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21/12/2016

 

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( Trigonella foenum-graecum \ Fenugreek)

 
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( ). 

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, - 

(1)  (2).

- (3).

 

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 2012  -  

20 " "  45 . 

 

 2005    .

 200 " " ,

 

 2014  ,  MCF-7,

(6).

 

 2011  -  MCF-7.

- . 

-50 "/"  24 ,

 

 2010   -  (MCF-7).

20-320 "/". -

 

 2009   , ,

Akt\PKB (Protein Kinase B),

 

 2009  .

10-15 "/"

 

 2007 

    MCF-7  . 

-DNA ,

(11).

 

 2011     ,     PC-3

 

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, , –

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  1. Aradhana, Rao AR, Kale RK.Diosgenin--a growth stimulator of mammary gland of ovariectomized mouse. Indian J Exp Biol. 1992 May;30(5):367-70.
  2. Medigović I, Ristić N, Živanović J, Šošić-Jurjević B, Filipović B, Milošević V, Nestorović N.Diosgenin does not express estrogenic activity: a uterotrophic assay. Can J Physiol Pharmacol. 2014 Apr;92(4):292-8.
  3. Raju J, Mehta R. Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin. Nutr Cancer. 2009;61(1):27-35.
  4. Jagadeesan J, Nandakumar N, Rengarajan T, Balasubramanian MP. Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma. J Environ Pathol Toxicol Oncol. 2012;31(2):121-9.
  5. Amin A, Alkaabi A, Al-Falasi S, Daoud SA. Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer. Cell Biol Int. 2005 Aug;29(8):687-94.
  6. Alshatwi AA, Shafi G, Hasan TN, Syed NA, Khoja KK. Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated independently by fas receptor change. Asian Pac J Cancer Prev. 2013;14(10):5783-8.
  7. Khoja KK, Shaf G, Hasan TN, Syed NA, Al-Khalifa AS, Al-Assaf AH, Alshatwi AA. Fenugreek, a naturally occurring edible spice, kills MCF-7 human breast cancer cells via an apoptotic pathway. Asian Pac J Cancer Prev. 2011;12(12):3299-304.
  8. Sreeja S, Anju VS, Sreeja S. In vitro estrogenic activities of fenugreek Trigonella foenum graecum seeds. Indian J Med Res. 2010 jun;131:814-9.
  9. Srinivasan S, Koduru S, Kumar R, Venguswamy G, Kyprianou N, Damodaran C. Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells. Int J Cancer. 2009 Aug 15;125(4):961-7.
  10. Shabbeer S, Sobolewski M, Anchoori RK, Kachhap S, Hidalgo M, Jimeno A, Davidson N, Carducci MA, Khan SR. Fenugreek: a naturally occurring edible spice as an anticancer agent. Cancer Biol Ther. 2009 Feb;8(3):272-8.
  11. Sebastian KS, Thampan RV. Differential effects of soybean and fenugreek extracts on the growth of MCF-7 cells. Chem Biol Interact. 2007 Nov 20;170(2):135-43.
  12. Chen PS, Shih YW, Huang HC, Cheng HW. Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression. PLoS One. 2011;6(5):e20164.