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29/09/2021

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  1. - Chamaemelum nobile, Matricaria recutita, Melissa officinalis, Nepeta cataria, Passiflora incarnata, Tilia europea, Verbena officinalis, Scutellaria lateriflora, Humulus lupulus, Viburnum spp, Valeriana officinalis
  2. - , Verbena officinalis , Hypericum perforatum, Scutellaria lateriflora 
  3. -  Astragalus membranaceus, Glycyrrhiza glabra, Withania somnifera, Centella asiatica, Schisandra chinensis 
  4. - Eschscholzia californicaValeriana officinalis

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30% Withania somnifera
30% Verbena officinalis
30% Scutellaria lateriflora
10% Glycyrrhiza glabra 1:1

: 5-10 ", 3

 

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100mg Withania somnifera
100mg Centella asiatica
100mg Scutellaria lateriflora
50mg  Glycyrrhiza glabra

: 1-2 , 3


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90% Valeriana officinalis
10% Glycyrrhiza glabra 1:1

: 20-80 ,

 

(Matricaria recutita), (Passiflora incarnata) (Tilia europea), (Melissa officinalis) (Lavandula officinalis) 1-2 , 3-4 .

 

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, (Citrus aurantium amara), (Origanum majorana), (Pogostemon Patchouli) - (Cananga odorata).
, (Cedrus atlantica), (Rosa damascene), (Origanum majorana), (Salvia sclaria) (Citrus aurantium sinensis) (Salvia sclaria), (Citrus aurantium sinensis).

 

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(Lavandula officinalis) 10 
(Boswellia carteri) 10
(Melissa officinalis)   5
(Chamamelum nobilis) 1

 

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(, , ') - " 50
 
(Lavandula officinalis)
(Boswellia carteri) 6
(Salvia sclaria) 4
(Citrus aurantium sinensis) 4
(Melissa officinalis 3
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-  (2020) . 20 ( 1,284 ), 7 : , ( ), , , , , . -15 ,

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https://pubmed.ncbi.nlm.nih.gov/32147030/

, (2019) . , -, . , . 21 , 1,503 (10 ), (6 ) ( , , , 2). , , . ( Lactobacillus), . 

21 , -11 , 5 -6 FODMAP. 86% (6 7 ). 

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https://www.ncbi.nlm.nih.gov/pubmed/31179435

- (2018) .

32 , , . , , ( , , ), ( ) -. , (Piper methysticum), (Lavandula angustifolia) (Crataegus oxycantha), (Eschscholzia californica) .

, () (paroxetine). , . , .

https://www.ncbi.nlm.nih.gov/pubmed/29508154

 (2018) 25. , 109 , 50 . , 103 - , , , , , , , , . , . 38 , : (16 ), (10 ), (5 ), (3 ), (2 ), ( ) ( ).

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https://www.ncbi.nlm.nih.gov/pubmed/30522980

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https://pubmed.ncbi.nlm.nih.gov/31951670/

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https://www.ncbi.nlm.nih.gov/pubmed/29985786

( 2013)   .

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http://www.ncbi.nlm.nih.gov/pubmed/23769610

, (2020) . , , 47 45 (12 ), . , . 

, , (12 ). 24 12 , (HAM-A). 17 -14 . 11 . 

, , -19.91 -10.00 -6.91 12 ( 0-56). 

, , . 

-NIH. 

https://pubmed.ncbi.nlm.nih.gov/33197668/

( ) (2019) (EFT (Emotional Freedom Technique . -EFT . , . 

, , . , . 203 , 4 , , 31 , . , , PTSD, . , -IgA , , . . EFT . 

.

https://www.ncbi.nlm.nih.gov/pubmed/30777453

 (2020) . , / , . 121,008 18-93, – ( , , ). 3.6 (65.342 ). 

, , . , . . , , .       

https://pubmed.ncbi.nlm.nih.gov/32654840/

(2020) , . 11,067 9-11, MRI. 

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https://pubmed.ncbi.nlm.nih.gov/32015467

 (2017) , . , , , -, . , : , , , . , .

: (Hypericum perforatum), - (Piper methysticum), (Withania somnifera), ' (Panax ginseng), '  (Panax quinquefolius), (Rhodiola rosea), (Melissa officinalis), (Humulus lupulus), 

(Lavendula angustifolia), (Matricaria recutita), (Valeriana officinalis). 

: 3, SAM-e, , , , , --. 

https://www.ncbi.nlm.nih.gov/pubmed/28501230

, (2019) " 2012, -20% ( ADHD, , , ) , -10% . , - . . 

https://www.ncbi.nlm.nih.gov/pubmed/30157825

( 2009)   .

75 , 8 . 

, , , , (Withania somnifera) 300 " .

. 30.5% 56.5%. 

http://www.ncbi.nlm.nih.gov/pubmed/19718255

 ( 2018) , ( ), . , , , .

422 18-25, - ". , , ( , , , ) . , , .

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https://www.ncbi.nlm.nih.gov/pubmed/29692750

,(2019) , D . 273 5-12, D , . D ( 50 /) 10.3%. 

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https://www.ncbi.nlm.nih.gov/pubmed/31429909

( 2016) ,   .

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http://www.ncbi.nlm.nih.gov/pubmed/27188471

( 2015)    , ,  , .

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http://www.ncbi.nlm.nih.gov/pubmed/25657360

(2014)   .  -17% , .

, , , , , -47% 56% .

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http://jncimono.oxfordjournals.org/content/2014/50/330

 ( 2018), -16,000 , , - . , -ADHD.

https://www.ncbi.nlm.nih.gov/pubmed/29648599

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https://www.ncbi.nlm.nih.gov/pubmed/31645720

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453 -400 , . , - .

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http://www.ncbi.nlm.nih.gov/pubmed/18495296

 

 

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https://pubmed.ncbi.nlm.nih.gov/31947912/

 ( 2018).

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https://www.ncbi.nlm.nih.gov/pubmed/29712690

(2015)     .

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http://www.ncbi.nlm.nih.gov/pubmed/25923849

- 2015 3 - (nested case-control)       , .

1995-2013 . -200,000 , 14,000 -2,700 , .

23-25% , ( 56% 5 ). . . -, . 

http://www.psychiatrist.com/jcp/article/Pages/2015/aheadofprint/15m09961.aspx

 (2018) .

192 67 , . , , , , . ( ) ( ), 10 20% 25% .

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https://www.ncbi.nlm.nih.gov/pubmed/29738418

 (2019) . , ( ). , , . 115 18 229 . , 110 , . , 4 .

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https://www.ncbi.nlm.nih.gov/pubmed/30919798

, (2018) 3,720 13, 76% ' -31 ,

https://www.ncbi.nlm.nih.gov/pubmed/29874357

( 2015)   . 3,363 , .

-44% -52% .

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http://www.ncbi.nlm.nih.gov/pubmed/26607943

(2020) , . 11,067 9-11, MRI. 

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https://pubmed.ncbi.nlm.nih.gov/32015467

( 2013),    

332 , 147 . 20 .

51% -40% , 20% -16%, , .

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http://www.ncbi.nlm.nih.gov/pubmed/23940244

 ( 2018) - . 270 , PET - Geriatric Depression Scale 1-5 .

 

- , . - - - .  
https://www.ncbi.nlm.nih.gov/pubmed/29325447

 ( 2017), 80 4-12 , .
https://www.ncbi.nlm.nih.gov/pubmed/28595764

( 2016) -23,000 IVF   / - IVF

http://www.ncbi.nlm.nih.gov/pubmed/26920258

  ( 2015)   -15 .  -70,000 " ( ), -15% .

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http://www.ncbi.nlm.nih.gov/pubmed/25810495

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1046 20-93, , .

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http://www.ncbi.nlm.nih.gov/m/pubmed/20048020/

, ( 2018) , .

, . , . , .

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https://www.ncbi.nlm.nih.gov/pubmed/29910467

( 2015)    

http://www.ncbi.nlm.nih.gov/pubmed/26472268

 

 

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(, , , ), , , , , , , .

" , " (MAO) . (Hypericum perfoliatum),  Siphocampylus verticillatus,  Fructus Akebiae   Sideritis scardica. / (Glycyrrhiza glabra) .

, . .

http://www.ncbi.nlm.nih.gov/pubmed/24134856

,(2020) , . , , (1-1.5 – 10 ) , , ,

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https://pubmed.ncbi.nlm.nih.gov/33050315/

  ( 2015)      .

710 , . , , , . , , .

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http://www.ncbi.nlm.nih.gov/pubmed/25998000

( 2013)   . , 72 500 " 250 " , , 30 . 

, 2.5 -4 , 30 . 30 .

http://www.ncbi.nlm.nih.gov/pubmed/23364814?dopt=Abstract

 (2021) , (BCAAs) , , . 3,175 18-55 . , 26.4% , 11.9% , -20.9% . 

BCAAs, , -24% -34% . , . . - BCAAs . BCAAs mTor , , .    

https://pubmed.ncbi.nlm.nih.gov/33514378

, (2020) , . 482 20-50. , , ( ) . , (DASS (Depression, Anxiety, Stress Scales. 

, 34%, 40% -42%, . ( 54 /) , 2.5, 1.82 3.47, , ( 21 /). .

, , . 

https://pubmed.ncbi.nlm.nih.gov/33197663/

( 2015) (anxiolytic .

http://www.ncbi.nlm.nih.gov/pubmed/26476141

 

 

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7 469 -419 .

, . , , .

, -12 . 

http://www.ncbi.nlm.nih.gov/pubmed/26559246

( 2013) . , .

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http://www.ncbi.nlm.nih.gov/pubmed/24107199

-  (2021) . , , . 11,605 -136 -29 , 77% 18 -73. 

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https://pubmed.ncbi.nlm.nih.gov/33428616/

 (2018) 25. , 109 , 50 . , 103 - , , , , , , , , . , . 38 , : (16 ), (10 ), (5 ), (3 ), (2 ), ( ) ( ).

, . , . , . .

https://www.ncbi.nlm.nih.gov/pubmed/30522980

( 2015)   , - (PTSD) .

- 13 185 .

, , . . , .

http://www.ncbi.nlm.nih.gov/pubmed/26656487

25 ( 2013), .

http://www.ncbi.nlm.nih.gov/pubmed/24224228

( 2013)   .

, , 3SAMe  .

http://www.ncbi.nlm.nih.gov/pubmed/23769610

 (2020) , . , , . 

60 14-16, . , 30 , , . MSRT (Mind Sound Resonance Technique), , . , , , . 

, MSRT , .

https://pubmed.ncbi.nlm.nih.gov/33197570/

 (2020) - (CBT) (GAD). 226 GAD, :

  • () – 93 .

  • CBT – 90 .

  • ( ) – 43 .

4-6 12 ( – ) 20 .

( ) -CBT -70% -54%, , -33%. 5 2.46, , .

-GAD, CBT , -CBT -.    

https://pubmed.ncbi.nlm.nih.gov/32805013/

 (2019) ( , -, , , ), , . 100 18, . , - .

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https://www.ncbi.nlm.nih.gov/pubmed/31192053

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, 7.43 - -14.17 . . , . - , .
https://www.ncbi.nlm.nih.gov/pubmed/29695937

 ( 2017) . 82 , ( 43 STICSA ).

(Mindfulness Attention Awareness Scale - MAAS) (Positive and Negative Affect Schedule - PANAS), . , , 10 , ( ) ( ) .

, 10 . ( " ") .

.
https://www.ncbi.nlm.nih.gov/pubmed/28376373

( 2013)   . 93 , 8 , . .

http://www.ncbi.nlm.nih.gov/pubmed/23541163

( ) (2020) . , , , . 87 , 30 . , , , , , , . 

, , , , . . ( ), .    

https://pubmed.ncbi.nlm.nih.gov/32147061/

( 2015) .

5 32 . -4 : , - . . .

32.9% -32.6% . , 98.8% .

- .
:  . 

https://pdfs.semanticscholar.org/6268/f2d539d17cf06B2c48a7e346a2f9a8b97593.pdf

( 2013)   .

: , . .

http://www.ncbi.nlm.nih.gov/pubmed/24135553

121 ( 2016)  

http://www.ncbi.nlm.nih.gov/pubmed/26853501

( 2015) , ,  .  

http://www.ncbi.nlm.nih.gov/pubmed/26690627

 

 

 |   |   |  |  |  |  |   |  |   |  | 

 

- (2020) (Crocus sativus) -CRP. 21 , 1,052 , . 22-1,000 "/, 4 12 . 

(Beck Depression Inventory), (Beck Anxiety Inventory) (Pittsburgh Sleep Quality Index). (Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale) -CRP. 

.

https://pubmed.ncbi.nlm.nih.gov/31987241/

 (2020) (Passiflora incarnata) -, , , . , , -30 . , , . 

. , . , -. 

-.     

https://pubmed.ncbi.nlm.nih.gov/33352740/

(2019) . : ( ); ( ); , ; ; , ; ( ); ; , ; ( ), . , , , , . 
, .
https://www.ncbi.nlm.nih.gov/pubmed/30553144
( 2017) (Camellia sinensis) .
21 - 4 , 12 , 4 . ( ) , , .
, - . 
https://www.ncbi.nlm.nih.gov/pubmed/28899506

 (2021) , , . 

https://pubmed.ncbi.nlm.nih.gov/33549281/

 (2020) , , ' (Panax ginseng), (Scutellaria lateriflora), (Matricaria recutita), (Passiflora incarnata), (Hypericum perforatum) . 

https://pubmed.ncbi.nlm.nih.gov/33350538/
(2017) , - (Piper methysticum), (Passiflora incarnata), (Valeriana officinalis), (Matricaria recutita), (Hypericum perforatum) (Scutellaria lateriflora), (Melissa officinalis). .
https://www.ncbi.nlm.nih.gov/pubmed/27804869
( 2016) - , -, ( -) , : (Hypericum perforatum), (Passiflora incarnata), (Piper methysticum), (Valeriana officinalis) (Cimicifuga racemosa). 
https://www.ncbi.nlm.nih.gov/pubmed/26851117
- ( 2015) , , .
4 60.
.
.
http://www.ncbi.nlm.nih.gov/pubmed/26092515
( 2015), , , , .
, - , . , .
, . - , ( ) : (Passiflora incarnata), (Emblica officinalis), (Ocimum tenuiflorum sanctum) Hypericum perforatum
, . 
https://www.ncbi.nlm.nih.gov/pubmed/26409901
(2015) - (EGb761) ( , ) .
, , , ( ).
-9 , , .
, , .
4 - , . (2 ) ( ).
( 24% -6% ) . .
120-240 " , . . 
http://www.ncbi.nlm.nih.gov/pubmed/25642989
( 2014) - .
, (open-label) , -.
, , -11 .
(Valeriana officinalis) -.
: Melissa officinalis, Passiflora incarnate, Matricaria recutita, Humulus lupulus, Scutellaria lateriflora, Ginkgo biloba, Centella asiatica, Rhodiola rosea, Hypericum perforatum, Piper methysticum.
http://www.ncbi.nlm.nih.gov/pubmed/24947278
( 2014) , , .
( - ) , .
D-cycloserine, , , yohimbine .
, , , 3.
http://www.ncbi.nlm.nih.gov/pubmed/23542909
( 2013) .
: - (Piper methysticum), (Matricaria recutita), (Ginkgo biloba), (Scutellaria lateriflora), (Silybum marianum), (Passiflora incarnate), (Withania somnifera), (Centella asiatica), (Rhodiola rosea), (Echinacea spp) (Melissa officinalis).
, : (Centella asiatica), (Salvia spp), (Melissa officinalis), (Passiflora incarnate).
, (Bacopa monnieri).
http://www.ncbi.nlm.nih.gov/pubmed/23653088
(/ 2013), - .
-53 , 32 - -21 .
-, - GABA .
, .
.
( ): Matricaria recutita, Scutellaria lateriflora, Passiflora incarnata, Withania somniferum, Centella asiatica, Rhodiola rosea, Melissa officinalis
http://www.ncbi.nlm.nih.gov/pubmed/23436255
http://www.ncbi.nlm.nih.gov/pubmed/23653088
( 2011) , (Hypericum perforatum) '.
(Rhodiola rosea) .
(Piper methysticum), (Matricaria recutita), (Ginkgo biloba), (Passiflora incarnata) (Scutellaria lateriflora).
http://www.ncbi.nlm.nih.gov/pubmed/21601431
( 2007) .
(Hypericum perforatum) (Piper methysticum) .
(Rhodiola rosea) (Crocus sativus) (Passiflora incarnate), (Scutellaria lateriflora) (Ziziphus jujuba) .
http://www.ncbi.nlm.nih.gov/pubmed/17562566
(2017) , . , , , -, . , : , , , . , .
: (Hypericum perforatum), - (Piper methysticum), (Withania somnifera), ' (Panax ginseng), ' (Panax quinquefolius), (Rhodiola rosea), (Melissa officinalis), (Humulus lupulus), 
(Lavendula angustifolia), (Matricaria recutita), (Valeriana officinalis). 
: 3, SAM-e, , , , , --. 
https://www.ncbi.nlm.nih.gov/pubmed/28501230
- , (2018) 80 12-16 , ®affron, (Crocus sativus). 
Pharmactive Biotech Products . 
https://www.ncbi.nlm.nih.gov/pubmed/29510352

-  (2021) , . 79 500 "/ ™Curcugen, , . ™Curcugen , . GSRS (Gastrointestinal Symptom Rating Scale), , , (DASS-21), (SF-36), (SIBO).

, , . , . 

, , . , , , , . 

DolCas Biotech . 

https://pubmed.ncbi.nlm.nih.gov/33478482/

-  (2020) (Echinacea angustifolia). 62 , ( 45 STAI, -35 ). 40 " - 7 . AnxioCalm, EP107 ™, . , Echinacea purpurea -Echinacea angustifolia; CB1 fatty acid amide hydrolase (FAAH), . 

, 3 ( STAI), ( BDI) ( PSS). 

11 , 3 (p<0.01). . . . 

https://pubmed.ncbi.nlm.nih.gov/31876052/

-  (2019) - , . 80 , 80 "/ - - 8 . , , , , DASS-21-items. 

, . . , . 

https://pubmed.ncbi.nlm.nih.gov/31788880/

-  (2018) (Rosmarinus officinalis) , , . 68 , 500 " - . , , . 

 

 

 

35.53

35.5

30.65

35.59

6.3

6.48

4.63

6.52

4.62

3.6

2.94

3.9

6.13

6.57

4.34

6.2

1.16

1.47

0.63

1.2

0.97

0.9

0.94

1

, , .

https://www.ncbi.nlm.nih.gov/pubmed/29389474

( 2016) (Crocus sativus) .
60 50 " , 12 .
, 6 .
, 12 , (p<0.001), . 
http://www.ncbi.nlm.nih.gov/pubmed/27101556
- ( 2016), , Gan May Zao . 89 , : , 15 -50 " 3 - 3 . Gan May Zao (Glycyrrhiza uralensis), (Ziziphus jujube).
( " " " ") , . , , .
https://www.ncbi.nlm.nih.gov/pubmed/27982406
- ( 2015) - (MVMH) , .
76 50-75. , .
, .
http://www.ncbi.nlm.nih.gov/pubmed/25903286
( 2015) MLC901 ( : NurAiDII) . 9 , : Astragalus membranaceus, Salvia miltiorrhiza, Paeonia spp, Ligusticum striatum, Angelica sinensis. . 
, .
, . , .
http://www.ncbi.nlm.nih.gov/pubmed/25821139
(Ganoderma lucidum) 20-130 "/" diazepam 1 "/".
https://www.ijmrhs.com/abstract/anxiolyticlike-activity-of-ethanol-extract-of-ganoderma-lucidum-reishi-in-mice-1830.html
Astragaloside IV (immobilization stress model), ( ) buspirone ( ). 5-HT1A GABAA. , , IL-6 -TNFɑ . .
https://www.ncbi.nlm.nih.gov/pubmed/24709311

 

 

 (2021) - - (Withania somnifera), , , , . . , , . 

- – – , GABA . withanolide, . - , . , . 

https://pubmed.ncbi.nlm.nih.gov/34254920/

 (2016) - , (Withania somnifera) . - ( ) , , .

, , , , , , . 
, . , . , .
https://www.ncbi.nlm.nih.gov/pubmed/27316579

( 2014) . 5 , -3 2 . 56% 30%. 44% 5% .
, -.
http://www.ncbi.nlm.nih.gov/pubmed/25405876
(/ 2013), - .
-53 , 32 - -21 .
-, - GABA .
, .
.
( ): Matricaria recutita, Scutellaria lateriflora, Passiflora incarnata, Withania somniferum, Centella asiatica, Rhodiola rosea, Melissa officinalis
http://www.ncbi.nlm.nih.gov/pubmed/23436255
http://www.ncbi.nlm.nih.gov/pubmed/23653088

- , (2019) , (Withania somnifera), . 60 , ( 2:1) . 300 " - - 10 .
(sleep onset latency), . , , . 
, .
https://pubmed.ncbi.nlm.nih.gov/31728244/

( 2000) (Generalised anxiety disorder). -39 (ICD-10 – International Classification of Disease) ( 1 – -6-8 ) . . 500-2500 " ( 1250 "). (88.2%) (Hamilton Anxiety Scale) (50%), (19 ) . / .
http://www.ncbi.nlm.nih.gov/pubmed/21407960
( 2009) . 81 12 . , , (Swiss – senior multi one®) ( 1.5%withanolides) 600 " . , . 75 . , 56.5% (Beck Anxiety Inventory, p<0.0001) 30.5% (p<0.0001). (p=0.003).
/ (p<0.0001), (p<0.0001), (p<0.0001), (p=0.007) (p=0.0004). / , .
http://www.ncbi.nlm.nih.gov/pubmed/19718255

( 2012) . 64 ( 18-54) ( , -15 WHO-5, 14 Perceived stress scale) . ( 5% withanolides ) 600 " 60 . (p<0.0001), (27.9% 7.9%, p=0.0006). , .
https://www.ncbi.nlm.nih.gov/pubmed/23439798

( 2008) ( ®Sensoril Essentra) (Chronic stress). -130 125 " , 125 " , 250 " 60 . 12% withanolides -1% withaferin A 125 " -1 ( 8:1). 32 . (A modified Hamilton Anxiety Scale – Mham-A)(p<0.001) -70%. 250 " . . (p<0.05 p<0.001). .
https://blog.priceplow.com/wp-content/uploads/2014/08/withania_review.pdf
(- 2013) (Generalised anxiety disorder). -101 ( 16-60) -DSM-IV 12 60 . 86 (44 -42 ) . (Hamilton's Anxiety Rating Scale) (Anxious mood) (p<0.001). , 58% ( 51-75%) . , 82% ( 26-50%) -40% . http://iamj.in/posts/images/upload/01.05.14_IAMJ.pdf
( 2016) . 30 -DSM-IV-TR 120 " . (SSRI's). - (The Yale-Brown Obsessive-Compulsive Scale) ( p<0.001). -SSRI .

https://www.ncbi.nlm.nih.gov/pubmed/27515872

 

 

 (Valeriana officinalis)

 (2017) , - (Piper methysticum), (Passiflora incarnata), (Valeriana officinalis), (Matricaria recutita), (Hypericum perforatum) (Scutellaria lateriflora), (Melissa officinalis). .
https://www.ncbi.nlm.nih.gov/pubmed/27804869

( 2014)   -

.

, (open-label) , -.

, , -11 .

(Valeriana officinalis) -.

http://www.ncbi.nlm.nih.gov/pubmed/24947278

( 2006)  (Valeriana officinalis). () .

http://www.ncbi.nlm.nih.gov/pubmed/17054208

 

 (2019) (Valeriana officinalis) . 64 , , - 100 " 4 .

(") . , . , , . , -

https://www.ncbi.nlm.nih.gov/pubmed/30632220

 

-  (2019) (Valeriana officinalis) , . (EEG) . 64 , . 100 " 3 - 4 .

, . , -EEG , , . , -.

https://www.ncbi.nlm.nih.gov/pubmed/30632220

( 2007) (Valeriana wallichii). 33 34   500 " , .

, .

http://www.ncbi.nlm.nih.gov/pubmed/17593676

 

 

 (Matricaria recutita)

-  (2019) Matricaria recutita Chamaemelum nobile . 12 , 965 . , - , - - (). , - , , , , . 400 " 2 , ' . 

( ) ( ). , . , . 

, . 

https://www.ncbi.nlm.nih.gov/pubmed/31006899

 ( 2016) (Matricaria recutita) . 179 . 
, 500 "* 3 8 . GAD-7 . 58% -15.6% . -11.7% . , . 
93 - . (500 "* 3 ) - 26 . . (25.5% 15.2%), 11.4 6.3 .

-50% , (p=0.16). , . . , . . , .  
.  
https://www.ncbi.nlm.nih.gov/pubmed/27912871
https://www.ncbi.nlm.nih.gov/pubmed/27912875

 (2020) , , ' (Panax ginseng), (Scutellaria lateriflora), (Matricaria recutita), (Passiflora incarnata), (Hypericum perforatum) . 

https://pubmed.ncbi.nlm.nih.gov/33350538/

 (2017) , - (Piper methysticum), (Passiflora incarnata), (Valeriana officinalis), (Matricaria recutita), (Hypericum perforatum) (Scutellaria lateriflora), (Melissa officinalis). .
https://www.ncbi.nlm.nih.gov/pubmed/27804869

(/ 2013), - .

-53 , 32 - -21 .

-, - GABA  .

, .

.

( ): Matricaria recutita, Scutellaria lateriflora, Passiflora incarnata, Withania somniferum, Centella asiatica, Rhodiola rosea, Melissa officinalis

http://www.ncbi.nlm.nih.gov/pubmed/23436255

http://www.ncbi.nlm.nih.gov/pubmed/23653088

( 2013)   .

http://www.nursingcenter.com/lnc/JournalArticle?Article_ID=1613077

( 2013)   .     (Matricaria recutita).

http://www.ncbi.nlm.nih.gov/pubmed/23653088

( 2011)   ,      (Piper methysticum),  (Matricaria recutita),  (Ginkgo biloba),  (Passiflora incarnata)  (Scutellaria lateriflora).

http://www.ncbi.nlm.nih.gov/pubmed/21601431

( 2009)    (Matricaria recutita)  . 57 (220 " ) 8 .

, , .

http://www.ncbi.nlm.nih.gov/pubmed/19593179

 

 

(Melissa officinalis

 (2017) , - (Piper methysticum), (Passiflora incarnata), (Valeriana officinalis), (Matricaria recutita), (Hypericum perforatum) (Scutellaria lateriflora), (Melissa officinalis). .
https://www.ncbi.nlm.nih.gov/pubmed/27804869
( 2013)   .    (Melissa officinalis). .

 

http://www.ncbi.nlm.nih.gov/pubmed/23653088

(/ 2013), - .

-53 , 32 - -21 .

-, - GABA  .

, .

.

( ): Matricaria recutita, Scutellaria lateriflora, Passiflora incarnata, Withania somniferum, Centella asiatica, Rhodiola rosea, Melissa officinalis

http://www.ncbi.nlm.nih.gov/pubmed/23436255

http://www.ncbi.nlm.nih.gov/pubmed/23653088

- ( 2015)   . 71 500 " 14 .

55 , . .  

http://www.ncbi.nlm.nih.gov/pubmed/25680840

- ( 2015)   (Melissa officinalis .

  55 500 " .

, . .

http://www.ncbi.nlm.nih.gov/pubmed/25680840

 

 

 (Scutellaria lateriflora) 

 (2020) , , ' (Panax ginseng), (Scutellaria lateriflora), (Matricaria recutita), (Passiflora incarnata), (Hypericum perforatum) . 

https://pubmed.ncbi.nlm.nih.gov/33350538/

 (2017) , - (Piper methysticum), (Passiflora incarnata), (Valeriana officinalis), (Matricaria recutita), (Hypericum perforatum) (Scutellaria lateriflora), (Melissa officinalis). .
https://www.ncbi.nlm.nih.gov/pubmed/27804869

(/ 2013), - .

-53 , 32 - -21 .

-, - GABA  .

, .

.

( ): Matricaria recutita, Scutellaria lateriflora, Passiflora incarnata, Withania somniferum, Centella asiatica, Rhodiola rosea, Melissa officinalis

http://www.ncbi.nlm.nih.gov/pubmed/23436255

http://www.ncbi.nlm.nih.gov/pubmed/23653088

( 2013)   .      (Scutellaria lateriflora).

http://www.ncbi.nlm.nih.gov/pubmed/23653088

( 2011)   ,      (Piper methysticum),  (Matricaria recutita),  (Ginkgo biloba),  (Passiflora incarnata)  (Scutellaria lateriflora).

http://www.ncbi.nlm.nih.gov/pubmed/21601431

( 2013)    (Scutellaria lateriflora)  . 43 350 " , .

, . , .

http://www.ncbi.nlm.nih.gov/pubmed/23878109

 

 

(Centella asiatica)

, (Centella asiatica) (GAD). 33 ( , ). 60 ( 1.5-1.8% ursolic acid) 1 ( -9 ), . , , . (26%), (23%), (22%), (35%) (28%). .
: , ; , .
https://www.ncbi.nlm.nih.gov/pubmed/20677602

- - (Centella asiatica) , ; , . , 40 (20 ) (20 ). ( , ) 12 . , . , , . , , .
https://www.ncbi.nlm.nih.gov/pubmed/11106141

( 2013)   . (Centella asiatica). .

http://www.ncbi.nlm.nih.gov/pubmed/23653088

(/ 2013), - .

-53 , 32 - -21 .

-, - GABA  .

, .

.

( ): Matricaria recutita, Scutellaria lateriflora, Passiflora incarnata, Withania somniferum, Centella asiatica, Rhodiola rosea, Melissa officinalis

http://www.ncbi.nlm.nih.gov/pubmed/23436255

http://www.ncbi.nlm.nih.gov/pubmed/23653088

 

 

(Piper methysticum

- ( 2018), 12 , - (Piper methysticum) . - 4-8 120-180 "/ Kavalactones. 
https://www.ncbi.nlm.nih.gov/pubmed/29641222

- ( 2013)   - (Piper methysticum (GAD).

75 120/240 " 6 .

, . , 26% 6% .

-  GABA. -.

http://www.ncbi.nlm.nih.gov/pubmed/23635869

( 2013)   .  - (Piper methysticum).

http://www.ncbi.nlm.nih.gov/pubmed/23653088

( 2011)   ,      (Piper methysticum),  (Matricaria recutita),  (Ginkgo biloba),  (Passiflora incarnata)  (Scutellaria lateriflora).

http://www.ncbi.nlm.nih.gov/pubmed/21601431

 

 

(Passiflora incarnate)

 (2020) , , ' (Panax ginseng), (Scutellaria lateriflora), (Matricaria recutita), (Passiflora incarnata), (Hypericum perforatum) . 

https://pubmed.ncbi.nlm.nih.gov/33350538/

( 2013) – , .

, .
-   , , - . , .  

http://www.ncbi.nlm.nih.gov/pubmed/24140586

( 2013)   .  (Passiflora incarnate). .

http://www.ncbi.nlm.nih.gov/pubmed/23653088

( 2011)   ,      (Piper methysticum),  (Matricaria recutita),  (Ginkgo biloba),  (Passiflora incarnata)  (Scutellaria lateriflora).

http://www.ncbi.nlm.nih.gov/pubmed/21601431

(/ 2013), - .

-53 , 32 - -21 .

-, - GABA  .

, .

.

( ): Matricaria recutita, Scutellaria lateriflora, Passiflora incarnata, Withania somniferum, Centella asiatica, Rhodiola rosea, Melissa officinalis

http://www.ncbi.nlm.nih.gov/pubmed/23436255

http://www.ncbi.nlm.nih.gov/pubmed/23653088

 

 

 (Ginkgo biloba)

(2015) - (EGb761) ( , )   .

, , , ( ).
-9 , , .

,    , .

4 - , . (2 )  ( ).

( 24% -6% ) .    .

120-240 " , . . 

http://www.ncbi.nlm.nih.gov/pubmed/25642989

( 2013)   .  (Ginkgo biloba).

http://www.ncbi.nlm.nih.gov/pubmed/23653088

( 2011)   ,      (Piper methysticum),  (Matricaria recutita),  (Ginkgo biloba),  (Passiflora incarnata)  (Scutellaria lateriflora).

http://www.ncbi.nlm.nih.gov/pubmed/21601431

 

 

, (2020) ,   . 60 , . ( 2 ) - - . . 

, (p<0.001).

https://pubmed.ncbi.nlm.nih.gov/32444033/

 (Silybum marianum)

( 2010) (OCD) Fluoxetine (). 35 -DSM-IV 600 " Fluoxetine . , , . 
https://www.ncbi.nlm.nih.gov/pubmed/20035818
 

 

 |  B |  3 |  | 

 

-, ,(2019) . 33 -, 10,951 , : , , , , - -ADHD. , , , , . -, , - 3 . - . .

:

  • 3 – EPA (2.2 ) , SSRIs.
  • – 15 "/ - .
  • D – 50,000 '/ .
  • - – 2 /. 

-:

  • - – 2 /. 

:

  • 3 – . 
  • – , 15 "/ -. 

, . , 3 , -.  

https://www.ncbi.nlm.nih.gov/pubmed/31496103

- , (2020) - ( / ) . 16 1,719 , : , , -, , ADHD, . 

. B6, B9 B12, -13 D, -14 . . , . , B , ADHD. - , . , - . 

-NIH .   

https://pubmed.ncbi.nlm.nih.gov/33158241/

,  (2021) D . D , . 24 . D , , , , .

, D . , . 

, D, , . 

https://pubmed.ncbi.nlm.nih.gov/33809478/

 (2019) . , . , , , - . , - , B12. , , .

, , , , , , . . , , , , , , . .

https://pubmed.ncbi.nlm.nih.gov/31735529/

 (2016) , , -, , -, , . . , , -, B, , , , , , C, E; , , , . , (, , )

https://www.ncbi.nlm.nih.gov/pubmed/27651266

( 2013),  GABA  .

  100 " GABA   .  GABA   B3  , , .

http://www.ncbi.nlm.nih.gov/pubmed/23538074

( 2013)   .

, , 3SAMe  .

http://www.ncbi.nlm.nih.gov/pubmed/23769610

 (2017) , . , , , -, . , : , , , . , .

: 3, SAM-e, , , , , --. 

https://www.ncbi.nlm.nih.gov/pubmed/28501230

-  (2020) SAMe . 90 18-60 , 6 . , 200 " (SAMe (S-adenosylmethionine -1 Lactobacillus plantarum, . 

(Z-SDS (Zung Self-Rating Depression Scale, . , 2 - .  

SAMe , , . 

Nutrilinea, . 

https://pubmed.ncbi.nlm.nih.gov/32589828/

- ( 2015)   C  . 42 500 "   C  .

  C    C  .  C  .

http://www.ncbi.nlm.nih.gov/pubmed/26353411

- ( 2015)   - (MVMH) , .

76 50-75. , .

, .

http://www.ncbi.nlm.nih.gov/pubmed/25903286

 
( 2015)  . -2013, - .

56 23-66  D, B - , 6 .

, B -  D.

http://www.ncbi.nlm.nih.gov/pubmed/26154816

( 2012) C, E A , . 80 20-60 .

C, E A .

, E .

http://www.ncbi.nlm.nih.gov/pubmed/23226848

, (2018) , (SCFA) . , . SCFA, . , SCFA (, ). , 3 - . 

 

, , . , -SCFA . (" -") .  

https://www.ncbi.nlm.nih.gov/pubmed/30066368

 

 

B

- , (2020) - ( / ) . 16 1,719 , : , , -, , ADHD, . 

. B6, B9 B12, -13 D, -14 . . , . , B , ADHD. - , . , - . 

-NIH .   

https://pubmed.ncbi.nlm.nih.gov/33158241/

 (2019) . , . , , , - . , - , B12. , , .

, , , , , , . . , , , , , , . .

https://pubmed.ncbi.nlm.nih.gov/31735529/

( 2013)     B .

60 B  .  Bx  , . .

http://www.ncbi.nlm.nih.gov/pubmed/23738221

 (2021) , B6, . 264 18-50 , (0.66-0.84 /). 300 " -30 " B6 (Magne B6®) 300 " (®Magnespasmyl)  . , ,

, . , . , . . 

, B6, . , , . 

https://pubmed.ncbi.nlm.nih.gov/33864354/

( 2015)  . -2013, - .

56 23-66  D, B - , 6 .

, B -  D.

http://www.ncbi.nlm.nih.gov/pubmed/26154816

(2013)  B2B6B12  - , .    B6  -.

http://www.ncbi.nlm.nih.gov/pubmed/23603926

 

 

3

- (2018) 3 . 19 (16 ), " 1,203 3 -1.6 -1,037 3. , , 3 . - 3 -2 . 3 , 3

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2702216

 (2018) 3 . , " 496 , , 3 :

  1. .
  2. (BDNF), .
  3. , . 

, 3 . , , 3, , / , . 

https://www.ncbi.nlm.nih.gov/pubmed/30264663

 (2019) . , . , , , - . , - , B12. , , .

, , , , , , . . , , , , , , . .

https://pubmed.ncbi.nlm.nih.gov/31735529/

 (2016)  3 . , - ALA, EPA, DHA -DPA - . , 3 - , - . , 3 , , . : , , ADHD, , . , 3 3 -. , 3. , 3 - - . 3 , , 3 .

https://www.ncbi.nlm.nih.gov/pubmed/27651257

( 2013)   .

, , 3SAMe  .

http://www.ncbi.nlm.nih.gov/pubmed/23769610

( 2015)   3 6 -, .

, - EPA. EPA .   . - , .

- 3

http://www.ncbi.nlm.nih.gov/pubmed/26424416

3 . ( 2013) 3 , 3.

      3 .

, .

http://www.ncbi.nlm.nih.gov/pubmed/23890734

( 2013),   3.

. , .

http://www.ncbi.nlm.nih.gov/pubmed/23768007

 

 

, (2019) . , -, . , . 21 , 1,503 (10 ), (6 ) ( , , , 2). , , . ( Lactobacillus), . 

21 , -11 , 5 -6 FODMAP. 86% (6 7 ). 

,

https://www.ncbi.nlm.nih.gov/pubmed/31179435

 (2020) - . , . . Lactobacillus acidophilus, Lactobacillus casaei, Bifidobacterium bifidium. , - - . 

( , , ) , . 

- , , . , , . 

https://nutrition.bmj.com/content/early/2020/06/09/bmjnph-2019-000053

 (2018) , , .

:

  • , -, .
  • - (FOS -GOS) -5 bifidobacteria. 
  • ,
  • .

, 3, - .

https://www.ncbi.nlm.nih.gov/pubmed/29985786

-  (2020) SAMe . 90 18-60 , 6 . , 200 " (SAMe (S-adenosylmethionine -1 Lactobacillus plantarum, . 

(Z-SDS (Zung Self-Rating Depression Scale, . , 2 - .  

SAMe , , . 

Nutrilinea, . 

https://pubmed.ncbi.nlm.nih.gov/32589828/

-  (2019) . 103 32 , . 12 . 2 /, 20 Lactobacillus plantarum. 

, 4 . , - IFN-γ -TNF-α. , . 

, .

, . 

https://pubmed.ncbi.nlm.nih.gov/30266270/

-  (2018) . 103 , . 20 Lactobacillus plantarum 12 .

, , , , . (IFN-γ, TNF-α). , , . , - . , . 

Beijing Scitop Biotech Co : JinHua YinHe Biological Technology Co. Ltd., China. 

https://www.clinicalnutritionjournal.com/article/S0261-5614(18)32448-8/fulltext

- ( 2017) Bifidobacterium longum (IBS).

48 IBS, / . ( 10 -100-200 , - -20 ) () - 6 . , , IBS , 6 4 (" 10 ). (fMRI) .

(14/22 7/22, p=0.04). IBS, . ,
: ( "") . 

 https://www.ncbi.nlm.nih.gov/pubmed/28483500

 (2021) , , IT . 36 ©PS128, -20 Lactobacillus plantarum. 20% PSS (Perceived Stress Scale). ,

, , , , , , , , . -, , , .

, , .   

.Bened Biomedical Co., Ltd . 

https://pubmed.ncbi.nlm.nih.gov/33842519

 (2020) . , -, . -655 42 -20 ; ". . 

, .

- , . - .    

https://www.sciencedirect.com/science/article/pii/S2452231719300181

  ( 2015)      .

710 , . , , , . , , .

  .  

http://www.ncbi.nlm.nih.gov/pubmed/25998000

 

 

 | 

 

 (2020) . , ,

32 , (18 ), (4 ), ADHD (4 ), (4 ), OCD ( ), ( ) ( ). 

:

  • -12

  • 5 , -3 -2 . 

  • ,

  • ADHD.

  • 3 , .

, , . , -

https://pubmed.ncbi.nlm.nih.gov/32503201/

(2017) 18 , , " " . , , .

https://www.ncbi.nlm.nih.gov/pubmed/28445426

(2017) 26 52 , 248 " 6 (P<0.001) 56% (6 ) (PHQ-9 (Patient Health Questionnaire-9 - , (P<0.001) 52% (4.5 ) GAD-7) Generalized Anxiety Disorder-7 – ).

https://www.ncbi.nlm.nih.gov/pubmed/28654669

(1987-1988), 300 " 750 " B6, 6 , , Lorazepam. , .

Bourgeois M. Rôle du Magne-B6 dans les manifestations anxieuses en pratique médicale courante. Psychiatr Pract Med . 1987; 39: 18-22.

Scharbach H. . Anxiété et Magné B6. La Vie Médicale. . 1988;17:867.

 (2021) , B6, . 264 18-50 , (0.66-0.84 /). 300 " -30 " B6 (Magne B6®) 300 " (®Magnespasmyl)  . , ,

, . , . , . . 

, B6, . , , . 

https://pubmed.ncbi.nlm.nih.gov/33864354/

 

: - (HPA); CRH (PVN); ACTH NMDA -BDNF .

  - .

 

 

 | 

 

 

-  (2020) . 20 ( 1,284 ), 7 : , ( ), , , , , . -15 ,

, , , , , . . , . , , .  

https://pubmed.ncbi.nlm.nih.gov/32147030/

-  (2019) Matricaria recutita Chamaemelum nobile . 12 , 965 . , - , - - (). , - , , , , . 400 " 2 , ' . 

( ) ( ). , . , . 

, . 

https://www.ncbi.nlm.nih.gov/pubmed/31006899

- (2018) . , ( ) , . , .

, , . 

https://www.ncbi.nlm.nih.gov/pubmed/30202763

,(2019)  , 160 , , , .

https://www.ncbi.nlm.nih.gov/pubmed/30817616

 (2020) - , . , , . 

, (Boswellia), (Cananga odorata), (Cinnamomum verum), (Citrus aurantium), (Citrus bergamia), (Citrus sinensis), (Cymbopogon citratus), (Lavandula angustifolia), (Citrus paradisi), (Pelargonium graveolens), (Rosa damascena), (Rosmarinus officinali), (Salvia sclarea), (Anthemis nobilis), ' (Pogostemon cablin), (Mentha piperita), (Salvia officinalis). 

, , , . . , , , , , . 

, , , .   

https://pubmed.ncbi.nlm.nih.gov/32860651/

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https://www.ncbi.nlm.nih.gov/pubmed/29724056

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https://pubmed.ncbi.nlm.nih.gov/31211612

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https://www.ncbi.nlm.nih.gov/pubmed/30712728

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https://pdfs.semanticscholar.org/6268/f2d539d17cf06B2c48a7e346a2f9a8b97593.pdf

 

 

-  (2019) , , . 90 , 65 , 37 , 3,964 . 

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http://www.ncbi.nlm.nih.gov/pubmed/26092515

 

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http://www.ncbi.nlm.nih.gov/pubmed/23808618

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http://www.ncbi.nlm.nih.gov/pubmed/24733781
http://www.ncbi.nlm.nih.gov/pubmed/26330438

( 2013)   ,   .

http://www.ncbi.nlm.nih.gov/pubmed/24199975?dopt=Abstract

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https://www.ncbi.nlm.nih.gov/pubmed/30205934