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21/12/2016
 
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(Cimicifuga racemosa)

.

.

,  

-.

, ,  

/ .

.

 

-2007 , .

-949 -1542 .

 

-2007, , .

-18,861 , -1102 . 3.6 .

 

-2001(3), .

, .

.

,  LH -FSH  .

-85 (59 ), 42 -43 .

 

-2007 2.5% , .

-2 :

(Trace amounts) 2.5% .

-12 .

 

-2007 .

5 -21 -

.

 

-2013, .

.

2012.

450 , 26 : 14 -, 7 -5 .

,

 

-2012 , , .

35.7 "\" .

4 -12,6 -24 .

 

-2012 - -.

-4 (27%) -40 .

35.7, 7.14, 0.714 -0 "\" . .

 

-2002 .

 

.

-2004 , .

 

-2004 - , .

 

-2004, , ,

(Cinnamic acid).

 

-2006  Ze 450  .

 

-2007 - ,

.

 

-2007  MDA-MB 231.

 

-2013 (Actein) .

 

-2011 50 .

, .

, 1-4 2.5 " -6 (MRS II).

 

-2003 , .

-136 , :

-20 " ,

20 " (Menfen\Klimadynon).

-5 -12 .

.

 

-2007 , - (Formestane) .

-60 "\" 3.5 5.0 "   .

-21

 

-2007 ,

.

 

-2007(22)  (Actein), , ,

 MDA-MB-453.

 

-2007(23)  , '' (Irinotecan) .

.

 

.

-2006, , ,

  -.

 

-2005 .

 

-2005 , -

(LNCaP, PC-3,DU-145).

,

 

-2007 -  LNCap,  Petasiphenone  .

 

-2013, - .

,

 

-2004 , .

. , .

,

 

,

, .

 

.

 

:

 

  1. Rebbeck TR1, Troxel AB, Norman S, Bunin GR, DeMichele A, Baumgarten M, Berlin M, Schinnar R, Strom BL. A retrospective case-control study of the use of hormone-related supplements and association with breast cancer. Int J Cancer. 2007 Apr 1;120(7):1523-8.
  2. Henneicke-von Zepelin HH1, Meden H, Kostev K, Schröder-Bernhardi D, Stammwitz U, Becher H. Isopropanolic black cohosh extract and recurrence-free survival after breast cancer. Int J Clin Pharmacol Ther. 2007 Mar;45(3):143-54.
  3. Jacobson JS1, Troxel AB, Evans J, Klaus L, Vahdat L, Kinne D, Lo KM, Moore A, Rosenman PJ, Kaufman EL, Neugut AI,Grann VR. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol. 2001 May 15;19(10):2739-45.
  4. Ruhlen RL1, Haubner J, Tracy JK, Zhu W, Ehya H, Lamberson WR, Rottinghaus GE, Sauter ER. Black cohosh does not exert an estrogenic effect on the breast. Nutr Cancer. 2007;59(2):269-77.
  5. Walji R1, Boon H, Guns E, Oneschuk D, Younus J. Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patients. Support Care Cancer. 2007 Aug;15(8):913-21. Epub 2007 Jun 30.
  6. Fritz H1, Seely D, McGowan J, Skidmore B, Fernandes R, Kennedy DA, Cooley K, Wong R, Sagar S, Balneaves LG,Fergusson D. Black cohosh and breast cancer: a systematic review. Integr Cancer Ther. 2014 Jan;13(1):12-29. doi: 10.1177/1534735413477191. Epub 2013 Feb 25.
  7. Einbond LS1, Soffritti M, Esposti DD, Wu HA, Tibaldi E, Lauriola M, He K, Park T, Su T, Huggins L, Wang X, Roller M,Brennan R. Pharmacological mechanisms of black cohosh in Sprague-Dawley rats. Fitoterapia. 2012 Apr;83(3):461-8. doi: 10.1016/j.fitote.2011.12.011. Epub 2011 Dec 16.
  8. Einbond LS1, Soffritti M, Degli Esposti D, Tibaldi E, Lauriola M, Bua L, He K, Genovese G, Su T, Huggins L, Wang X,Roller M, Wu HA. Chemopreventive potential of black cohosh on breast cancer in Sprague-Dawley rats. Anticancer Res. 2012 Jan;32(1):21-30.
  9. Bodinet C1, Freudenstein J. Influence of Cimicifuga racemosa on the proliferation of estrogen receptor-positive human breast cancer cells. Breast Cancer Res Treat. 2002 Nov;76(1):1-10.
  10. Einbond LS1, Shimizu M, Xiao D, Nuntanakorn P, Lim JT, Suzui M, Seter C, Pertel T, Kennelly EJ, Kronenberg F,Weinstein IB. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Breast Cancer Res Treat. 2004 Feb;83(3):221-31.
  11. Hostanska K1, Nisslein T, Freudenstein J, Reichling J, Saller R. Cimicifuga racemosa extract inhibits proliferation of estrogen receptor-positive and negative human breast carcinoma cell lines by induction of apoptosis. Breast Cancer Res Treat. 2004 Mar;84(2):151-60.
  12. Hostanska K1, Nisslein T, Freudenstein J, Reichling J, Saller R. Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells. Biol Pharm Bull. 2004 Dec;27(12):1970-5.
  13. Garita-Hernandez M1, Calzado MA, Caballero FJ, Macho A, Muñoz E, Meier B, Brattström A, Fiebich BL, Appel K. The growth inhibitory activity of the Cimicifuga racemosa extract Ze 450 is mediated through estrogen and progesterone receptors-independent pathways. Planta Med. 2006 Mar;72(4):317-23.
  14. Gaube F1, Wolfl S, Pusch L, Kroll TC, Hamburger M. Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7. BMC Pharmacol. 2007 Sep 20;7:11.
  15. Einbond LS1, Su T, Wu HA, Friedman R, Wang X, Jiang B, Hagan T, Kennelly EJ, Kronenberg F, Weinstein IB. Gene expression analysis of the mechanisms whereby black cohosh inhibits human breast cancer cell growth. Anticancer Res. 2007 Mar-Apr;27(2):697-712.
  16. Hostanska K1, Nisslein T, Freudenstein J, Reichling J, Saller R. Inhibitory effect of an isopropanolic extract of black cohosh on the invasiveness of MDA-mB 231 human breast cancer cells. In Vivo. 2007 Mar-Apr;21(2):349-55.
  17. Einbond LS1, Mighty J, Redenti S, Wu HA. Actein induces calcium release in human breast cancer cells. Fitoterapia. 2013 Dec;91:28-38. doi: 10.1016/j.fitote.2013.07.025. Epub 2013 Aug 9.
  18. Rostock M1, Fischer J, Mumm A, Stammwitz U, Saller R, Bartsch HH. Black cohosh (Cimicifuga racemosa) in tamoxifen-treated breast cancer patients with climacteric complaints - a prospective observational study. Gynecol Endocrinol. 2011 Oct;27(10):844-8. doi: 10.3109/09513590.2010.538097. Epub 2011 Jan 13.
  19. Hernández Muñoz G1, Pluchino S. Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer. Maturitas. 2003 Mar 14;44 Suppl 1:S59-65.
  20. Nisslein T1, Freudenstein J. Coadministration of the aromatase inhibitor formestane and an isopropanolic extract of black cohosh in a rat model of chemically induced mammary carcinoma. Planta Med. 2007 Apr;73(4):318-22. Epub 2007 Mar 12.
  21. Al-Akoum M1, Dodin S, Akoum A. Synergistic cytotoxic effects of tamoxifen and black cohosh on MCF-7 and MDA-MB-231 human breast cancer cells: an in vitro study. Can J Physiol Pharmacol. 2007 Nov;85(11):1153-9.
  22. Einbond LS1, Shimizu M, Nuntanakorn P, Seter C, Cheng R, Jiang B, Kronenberg F, Kennelly EJ, Weinstein IB. Actein and a fraction of black cohosh potentiate antiproliferative effects of chemotherapy agents on human breast cancer cells. Planta Med. 2006 Oct;72(13):1200-6. Epub 2006 Sep 20.
  23. Gorman GS1, Coward L, Darby A, Rasberry B. Effects of herbal supplements on the bioactivation of chemotherapeutic agents. J Pharm Pharmacol. 2013 Jul;65(7):1014-25. doi: 10.1111/jphp.12055. Epub 2013 Mar 25.
  24. Seidlová-Wuttke D1, Thelen P, Wuttke W. Inhibitory effects of a black cohosh (Cimicifuga racemosa) extract on prostate cancer. Planta Med. 2006 May;72(6):521-6.
  25. Jarry H1, Thelen P, Christoffel V, Spengler B, Wuttke W. Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP. Phytomedicine. 2005 Mar;12(3):178-82.
  26. Hostanska K1, Nisslein T, Freudenstein J, Reichling J, Saller R. Apoptosis of human prostate androgen-dependent and -independent carcinoma cells induced by an isopropanolic extract of black cohosh involves degradation of cytokeratin (CK) 18. Anticancer Res. 2005 Jan-Feb;25(1A):139-47.
  27. Jarry H1, Stromeier S, Wuttke W, Nahrstedt A. Petasiphenone, a phenol isolated from Cimicifuga racemosa, in vitro inhibits proliferation of the human prostate cancer cell line LNCaP. Planta Med. 2007 Feb;73(2):184-7. Epub 2007 Feb 13.
  28. Dueregger A1, Guggenberger F, Barthelmes J, Stecher G, Schuh M, Intelmann D, Abel G, Haunschild J, Klocker H,Ramoner R, Sampson N. Attenuation of nucleoside and anti-cancer nucleoside analog drug uptake in prostate cancer cells by Cimicifuga racemosa extract BNO-1055. Phytomedicine. 2013 Nov 15;20(14):1306-14. doi: 10.1016/j.phymed.2013.07.009. Epub 2013 Aug 23.
  29. Nisslein T1, Freudenstein J. Concomitant administration of an isopropanolic extract of black cohosh and tamoxifen in the in vivo tumor model of implanted RUCA-I rat endometrial adenocarcinoma cells. Toxicol Lett. 2004 May 2;150(3):271-5.