int Med. 2013, 27:46–9.
Cao S. Clinical observation of Huangqi Guizhi Wuwu decoction on Oxaliplatin-induced neurotoxicity for the treatment with colorectal cancer patients. Guang Ming J Chin Med. ₍₂₀₁₃₎ 28:88–9.
Zhu Y. The Relevant Clinical Research on the Side Effects and Toxicity of Chemotherapy by TCM Intervention at Different Time for the Treatment of Colorectal Cancer Patients. Wuhan: Hubei University of Chinese Medicine. 2012.
Luo M. The Clinical Research of Preventing Neurotoxicity Caused by Oxaliplatin with Huangqi Injection. Hubei University of Chinese Medicine. 2012.
Rong Y, Zhang B, Wu H, et al. The clinical research of Astragalus Polysaccharide injection for preventing side effects caused by chemotherapy in the treatment of stage II colorectal cancer patients. J Chin Med Mater. 2011;34:657-9.
Qiu Z. Clinical observation of Kangai injection plus chemotherapy for the treatment with 22 advanced colon cancer patients. Shaanxi J Tradit Chin Med. ₍₂₀₁₁₎ 32:3–4.
Liu W, Liu Q, Liu H, et al. Clinical observation of integrated traditional Chinese and Western medicine for the treatment of 16 advanced colorectal cancer patients. Jilin J Tradit Chin Med. 2011;31:984-5.
Cao B, Li ST, Li Z, Deng WL. Yiqi zhuyu decoction combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer. Chin J Integr Med. 2011 Aug;17₍₈₎:593-9. https://pubmed.ncbi.nlm.nih.gov/21826593/
Huang ZB, Huang ZM, Chen GQ, et al. Clinical study on external bath of “Huangqiguizhiwuwu Decoction” in relieving peripheral neurotoxicity induced by oxaliplatin. Shanghai J Tradit Chin Med. 2010;44₍₅₎:40-2.
Chen F. Effect observation of Huangqi injection combined with chemotherapy on quality of life of advanced colorectal cancer patients after surgery. Hebei J Tradit Chin Med. 2009;31:1696-98.
Chen Y, Cheng CS, Tan HY, et al. Efficacy of Herbal Medicines Intervention for Colorectal Cancer Patients With Chemotherapy-Induced Gastrointestinal Toxicity - a Systematic Review and Meta-Analysis. Front Oncol. 2021 Mar 25;11:629132. https://pubmed.ncbi.nlm.nih.gov/33869014/
Zheng XY. Guidelines for clinical research of new Chinese medicines. Beijing, China: China Medical Science Press. 2002;1:68-73.
Moher D, Pham B, Jones A, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? Lancet. 1998 Aug 22;352₍₉₁₂₈₎:609-13. https://pubmed.ncbi.nlm.nih.gov/9746022/
Xu HX, Huang XE, Li Y, et al. A clinical study on safety and efficacy of Aidi injection combined with chemotherapy. Asian Pac J Cancer Prev. 2011;12₍₉₎:2233-6. https://pubmed.ncbi.nlm.nih.gov/22296362/
Huang SM, Xu J. Effect of Chinese medicine on gastrointestinal function of patients with colorectal cancer after chemotherapy. Chin Gastroenterol J. ₍₂₀₁₆₎ 24:6189–91.
Xiao H, Yang J. [Immune enhancing effect of modified sijunzi decoction on patients with colorectal cancer undergoing chemotherapy]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Feb;31₍₂₎:164-7. Chinese. https://pubmed.ncbi.nlm.nih.gov/21425566/
Nan B, Li X. Clinical observation of shenling baishu powder addition and subtraction combined with chemotherapy in the treatment of advanced colorectal cancer. China Pharmacy. 2016;33(10.6039):1001-0408.
Zhang C, Han ZG. Clinical effect observation of chemotherapy combined with Chinese herbs treatment after colorectal cancer surgery. China Modern Med. ₍₂₀₁₅₎ 22.
Zeng HF. An effect of chemotherapy plus TCM medicine on colorectal cancer after operation. Clin J Chin Med. ₍₂₀₁₈₎ 2:52–3.
Han J, Lai H, Li W, et al. Efficacy and safety of traditional plant-based medicines for preventing chronic oxaliplatin-induced peripheral neurotoxicity in patients with colorectal cancer: A systematic review and meta-analysis with core herb contribution. J Ethnopharmacol. 2024 May 23;326:117735. https://pubmed.ncbi.nlm.nih.gov/38211824/
Wen L, Xie L, Gong F, et al. Efficacy and safety of Chinese medicine injections in combination with docetaxel and cisplatin for non-small cell lung cancer: a network meta-analysis. Front Pharmacol. 2023 Dec 11;14:1277284. https://pubmed.ncbi.nlm.nih.gov/38146464/
Wang R, Ma L, Liao Z, et al. Effects of Astragalus injection on bone marrow system and tumor markers in patients with advanced NSCLC after chemotherapy. World Chin. Med. 2018;13₍₁₁₎:2795-9.
Dai Z, Tan C, Wang J, et al. Traditional Chinese medicine for gastric cancer: An evidence mapping. Phytother Res. 2024 Jun;38₍₆₎:2707-2723. https://pubmed.ncbi.nlm.nih.gov/38517014/
Qin W, Li S, Cheng Z, et al. Astragaloside IV attenuates sunitinib-associated cardiotoxicity by inhibiting COUP-TFII. Heliyon. 2024 Jan 18;10₍₃₎:e24779. https://pubmed.ncbi.nlm.nih.gov/38314260/
Yu J, Chen S, Wei G, et al. Efficacy and Safety of Huangqi Guizhi Wuwu Decoction for Oxaliplatin-Induced Peripheral Neurotoxicity: A Systematic Review and Meta-Analysis. Altern Ther Health Med. 2024 Jan;30₍₁₎:446-453.. https://pubmed.ncbi.nlm.nih.gov/37820675/
Yang Q, Meng D, Zhang Q, Wang J. Advances in research on the anti-tumor mechanism of Astragalus polysaccharides. Front Oncol. 2024 Mar 6;14:1334915. https://pubmed.ncbi.nlm.nih.gov/38515577/
Lu QZ, Luo YY, Wang X, et al. Astragalus polysaccharide regulates cisplatin resistance in colorectal cancer cells through Mir-10b-5p/Ag Pat3 molecular axis. J Shenyang Pharm Univ. 2022; 39:970–8.
Yang YL, Lin ZW, He PT, et al. Inhibitory Effect of Astragalus Polysaccharide Combined with Cisplatin on Cell Cycle and Migration of Nasopharyngeal Carcinoma Cell Lines. Biol Pharm Bull. 2021 Jul 1;44₍₇₎:926-931. https://pubmed.ncbi.nlm.nih.gov/33952795/
copy of 369
Gong Q, Yu H, Ding G, et al. Suppression of stemness and enhancement of chemosensibility in the resistant melanoma were induced by Astragalus polysaccharide through PD-L1 downregulation. Eur J Pharmacol. 2022 Feb 5;916:174726. https://pubmed.ncbi.nlm.nih.gov/34954232/
Li M, Duan F, Pan Z, et al. Astragalus Polysaccharide Promotes Doxorubicin-Induced Apoptosis by Reducing O-GlcNAcylation in Hepatocellular Carcinoma. Cells. 2023 Mar 10;12₍₆₎:866. https://pubmed.ncbi.nlm.nih.gov/36980207/
Wei J, Li Y, Xu B, Yu J. Astragalus polysaccharides reverse gefitinib resistance by inhibiting mesenchymal transformation in lung adenocarcinoma cells. Am J Transl Res. 2020 May 15;12₍₅₎:1640-1657. https://pubmed.ncbi.nlm.nih.gov/32509166/
Bao WR, Li ZP, Zhang QW, et al. Astragalus Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis. Front Pharmacol. 2019 Feb 11;9:1580. https://pubmed.ncbi.nlm.nih.gov/30804792/
Wu J, Wang J, Su Q, et al. Traditional Chinese medicine Astragalus polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation, invasiveness, and apoptosis. Onco Targets Ther. 2018 May 9;11:2685-2698. https://pubmed.ncbi.nlm.nih.gov/29785118/
Liu Y, Chen LY. Effect of astragalus polysaccharide on cisplatin resistance of human lung cancer A549/Ddp cells and its mechanism. J Jilin Univ Med Edit. 2020;46:1162-8.
Liu S, Wang L, Zhang Z, et al. The potential of astragalus polysaccharide for treating diabetes and its action mechanism. Front Pharmacol. 2024 Apr 10;15:1339406. https://pubmed.ncbi.nlm.nih.gov/38659573/
Lai HC, Cheng JC, Yip HT, et al. Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management. World J Gastrointest Oncol. 2024 Mar 15;16₍₃₎:716-731. https://pubmed.ncbi.nlm.nih.gov/38577471/
Yu L, Zhou C, Luo Z, et al. The lipid-lowering effects of Danhong and Huangqi injections: a meta-analysis of clinical controlled trials. Lipids Health Dis. 2018 May 10;17₍₁₎:106. https://pubmed.ncbi.nlm.nih.gov/29747663/
Zhao YJ, Jing ZX. Effect of Huangqi injection on renal injury due to primary hypertension. Zhongguo Xun Zheng Xin Xue Guan Yi Xue Za Zhi. 2015;7:248–250.
Li XY, Zheng JJ, Zheng XY, Meng Q. Clinical observation on the treatment for diabetic nephropathy by astragalus injection. Zhongguo Shi Yong Yi Yao. 2012;7:3–4.
Ming H, Xie H, Zhang H, AI K. Efficacy of astragalus injection on patients with hemiplegia after ischemic stroke. Chinese Journal of Rehabilitation Theory and Practice. 2016:684-7. http://wprim.whocc.org.cn/admin/article/articleDetail?WPRIMID=494338&articleId=494338
Wu CL, Zhang XL. Clinical observation of astragalus injection in the treatment of diabetic nephropathy. Lin Chuang Yi Yao Shi Jian. 2010;20:601–602.
Wang GJ, Yang XQ, Zhang JF. Clinical observation of astragalus injection in the treatment of early-stage diabetic nephropathy. Wei Xun Huan Xue Za Zhi. 2009;19:44–45.
Yu WZ, Gao GS, He XS. Effect of astragale injection on serum lipids in nephrotic syndrome. Shi Yong Yao Wu Yu Lin Chuan. 2011;14:194–195.
Liu MH. Clinical observation of astragalus injection in the treatment of nephrotic syndrome in children. Zhongguo Yi Yao Zhi Nan. 2014;12:181–182.
Han X, Yu T, Chen X, et al. Effect of Astragalus membranaceus on left ventricular remodeling in HFrEF: a systematic review and meta-analysis. Front Pharmacol. 2024 Jan 12;15:1345797. https://pubmed.ncbi.nlm.nih.gov/38283626/
Liu M, Di YM, May B, et al. Renal protective effects and mechanisms of Astragalus membranaceus for diabetic kidney disease in animal models: An updated systematic review and meta-analysis. Phytomedicine. 2024 Jul;129:155646. https://pubmed.ncbi.nlm.nih.gov/38733903/
Lin YQ, Yu F, Chen HJ, et al. Efficacy of astragalus combined with renin-angiotensin-aldosterone system blockers in the treatment of stage III diabetic nephropathy: a systematic review and meta-analysis. Ren Fail. 2024 Dec;46₍₂₎:2359033. https://pubmed.ncbi.nlm.nih.gov/38836372/
Chan KW, Kwong ASK, Tsui PN, et al; READY and SCHEMATIC research group. Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial. Phytomedicine. 2024 Jul 25;130:155457. https://pubmed.ncbi.nlm.nih.gov/38810556/
Zhi X, Ren C, Li Q, et al. Therapeutic potential of Angelica sinensis in addressing organ fibrosis: A comprehensive review. Biomed Pharmacother. 2024 Apr;173:116429. https://pubmed.ncbi.nlm.nih.gov/38490157/
Zhang X, Zhao S, Zhao X, et al. Dang-Gui-Bu-Xue decoction improves wound healing in diabetic rats by the activation of Notch signaling. Heliyon. 2024 Feb 20;10₍₅₎:e26711. https://pubmed.ncbi.nlm.nih.gov/38444491/
Mak DH, Chiu PY, Dong TT, et al. Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes. Phytother Res. 2006 Jul;20₍₇₎:561-7. https://pubmed.ncbi.nlm.nih.gov/16619337/
Lv J, Zhao Z, Chen Y, et al. The chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis. Evid Based Complement Alternat Med. 2012;2012:284963. https://pubmed.ncbi.nlm.nih.gov/22927877/
Cui H, Zhang E, Tan M. Effect of DGBXD on myocardial fibrosis in rats with incomplete abdominal aorta ligation Pharm. Clin. Tradit. Chin. Med, 34 ₍₀₅₎ ₍₂₀₁₈₎, pp. 18-21
Ren C, Wang L, Li X, et al. Elucidating the mechanism of action of Radix Angelica sinensis (Oliv.) Diels and Radix Astragalus mongholicus Bunge ultrafiltration extract on radiation-induced myocardial fibrosis based on network pharmacology and experimental research. Eur J Pharm Sci. 2024 Aug 1;199:106794. https://pubmed.ncbi.nlm.nih.gov/38788908/
Qiu H, Chen X, Zhang L, et al. Clinical remission of moderate generalized myasthenia gravis through exclusive use of Buzhong Yiqi decoction: A case report. Explore (NY). 2024 Jul-Aug;20₍₄₎:588-591. https://pubmed.ncbi.nlm.nih.gov/38744568/
Zhang WZ, Qi XM, et al. [Protective effect and mechanism of Astragalus membranaceus and Angelica sinensis compatibility against triptolide-induced hepatotoxicity by regulating Keap1/Nrf2/PGC-1α]. Zhongguo Zhong Yao Za Zhi. 2023 Dec;48₍₂₃₎:6378-6386. Chinese. https://pubmed.ncbi.nlm.nih.gov/38211994/
Wang Q, Zhen W, Lippi G, Liu Q. The effect of Astragali Radix-Radix Angelica sinensis on acute kidney injury: a network pharmacology and molecular docking study. Transl Androl Urol. 2024 Jan 31;13₍₁₎:91-103. https://pubmed.ncbi.nlm.nih.gov/38404557/
Sun C, Liu H, Chi B, et al. Improvement of idiopathic pulmonary fibrosis through a combination of Astragalus radix and Angelica sinensis radix via mammalian target of rapamycin signaling pathway-induced autophagy in rat. J Thorac Dis. 2024 Feb 29;16₍₂₎:1397-1411. https://pubmed.ncbi.nlm.nih.gov/38505077/
Liu S, Xiao G, Wang Q, et al. Effects of dietary Astragalus membranaceus and Codonopsis pilosula extracts on growth performance, antioxidant capacity, immune status, and intestinal health in broilers. Front Vet Sci. 2023 Dec 7;10:1302801. https://pubmed.ncbi.nlm.nih.gov/38144468/
Tang S, Liu W, Zhao Q, et al. Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms. J Ethnopharmacol. 2021 Jan 10;264:113280. https://pubmed.ncbi.nlm.nih.gov/32822821/
Ko PH, Huang CW, Chang HH, et al. Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells. Chin Med. 2019 Mar 20;14:10. https://pubmed.ncbi.nlm.nih.gov/30936938/
Xu J, Zhang Z, Zhou K, et al. Integration of network pharmacology and molecular docking technology reveals the mechanism of the herbal pairing of Codonopsis pilosula (Franch.) Nannf and Astragalus Membranaceus (Fisch.) Bge on chronic heart failure. Ann Palliat Med. 2021Jul;10₍₇₎:7942-7959. https://pubmed.ncbi.nlm.nih.gov/34353081/
Chang WT, Lai TH, Chyan YJ, et al. Specific medicinal plant polysaccharides effectively enhance the potency of a DC-based vaccine against mouse mammary tumor metastasis. PLoS One. 2015 Mar 31;10₍₃₎:e0122374. https://pubmed.ncbi.nlm.nih.gov/25825910/
Wang ZT, Wang SR, Zhao MJ. [Comparative study on effect of recipe for activating blood circulation and replenishing Qi on left ventricular remodeling in rats with left heart failure after myocardial infarction]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 May;22₍₅₎:376-8. Chinese. https://pubmed.ncbi.nlm.nih.gov/12584842/
Tran MN, Kim NS, Lee S. Biological network comparison identifies a novel synergistic mechanism of Ginseng Radix-Astragali Radix herb pair in cancer-related fatigue. J Ethnopharmacol. 2024 Oct 28;333:118447. https://pubmed.ncbi.nlm.nih.gov/38885914/
Fan W, Jiang ZZ, Wan SR. Based on network pharmacology and molecular docking to explore the molecular mechanism of Ginseng and Astragalus decoction against postmenopausal osteoporosis. Medicine (Baltimore). 2023 Nov 17;102₍₄₆₎:e35887. https://pubmed.ncbi.nlm.nih.gov/37986389/
Zhang J. Observation on the effect of Shenjiangtang granule combined with Xuesaitong on reducing renal damage of early onset diabetic nephropathy. Clinical Journal of Traditional Chinese Medicine . 2010;22:312–313.
Han XY, Du YM. Observation on therapeutic effect of compound Xueshuantong capsule and Shenqi Jiangtang granule on diabetic nephropathy. Shaanxi Journal of Traditional Chinese Medicine . 2017;38₍₇₎:916–917.
Song W. Clinical effect of compound xueshuantong capsule combined with shenqi jiangtang granule in treating diabetic nephropathy. Journal of China Prescription Drug . 2018;16₍₄₎:57–58.
Jiao QL. Clinical observation of Huangqi Xuesaitong injection combined with irbesartan in the treatment of early diabetic nephropathy. Guangxi Medical Journal . 2004;26:1484–1485.
Liu GF, Yang W. Clinical observation of Huangqi injection and Xuesaitong injection combined with irbesartan in the treatment of early diabetic nephropathy. Journal of Qiqihar Medical College . 2002;23:303–304.
Jia ZJ, Wang J, Zhang A. Observation on therapeutic effect of Xueshuantong and Huangqi injection on diabetic nephropathy. Journal of Shandong University of Traditional Chinese Medicine . 2002;26₍₅₎:361–362.
Ma CF. Clinical effect of compound xueshuantong capsule and shenqi jiangtang granule on diabetic nephropathy. China Health Standard Management . 2017;18₍₂₁₎:104–105.
Tian CH. Clinical observation of compound xueshuantong capsule combined with shenqi jiangtang granule in treating diabetic nephropathy. World Latest Medicine Information . 2018;18₍₇₀₎:98–99.
Mo SA. Clinical observation on 35 cases of type 2 diabetic nephropathy with deficiency of both qi and yin and blood stasis treated by TangShen Formula. Chin J Tradit Chin Med Pharm . 2014;29₍₁₀₎:3340–3343.
Zhang LJ, Zhao G. Clinical observation on treatment of early diabetic nephropathy with Huangqi Xuesaitong intravenous injection combined with Shenfang oral administration. Chinese Archives of Traditional Chinese Medicine. 2005;23₍₆₎:145–146.
Xiang SW. Clinical observation on treatment of diabetic nephropathy with integrated traditional Chinese and western medicine. Journal of Guangzhou University of Traditional Chinese Medicine . 2005;22₍₁₎:16–18.
Zhang YJ. Clinical observation of Shenqi jiangtang granule combined with compound Xueshuantong capsule in treating diabetic nephropathy. 2013;35₍₅₎:401–410.
Yang X, Zhang B, Lu X, et al. Effects of Tangshen Formula on urinary and plasma liver-type fatty acid binding protein levels in patients with type 2 diabetic kidney disease: post-hoc findings from a multi-center, randomized, double-blind, placebo-controlled trial investigating the efficacy and safety of Tangshen Formula in patients with type 2 diabetic kidney disease. BMC Complement Altern Med. 2016 Jul 26;16:246. https://pubmed.ncbi.nlm.nih.gov/27460780/
Li P, Chen Y, Liu J, et al. Efficacy and safety of tangshen formula on patients with type 2 diabetic kidney disease: a multicenter double-blinded randomized placebo-controlled trial. PLoS One. 2015 May 4;10₍₅₎:e0126027. https://pubmed.ncbi.nlm.nih.gov/25938778/
Jiang WG, Hong B. Effect of shenqiyiqi dropping pill combined with telmisartan on early diabetic nephropathy and its influence on serum SSA, IL-6 and TNF-α levels. Chinese Traditional Patent Medicine. 2014;36₍₉₎:1822–1826.
Gao J. Clinical study on 40 cases of type 2 diabetic nephropathy with deficiency of both qi and yin and blood stasis in stage III and IV treated by supplementing qi and yin, activating blood circulation and removing blood stasis. World Chinese Medicine. 2013;8₍₅₎:530–534.
Liu KZ, Li JB, Lu HL, Wen JK, Han M. [Effects of Astragalus and saponins of Panax notoginseng on MMP-9 in patients with type 2 diabetic macroangiopathy]. Zhongguo Zhong Yao Za Zhi. 2004 Mar;29₍₃₎:264-6. Chinese. https://pubmed.ncbi.nlm.nih.gov/15706857/
Zhai R, Jian G, Chen T, et al. Astragalus membranaceus and Panax notoginseng, the Novel Renoprotective Compound, Synergistically Protect against Podocyte Injury in Streptozotocin-Induced Diabetic Rats. J Diabetes Res. 2019 Apr 16;2019:1602892. https://pubmed.ncbi.nlm.nih.gov/31179338/
Huang XP, Liu XD, Deng CQ. [Effects of the combination of active component extracts from Astragalus membranaceus and Panax notoginseng on apoptosis, reactive oxygen species and mitochondrial membrane potential of PC12 cells with oxidative injury]. Zhong Xi Yi Jie He Xue Bao. 2012 Oct;10₍₁₀₎:1127-34. Chinese. https://pubmed.ncbi.nlm.nih.gov/23073196/
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D, Castenmiller J, De Henauw S, et al. Safety of a botanical extract derived from Panax notoginseng and Astragalus membranaceus (AstraGin™) as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J. 2020 May 13;18₍₅₎:e06099. https://pubmed.ncbi.nlm.nih.gov/37649518/
Murbach TS, Glávits R, Endres JR, et al. Toxicological Evaluation of a Mixture of Astragalus membranaceus and Panax notoginseng Root Extracts (InnoSlim®). J Toxicol. 2019 Jul 1;2019:5723851. https://pubmed.ncbi.nlm.nih.gov/31354815/
Joung JY, Lee JS, Choi Y, et al. Evaluating myelophil, a 30% ethanol extract of Astragalus membranaceus and Salvia miltiorrhiza, for alleviating fatigue in long COVID: a real-world observational study. Front Pharmacol. 2024 Jun 20;15:1394810. https://pubmed.ncbi.nlm.nih.gov/38966550/
Zhai P, Chen Q, Wang X, et al. The combination of Tanshinone IIA and Astragaloside IV attenuates myocardial ischemia-reperfusion injury by inhibiting the STING pathway. Chin Med. 2024 Feb 28;19₍₁₎:34. https://pubmed.ncbi.nlm.nih.gov/38419127/
Liang Y, Xie Y, Liu X, et al. Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Astragalus-Atractylodes Herb Pair in Treating Hepatocellular Carcinoma. Drug Des Devel Ther. 2024 Jun 11;18:2169-2187. https://pubmed.ncbi.nlm.nih.gov/38882048/
Qin L, Luan ZX, Li M, Xiang Y, Qi XR. [Astragali Radix-Salviae Miltiorrhizae Radix et Rhizoma alleviates acute lung injury in rats by regulating autophagy via PI3K/Akt/mTOR pathway]. Zhongguo Zhong Yao Za Zhi. 2024 Jun;49₍₁₂₎:3295-3301. Chinese. https://pubmed.ncbi.nlm.nih.gov/39041092/
Wu TH, Yeh KY, Wang CH, Wang H, Li TL, Chan YL, Wu CJ. The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function. J Oncol. 2019 Nov 3;2019:9206951. https://pubmed.ncbi.nlm.nih.gov/31781219/
Liu HX, Lian L, Hou LL, et al. Herb pair of Huangqi-Danggui exerts anti-tumor immunity to breast cancer by upregulating PIK3R1. Animal Model Exp Med. 2024 Jun;7₍₃₎:234-258. https://pubmed.ncbi.nlm.nih.gov/38863309/
Sheng F, Yang S, Li M, Wang J, Liu L, Zhang L. Research Progress on the Anti-Cancer Effects of Astragalus membranaceus Saponins and Their Mechanisms of Action. Molecules. 2024 Jul 18;29₍₁₄₎:3388. https://pubmed.ncbi.nlm.nih.gov/39064966/
Li Z, Liu J, Cui H, Qi W, Tong Y, Wang T. Astragalus membranaceus: A Review of Its Antitumor Effects on Non-Small Cell Lung Cancer. Cancer Manag Res. 2024 Jul 25;16:909-919. https://pubmed.ncbi.nlm.nih.gov/39081698/
Li L, Li G, Chen M, Cai R. Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy. Drug Dev Res. 2022 Apr;83₍₂₎:461-469. https://pubmed.ncbi.nlm.nih.gov/34499759/
Lai ST, Wang Y, Peng F. Astragaloside IV sensitizes non-small cell lung cancer cells to cisplatin by suppressing endoplasmic reticulum stress and autophagy. J Thorac Dis. 2020 Jul;12₍₇₎:3715-3724. https://pubmed.ncbi.nlm.nih.gov/32802451/
Ma Q, Xu Y, Tang L, et al. Astragalus Polysaccharide Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Damage and Mitochondrial Dysfunction. Biomed Res Int. 2020 Jan 3;2020:2851349. https://pubmed.ncbi.nlm.nih.gov/31998784/
Lin J, Fang L, Li H, et al. Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress. Eur J Pharmacol. 2019 Sep 15;859:172490. https://pubmed.ncbi.nlm.nih.gov/31229536/
Luo LF, Guan P, Qin LY, et al. Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling. Mol Cell Biochem. 2021 Jul;476₍₇₎:2603-2611. https://pubmed.ncbi.nlm.nih.gov/33656642/
Zheng Y, Dai Y, Liu W, et al. Astragaloside IV enhances taxol chemosensitivity of breast cancer via caveolin-1-targeting oxidant damage. J Cell Physiol. 2019 Apr;234₍₄₎:4277-4290. https://pubmed.ncbi.nlm.nih.gov/30146689/
He Y, Zhang Q, Chen H, et al. Astragaloside IV enhanced carboplatin sensitivity in prostate cancer by suppressing AKT/NF-κB signaling pathway. Biochem Cell Biol. 2021 Apr;99₍₂₎:214-222. https://pubmed.ncbi.nlm.nih.gov/32813978/
Hu T, Fei Z, Wei N. Chemosensitive effects of Astragaloside IV in osteosarcoma cells via induction of apoptosis and regulation of caspase-dependent Fas/FasL signaling. Pharmacol Rep. 2017 Dec;69₍₆₎:1159-1164. https://pubmed.ncbi.nlm.nih.gov/29128795/
Zhang L, Liu Y, Lei X, et al. Astragaloside II enhanced sensitivity of ovarian cancer cells to cisplatin via triggering apoptosis and autophagy. Cell Biol Int. 2023 Sep;47₍₉₎:1600-1613. https://pubmed.ncbi.nlm.nih.gov/37323083/
He CS, Liu YC, Xu ZP, et al. Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3. Cell Physiol Biochem. 2016;40₍₅₎:1221-1229. https://pubmed.ncbi.nlm.nih.gov/27960166/
Xie T, Li Y, Li SL, Luo HF. Astragaloside IV Enhances Cisplatin Chemosensitivity in Human Colorectal Cancer via Regulating NOTCH3. Oncol Res. 2016 Oct 27;24₍₆₎:447-453. https://pubmed.ncbi.nlm.nih.gov/28281965/
Qu X, Gao H, Zhai J, et al. Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2. Eur J Pharm Sci. 2020 May 30;148:105325. https://pubmed.ncbi.nlm.nih.gov/32259679/
Qu X, Gao H, Tao L, et al. Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats. J Toxicol Sci. 2019;44₍₃₎:167-175. https://pubmed.ncbi.nlm.nih.gov/30842369/
Wang PP, Xu DJ, Huang C, et al. Astragaloside Ⅳ reduces the expression level of P-glycoprotein in multidrug-resistant human hepatic cancer cell lines. Mol Med Rep. 2014 Jun;9₍₆₎:2131-7. https://pubmed.ncbi.nlm.nih.gov/24676670/
Wang PP, Luan JJ, Xu WK, et al. Astragaloside IV downregulates the expression of MDR1 in Bel‑7402/FU human hepatic cancer cells by inhibiting the JNK/c‑Jun/AP‑1 signaling pathway. Mol Med Rep. 2017 Sep;16₍₃₎:2761-2766. https://pubmed.ncbi.nlm.nih.gov/28713943/
Wang M, Huang C, Su Y, et al. Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy. J Pharm Pharmacol. 2017 Jun;69₍₆₎:743-752. https://pubmed.ncbi.nlm.nih.gov/28266023/
Wen T, Wang T, Zhu H, et al. Efficacy of Hepatoprotective Formula, Entecavir, and Continuous Nursing in Patients with Hepatitis B Cirrhosis. Altern Ther Health Med. 2024 Jul 19:AT10567. Epub ahead of print. https://pubmed.ncbi.nlm.nih.gov/39038336/
Han X, Huang L, Li G, et al. Effect of astragalus injection on left ventricular remodeling in HFmrEF: a systematic review and meta-analysis. Front Cardiovasc Med. 2024 Aug 6;11:1374114. https://pubmed.ncbi.nlm.nih.gov/39165261/
Chang WN, Wang X, Chu PP, Ma KY. Clinical efficacy and influence on myocardial fibrosis of Astragalus injection combined with ivabradine in the refractory heart failure patients. J North China Univ Techno. 2022, 24₍₅₎:388–92.
Gu X, Shang SZ, Guo R. Observation of clinical effects of Astragalus injection in treatment of 68 patients with chronic heart failure. Herald Med. 2003, 22₍₈₎:556–7.
Liu H, Lin DN, Lin YC, Zeng YP. Effects of combined Astragalus injection and valsartan on cardiac function and left ventricular function in patients with congestive heart failure. J New Chin Med. 2008, 40₍₈₎:33–4.
Pei YY. Effects of rosuvastatin calcium tablets and Astragalus injection on elderly patients with heart failure, including atrial natriuretic peptide (ANP) and left ventricular remodeling. Clin Res. 2020, 28₍₃₎:113–4.
Sun JJ. Clinical research on the treatment of chronic heart failure with Astragalus injection. J New Chin Med. 2016, 48₍₂₎:28–30.
Yan FY, Lin HZ. Observation of clinical effects of Astragalus injection in treatment of 80 patients with chronic heart failure. Jiangxi Trad China Med. 2015, 40₍₁₁₎:27–8.
Zhang XH. Effects of Astragalus injection on cardiac function and neuroendocrine function in patients with heart failure. Henan Med Res. 2020, 29₍₅₎:857–9.
Zhang ZB. Clinical observation of Astragalus injection combined with conventional western medicine for patients of chronic heart failure. J New Chin Med. 2017, 49₍₁₎:25–7.
Zhao FR, Zhang DB. The effects of Astragalus injection in the treatment of 51 cases of chronic heart failure and its impact on serum galectin-3 and B-type natriuretic peptide. Chin Pharm. 2015, 24₍₉₎:22–4.
Zhao Y, Yan SH, Wang HD, Wang XY. The efficacy of Astragalus injection in the treatment of chronic heart failure and its effects on MDA, HO-1, and NO. Chin ArchTradit Chin Med. 2017, 35₍₈₎:2055–7.
Joung JY, Lee JS, Cho JH, Lee DS, Ahn YC, Son CG. The Efficacy and Safety of Myelophil, an Ethanol Extract Mixture of Astragali Radix and Salviae Radix, for Chronic Fatigue Syndrome: A Randomized Clinical Trial. Front Pharmacol. 2019 Sep 10;10:991. https://pubmed.ncbi.nlm.nih.gov/31551788/
Zhang Y, Chen Z, Chen L, et al. Astragali radix (Huangqi): a time-honored nourishing herbal medicine. Chin Med. 2024 Aug 30;19₍₁₎:119. https://pubmed.ncbi.nlm.nih.gov/39215362/
Huang R, Cai Y, Yang L, et al. Safety of traditional Chinese medicine injection based on spontaneous report ing system from 2014 to 2019 in Hubei Province, China. Sci Rep. 2021;11₍₁₎:8875. https://www.nature.com/articles/s41598-021-88339-9
Wan C, Yan S, Lu R, et al. Astragalus Polysaccharide improves immunogenicity of influenza vaccine as well as modulate gut microbiota in BALB/c mice. Microb Pathog. 2024 Aug 27;195:106893. https://pubmed.ncbi.nlm.nih.gov/39197333/
Ma Y, Bai B, Liu D, et al. Shenqi Fuzheng Injection Reduces Cisplatin-Induced Kidney Injury via cGAS/STING Signaling Pathway in Breast Cancer Mice Model. Breast Cancer (Dove Med Press). 2024 Aug 16;16:451-469. https://pubmed.ncbi.nlm.nih.gov/39165276/
Zhang MY, Zheng SQ. Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease. World J Diabetes. 2024 Jul 15;15₍₇₎:1562-1588. https://pubmed.ncbi.nlm.nih.gov/39099827/
Lin M, Mao ZJ. lncRNA-mRNA competing endogenous RNA network in IR-hepG2 cells ameliorated by APBBR decreasing ROS levels: a systematic analysis. PeerJ. 2020 Feb 24;8:e8604. https://pubmed.ncbi.nlm.nih.gov/32140303/
Liu X, Gao L, Huang X, et al. Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice. Front Pharmacol. 2023 Nov 16;14:1236820. https://pubmed.ncbi.nlm.nih.gov/38034992/
Zhong B, Liang W, Zhao Y, et al. Combination of Lactiplantibacillus Plantarum ELF051 and Astragalus Polysaccharides Improves Intestinal Barrier Function and Gut Microbiota Profiles in Mice with Antibiotic-Associated Diarrhea. Probiotics Antimicrob Proteins. 2024 Oct 1.. https://pubmed.ncbi.nlm.nih.gov/39354215/
Rong X, Shu Q. Enhancing immunomodulation in cyclophosphamide-induced immunosuppressed mice through targeted modulation of butyrate-producing gut microbiota via oral administration of astragalus polysaccharides. Food Sci Nutr. 2024 Aug 5;12₍₁₀₎:7683-7695. https://pubmed.ncbi.nlm.nih.gov/39479666/
Cheon C, Lee HW, Sym SJ, Ko SG. Safety of the Herbal Medicine SH003 in Patients With Solid Cancer: A Multi-Center, Single-Arm, Open-Label, Dose-Escalation Phase I Study. Integr Cancer Ther. 2024 Jan-Dec;23:15347354241293451. https://pubmed.ncbi.nlm.nih.gov/39469996/
Shen WC, Chen SC, Wang CH, et al. Astragalus polysaccharides improve adjuvant chemotherapy-induced fatigue for patients with early breast cancer. Sci Rep. 2024 Oct 28;14₍₁₎:25690. https://pubmed.ncbi.nlm.nih.gov/39465324/
Wang Y, Qin Y, Kang Q, et al. Therapeutic potential of Astragalus membranaceus-Pueraria lobata decoction for the treatment of chemotherapy bowel injury. FASEB J. 2024 Oct 15;38₍₁₉₎:e70102. https://pubmed.ncbi.nlm.nih.gov/39382026/
Wen J, Wang S, Sun K, et al. Chang-Wei-Qing Combined with PD-1 Inhibitor Alleviates Colitis-Associated Colorectal Tumorigenesis by Modulating the Gut Microbiota and Restoring Intestinal Barrier. Biol Proced Online. 2024 Dec 19;26₍₁₎:32. https://pubmed.ncbi.nlm.nih.gov/39701930/
Wu X, Liu A, Lv X, et al. Network pharmacology and experimental study of Angelica sinensis and Astragalus membranaceus capsules in treating heart failure. Heliyon. 2024 Oct 4;10₍₂₀₎:e38851. https://pubmed.ncbi.nlm.nih.gov/39640819/
Bai X, Wei H, Liu G, Li L. Astragalus polyphenols attenuates doxorubicin-induced cardiotoxicity by activating the PI3K/AKT/NRF2 pathway. PLoS One. 2025 Feb 25;20₍₂₎:e0319067. https://pubmed.ncbi.nlm.nih.gov/39999034/
Cao W, Huang L, Yu H, et al. Calycosin extracted from Astragali Radix reduces NETs formation to improve renal fibrosis via TLR4/NF-κB pathway. J Ethnopharmacol. 2025 Feb 27;342:119391. https://pubmed.ncbi.nlm.nih.gov/39855434/
Lu KC, Wu SC, Lu TC, et al. Therapeutic effects of Huangqi formula (Eefooton) in chronic kidney disease: clinical research and narrative literature review. Aging (Albany NY). 2024 Dec 7;16₍₂₂₎:13627-13647. https://pubmed.ncbi.nlm.nih.gov/39652245/
Shi W, Zhang H, Tang H, et al. Effect of Astragalus polysaccharide combined with cisplatin on exhaled volatile organic compounds as biomarkers for lung cancer and its anticancer mechanism. J Pharm Biomed Anal. 2025 Jul 15;259:116759. https://pubmed.ncbi.nlm.nih.gov/40020348/
Sun LI, Zhuo S, Li X, et al. Astragalus polysaccharide enhances the therapeutic efficacy of cisplatin in triple-negative breast cancer through multiple mechanisms. Oncol Res. 2025 Feb 28;33₍₃₎:641-651. https://pubmed.ncbi.nlm.nih.gov/40109863/
Chen R, Li Y, Zuo L, et al. Astragalus polysaccharides inhibits tumor proliferation and enhances cisplatin sensitivity in bladder cancer by regulating the PI3K/AKT/FoxO1 axis. Int J Biol Macromol. 2025 May 2;311(Pt 2):143739. https://pubmed.ncbi.nlm.nih.gov/40318719/
Manshu YU, Chunchun J, Min Y, et al. Yunpiqiangshen gel improves quality of life in dialysis patients. J Tradit Chin Med. 2025 Feb;45₍₁₎:123-131. https://pubmed.ncbi.nlm.nih.gov/39957166/
Zhang L, Zhang J, Chen Y, et al. Improvement of classical therapy in EGFR inhibitors-induced cutaneous adverse reaction by microneedle delivery and Astragalus polysaccharide. Int J Biol Macromol. 2025 Apr;304(Pt 1):140762. https://pubmed.ncbi.nlm.nih.gov/39922340/
Zhang X, Yan Q, Xiao Y, et al. Integrating network pharmacology, molecular docking, and animal studies to investigate the protective effect of astragalus polysaccharide on fluoride-induced renal injury in rats. Ecotoxicol Environ Saf. 2025 Apr 1;294:118109. https://pubmed.ncbi.nlm.nih.gov/40154226/
Xiying T, Ruxin GU, Jing T, et al. Integrating network pharmacology and experimental validation to uncover the synergistic effects of Huangqi ()-Ezhu () with 5-fluorouracil in colorectal cancer models. J Tradit Chin Med. 2025 Apr;45₍₂₎:385-398. https://pubmed.ncbi.nlm.nih.gov/40151125/
Wu J, Xiao D, Zhan T, et al. [Effects and Efficacy of Wenyang Huayin Yangxin Prescription on the Traditional Chinese Medicine Syndromes of Patients With Chronic Heart Failure Combined With Diuretic Resistance]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025 Jan 20;56₍₁₎:94-101. Chinese. https://pubmed.ncbi.nlm.nih.gov/40109465/
Li J, Wu M, Liu W. Astragalus-containing Chinese herbal medicine used with Western medicine for lupus nephritis: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. 2025 Feb 21;15:1395844. https://pubmed.ncbi.nlm.nih.gov/40061256/
Chan KW, Kwong ASK, Tsui PN, et al. Add-on astragalus therapy for diabetic kidney disease: an open-label randomised controlled trial with responder regression analysis (abridged secondary publication). Hong Kong Med J. 2025 Feb;31 Suppl 1₍₁₎:19-22. https://pubmed.ncbi.nlm.nih.gov/40038082/
Sheng X, Yang L, Huang B, et al. Efficacy of Astragalus Membranaceus (Huang Qi) for Cancer-Related Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Studies. Integr Cancer Ther. 2025 Jan-Dec;24:15347354241313344. https://pubmed.ncbi.nlm.nih.gov/40302232/

דוגמא למונוגרף מלא

לרכישת מנוי | כניסת מנויים

בחזרה לדף הראשי של האינדקס

חזרה לתחילת העמוד

חזרה לעמוד הקודם

קדד קרומי, אסטרגלוס - Astragalus membranaceus

Astragalus - Huang Qi

יש לנו עדכונים בשבילך

הצהרה