, - Uncaria tomentosa

04/07/2022

Una de gato, Cats Claw


: Rubiaceae

 |  |   |  |  |  |   | 

 |  |   |  |  |  | 

 

, ā , (Calendula officinalis).

U. tomentosa U. guianensis, U. tomentosa .

(liana). ( ).

.

 

, .

 

: .

: .

: , .

 

* (0.15-4.60% , formosanine (uncarine B), pteropodine (uncarine C), isopteropodine (uncarine E), speciophylline (uncarine D), uncarine F, mitraphylline, isomitraphylline , rhynchophylline -isorhynchophylline), (quinovic acid = tomentoside A, B, Ursolic acid, uncaric acid, oleanolic acid, floridic acid, cincholic acid), , (β-sitosterol, stigmasterol, campesterol).

 

* (1-3). 0.036-3.83% (3). (chemotype) ; (POA), (TOA). (3). , -TOA -0.02% ; -TAO POA ( )(1,4-6).

 

, , , (, EBV), (CFS),  (RA), (OA), , , , , , .

.

 

 

  1:3, 45% – 6-18 . 

 – . - 2-6 .

 – 2-15 . 

 – 20-30%.

 

.

 

 

TOA  

POA  

,  

38  

 

,  

 

 – , (7,14).

(SLE) 35  

, 60 (POA) - 40 (RA),  

, , - -(11). 60 , 900 ( ) , 6 .

 – ( TOA) - 10-14 . ,

 

POA  

 

 

(1,11,23-26).

,  

LD50:  

 

   

 

 

 

/  

 

 (Atazanavir, Ritonavir, Saquinavir)  

 

 (FOLFOX-4, FAC)  

 

 (RA)  

 

 ()  

 

 

 

 

 

 

(7,8,15,15,40).

,  

 

,  

 

.

POA ,  

,  

, (7,8,14,15,21).

 

 

  1. European Medicines Agency. Assessment report on Uncaria tomentosa (Willd. ex Schult.) DC. cortex. Committee on Herbal Medicinal Products (HMPC). 24 Nov. 2015. https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-uncaria-tomentosa-willd-ex-schult-dc-cortex_en.pdf
  2. Kemper KJ. Cat’s Claw (Uncaria tomentosa). Longwood Herbal Task Force 1999, 1-13. https://mafiadoc.com/cats-claw-uncaria-tomentosa-longwood-herbal-task-force_59f72e961723dd5fd7a130ea.html
  3. Laus G, Keplinger K. Separation of stereoisomeric oxindole alkaloids from Uncaria tomentosa by high performance chromatography. Journal of Chromatography 1994, 662:243-249. https://www.sciencedirect.com/science/article/abs/pii/0021967394805113
  4. Wurm M, Kacani L, Laus G, Keplinger K, Dierich MP. Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor. Planta Medica 1998, 64(8):701-704. https://www.ncbi.nlm.nih.gov/pubmed/9933988
  5. Keplinger K, Laus G, Wurm M, Dierich MP, Teppner H. Uncaria tomentosa (Willd.) DC.- Ethnomedicinal use and new pharmacological, toxicological and botanical results. J Ethnopharmacol. 1999 Jan;64(1):23-34. https://pubmed.ncbi.nlm.nih.gov/10075119/
  6. Barnes J, Anderson LA, Phillipson JD. Herbal Medicines. 3rd ed. Pharmaceutical Press, Chicago 2007. https://naturalingredient.org/wp/wp-content/uploads/HerbalMedicines,Thirdedition-JoanneBarnesJ.DavidPhillipsonLindaA.Anderson.pdf
  7. Mills S, Bone K. The Essential Guide to Herbal Safety. Churchill Livingstone, 2005. https://www.elsevier.com/books/the-essential-guide-to-herbal-safety/mills/978-0-443-07171-3
  8. Reinhard KH. Uncaria tomentosa (Willd.) D.C Cat’s Claw, Una de Gato or Savéntero. The Journal of Alternative and Complementary Medicine 1999, 2:143-151. https://www.ncbi.nlm.nih.gov/pubmed/10328636
  9. Obregón Vilches LE. Cat's claw: Uncaria genus. Botanical, chemical, and pharmacological studies of Uncaria tomentosa and Uncaria guianensis, English ed, Lima, 1995, Instituto de Fitoterapia Americano, p 124.
  10. Mur E, Hartig F, Eibl G Schirmer M. Randomized Double Blind Trial of an extract from the Pentacyclic Alkaloid-Chemotype of Uncaria tomentosa for the Treatment of Rheumatoid Arthritis. The Journal of Rheumatology 2002, 29:678-81. https://www.ncbi.nlm.nih.gov/pubmed/11950006
  11. Castañeda DO, León G, León D, Calvo A, Chávez J, Escalante J et al. [Uña de Gato en Artritis Reumatoide: Estudio doble ciego, en comparación con placebo]. Revista Peruana de Reumatología 1998, 4(1):15-21. https://sisbib.unmsm.edu.pe/BVRevistas/reuma/v04_n1/u%C3%B1agato.htm
  12. de Paula LCL, Fonseca F, Perazzo F, Cruz FM, Cubero D, Trufelli DC, et al. Uncaria tomentosa (cat’s claw) improves quality of life in patients with advanced solid tumors. J Altern Complement Med. 2015 Jan;21(1):22–30. https://pubmed.ncbi.nlm.nih.gov/25495394/https://pubmed.ncbi.nlm.nih.gov/25495394/
  13. Piscoya J, Rodriguez Z, Bustamante SA, Okuhama NN, Miller MJ, Sandoval M. Efficacy and safety of freeze-dried cat’s claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res. 2001 Sep;50(9):442–8. https://pubmed.ncbi.nlm.nih.gov/11603848/
  14. Cosentino C, Torres L. Reversible worsening of Parkinson disease motor symptoms after oral intake of Uncaria tomentosa (cat's claw). Clinical Neuropharmacology 2008, 31(5):293-294. https://www.ncbi.nlm.nih.gov/pubmed/18836348
  15. Jones K. Cat's claw: healing vine of Peru, Seattle, 1995, Sylvan Press. https://books.google.co.il/books/about/Cats_Claw.html?id=niUJAQAAMAAJ&redir_esc=y
  16. Brinker F. Herb Contraindications and Drug Interactions, 4th ed. Sandy (OR): Eclectic Medical Publications; 2010. https://www.eclecticherb.com/herb-contraindications-drug-interactions/
  17. Hilepo JN, Bellucci AG, Mossey RT. Acute renal failure caused by ’cat’s claw’ herbal remedy in a patient with systemic lupus erythematosus. Nephron. 1997;77(3):361. https://www.karger.com/Article/PDF/190304
  18. Erowele GI, Kalejaiye AO. Pharmacology and therapeutic uses of cat's claw. Am. J. Health-Syst. Pharm. 2009 Jun 1;66(11):992–5. https://www.ncbi.nlm.nih.gov/pubmed/19451609
  19. Zhou JY, Zhou SW. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 2012;83(4):617-626. https://www.ncbi.nlm.nih.gov/pubmed/22406453
  20. Chen CX, Jin RM, Li YK, Zhong J, Yue L, Chen SC, Zhou JY. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130. https://www.ncbi.nlm.nih.gov/pubmed/1317985
  21. Williams JE. Review of Antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on una de gato and sangre de grado. Altern. Med. Rev., 6(6):567-579, 2001. https://www.ncbi.nlm.nih.gov/pubmed/11804547
  22. Immodal Pharmaka: Krallendorn®. Uncaria tomentosa (Willd.) DC. mod. pent. root extract. Report on experiences with probands. Volders/Tirol, Austria,1996, Immodal Pharmaka GmbH, pp 1-20.
  23. McGuffin M, Hobbs C, Upton R, Goldberg A (ed.). Botanical Safety Handbook. CRC Press, Boca Raton, 1997. http://abc.herbalgram.org/site/DocServer/AHPABotanicalSafety_FMexcerpt.pdf?docID=4601
  24. Farias I, Araujo MdoCS, Zimmermann ES, Dalmora SL, Benedetti AL, Alvarez-Silva M, et al. Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells. Journal of Ethnopharmacology 2011, 137(1):856-863. https://www.ncbi.nlm.nih.gov/pubmed/21771655
  25. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced toxicity of C- MED-100TM, a novel aqueous extract from Uncaria tomentosa. Journal of Ethnopharmacology 2000a, 69(2):115–126. https://www.ncbi.nlm.nih.gov/pubmed/10687868
  26. Sheng Y, Li L, Holmgren K, Pero R.W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001, 8(4):275–282. https://www.ncbi.nlm.nih.gov/pubmed/11515717
  27. Lamm S, Sheng Y, Pero RW. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100®. Phytomedicine 2001, 8(4):267– 274. https://www.ncbi.nlm.nih.gov/pubmed/11515716
  28. Pino A, Salazar M, Vargas K, et al: 2nd International Congress on Phytomedicine and 7th Congress of the German Society of Phytotherapy in cooperation with ESCOP (European Scientific cooperative for Phytotherapy). September 11-14, 1996. Munich, Germany. Abstract no SL-18.
  29. Svendson O, Skydsgaard K: Test report: extractum radicis Uncariae tomentosae, Denmark, 1986, Scantox Biological Laboratory, cited in Keplinger K, Laus G, Wurm M, et al: J Ethnopharmacol 64:23-34, 1999.
  30. Ibrahim KE, Al-Ashban RM, El-Sammani SA. A Study of the Toxicity of Cat’s Claw Herbal Medicine.Research Journal of Pharmacology 2009, 3(3):52-57. https://www.researchgate.net/publication/289077277
  31. Kynock SR, Lloyd GK. Acute oral toxicity to mice of substance E-2919, Huntingdon, 1975, Huntington Research Centre, cited in Reinhard KH: J Altern Complement Med 1999; 5(2): 143-151. https://pdfs.nutramedix.ec/Uncaria_tomentosa_Willd_D_C_Cat'.pdf
  32. Valerio LG Jr, Gonzales GF. Toxicological Aspects of the South American Herbs Cat’s Claw (Uncaria tomentosa) and Maca (Lepidium meyenii). A Critical synopsis. Toxicological Reviews 2005, 24(1):11-35. https://www.ncbi.nlm.nih.gov/pubmed/16042502
  33. Weiss J. Herb−Drug Interaction Potential of Anti-Borreliae Effective Extracts from Uncaria tomentosa (Samento) and Otoba parvifolia (Banderol) Assessed In Vitro. Molecules. 2018 Dec 31;24(1). https://pubmed.ncbi.nlm.nih.gov/30602711/
  34. Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine, vol. 10, no. 4, pp. 334–342, 2003. https://pubmed.ncbi.nlm.nih.gov/12809364
  35. Lopez Galera RM, Ribera Pascuet E, Esteban Mur JI, et al. Interaction between cat’s claw and protease inhibitors atazanavir, ritonavir and saquinavir. Eur J Clin Pharmacol. Dec 2008;64(12):1235-1236. https://link.springer.com/article/10.1007/s00228-008-0551-1
  36. Santos Araújo Mdo C, Farias IL, Gutierres J, et al. Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial. Evidence-based Complementary and Alternative Medicine. 2012;2012:676984. https://www.ncbi.nlm.nih.gov/pubmed/22811748
  37. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine. 2000 Jul;7(4):273-82. https://www.ncbi.nlm.nih.gov/pubmed/10969720
  38. Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K. Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines. J Pharm Pharm Sci. 2015 Nov;18(4):316-27. https://www.ncbi.nlm.nih.gov/pubmed/26626238
  39. Jalloh MA, Gregory PJ, Hein D, Risoldi Cochrane Z, Rodriguez A. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017;28(1):4–15. https://pubmed.ncbi.nlm.nih.gov/27655839/
  40. Müller AC, Kanfer I. Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicines. Biopharm Drug Dispos. 2011 Nov;32(8):458–70. https://pubmed.ncbi.nlm.nih.gov/22024968/
  41. Kajimoto O, et al. Evaluation of effect and safety of “cat’s claw” in treatment of lumbago and neuralgia. https://www.schuler.pe/assets/uploads/estudios_1uq0_seguridaddelaunadegato.pdf
  42. Jürgensen S, Dalbó S, Angers P, Santos ARS, Ribeiro-do-Valle RM. Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa. Pharmacol Biochem Behav. 2005 Jul;81(3):466–77. https://pubmed.ncbi.nlm.nih.gov/15907989/
  43. Moraes RC, Carvalho AR, Lana AJ, Kaiser S, Pippi B, Fuentefria AM, Ortega GG. In vitro synergism of a water insoluble fraction of Uncaria tomentosa combined with fluconazole and terbinafine against resistant non-Candida albicans isolates. Pharm Biol. 2017 Dec;55(1):406-415. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130498/
  44. Zhou J, Zhou S. Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J Ethnopharmacol. 2010 Oct 28;132(1):15-27. https://pubmed.ncbi.nlm.nih.gov/20736055/
  45. Zhou JY, Zhou SW. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia. 2012 Jun;83(4):617-26. https://pubmed.ncbi.nlm.nih.gov/22406453/
  46. Choi JG, Eom SM, Kim J, et al., A Comprehensive Review of Recent Studies on Herb-Drug Interaction: A Focus on Pharmacodynamic Interaction. J Altern Complement Med. 2016 Apr;22(4):262-79. https://www.ncbi.nlm.nih.gov/pubmed/27003511
  47. Quı’lez AM, Saenz MT, Garcı’a MD. Uncaria tomentosa (Willd. ex. Roem. & Schult.) DC. and Eucalyptus globulus Labill. interactions when administered with diazepam. Phytother Res 2012;26:458–461. https://www.ncbi.nlm.nih.gov/pubmed/21928376
  48. Farias IL, Araújo MdoCS, Farias JG, Rossato LV, Elsenbach LI, Dalmora SL, et al. Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial. Evidence-Based Complementary and Alternative Medicine 2012. https://www.academia.edu/14589328
  49. Kośmider A, Czepielewska E, Kuraś M, Gulewicz K, Pietrzak W, Nowak R, Nowicka G. Uncaria tomentosa Leaves Decoction Modulates Differently ROS Production in Cancer and Normal Cells, and Effects Cisplatin Cytotoxicity. Molecules. 2017 Apr 12;22(4):620. https://pubmed.ncbi.nlm.nih.gov/28417940/
  50. de Oliveira LZ, Farias IL, Rigo ML, et al. Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells. Evid Based Complement Alternat Med. 2014;2014:274786. https://europepmc.org/article/med/25505920
  51. Almeida IV, Soares LC, Lucio FT, Cantagalli LB, Reusing AF, Vicentini VEP. Chemotherapeutical effects of the herbal medicine Uncaria tomentosa (Willd.) DC. Genet Mol Res. 2017 Sep 27;16(3). https://pubmed.ncbi.nlm.nih.gov/28973761/
  52. Dietrich F, Pietrobon Martins J, Kaiser S, Madeira Silva RB, Rockenbach L, Albano Edelweiss MI, Ortega GG, Morrone FB, Campos MM, Battastini AM. The Quinovic Acid Glycosides Purified Fraction from Uncaria tomentosa Protects against Hemorrhagic Cystitis Induced by Cyclophosphamide in Mice. PLoS One. 2015 Jul 8;10(7):e0131882. ECollection 2015. https://www.ncbi.nlm.nih.gov/pubmed/26154141
  53. Sheng Y, Pero RW, Wagner H. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000 Apr;7(2):137-43. https://www.ncbi.nlm.nih.gov/pubmed/10839217
  54. Farnsworth NR, Bingel AS, Cordell GA, et al. Potential value of plants as sources of new antifertility agents I. J. Pharm. Sci., 64:535-598, 1975. https://www.ncbi.nlm.nih.gov/pubmed/167146
  55. Taylor L. The Healing Power of Rainforest Herbs. Square One Publishers. 2005. http://www.squareonepublishers.com/Title/9780757001444
  56. Cabieses F. The Saga of the Cat’s Claw. Via Lactera Editores, Lima 1994. https://books.google.co.il/books/about/The_Saga_of_the_Cat_s_Claw.html?id=UB0xHQAACAAJ&redir_esc=y
  57. Keplinger K. Composition allowing for modifying the growth of living cells, preparation and utilization of such a composition, international Patent WO8201130 A1, April 1982. https://patents.google.com/patent/WO1982001130A1/en
  58. Iziga R, Gutierrez-Pajares J, Pino J. Efecto in vivo de Uncaña tomentosa (Willd.) D C. (Rubiaceae) "Uña de Gato" en el desarrollo de embriones preimplantacionales de ratón de 72 h.p.c Boletin de la Sociedad de Biologia de Concepcion 69:141-145, 1998. https://archive.org/stream/boletindelasocie691998soci/boletindelasocie691998soci_djvu.txt
  59. Keplinger K. Cytostat, contraceptive, and antiinflammatory agent from Uncaria tomentosa roots, PCT Int. Appl. WO 821130 A1, April 1982.
  60. McKenna DJ, Jones K, Hughes K, Humphrey S, editors. Botanical Medicines. The desk reference for Major Herbal Supplements. 2nd ed. The Haworth Herbal Press, Binghampton, NY, USA 2002. https://pubs.acs.org/doi/abs/10.1021/np030722e
  61. Nogueira Neto J, Cavalcante FL, Carvalho RA, Rodrigues TG, Xavier MS, Furtado PG, Schor E. Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis. Acta Cir Bras. 2011;26 Suppl 2:15-9. https://www.ncbi.nlm.nih.gov/pubmed/22030809
  62. Jin RM, Chen CX, Li YK, Xu PK. [Effect of rhyncophylline on platelet aggregation and experimental thrombosis]. Yao Xue Xue Bao. 1991;26(4):246-9. Chinese. https://pubmed.ncbi.nlm.nih.gov/1957668/
  63. Roberts KE, Adsett IT, Rickett K, et al. Systemic therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer. Cochrane Database Syst Rev. 2022 Jan 10;1(1):CD013167. https://pubmed.ncbi.nlm.nih.gov/35005781/
     



 |