, , - Aloe spp

20/10/2018

Aloe vera


: - Asphodelaceae

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 –  (aloin, aloeemodin, barbaloin).

 

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– , (), , , .

 

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:  ' – 15-30 " .

: -5% 200:1 (A. barbadensis) ' .

 

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  1:10, 25% + 25% – 1.5-4 " ( ).

   5:1 – 50-200 " , (" ).

 

 

 

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(1)

LD50: 

 

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 – '  

 

 (Cisplatin) – (20),  

 

 –   . 248 -3 : , . 4 . 

 

HIV

 

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() – ,

 

( Glycyrrhiza glabra) –

 

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 – (30 " -300 , 500 -40 " 40%)

 

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(1,2).

 

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  1. Stargrove M B, Treasure J,McKee D. L, Herb, Nutrient, and Drug Interactions, Elsevier, 2008. https://www.us.elsevierhealth.com/herb-nutrient-and-drug-interactions-9780323029643.html.
  2. Brinker F. Herb Contraindications and Drug Interactions, 4th ed. Sandy (OR): Eclectic Medical Publications; 2010. https://www.eclecticherb.com/herb-contraindications-drug-interactions/.
  3. Reynolds, T. and Dweck, A. C. Aloe vera leaf gel: a review update. J Ethnopharmacol. 12-15-1999;68(1-3):3-37. https://www.ncbi.nlm.nih.gov/pubmed/10624859.
  4. Wohlrab, J., Kreft, B., and Tamke, B. Skin tolerability of transdermal patches. Expert.Opin.DrugDeliv. 2011;8(7):939-948. https://www.ncbi.nlm.nih.gov/pubmed/21506903.
  5. Mills. S, Bone K, The Essential Guide to Herbal Safety. Churchill Livingstone, 2005. https://www.elsevier.com/books/the-essential-guide-to-herbal-safety/mills/978-0-443-07171-3.
  6. Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci. 2010 Mar;25(3):492-5. https://www.ncbi.nlm.nih.gov/pubmed/20191055.
  7. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, and et al. Antidiabetic activity of Aloe vera L. juice. I Clinical trial in new cases of diabetes mellitus. Phytomedicine 1996;3(3):241-243. https://www.ncbi.nlm.nih.gov/pubmed/23195077.
  8. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, and et al. Antidiabetic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed 1996;3(3):245-248. https://www.ncbi.nlm.nih.gov/pubmed/23195078.
  9. Huseini, H. F., Kianbakht, S., Hajiaghaee, R., and Dabaghian, F. H. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78(4):311-316. https://www.ncbi.nlm.nih.gov/pubmed/22198821
  10. Vogler, B. K. and Ernst, E. Aloe vera: a systematic review of its clinical effectiveness. Br.JGen.Pract. 1999;49(447):823-828. https://www.ncbi.nlm.nih.gov/pubmed/10885091.
  11. Yun, J. M., Singh, S., Jialal, R., Rockwood, J., Jialal, I., and Devaraj, S. A randomized placebo-controlled crossover trial of Aloe vera on bioavailability of vitamins C and B(12), blood glucose, and lipid profile in healthy human subjects. J.Diet.Suppl 2010;7(2):145-153. https://www.ncbi.nlm.nih.gov/pubmed/22435613.
  12. Vinson, J. A., Al Kharrat, H., and Andreoli, L. Effect of Aloe vera preparations on the human bioavailability of vitamins C and E. Phytomedicine 2005;12(10):760-765. https://www.ncbi.nlm.nih.gov/pubmed/16323295.
  13. Djuv A, Nilsen OG. Aloe Vera Juice: IC(50) and Dual Mechanistic Inhibition of CYP3A4 and CYP2D6. Phytother Res. 2011 Aug 15. doi: 10.1002/ptr.3564. https://www.ncbi.nlm.nih.gov/pubmed/21842479.
  14. Blumenthal M (ed.). The Complete German Commission E Monographs. Integrative Medicine Communications, Boston, Mass., 1998. https://www.elsevier.com/books/the-complete-german-commission-e-monographs/unknown/978-0-9655555-0-0
  15. Gruenwald J, Brendler T, Jaenicke C (eds.). PDR for Herbal Medicines. Medical Economics Co., Inc., Montvale, NJ, 1998. https://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf
  16. De Smet PAGM et al. (eds.). Adverse Effects of Herb Drugs 2. Springer-Verlag, Berlin, 1993.
  17. Lee A, Chui PT, Aun CST, et al. Possible interaction between sevoflurane and Aloe vera. Ann. Pharmacother., 38:1651-1654, 2004. https://www.ncbi.nlm.nih.gov/pubmed/15292490.
  18. Vazquez B, Avila G, Segura D, et al. Antiinflammatory activity of extracts from Aloe vera gel. J. Ethnopharm., 55:69-75, 1996. https://www.ncbi.nlm.nih.gov/pubmed/9121170.
  19. Lissoni, P., Rovelli, F., Brivio, F., Zago, R., Colciago, M., Messina, G., Mora, A., and Porro, G. A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. In Vivo 2009;23(1):171-175. https://www.ncbi.nlm.nih.gov/pubmed/19368145
  20. Hussain A, Sharma C, Khan S, Shah K, Haque S. Aloe vera inhibits proliferation of human breast and cervical cancer cells and acts synergistically with cisplatin. Asian Pac J Cancer Prev. 2015;16(7):2939-46. https://www.ncbi.nlm.nih.gov/pubmed/25854386.
  21. Hoopfer D, et al. Three-Arm Randomized Phase III Trial: Quality Aloe and Placebo Cream Versus Powder as Skin Treatment During Breast Cancer Radiation Therapy. Clin Breast Cancer. 2015 Jun;15(3):181-90.e1-4. Epub 2014 Dec 24. https://www.ncbi.nlm.nih.gov/pubmed/25619686.
  22. Siegers CP, von Hertzberg-Lottin E, Otte M, Schneider B. Anthranoid laxative abuse--a risk for colorectal cancer? Gut. 1993 Aug;34(8):1099-101. https://www.ncbi.nlm.nih.gov/pubmed/8174962.
  23. Pigatto, P.D.; Guzzi, G. Aloe linked to thyroid dysfunction. Arch. Med. Res 2005, 36(5), 608. http://zjrms.ir/files/site1/user_files_10e1c1/vahidasgary-A-10-1431-1-c525cc7.pdf.
  24. McDaniel, H., C.H.R.M. COmbs, Carpenter R, M. Kemp, B. McAnalley, 1990. An increase in circulating monocyte/macrophages (M/M) is induced by oral acemannan in HIV-1 patients. Am J Clin Pathol, 94: 516-7. https://pdfs.semanticscholar.org/B2ce/ee50bf076a9063da99577B6f15f82f904348.pdf.
  25. McDaniel, H., R. Carpenter, M. Kemp, J. Kahlon, B. McAnalley, 1990. Extended survival and prognostic criteria for Acemannan (ACE-M) treated HIV Patients. Antiviral Res Suppl, 1: 117. https://pdfs.semanticscholar.org/B2ce/ee50bf076a9063da99577B6f15f82f904348.pdf.
  26. M. C. Kemp, J. B. Kahlon, A. D. Chinnah, R. H. Carpenter, B. H. McAnalley, H. R. McDaniel and W. M. Shannon, “In Vitro Evaluation of the Antiviral Effects of Acemannan on the Replication and Pathogenesis of HIV-1 and Other Enveloped Viruses: Modification of the Processing of Glycoprotein Glycoprotein Precursors,” Antiviral Res, Vol. 13, Suppl. 1, 1990, p. 83. https://www.sciencedirect.com/science/article/pii/0166354290901562?via%3Dihub.
  27. Kahlon, J.B., M.C. Kemp, N. Yawei, R.H. Carpenter, W.M. Shannon, B.H. McAnalley, 1991. In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azidothymidine and acyclovir. Mol Biother, 3: 214-23. https://www.ncbi.nlm.nih.gov/pubmed/1662957.
  28. Montaner JS, Gill J, Singer J, Raboud J, Arseneau R, McLean BD, Schechter MT, Ruedy J. Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):153-7. https://www.ncbi.nlm.nih.gov/pubmed/8680886.

 

 

 




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