, - Uncaria tomentosa

11/08/2018

Uña de gato, Cats Claw


: Rubiaceae

 |  |   |  |  |  |   | 

 |  |   |  |  |  | 

 

, , (Calendula officinalis).

U. tomentosa U. guianensis, U. tomentosa .

(liana). ( ).

.

 

, .

 

: .

: .

: , .

 

* (0.15-4.60% , formosanine (uncarine B), pteropodine (uncarine C), isopteropodine (uncarine E), speciophylline (uncarine D), uncarine F, mitraphylline, isomitraphylline , rhynchophylline -isorhynchophylline), (quinovic acid = tomentoside A, B, Ursolic acid, uncaric acid, oleanolic acid, floridic acid, cincholic acid), , (β-sitosterol, stigmasterol, campesterol).

 

* (1-3). 0.036-3.83% (3). (chemotype) ; (POA), (TOA). (3). , -TOA -0.02% ; -TAO POA ( )(1,4-6).

 

, , , (, EBV), (CFS),  (RA), (OA), , , , , , .

.

 

 

  1:3, 45% – 6-18 . 

 – . - 2-6 .

 – 2-15 . 

 – 20-30%.

 

.

 

 

TOA  

POA  

,  

38  

 

,  

 

 – , (7,14).

(SLE) 35  

, 60 (POA) - 40 (RA),  

, , - -(11). 60 , 900 ( ) , 6 .

 – ( TOA) - 10-14 . ,

 

POA  

 

 

(1,11,23-26).

,  

LD50:  

 

   

 

 

/  

 

 (Atazanavir, Ritonavir, Saquinavir)  

 

 (FOLFOX-4, FAC)  

 

 (RA)  

 

 ()  

 

 

 

 

 

(7,8,15,15,40).

,  

 

,  

 

.

POA ,  

,  

, (7,8,14,15,21).

 

 

  1. European Medicines Agency. Assessment report on Uncaria tomentosa (Willd. ex Schult.) DC., cortex. Committee on Herbal Medicinal Products (HMPC). 10 March 2015. Available here
  2. Kemper K. J. Cat’s Claw (Uncaria tomentosa). Longwood Herbal Task Force 1999, 1-13
  3. Laus G, Keplinger K. Separation of stereoisomeric oxindole alkaloids from Uncaria tomentosa by high performance chromatography. Journal of Chromatography 1994, 662:243 249
  4. Wurm M, Kacani L, Laus G, Keplinger K, Dierich MP. Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor. Planta Medica 1998, 64(8):701-704
  5. Laus G, Keplinger K. Radix Uncariae tomentosae (Wild.) DC. Zeitschrift für Phytotherapie 1997, 18:122-126
  6. Barnes J, Anderson LA, Phillipson JD. Herbal Medicines. 2nd ed. Pharmaceutical Press, London, Chicago 2002
  7. Mills. S, Bone K, The Essential Guide to Herbal Safety. Churchill Livingstone, 2005
  8. Reinhard KH. Uncaria tomentosa (Willd.) D.C Cat’s Claw, Una de Gato or Savéntero. The Journal of Alternative and Complementary Medicine 1999, 2:143-151
  9. Obregón Vilches LE: Cat's claw: Uncaria genus. Botanical, chemical, and pharmacological studies of Uncaria tomentosa and Uncaria guianensis, English ed, Lima, 1995, Instituto de Fitoterapia Americano, p 124.
  10. Mur E, Hartig F, Eibl G Schirmer M. Randomized Double Blind Trial o fan extract from the Pentacyclic Alkaloid-Chemotype of Uncaria tomentosa for the Treatment of Rheumatoid Arthritis. The Journal of Rheumatology 2002, 29:678-81
  11. Castañeda DO, León G, León D, Calvo A, Chávez J, Escalante J et al. Uña de Gato en Artritis Reumatoide: Estudio doble ciego, en comparación con placebo. Revista Peruana de Reumatología 1998, 4(1):15-21 [Spanish]
  12. Cosentino C, Torres L. Reversible worsening of Parkinson disease motor symptoms after oral intake of Uncaria tomentosa (cat's claw). Clinical Neuropharmacology 2008, 31(5):293-294
  13. Jones K: Cat's claw: healing vine of Peru, Seattle, 1995, Sylvan Press, p 29. 
  14. Brinker F. Herb Contraindications and Drug Interactions, 4th ed. Sandy (OR): Eclectic Medical Publications; 2010
  15. Williams JE. Review of Antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on una de gato and sangre de grado. Altern. Med. Rev., 6(6):567-579, 2001
  16. Hilepo JN, Bellucci AG, Mossey RT. Acute renal failure caused by ’cat’s claw’ herbal remedy in a patient with systemic lupus erythematosus. Nephron. 1997;77(3):361.
  17. Erowele GI, Kalejaiye AO. Pharmacology and therapeutic uses of cat's claw. Am. J. Health-Syst. Pharm., 66:992-995, 2009
  18. Zhou, J. Y. and Zhou, S. W. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 2012;83(4):617-626.
  19. Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., and Zhou, J. Y. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130.
  20. Immodal Pharmaka: Krallendorn®. Uncaria tomentosa (Willd.) DC. mod. pent. root extract. Report on experiences with probands. Volders/Tirol, Austria,1996, Immodal Pharmaka GmbH, pp 1-20.
  21. McGuffin M, Hobbs C, Upton R, Goldberg A (ed.). Botanical Safety Handbook. CRC Press, Boca Raton, 1997
  22. Jones K: Cat's claw: healing vine of Peru, Seattle, 1995, Sylvan Press, p 46.
  23. Farias I, Araujo MdoCS, Zimmermann ES, Dalmora SL, Benedetti AL, Alvarez-Silva M, et al. Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells. Journal of Ethnopharmacology 2011, 137(1):856-863
  24. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced toxicity of C- MED-100TM, a novel aqueous extract from Uncaria tomentosa. Journal of Ethnopharmacology 2000a, 69(2):115–126
  25. Sheng Y, Li L, Holmgren K, Pero R.W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001, 8(4):275–282
  26. Lamm S, Sheng Y, Pero RW. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100®. Phytomedicine 2001, 8(4):267– 274
  27. Pino A, Salazar M, Vargas K, et al: 2nd International Congress on Phytomedicine and 7th Congress of the German Society of Phytotherapy in cooperation with ESCOP (European Scientific cooperative for Phytotherapy). September 11-14, 1996. Munich, Germany. Abstract no SL-18.
  28. Svendson O, Skydsgaard K: Test report: extractum radicis Uncariae tomentosae, Denmark, 1986, Scantox Biological Laboratory, cited in Keplinger K, Laus G, Wurm M, et al: J Ethnopharmacol 64:23-34, 1999.
  29. Ibrahim KE, Al-Ashban RM, El-Sammani SA. A Study of the Toxicity of Cat’s Claw Herbal Medicine.Research Journal of Pharmacology 2009, 3(3):52-57
  30. Keplinger K, Laus G, Wurm M, Dierich MP, Teppner H. Uncaria tomentosa (Willd.) DC.—Ethnomedicinal use and new pharmacological, toxicological and botanical results. Journal of Ethnopharmacology 1999, 64(1):23–34
  31. Kynock SR, Lloyd GK: Acute oral toxicity to mice of substance E-2919, Huntingdon, 1975, Huntington Research Centre, cited in Reinhard KH: J Altern Complement Med 1999; 5(2): 143-151.
  32. Valerio LG Jr, Gonzales GF. Toxicological Aspects of the South American Herbs Cat’s Claw (Uncaria tomentosa) and Maca (Lepidium meyenii). A Critical synopsis. Toxicological Reviews 2005, 24(1):11-35
  33. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine. 2000 Jul;7(4):273-82.
  34. Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K. Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines. J Pharm Pharm Sci. 2015 Nov;18(4):316-27.
  35. Lopez Galera RM, Ribera Pascuet E, Esteban Mur JI, et al. Interaction between cat’s claw and protease inhibitors atazanavir, ritonavir and saquinavir. Eur J Clin Pharmacol. Dec 2008;64(12):1235-1236.
  36. Araújo MdoCS, Farias IL, Gutierres J, Dalmora SL, Flores N, Farias J et al. Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial. Evidence-based Complementary and Alternative Medicine 2012, Article ID:676984, 8 pages, doi:10.1155/2012/676984
  37. Farias IL, Araújo MdoCS, Farias JG.,Rossato LV, Elsenbach LI, Dalmora SL, et al. Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial. Evidence-Based Complementary and Alternative Medicine 2012, Article ID 892182, 8 pages, doi:10.1155/2012/89218
  38. Sheng Y, Pero RW, Wagner H. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000 Apr;7(2):137-43.
  39. Dietrich F, Pietrobon Martins J, Kaiser S, Madeira Silva RB, Rockenbach L, Albano Edelweiss MI, Ortega GG, Morrone FB, Campos MM, Battastini AM. The Quinovic Acid Glycosides Purified Fraction from Uncaria tomentosa Protects against Hemorrhagic Cystitis Induced by Cyclophosphamide in Mice. PLoS One. 2015 Jul 8;10(7):e0131882. ECollection 2015.
  40. Farnsworth NR, Bingel AS, Cordell GA, et al. Potential value of plants as sources of new antifertility agents I. J. Pharm. Sci., 64:535-598, 1975
  41. De Feo V: Fitoterapia 63:417-440, 1992.
  42. Obregón Vilches LE: Cat's claw: Uncaria genus. Botanical, chemical, and pharmacological studies of Uncaria tomentosa and Uncaria guianensis, English ed, Lima, 1995, Instituto de Fitoterapia Americano, p 124.
  43. Jones K: Cat's claw: healing vine of Peru, Seattle, 1995, Sylvan Press, p 64.
  44. Taylor L. Herbal Secrets of the Rainforests 2nd ed. Sage Press, Inc., Austin, TX, USA 2002
  45. Cabieses F. The Saga of the Cat’s Claw. Via Lactera Editores, Lima 1994
  46. Rain-tree Tropical Plant database, Uncaria tomentosa, Cat’s Claw. The text has been printed from “The Healing Power of Rainforest Herbs “ by Leslie Taylor, copyrighted Š 2004. Available here. Accessed 09/20/2014
  47. Keplinger K: Composition allowing for modifying the growth of living cells, preparation and utilization of such a composition [in german], international Patent WO8201130, April 1982. 
  48. Iziga R, Gutierrez-Pajares J, Pino J: Boletin de la Sociedad de Biologia de Concepcion 69:141-145, 1998. 
  49. Keplinger K: Cytostat, contraceptive, and antiinflammatory agent from Uncaria tomentosa roots, PCT Int.Appl. WO 821130 A1,April 1982.
  50. McKenna DJ, Jones K, Hughes K, Humphrey S, editors. Botanical Medicines. The desk reference for Major Herbal Supplements. 2nd ed. The Haworth Herbal Press, Binghampton, NY, USA 2002
  51. Nogueira Neto J, Cavalcante FL, Carvalho RA, Rodrigues TG, Xavier MS, Furtado PG, Schor E. Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis. Acta Cir Bras. 2011;26 Suppl 2:15-9.
  52. Jones K: Cat's claw: healing vine of Peru, Seattle, 1995, Sylvan Press, p 25.



 |