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אדמונית - Paeonia spp.

עודכן בתאריך 12/05/2022

Peony - Bai shao / Chi shao / Mu dan pi


משפחה בוטנית: אדמוניתיים – Paeoniaceae

חלק הצמח | איכויות | רכיבים פעילים | התוויות | מינונים | רגישות | תופעות לוואי | 

מינון יתר | אזהרות | התוויות נגד | רעילות | אינטראקציות | הריון | הנקה

 

מונוגרף זה מתייחס לשלושת המינים הבאים:

P. lactiflora / Alba (שם עממי: White Peony), המוכר ברפואה הסינית תחת השם Bai shao (כאשר הקליפה קולפה מן השורש);

P. veitchii / Rubra (שם עממי: Red Peony / Veitch's peony), המוכר ברפואה הסינית תחת השם Chi shao (אם כי גם שורש P. lactiflora שאינו מקולף יכול לשמש כחומר גלם לתמצית זו);

P. suffruticosa (שם עממי: Chinese tree peony), המוכר ברפואה הסינית תחת השם Mu dan pi.

שם הסוג הבוטני נגזר משמו של Paeon, רופא האלים במיתולוגיה היוונית, שהיה תלמידו של אסקלפיוס (אל הרפואה). האגדה מספרת שאסקלפיוס קינא בתלמידו, וכדי להציל אותו מחרון אפו, זאוס הפך את פאון לצמח האדמונית.

שם המין lactiflora נובע מצבעם הלבן כחלב של עלי הכותרת; 

המין veitchii נקרא כך על שם משתלת ווייץ׳ (Veitch), ממנה נלקחה דגימה של הצמח.

הצבעים המוזכרים בשמות העממיים של המינים השונים מתייחסים לצבע השורש (עם או ללא קליפת הגזע) ולא לצבעי הפרחים.

אדמונית הינה צמח רב שנתי עשבוני. מוצאם של מיני האדמונית השונים הינו בסין.

מיני האדמונית השונים המוזכרים במונוגרף זה, מותרים לשיווק בישראל.

 

חלק הצמח בשימוש

שורש.

 

איכויות

טמפרטורה: קריר.

לחות: ניטראלי.

טעם: מריר, חמוץ, מתקתק.

 

רכיבים פעילים עיקריים

גליקוזידים מונוטרפניים (החשוב מביניהם הוא paeoniflorin, המהווה 0.05-6.01% מסך הצמח; oxypaeoniflorin, benzoylpaeoniflorin, albiflorin), טריטרפנים, פרואנתוציאנידינים, פלבונואידים, פנולים, טאנינים, פוליסכרידים, סטרולים, סידן (0.5-4%).

 

התוויות

כאבי מחזור (דיסמנוריאה), תסמונת קדם וסתית (PMS), אנדומטריוזיס, אל וסת (אמנוריאה), דימום וסתי מוגבר (מנורגיה), תסמונת גיל המעבר, אבנים בכיס המרה, דלקת בכיס המרה, מיומות, שחלות פוליציסטיות, דלקות כבד, מחלות מעי דלקתיות (IBD), קרוהן, קוליטיס,  כיב פפטי, תסמונת המעי הרגיש (IBS), כאבי ראש, מחלות אוטואימוניות, זאבת (לופוס), פיברומיאלגיה, תסמונת העייפות הכרונית (CFS), מחלת הסעיפים (דיברטיקולוזיס), דיכאון, אנמיה, בעיות פריון, דלקת מפרקים שגרונית (RA).

 

מינונים

תמצית נוזלית בריכוז 1:3, 45% אלכוהול – 10-25 מ״ל ביום.

תמצית יבשה – תלוי בריכוז התמצית. מינון המקביל ל- 3-12 גרם צמח ביום.

מרתח – 3-12 גרם ביום.

בפורמולה – 20-30%.

 

רגישות

לא ידועה רגישות מיוחדת לאדמונית.

 

תופעות לוואי

לא ידועות תופעות לוואי לשימוש באדמונית, למעט  למידע השלם למנויים

 

מינון יתר

לא ידוע על תופעות הנגרמות ממינון יתר של אדמונית.

 

אזהרות וצעדי מנע

יש לנקוט זהירות במתן אדמונית לאנשים הסובלים מ  למידע השלם למנויים

יש לנקוט זהירות במתן אדמונית (Chi shao) לאנשים הסובלים מ  למידע השלם למנויים

 

התוויות נגד

לא ידוע על התוויות נגד.

 

רעילות

לא נצפתה כל רעילות בשימוש באדמונית במינונים הרפואיים המקובלים.

בתנאי מעבדה, תמציות אדמונית  למידע השלם למנויים

מדד רעילותLD50:  למידע השלם למנויים

 

תגובות הדדיות עם תרופות / צמחי מרפא / תוספי תזונה

חילוף חומרים תרופתי

במחקרים קלינים(14,52) אדמונית לא השפיעה על הפעילות של אנזימיCYP2A6, CYP2C9, CYP2C19 , UGT וקשירת אלבומין. מחקרים פרה-קליניים (36,9,11,12,51) מראים תוצאות מעורבות בהקשר לאנזימים השונים כפי שמפורט להלן.

הרלוונטיות הקלינית של ממצאים אלו אינם ברורים.

תרופות אנטי-פסיכוטיות למידע השלם למנויים

תרופות מעכבות טסיות למידע השלם למנויים

תרופות נוגדות קרישה למידע השלם למנויים

תרופות DMARDs (למחלות אוטואימוניות) למידע השלם למנויים

סטרואידים למידע השלם למנויים

טיפול בשחפת למידע השלם למנויים

השריית ביוץ (clomiphene)  למידע השלם למנויים

התרופה Carbamazepine למידע השלם למנויים

התרופה Phenytoin למידע השלם למנויים

התרופה Midazolam למידע השלם למנויים

התרופה Losartan למידע השלם למנויים

התרופה Cetirizine (Zyrtec) למידע השלם למנויים

התרופה valproate למידע השלם למנויים

 אנטיביוטיקה למידע השלם למנויים

התרופה Hydroxychloroquin למידע השלם למנויים

התרופה Tacrolimus למידע השלם למנויים

נוגדות דיכאון למידע השלם למנויים

 

תרופות למחלת הסרְטן 

 למידע השלם למנויים Meloxicam

למידע השלם למנויים Cytarabine

 למידע השלם למנויים Cyclophosphamide 

למידע השלם למנויים Cisplatin

למידע השלם למנויים Carboplatin

למידע השלם למנויים Paclitaxel

צמחי מרפא ותוספי תזונה

אנג'לִיקה סינית למידע השלם למנויים

שוּמר למידע השלם למנויים

שוּש קירח למידע השלם למנויים

 

הריון

מוטב להימנע משימוש באדמונית במהלך ההריון, במיוחד  למידע השלם למנויים

בחלק מהמחקרים שנערכו בבעלי חיים, נצפתה השפעה  למידע השלם למנויים

עם זאת, במחקר קליני לא מבוקר, אדמונית (לצד  למידע השלם למנויים

 

הנקה

חסר מידע בנושא.

 

מקורות

 

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