τϊιηϊ ϊτψιθ πβιωεϊ
βιωδ ξδιψδ μγσ δαιϊ

φιτεψπι ηϊεμ τψεΰπιιν, ΰεπχψιδ - Uncaria tomentosa

ςεγλο αϊΰψικ 04/07/2022

Una de gato, Cat’s Claw


ξωτηδ αεθπιϊ: τεΰϊιιν – Rubiaceae

ημχ δφξη | ΰιλειεϊ | ψλιαιν τςιμιν | δϊεειεϊ | ξιπεπιν | ψβιωεϊ | ϊετςεϊ μεεΰι | 

ξιπεο ιϊψ | ΰζδψεϊ | δϊεειεϊ πβγ | ψςιμεϊ | ΰιπθψΰχφιεϊ | δψιεο | δπχδ

 

φΔιτεψπι ηϊεμ τψεΰπιιν πχψΰ λκ ςμ ων δχεφιν δξΰεπχμιν δξςθψιν ΰϊ δφξη μΰεψλε. 

ξθςξι πεηεϊ, μΰεψκ δξεπεβψσ ΰπε ξωϊξωιν αων δαεθπι ΧΰεπχψιδΧ εμΰ αων δςαψι δΰψεκ Χφāιτεψπι ηϊεμ τψεΰπιινΧ, δξαγιμ ΰϊ δφξη ξΧφΔιτεψπι ηϊεμΧ (Calendula officinalis).

ιω μφιιο λι ϊξφιεϊ ΰεπχψιδ μςιϊιν ςμεμεϊ μδλιμ ωιμεα αιο δξιο U. tomentosa μξιο U. guianensis, ΰεμν ξεπεβψσ ζδ ξϊιιηρ μαθιηεϊ ειςιμεϊ δωιξεω αξιο U. tomentosa αμαγ.

ΰεπχψιδ διπε φξη ξθτρ ξςεφδ (liana). ξεφΰε αβΧεπβμιν δθψετιιν ωαξψλζ εγψεν ΰξψιχδ (αςιχψ ιςψ δΰξζεπρ).

ΰεπχψιδ ξεϊψ μωιεεχ αιωψΰμ.

 

ημχ δφξη αωιξεω

χμιτϊ βζς, χμιτϊ ωεψω.

 

ΰιλειεϊ

θξτψθεψδ: χψ.

μηεϊ: ιαω.

θςν: ξψ, φεψα.

 

ψλιαιν τςιμιν ςιχψιιν

ΰμχμεΰιγιν ΰεχριπγεμιιν* εΰιπγεμιιν (0.15-4.60% ρκ δλμ, πημχιν μτπθφιχμιιν λβεο formosanine (uncarine B), pteropodine (uncarine C), isopteropodine (uncarine E), speciophylline (uncarine D), uncarine F, mitraphylline, isomitraphylline ΰε θθψφιχμιιν, αιπιδν rhynchophylline ε-isorhynchophylline), θψιθψτπιν (quinovic acid = tomentoside A, B, Ursolic acid, uncaric acid, oleanolic acid, floridic acid, cincholic acid), τψεΰπϊεφιΰπιπιν, ρθψεμιν (β-sitosterol, stigmasterol, campesterol).

 

*ϊλεμϊ δΰμχμεΰιγιν ςμεμδ μδωϊπεϊ αΰετο ξωξςεϊι λϊμεϊ αωιθεϊ βιγεμ εςιϊει δχφιψ(1-3). ρκ δΰμχμεΰιγιν αχμιτϊ δωεψω διαωδ ςμεμ μδωϊπεϊ αθεεη ωμ 0.036-3.83% αδϊΰν μϊχετϊ δχφιψ(3). χιιξιν ωπι ζπιν αςμι θιτεριν λιξιιν (chemotype) ωεπιν ωμ ΰεπχψιδ; δΰηγ ξλιμ αςιχψ ΰμχμεΰιγιν ΰεχριπγεμιιν τπθφιχμιιν (POA), εδωπι ςωιψ αΰμχμεΰιγιν ΰεχριπγεμιιν θθψφιχμιιν (TOA). φξη ρτφιτι ςωει μδωϊπεϊ ςν δζξο εμδημισ ξγτερ ΰμχμεΰιγιν ΰηγ μΰηψ(3). ςψαεα αιο ωπι θιτερι ΰεπχψιδ ωεπιν πξφΰ μΰ ξϊΰιν μωιξεω ψτεΰι, ΰμΰ ΰν ϊλεμϊ δ-TOA χθπδ ξ-0.02% αξεφψ δρετι; πξφΰ ω-TAO ρεϊψιν ΰϊ δτςιμεϊ δψτεΰιϊ ωμ ΰμχμεΰιγιν ξρεβ POA (δςμΰϊ ψξεϊ μειχεφιθιν)(1,4-6).

 

δϊεειεϊ

ωιξεω τπιξι – ζιδεξιν ΰχεθιιν, ΰιιγρ, δψτρ εζιδεξι ωμαχϊ, ξημϊ δπωιχδ (ξεπεπεχμιΰεζιρ, EBV), ϊρξεπϊ δςιιτεϊ δλψεπιϊ (CFS), γμχϊ ξτψχιν ωβψεπιϊ (RA), γμχϊ ξτψχιν πιεεπιϊ (OA), ρψθο, ωτςϊ, δφθππεϊ, γμχϊ ψιΰεϊ, ριπεριθιρ, χπγιγδ.

ωιξεω ηιφεπι – δψτρ.

 

ξιπεπιν 

ϊξφιϊ πεζμιϊ αψιλεζ 1:3, 45% ΰμλεδεμ – 6-18 ξΨμ αιεν. 

ϊξφιϊ ιαωδ – ϊμει αψιλεζ δϊξφιϊ. ξιπεο δξχαιμ μ- 2-6 βψν φξη αιεν.

ξψϊη – 2-15 βψν αιεν. 

ατεψξεμδ – 20-30%.

 

ψβιωεϊ

μΰ ιγεςδ ψβιωεϊ ξιεηγϊ μΰεπχψιδ.

 

ϊετςεϊ μεεΰι

αϊηιμϊ δωιξεω αΰεπχψιδ ςμεμεϊ μδετις  μξιγς δωμν μξπειιν

μωιξεω αϊξφιεϊ δξλιμεϊ αςιχψ TOA ςμεμεϊ μδϊμεεϊ  μξιγς δωμν μξπειιν

μωιξεω αϊξφιεϊ δξλιμεϊ αςιχψ POA ςμεμδ μδϊμεεϊ ςμιδ χμδ α  μξιγς δωμν μξπειιν

ςν ζΰϊ, αξηχψιν χμιπιιν ωεπιν  μξιγς δωμν μξπειιν

χιιν γιεεη ξχψδ αεγγ ΰεγεϊ ηεμδ τψχιπρεο αο 38 ωηεεδ  μξιγς δωμν μξπειιν

 

ξιπεο ιϊψ

μτι δψτεΰδ δτψεΰπιϊ δξρεψϊιϊ, ξιπεο βαεδ ωμ ξψϊηι χμιτϊ βζς ωμ ΰεπχψιδ ςμεμ μβψεν μ  μξιγς δωμν μξπειιν

 

ΰζδψεϊ εφςγι ξπς

ξημεϊ ΰεθεΰΔιξεπιεϊ – ιω μπχεθ ζδιψεϊ ψαδ αωιξεω αΰεπχψιδ αχψα ΰπωιν δρεαμιν ξξημεϊ ΰεθεΰιξεπιεϊ, εαξιεηγ αωιξεω ΰψεκ θεεη αξθετμιν ΰμε(7,14).

χιιν γιεεη ξχψδ αεγγ ΰεγεϊ ηεμϊ ζΰαϊ ΰγξπϊιϊ ξςψλϊιϊ (SLE) αϊ 35 ωηεεϊδ  μξιγς δωμν μξπειιν

ςν ζΰϊ, αξηχψ χμιπι ωλμμ πθιμϊ 60 ξΨβ ϊξφιϊ ωεψω ΰεπχψιδ (POA) ςμ-ιγι 40 ηεμι γμχϊ ξτψχιν ωβψεπιϊ (RA), πφτϊδ  μξιγς δωμν μξπειιν

ϊεφΰεϊ γεξεϊ πφτε αξηχψ χμιπι περσ, ψπγεξμι, ξαεχψ-τμραε εψα-ξψλζιν(11). αξηχψ ζδ δωϊϊτε 60 παγχιν, ωπθμε 900 ξΨβ ϊξφιϊ ΰεπχψιδ (ψιλεζ μΰ ιγες) αιεν ΰε τμραε, αξωκ 6 ηεγωιν.

δμιλιν λιψεψβιιν – ξεξμυ μδτριχ ΰϊ πθιμϊ δφξη (εαξιεηγ ϊξφιεϊ TOA) λ- 10-14 ιξιν μτπι δμιλιν λιψεψβιιν. αξηχψιν ωπςψλε αϊπΰι ξςαγδ εαχψα αςμι ηιιν, μξιγς δωμν μξπειιν

 

δϊεειεϊ πβγ

ιφψπι ϊξφιεϊ ξαερρεϊ POA ωμ ΰεπχψιδ ΰιπν ξξμιφιν ςμ ωιξεω αϊλωιψιν ΰμε αχψα ΰπωιν ωχιαμε ΰε ςϊιγιν μχαμ  μξιγς δωμν μξπειιν

δωιξεω αϊξφιεϊ ωεψω ΰεπχψιδ ΰρεψ αψηαι ΰιψετδ μ  μξιγς δωμν μξπειιν

 

ψςιμεϊ

αξηχψιν χμιπιιν μΰ πφτϊδ λμ ςγεϊ μψςιμεϊ ΰε πζχ αςχαεϊ ωιξεω αΰεπχψιδ αξιπεπιν δψτεΰιιν δξχεαμιν(1,11,23-26).

αξρτψ ξηχψιν ωπςψλε αχψα ξλψρξιν, μΰ πφτϊδ ψςιμεϊ ΰε πζχ αςχαεϊ φψιλδ τεξιϊ ωμ ϊξφιεϊ ΰεπχψιδ αξιπεπιν δπςιν αιο  μξιγς δωμν μξπειιν

ξγγ ψςιμεϊ LD50:  μξιγς δωμν μξπειιν

 

ϊβεαεϊ δγγιεϊ ςν ϊψετεϊ / φξηι ξψτΰ / ϊερτι ϊζεπδ

 

δωτςδ ςμ ηιμεσ ηεξψιν ϊψετϊι  μξιγς δωμν μξπειιν

 

θιτεμιν ηιρεπιιν ε/ΰε ωξχεψν ααςμι ηιιν  μξιγς δωμν μξπειιν

 

ξςλαι τψεθΰζεϊ (Atazanavir, Ritonavir, Saquinavir)  μξιγς δωμν μξπειιν

 

λιξεϊψτιδ (FOLFOX-4, FAC)  μξιγς δωμν μξπειιν

 

θιτεμ ϊψετϊι χεπαπφιεπΰμι μγμχϊ ξτψχΔιν ωβψεπιϊ (RA)  μξιγς δωμν μξπειιν

 

ηιρεο ξεξϊ (τπΰεξεχεχ)  μξιγς δωμν μξπειιν

 

ϊψετεϊ πεβγεϊ φιξεϊ θριεϊ  μξιγς δωμν μξπειιν

 

ϊψετεϊ μδεψγϊ μηυ γν  μξιγς δωμν μξπειιν

 

ϊψετεϊ πεβγεϊ ηψγδ μξιγς δωμν μξπειιν

 

δψιεο

ΰεπχψιδ ΰρεψ μωιξεω αξδμκ δδψιεο εαχψα πωιν ωξϊλππεϊ μδιλπρ μδψιεο(7,8,15,15,40).

αψτεΰδ δτψεΰπιϊ δξρεψϊιϊ, πςωδ ωιξεω αξιπεπιν βαεδιν ωμ ξψϊηι ΰεπχψιδ λ  μξιγς δωμν μξπειιν

αξηχψιν ωπςψλε αχψα ςλαψιν πφτϊδ  μξιγς δωμν μξπειιν

λξε λο, πθιμδ τεξιϊ ωμ δξιπεπιν δξγεαψιν εΰσ πξελιν ιεϊψ  μξιγς δωμν μξπειιν

 

δπχδ

ηρψ ξιγς απεωΰ.

ιφψπι ϊξφιεϊ ξαερρεϊ POA ωμ ΰεπχψιδ ΰιπν ξξμιφιν ςμ ωιξεω αϊλωιψιν ΰμε αχψα πωιν ξπιχεϊ, ςχα  μξιγς δωμν μξπειιν

ςν ζΰϊ, αψτεΰδ δτψεΰπιϊ δξρεψϊιϊ πςωδ ωιξεω αφξη λγι  μξιγς δωμν μξπειιν

αξιγδ επςωδ ωιξεω αΰεπχψιδ αξδμκ δδπχδ, ιω μςωεϊ λο αξωπδ ζδιψεϊ εϊηϊ τιχεη ξχφεςι αμαγ(7,8,14,15,21).

 

 

ξχεψεϊ

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