B-12 ()

15/08/2018

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B12 B. .

(IF – Intrensic Factor). , .

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  B12:

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  • - 30%-40% .

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 B12  . (IF – Intrinsic Factor). . 2 . 1. ,  B12  . , .

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  B12 ():

 B12. . ( ).

 

  B12  - RDA (Recommended daily allowance):

  • 6 - 0.4 "
  • 7 - 0.5 "

  • 1-3 - 0.9 "

  • 4-8 - 1.2 "

  • 9-13 - 1.8 "

  • 14 - 2.4 "

  • 9-13 - 1.8 "

  • 14 - 2.6 "

  • - 2.6 "

  • - 2.8 "

 

 ** - RDA, 2-6 " , .

 

B12 - (ODA(optimal daily allowance:

 B12  ( ) 2000 " .

  

B12:

  • - 1000 " " 100-200 " . - 30-50 " .
  • - 2-3 " .
  • - 30-50 " .
  •  - 250 " 3 , .

  ,  B12  , , .
 

– ()   B12:

  •  -  B12  (DNA) , .  B121.
  • C -  C  B  ( ).  C   B12  1.
  •  B6   B12   B   B6   2.
  • D -   B12  D  3.
  •    B12  (Metformin (Glucophage, Glucomin  4.
  •   (Gentamicin (Gentamicin -(Amikacin (Amikin  .  B12  5.
  • (Chloramphenicol) – 
    Chloramphenicol (Chloramphenicol)  .  B12   B6  6.
  • –   B   B12  -(SSRI  Fluoxetine (Flutine,Prozac,Prizma), Paroxetine (Seroxate,Paxxet

- (Citalopram (Cipramil,Recital  - SNRI  (Venlafaxine (Venla,Efexor,Viepax 
  - (Duloxetine (Cymbalta  7.  B12 

  .

  •    B12 

Simvastatin (Simvacor, Simvaxon), Pravastatin (Lipidal) -(Atorvastatin (Lipitor   

8.

  • -   B12  ( ) : ( 9Gestodene- Estrogen (Gynera, Minulet, Meliane, Harmonet, Emily.
  •    B12  10.

– ()   B12:

  •    B1211.
  •   :

    Gestodene- Estrogen (Gynera, Minulet, Meliane, Harmonet, Emily)   B129.

  •   : (Ciprofibrate  (Lipanor -

  • Bezafibrate (Bezafibrate, Norlip)   B1212.

  •   (Resins) (Colestyramine (Questran), Colistin (Coliracin - (Colestipol (Colestid   B1213.

  • -  (Biguanides) ,  Metformin (Glucophage, Glucomin)  ,  B1214,4.
    B12, -2,000 850 " 3.2 23. 9 . B12 5 13 . ,  B12. , B12 B12.  B12 .

  • (PPIs) –  - (Omeprazole (Omepradex, Losec - (Lantoprazole (Lanton  ,  B1215.

  • (Methotrexate– (Methotrexate (MTX  ,  B12   B  ( )16. ,  B  .
  • -   ( ), (Primidone  (Prysoline - (Carbamazepine  (Teril, Tegretol   B12,  B617.
  • (Chloramphenicol) –  (Chloramphenicol (Chloramphenicol   B12  18.
  • (Colchicine) –  (Colchicine (Colchicine  .  B12. ,  B12  19,20.

  • -  ( )  B12  21.

  • –  (Zidovudine (Combivir, Retrovir, Trizivir   B12 22

 

:

 B12.

 

B12:

 

- (double-blind) 16 " 140 18-68 .

, 2 " - 400 "  B12  .

 B12  , .

.

, .

http://archpsyc.jamanetwork.com/article.aspx?articleid=1660588

 B12  .  B12   B12  .

105 8 400 "  B12 (hydroxycobalamin) , .

.

 B12   B12.

, .

 B12  .

.

http://www.ncbi.nlm.nih.gov/pubmed/24025626

-100  B12  

– .

, ,  B12  . 

, -B12  " , 

, 0.7-8 " B12 -100 , .

, , .

http://www.ncbi.nlm.nih.gov/pubmed/23782218

,  B12. -26  B12  -184  B12.

 B12, . 

.

B1,  D, ) (, ) .

http://www.ncbi.nlm.nih.gov/pubmed/24327038

 B12  -POTS  ..

http://www.ncbi.nlm.nih.gov/pubmed/24366986

 B12  . 

790 70-81 -6 . 110 , 

 B12  ,

.

http://www.ncbi.nlm.nih.gov/pubmed/24129588

 B12  .

 B12  ,

.  B12

, .

 B12  .

 B12 

 B12, .

,  B12 

( 350-400).

http://www.ncbi.nlm.nih.gov/pubmed/24911144

 B12  , .

http://www.ncbi.nlm.nih.gov/pubmed/24699807

 B12  .

http://www.ncbi.nlm.nih.gov/pubmed/25195560

-7,000 ,  B6  B12,

.

http://www.ncbi.nlm.nih.gov/pubmed/25201007

 B12  .

http://www.ncbi.nlm.nih.gov/pubmed/25391305

.

,

-12 E  -6.1 " .

,   B12.

, .

http://www.ncbi.nlm.nih.gov/pubmed/25323849

( 2014)    B1   (DDT).

291  B  -DDT.

385 , 31% .

 B12 , -DDT   B12 

-DDT  .

, .

http://www.ncbi.nlm.nih.gov/pubmed/25411282

( 2015)    B12  .

http://www.ncbi.nlm.nih.gov/pubmed/25802345

( 2015)    B 
, 3
.
3
.
168
 B  (0.8 " , 20 " B6, 0.5 " B12).
(MRI) .
3, .
3 ( 590 ),
 B  -40% .
, 3 ( 390 )  B.

http://www.ncbi.nlm.nih.gov/pubmed/25877495

( 2015)    B12  ,

    .

 B12 ,  B12  10 .

, , .

.

 B12  .

http://www.ncbi.nlm.nih.gov/pubmed/26109103

( 2015)    B 

3 .

168 70  B 

(0.8 " , 20 " B6, 0.5 " B12) .

 MRI  .

 B  3 .

3  B  ,

3  B  .

http://www.ncbi.nlm.nih.gov/pubmed/25877495

- ( 2015)
 B12     B12.

-200 75  B12  107-210 / .

1 " B12  .  B12   B12 ,

.

.

http://www.ncbi.nlm.nih.gov/pubmed/26135351

- ( 2015)   B 

.

2,919 65  B12+ .

- 569 .

,  B  .

, .

.

http://www.ncbi.nlm.nih.gov/pubmed/26147383

(EFSA), ( 2015)
    (DRV) B1 E.

, (AR)

(AI). 
B12,  B12  .

(AI) 4 " , 1.5-4 " ,

4.5 " -5 " . 
E, E .

E .

(AI) 13 " -11 " , 5-9 " 10

-13 " / 11 " / 10-18.

, . 

http://www.efsa.europa.eu/en/efsajournal/doc/4150.pdf
http://www.efsa.europa.eu/en/efsajournal/doc/4149.pdf

- ( 2015)    B12

 B12  .

201 75  B12  107-210 / 1 " B12  .

 B12  .

http://www.ncbi.nlm.nih.gov/pubmed/26135351

( 2015)    B12  .

http://www.ncbi.nlm.nih.gov/pubmed/26374177

, ( 2016)    B12  .

2,919 500 "  B12 -400 " . 522 , CRP.

http://www.ncbi.nlm.nih.gov/pubmed/26774115

( 2015) -12,000   -BMI 5-6   B12 

http://www.ncbi.nlm.nih.gov/pubmed/26810674

( 2016)    B12  -14%, .

http://www.ncbi.nlm.nih.gov/pubmed/26781161

( 2016)    B12  ('). -2,000 850 " 3.2 . 9 .

 B12  5 13 . ,  B12. ,  B12   B12.

 B12  . 

http://www.ncbi.nlm.nih.gov/pubmed/26900641

( 2016)    B12  154 , (54) .

,  B12  .

,  B12  .

 B12  , . 

http://www.ncbi.nlm.nih.gov/pubmed/26927168


:

 

 

Stargrove M B, Treasure J, McKee D. L, Herb, Nutrient, and Drug Interactions, Elsevier, 2008. pp 338-355.

www.naturaldatabase.com – Cobalamin. found at -  http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=NONMP&s=ND&pt=100&id=926&ds=&name=B12+(VITAMIN+B12)&searchid=28163322

, -, " ", , 2005

www. Naturalstandard.com – Cobalamin. found at - http://naturalstandard.com/search-advanced.asp?text=b12&GO.x=0&GO.y=0

., ' ' ., " ", -, 1995

National Academy of Sciences. Institute of Medicine. Food and Nutrition Board

DRI table for DRI tables for recommended dietary allowances (RDA). found at - 

http://www.iom.edu/Activities/Nutrition/SummaryDRIs/DRI-Tables.aspx

U.S. Institutes Of Health – Office Of Dietary Supplements – RDA tables. found at -

http://ods.od.nih.gov/Health_Information/Dietary_Reference_Intakes.aspx

Patrick Holford, "Special Report: Supplements – Optimum Daily Allowances". found at – 

http://www.patrickholford.com/index.php/advice/betterhealtharticle/138/

 

  1. Stargrove M B, Treasure J, McKee D. L, Herb, Nutrient, and Drug Interactions, Elsevier, 2008. pp 338-355.

  2. Wilson A, Leclerc D, Rosenblatt DS, Gravel RA. Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism. Hum Mol Genet 1999;8:2009-2016.

  3. Sato Y, Honda Y, Iwamoto J et al. Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA 2005;293:1082-1088.

  4. Bauman WA, Shaw S, Jayatilleke E et al. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000;23:1227-1231.

  5. Shemesh Z, Attias J, Ornan M et al. Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss. Am J Otolaryngol 1993;14:94-99.

  6. Cocke JG Jr. Chloramphenicol optic neuritis: apparent protective effects of very high daily doses of pyridoxine and cyanocobalamin. Am J Dis Child 1967;114:424-426.

  7. Tiemeier H, van Tuijl HR, Hofman A et al. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatry 2002;159:2099-2101.

  8. MacMahon M, Kirkpatrick C, Cummings CE et al. A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH). Nutr Metab Cardiovasc Dis 2000;10:195-203.

  9. Briggs M. Oral contraceptives and vitamin requirements [letter]. Med J Aust 1975;1:407.

  10. Vogelzang NJ, Rusthoven JJ, Symanowski J et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003;21:2636-2644.

  11. Sato Y, Honda Y, Iwamoto J et al. Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA 2005;293:1082-1088.

  12. Robinson C, Weigly E. Clofibrate inhibits absorption of vitamin B12. Basic Nutrition and Diet Therapy. New York: Macmillan; 1984:46-54.

  13. Coronato A, Glass GB. Depression of the intestinal uptake of radio-vitamin B12 by cholestyramine. Proc Soc Exp Biol Med 1973;142:1341-1344.

  14. Adams JF, Clark JS, Ireland JT et al. Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy. Diabetologia 1983;24:16-18.

  15. Bradford GS, Taylor CT. Omeprazole and vitamin B12 deficiency. Ann Pharmacother 1999;33:641-643.

  16. Leeb BF, Witzmann G, Ogris E et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-463.

  17. Apeland T, Mansoor MA, Strandjord RE, Kristensen O. Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. Acta Neurol Scand 2000;101:217-223.

  18. Saidi P, Wallerstein RO, Aggeler PM. Effect of chloramphenicol on erythropoiesis. J Lab Clin Med 1961;57:247-256.

  19. Stopa EG, O’Brien R, Katz M. Effect of colchicine on guinea pig intrinsic factor–vitamin B12 receptor. Gastroenterology 1979;76:309-314.

  20. Palopoli JJ, Waxman J. Colchicine neuropathy or vitamin B12 deficiency neuropathy? N Engl J Med 1987;317:1290-1291.

  21. Kroes AC, Lindemans J, Abels J. [Interaction between nitrous oxide and vitamin B12]. Ned Tijdschr Geneeskd 1985;129:2243-2247.

  22. Paltiel O, Falutz J, Veilleux M et al. Clinical correlates of subnormal vitamin B12 levels in patients infected with the human immunodeficiency virus. Am J Hematol 1995;49:318-322.

  23. Aroda VR, et al. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metab. 2016 Feb 22:jc20153754. [Epub ahead of print]






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